Diazepam-based covalent modifiers of GPX4 induce ferroptosis in liver cancer cells
Chem. Commun., 2024, Accepted Manuscript DOI: 10.1039/D3CC06215E, CommunicationDharmendra Yadav, Sona Tiwari, Sathyapriya Senthil, Sai Kumari Vechalapu, Santhosh Duraisamy, Viral Rawat, Mohammed Isfahur Rahman, Shweta Khanna, Dharmaraja Allimuthu Developing new chemotherapeutics that are structurally and mechanistically unique is a need due to the rapid rise of cancer incidences across the globe. Here we report the identification of irreversible,... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Chem. Commun. latest articles)
Source: RSC - Chem. Commun. latest articles - January 15, 2024 Category: Chemistry Authors: Dharmendra Yadav Source Type: research
Rapid Rescue Treatment with Diazepam Nasal Spray Leads to Faster Seizure Cluster Termination in Epilepsy: An Exploratory Post Hoc Cohort Analysis
ConclusionEchoing the importance of early use of benzodiazepines in status epilepticus, the findings from this exploratory analysis of patients with refractory epilepsy and frequent seizure clusters identify a potential benefit of early diazepam nasal spray treatment leading to faster seizure resolution within the seizure cluster.Trial Registration Information: ClinicalTrials.gov identifier NCT02721069 (https://clinicaltrials.gov/ct2/show/NCT02721069). (Source: Neurology and Therapy)
Source: Neurology and Therapy - January 4, 2024 Category: Neurology Source Type: research
Latrodectus envenomation in Ethiopia
We described a black widow envenomation case that produced a significant reaction, including diaphoresis and excruciating pain throughout the left thigh that later spread to the lower leg, lower back, belly, and chest. Because of the patient ’s description of the spider that bit him and his typical clinical state, it was assumed that Latrodectus envenomation was the cause of his symptoms. The patient received 3 days of observation in the ED while receiving opioid analgesic pain management and muscle relaxant treatment with diazepam. The patient's pain and symptoms were satisfactorily managed, and he was sent home. This ...
Source: International Journal of Emergency Medicine - January 2, 2024 Category: Emergency Medicine Source Type: research
Combining surface ‐enhanced Raman spectroscopy and paper spray mass spectrometry for the identification and confirmation of psychotropic substances in alcoholic beverages
AbstractCriminal practices in which an individual becomes vulnerable and prone to sexual assault after ingesting drinks spiked with doping substances have become a social concern globally. As forensic protocols require a multi-tiered strategy for chemical evidentiary analysis, the backlog of evidence has become a significant problem in the community. Herein, a fast, sensible, and complementary dual analytical methodology was developed using a single commercial paper substrate for surface-enhanced Raman spectroscopy (SERS) and paper spray mass spectrometry (PS-MS) analysis to identify psychotropic substances added to alcoho...
Source: Journal of Mass Spectrometry - December 26, 2023 Category: Chemistry Authors: Marina Jurisch,
Cristiano Fantini,
Rodinei Augusti,
Mariana Ramos Almeida Tags: RESEARCH ARTICLE Source Type: research
Antiseizure Effects of < em > Peganum harmala < /em > L. and < em > Lavandula angustifolia < /em >
This study evaluated the effects of these two herbal extracts on pentylenetetrazol- (PTZ-) induced seizures in mice. We prepared hydroalcoholic extracts using P. harmala seeds and the aerial parts of L. angustifolia and then randomly divided 190 mice into 19 groups. Normal saline (10 mg/kg), diazepam (2 mg/kg), P. harmala (2.5, 5, 10, 15, 30, 45, and 60 mg/kg), and L. angustifolia (200, 400, 600, and 800 mg/kg) were intraperitoneally (IP) administrated 30 min before an IP administration of PTZ (90 mg/kg). Animals were observed for behavioral changes for one hour. In addition, the effects of flumazenil and naloxone on the a...
Source: Biomed Res - December 13, 2023 Category: Research Authors: Zahra Rahimian SeyedHassan Sadrian Mina Shahisavandi Hadi Aligholi Mohammad M Zarshenas Alireza Abyar Zahra Zeraatpisheh Ali A Asadi-Pooya Source Type: research
Effects of chronic diazepam exposure on the behaviors and oxidative stress homeostasis in the eyes and brains of female Japanese medaka
In this study, we exposed female Japanese medaka (Oryzias latipes) to environmentally relevant doses of DZP (800 and 8000 ng/L) for 4 weeks, aimed to investigate their behavioral responses and possible links with ocular and brain oxidative stress homeostasis. As a result, DZP exposure could significantly reduce swimming activity (800 ng/L) and anxiety (800 and 8000 ng/L), indicating a sedative effect on medaka. The DZP exposure also significantly increased the social interaction in medaka at 8000 ng/L. Furthermore, exposure to DZP could alter the ocular and brain oxidative stress homeostasis in medaka. The ocular CAT activ...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - December 6, 2023 Category: Biochemistry Authors: Sijing Wang Jiao Dong Kun Chen Yanhong Shi Xuchun Qiu Source Type: research
Corrigendum to "Diazepam enhances melanogenesis, melanocyte dendricity and melanosome transport via the PBR/cAMP/PKA pathway" [Int. J. Biochem. Cell Biol. 116 (2019) 105620]
Int J Biochem Cell Biol. 2023 Dec 5:106505. doi: 10.1016/j.biocel.2023.106505. Online ahead of print.NO ABSTRACTPMID:38057196 | DOI:10.1016/j.biocel.2023.106505 (Source: The International Journal of Biochemistry and Cell Biology)
Source: The International Journal of Biochemistry and Cell Biology - December 6, 2023 Category: Biochemistry Authors: Jinpeng Lv Ying Fu Rongyin Gao Jiawen Li Maofan Kang Guoqiang Song Changjun Yun Source Type: research
When the fever will not stop, stop the pills! A case report
CONCLUSION: Antipsychotic agents are commonly employed to manage behavioral changes linked to various disorders. However, their severe side effects necessitate a high degree of vigilance, the cessation of all medications, and the implementation of supportive care measures. A prompt and accurate diagnosis of NMS is crucial to alleviating the severe, prolonged morbidity and potential mortality associated with this syndrome.PMID:38055420 | DOI:10.1590/1516-3180.2022.0401.R1.13032023 (Source: Sao Paulo Medical Journal)
Source: Sao Paulo Medical Journal - December 6, 2023 Category: General Medicine Authors: C ésar Ricardo Coimbra de Matos Eduarda Maria da Concei ção Sério Pereira Beirão Rafael Sim ões Neves Ant ónio José Assunção Rui Moreