Fatal ODs From Illicit Tranquilizers Jumped 6-Fold During Pandemic
THURSDAY, Aug. 26, 2021 -- Overdose deaths linked to illicit " designer " benzodiazepines have surged in the United States, as underground labs crank out new synthetic variations on prescription tranquilizers like Valium, Xanax and Ativan. Overdose... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - August 26, 2021 Category: General Medicine Source Type: news

Aquestive Therapeutics Announces FDA Acceptance of New Drug Application (NDA) Resubmission for Libervant (diazepam) Buccal Film
WARREN, N.J., July 19, 2021 (GLOBE NEWSWIRE) -- Aquestive Therapeutics, Inc. (NASDAQ: AQST), a pharmaceutical company focused on developing and commercializing differentiated products that address patients’ unmet needs and solve therapeutic... (Source: Drugs.com - New Drug Applications)
Source: Drugs.com - New Drug Applications - July 19, 2021 Category: Drugs & Pharmacology Source Type: news

'Fake pills' leave several seriously ill in Swansea hospital
It is thought tablets are being sold as Valium and Xanax, prompting a warning from health officials. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - July 8, 2021 Category: Consumer Health News Source Type: news

Aquestive Therapeutics Resubmits New Drug Application for Libervant (diazepam) Buccal Film
WARREN, N.J., June 24, 2021 (GLOBE NEWSWIRE) -- Aquestive Therapeutics, Inc. (NASDAQ: AQST), a pharmaceutical company focused on developing and commercializing differentiated products that address patients’ unmet needs and solve therapeutic... (Source: Drugs.com - New Drug Applications)
Source: Drugs.com - New Drug Applications - June 24, 2021 Category: Drugs & Pharmacology Source Type: news

Suicide committed by a paramedic using a cocktail of drugs: morphine, etomidate, diazepam and rocuronium. case report and review of literature - Sm ędra A, Wochna K, Kaźmierski D, Berent J.
Suicide is still an important issue in developed countries. The problem affects all age groups and both sexes, although usually more commonly middle-aged men. Attempted suicides committed by taking drugs ended in death are rare (regardless of gender, age, ... (Source: SafetyLit)
Source: SafetyLit - June 8, 2021 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Hooked on the ANXIETY pills experts are calling the new VALIUM
Sharon Davies has a simple message for anyone whose GP recommends they start taking the drug pregabalin to deal with anxiety. 'Don't,' she says. 'Please, just don't.' (Source: the Mail online | Health)
Source: the Mail online | Health - April 26, 2021 Category: Consumer Health News Source Type: news

'Safe' Z-drug sleeping tablets given to MILLIONS each year are as addictive as Valium
When it was launched in Britain in the 1990s, zopiclone was touted as a user-friendly alternative to older and notoriously addictive tranquillisers. (Source: the Mail online | Health)
Source: the Mail online | Health - April 17, 2021 Category: Consumer Health News Source Type: news

Class 4 medicines defect information: Diazepam 2mg/5ml Oral Solution Sugar Free
Accord-UK Ltd has informed the Medicines and Healthcare products Regulatory Agency (MHRA) that important safety warnings for the excipient Propylene glycol are missing from the patient information lea (Source: Royal Pharmaceutical Society News)
Source: Royal Pharmaceutical Society News - March 9, 2021 Category: Drugs & Pharmacology Source Type: news

The Child in Status Epilepticus Dilemma
The following case is based on a real-life situation, highlighting the difficulties in applying ethical decisions in the prehospital critical care setting. While the case is based from the United Kingdom, it ought to be applicable to similar EMS systems and settings. Kassirer et al. highlight that discussing real-world scenarios helps exemplify reasoning (both good and bad) that the reader ought to relate to within similar and future contexts.1 During the start of a night shift, an ambulance crew consisting of a paramedic and an assistant (EMT-B) are dispatched to a 10-year-old child in status epilepticus (SE). The pati...
Source: JEMS Patient Care - January 12, 2021 Category: Emergency Medicine Authors: JEMS Staff Tags: Best Practices Exclusives Patient Care Pediatric Care Seizure Source Type: news

The Child in Status Epilepticus Dilemma
The following case is based on a real-life situation, highlighting the difficulties in applying ethical decisions in the prehospital critical care setting. While the case is based from the United Kingdom, it ought to be applicable to similar EMS systems and settings. Kassirer et al. highlight that discussing real-world scenarios helps exemplify reasoning (both good and bad) that the reader ought to relate to within similar and future contexts.1 During the start of a night shift, an ambulance crew consisting of a paramedic and an assistant (EMT-B) are dispatched to a 10-year-old child in status epilepticus (SE). The pati...
Source: JEMS Administration and Leadership - January 12, 2021 Category: Emergency Medicine Authors: JEMS Staff Tags: Best Practices Exclusives Patient Care Pediatric Care Seizure Source Type: news

The Child in Status Epilepticus Dilemma
The following case is based on a real-life situation, highlighting the difficulties in applying ethical decisions in the prehospital critical care setting. While the case is based from the United Kingdom, it ought to be applicable to similar EMS systems and settings. Kassirer et al. highlight that discussing real-world scenarios helps exemplify reasoning (both good and bad) that the reader ought to relate to within similar and future contexts.1 During the start of a night shift, an ambulance crew consisting of a paramedic and an assistant (EMT-B) are dispatched to a 10-year-old child in status epilepticus (SE). The pati...
Source: JEMS: Journal of Emergency Medical Services News - January 12, 2021 Category: Emergency Medicine Authors: JEMS Staff Tags: Best Practices Exclusives Patient Care Pediatric Care Seizure Source Type: news

The Child in Status Epilepticus Dilemma
The following case is based on a real-life situation, highlighting the difficulties in applying ethical decisions in the prehospital critical care setting. While the case is based from the United Kingdom, it ought to be applicable to similar EMS systems and settings. Kassirer et al. highlight that discussing real-world scenarios helps exemplify reasoning (both good and bad) that the reader ought to relate to within similar and future contexts.1 During the start of a night shift, an ambulance crew consisting of a paramedic and an assistant (EMT-B) are dispatched to a 10-year-old child in status epilepticus (SE). The pati...
Source: JEMS Operations - January 12, 2021 Category: Emergency Medicine Authors: JEMS Staff Tags: Best Practices Exclusives Patient Care Pediatric Care Seizure Source Type: news

The Child in Status Epilepticus Dilemma
The following case is based on a real-life situation, highlighting the difficulties in applying ethical decisions in the prehospital critical care setting. While the case is based from the United Kingdom, it ought to be applicable to similar EMS systems and settings. Kassirer et al. highlight that discussing real-world scenarios helps exemplify reasoning (both good and bad) that the reader ought to relate to within similar and future contexts.1 During the start of a night shift, an ambulance crew consisting of a paramedic and an assistant (EMT-B) are dispatched to a 10-year-old child in status epilepticus (SE). The pati...
Source: JEMS Special Topics - January 12, 2021 Category: Emergency Medicine Authors: JEMS Staff Tags: Best Practices Exclusives Patient Care Pediatric Care Seizure Source Type: news

The Child in Status Epilepticus Dilemma
The following case is based on a real-life situation, highlighting the difficulties in applying ethical decisions in the prehospital critical care setting. While the case is based from the United Kingdom, it ought to be applicable to similar EMS systems and settings. Kassirer et al. highlight that discussing real-world scenarios helps exemplify reasoning (both good and bad) that the reader ought to relate to within similar and future contexts.1 During the start of a night shift, an ambulance crew consisting of a paramedic and an assistant (EMT-B) are dispatched to a 10-year-old child in status epilepticus (SE). The pati...
Source: JEMS Latest News - January 12, 2021 Category: Emergency Medicine Authors: JEMS Staff Tags: Best Practices Exclusives Patient Care Pediatric Care Seizure Source Type: news

Seizure in the Skies of Remoteness: A Case Review
Conclusion While this case review describes an unusual approach to a medical retrieval, remote health care providers in developing nations face major clinical, ethical and legal challenges such as these described. The challenges of prehospital care are dynamic, yet in the remote context they are even more so. In these situations, a careful assessment of risk verses reward is paramount. In these situations, it I just as important to withhold certain interventions as it is to administer them. References Broughton W. Pre-hospital paediatric seizures: midazolam versus diazepam. Journal of Paramedic Practice. 2014;6(10...
Source: JEMS Patient Care - December 15, 2020 Category: Emergency Medicine Authors: JEMS Staff Tags: Exclusives International Patient Care Air Ambulance Case Report EMS Paramedic Source Type: news

Seizure in the Skies of Remoteness: A Case Review
Conclusion While this case review describes an unusual approach to a medical retrieval, remote health care providers in developing nations face major clinical, ethical and legal challenges such as these described. The challenges of prehospital care are dynamic, yet in the remote context they are even more so. In these situations, a careful assessment of risk verses reward is paramount. In these situations, it I just as important to withhold certain interventions as it is to administer them. References Broughton W. Pre-hospital paediatric seizures: midazolam versus diazepam. Journal of Paramedic Practice. 2014;6(10...
Source: JEMS Administration and Leadership - December 15, 2020 Category: Emergency Medicine Authors: JEMS Staff Tags: Exclusives International Patient Care Air Ambulance Case Report EMS Paramedic Source Type: news

Seizure in the Skies of Remoteness: A Case Review
Conclusion While this case review describes an unusual approach to a medical retrieval, remote health care providers in developing nations face major clinical, ethical and legal challenges such as these described. The challenges of prehospital care are dynamic, yet in the remote context they are even more so. In these situations, a careful assessment of risk verses reward is paramount. In these situations, it I just as important to withhold certain interventions as it is to administer them. References Broughton W. Pre-hospital paediatric seizures: midazolam versus diazepam. Journal of Paramedic Practice. 2014;6(10...
Source: JEMS: Journal of Emergency Medical Services News - December 15, 2020 Category: Emergency Medicine Authors: JEMS Staff Tags: Exclusives International Patient Care Air Ambulance Case Report EMS Paramedic Source Type: news

Seizure in the Skies of Remoteness: A Case Review
Conclusion While this case review describes an unusual approach to a medical retrieval, remote health care providers in developing nations face major clinical, ethical and legal challenges such as these described. The challenges of prehospital care are dynamic, yet in the remote context they are even more so. In these situations, a careful assessment of risk verses reward is paramount. In these situations, it I just as important to withhold certain interventions as it is to administer them. References Broughton W. Pre-hospital paediatric seizures: midazolam versus diazepam. Journal of Paramedic Practice. 2014;6(10...
Source: JEMS Operations - December 15, 2020 Category: Emergency Medicine Authors: JEMS Staff Tags: Exclusives International Patient Care Air Ambulance Case Report EMS Paramedic Source Type: news

Seizure in the Skies of Remoteness: A Case Review
Conclusion While this case review describes an unusual approach to a medical retrieval, remote health care providers in developing nations face major clinical, ethical and legal challenges such as these described. The challenges of prehospital care are dynamic, yet in the remote context they are even more so. In these situations, a careful assessment of risk verses reward is paramount. In these situations, it I just as important to withhold certain interventions as it is to administer them. References Broughton W. Pre-hospital paediatric seizures: midazolam versus diazepam. Journal of Paramedic Practice. 2014;6(10...
Source: JEMS Special Topics - December 15, 2020 Category: Emergency Medicine Authors: JEMS Staff Tags: Exclusives International Patient Care Air Ambulance Case Report EMS Paramedic Source Type: news

Seizure in the Skies of Remoteness: A Case Review
Conclusion While this case review describes an unusual approach to a medical retrieval, remote healthcare providers in developing nations face major clinical, ethical and legal challenges such as these described. The challenges of prehospital care are dynamic, yet in the remote context they are even more so. In these situations, a careful assessment of risk verses reward is paramount. In these situations, it I just as important to withhold certain interventions as it is to administer them. References Broughton W. Pre-hospital paediatric seizures: midazolam versus diazepam. Journal of Paramedic Practice. 2014;6(10)...
Source: JEMS Latest News - December 15, 2020 Category: Emergency Medicine Authors: JEMS Staff Tags: Exclusives International Patient Care Air Ambulance Case Report EMS Paramedic Source Type: news

Effects of diazepam on reaction times to stop and go - Sarkar S, Choudhury S, Islam N, Chowdhury MSJH, Chowdhury MTI, Baker MR, Baker SN, Kumar H.
INTRODUCTION: The ability to stop the execution of a movement in response to an external cue requires intact executive function. The effect of psychotropic drugs on movement inhibition is largely unknown. Movement stopping can be estimated by the Stop Sign... (Source: SafetyLit)
Source: SafetyLit - November 4, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Aquestive Therapeutics Receives Complete Response Letter from FDA for Libervant (diazepam) Buccal Film for Management of Seizure Clusters
WARREN, N.J., Sept. 25, 2020 (GLOBE NEWSWIRE) -- Aquestive Therapeutics, Inc. (NASDAQ: AQST), a pharmaceutical company focused on developing and commercializing differentiated products that address patients’ unmet needs and solve therapeutic... (Source: Drugs.com - New Drug Applications)
Source: Drugs.com - New Drug Applications - September 25, 2020 Category: Drugs & Pharmacology Source Type: news

FDA Adds Abuse Warning to Labels for Xanax, Valium
THURSDAY, Sept. 24, 2020 -- Reacting to an upsurge in abuse of benzodiazepine sedatives such as Valium, Xanax and Ativan, U.S. officials on Wednesday added a " Boxed Warning " to the drugs'labels, cautioning about the danger. Benzodiazepines are... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - September 24, 2020 Category: General Medicine Source Type: news

Valtoco (Diazepam Nasal Spray) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - September 10, 2020 Category: Drugs & Pharmacology Source Type: news

Psychiatrists sound alarm over the thousands hooked on 'Valium on steroids'
MIRANDA LEVY: For more than five years, I'd had many pills thrown at me, from antidepressants to Valium. I had a hell of a time getting off Valium, which is well known for being addictive (Source: the Mail online | Health)
Source: the Mail online | Health - August 22, 2020 Category: Consumer Health News Source Type: news

Lebanon County Man Charged with Trafficking Counterfeit Drugs
FDA OCI, Stefan Knoche, Lebanon PA, trafficking, counterfeit drugs, darknet, Viagra, Aurogra, Xanax, Levitra, Cialis, Valium, (Source: Office of Criminal Investigations (OCI) Press Releases)
Source: Office of Criminal Investigations (OCI) Press Releases - August 10, 2020 Category: Medical Law Authors: DOJ Source Type: news

Public Health England issues rare alert over illicit prescription drugs
Surge in tablets sold as benzodiazepines, used to treat anxiety or insomnia, linked to hospitalisations and deathsA surge in illicit prescription drugs that have been linked to hospitalisations and deaths in England has prompted health officials to issue a rare national alert.Public Health England (PHE)issued the alert to drug treatment services and healthcare providers about the availability of illicit tablets being sold as benzodiazepines, such as Xanax and diazepam, which can be prescribed to treat anxiety or insomnia.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - August 5, 2020 Category: Science Authors: Jamie Grierson Home affairs correspondent Tags: Drugs Health Society UK news Science NHS Source Type: news

Nigeria: Non-Medical Use of Prescription Drugs Among Skilled Workers - a Pilot Study
[The Conversation Africa] More than ever, the world is facing a challenge of non-medical use of prescription drugs among people of all ages, genders and occupations. Evidence shows that pharmaceutical opioids (tramadol, codeine, or morphine), barbiturates such as pentobarbital sodium, benzodiazepines (diazepam and alprazolam), and amphetamines are the most common types of prescription medication used in a non-medical context. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - June 25, 2020 Category: African Health Source Type: news

Nigeria: Drughelpnet - a Lifeline for Female Drug Users in the Midst of a Pandemic
[This Day] Abuja -Yemisi, a student in one of the more than 170 Nigerian universities, is pregnant and a drug user. As a result of the COVID-19 imposed lockdown, her university was closed and she had to go back home to stay with her family, a typically conservative Nigerian family, who are unaware of her drug use habit or that she is pregnant without being married. Yemisi, already five months pregnant, is yet to enroll in an antenatal programme and uses a cocktail of drugs (cannabis, codeine and diazepam) which are all harm (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - June 20, 2020 Category: African Health Source Type: news

Neurelis Announces Rapid and Broad Payer Coverage of the Company's Flagship Product, VALTOCO(R) (Diazepam Nasal Spray)
More than 176 million lives in the U.S. now covered by payers/managed care/insurance plans within months of FDA approval of VALTOCO, the first and only nasal spray treatment of seizure clusters in patients 6 years of age and older Neurelis' patient assi... Biopharmaceuticals, Reimbursement Neurelis, VALTOCO, diazepam, epilepsy (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - June 8, 2020 Category: Pharmaceuticals Source Type: news

Meds Like Valium, Xanax Linked to Higher Risk of Ectopic Pregnancy
WEDNESDAY, June 3, 2020 -- Taking benzodiazepines -- drugs such as Xanax, Valium, Klonopin, Halcion or Ativan -- to treat anxiety or insomnia before pregnancy boosts the risk of an ectopic pregnancy, new research suggests. Ectopic pregnancy is a... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - June 3, 2020 Category: General Medicine Source Type: news

Benzodiazepines Tied to Higher Risk of Ectopic Pregnancy
Use of drugs like Valium or Xanax before pregnancy may increase the risk for ectopic pregnancy. (Source: NYT Health)
Source: NYT Health - June 3, 2020 Category: Consumer Health News Authors: Nicholas Bakalar Tags: Pregnancy and Childbirth Women and Girls Drugs (Pharmaceuticals) Source Type: news

Diazepam Premedication in Primary Augmentation Mammoplasty Diazepam Premedication in Primary Augmentation Mammoplasty
What are the benefits and drawbacks of preoperative diazepam administration among patients undergoing primary augmentation mammoplasty?ePlasty, Open Access Journal of Plastic Surgery (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - June 2, 2020 Category: Surgery Tags: Plastic Surgery & Aesthetic Medicine Journal Article Source Type: news

Acute chloroquine poisoning: a comprehensive experimental toxicology assessment of the role of diazepam - Hughes DA.
BACKGROUND AND PURPOSE: Resurgence in the use of chloroquine as a putative treatment for COVID-19 has seen recent cases of fatal toxicity due to unintentional overdoses. Protocols for the management of poisoning recommend diazepam, although there are uncer... (Source: SafetyLit)
Source: SafetyLit - May 20, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

What Are Some Risk Factors for Cerebral Palsy?
Discussion The term, cerebral palsy, or CP has gone through many iterations with the first description in 1861 by W.J. Little who described it as “The condition of spastic rigidity of the limbs of newborn children.” The most recent definition is from Rosenbaun et al. in 2007 which states it is “a group of permanent disorders of the development of movement and posture, causing activity limitation, that are attributed to non-progressive disturbances that occurred in the developing fetal or infant brain. The motor disorders of cerebral palsy are often accompanied by disturbances of sensation, perception, cog...
Source: PediatricEducation.org - March 9, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Understanding the link between nicotine use and misuse of 'benzos'
(Georgetown University Medical Center) Lately, misuse of prescription benzodiazepines (such as alprazolam or Xanax, and diazepam or Valium) has been linked to nicotine use. Evidence of how nicotine 'sets up' a craving for benzodiazepines -- often called 'benzos' -- in animal laboratory studies has been published in the open-access journal eNeuro. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - February 26, 2020 Category: International Medicine & Public Health Source Type: news

Valtoco (Diazepam Nasal Spray) - new on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - February 5, 2020 Category: Drugs & Pharmacology Source Type: news

FDA Approves Valtoco (diazepam nasal spray) as a Seizure Rescue Treatment
SAN DIEGO, CA– January 13, 2020– Neurelis, Inc., today announced that the U.S. Food and Drug Administration (FDA) has approved Valtoco (diazepam nasal spray) as an acute treatment of intermittent, stereotypic episodes of frequent... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - January 13, 2020 Category: Drugs & Pharmacology Source Type: news

Heavy Drinking Plus Xanax, Valium: A Dangerous Mix
(Source: The Doctors Lounge - Psychiatry)
Source: The Doctors Lounge - Psychiatry - December 26, 2019 Category: Psychiatry Tags: Pharmacy, Psychiatry, Dependence, Preventive Medicine, News, Source Type: news

Heavy Drinking Plus Xanax, Valium: A Dangerous Mix
THURSDAY, Dec. 26, 2019 -- People who regularly drink to excess are also likely to use benzodiazepines, a new study finds. These drugs -- like Valium (diazepam), Xanax (alprazolam), Klonopin (clonazepam), Ativan (lorazepam), and Restoril... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - December 26, 2019 Category: General Medicine Source Type: news

More U.S. Teens Are Overdosing on Valium, Xanax
TUESDAY, Dec. 24, 2019 -- The number of kids overdosing on commonly prescribed anxiety medications such as Xanax, Valium or Ativan has risen dramatically during the past decade, a new study shows. Child and teenage ODs caused by these... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - December 24, 2019 Category: General Medicine Source Type: news

Children with epilepsy to have access to cannabis-based medicine
Treatment could reduce numbers of seizures by 40% Related items fromOnMedica Tougher restrictions on valproates Lorazepam no better than diazepam for child seizures One in 10 children in phase I cancer trials respond to drugs Children need access to cancer drug ‘goldmine’ Codeine not to be used for coughs and colds in children under 12 (Source: OnMedica Latest News)
Source: OnMedica Latest News - December 22, 2019 Category: UK Health Source Type: news

Seizures of illegal diazepam tablets double in a year
Doctors warn people cannot trust the authenticity of drugs bought from rogue online pharmacies or dealers. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - December 5, 2019 Category: Consumer Health News Source Type: news

Aquestive Therapeutics Completes Rolling Submission of New Drug Application (NDA) to U.S. Food and Drug Administration (FDA) for Libervant (diazepam) Buccal Film for Management of Seizure Clusters
WARREN, N.J., Dec. 02, 2019 (GLOBE NEWSWIRE) -- Aquestive Therapeutics, Inc. (NASDAQ:AQST), a specialty pharmaceutical company focused on developing and commercializing differentiated products that meet patients’ unmet needs and... (Source: Drugs.com - New Drug Applications)
Source: Drugs.com - New Drug Applications - December 2, 2019 Category: Drugs & Pharmacology Source Type: news

'Street valium' deaths prompt public health warning
A drug that's 10 times more toxic than Valium and is often mixed with powerful opioids has killed at least five people this year in Ontario, and public health officials worry there may be more deaths. (Source: CBC | Health)
Source: CBC | Health - October 17, 2019 Category: Consumer Health News Tags: News/Canada/Ottawa Source Type: news

‘Sticky’ gene may help Valium calm nerves
NIH mouse study could prompt scientists to rethink how benzodiazepines work. (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - October 10, 2019 Category: American Health Source Type: news

Shisa7 is a GABAA receptor auxiliary subunit controlling benzodiazepine actions
The function and pharmacology of -aminobutyric acid type A receptors (GABAARs) are of great physiological and clinical importance and have long been thought to be determined by the channel pore–forming subunits. We discovered that Shisa7, a single-passing transmembrane protein, localizes at GABAergic inhibitory synapses and interacts with GABAARs. Shisa7 controls receptor abundance at synapses and speeds up the channel deactivation kinetics. Shisa7 also potently enhances the action of diazepam, a classic benzodiazepine, on GABAARs. Genetic deletion of Shisa7 selectively impairs GABAergic transmission and diminishes t...
Source: ScienceNOW - October 9, 2019 Category: Science Authors: Han, W., Li, J., Pelkey, K. A., Pandey, S., Chen, X., Wang, Y.-X., Wu, K., Ge, L., Li, T., Castellano, D., Liu, C., Wu, L.-G., Petralia, R. S., Lynch, J. W., McBain, C. J., Lu, W. Tags: Neuroscience reports Source Type: news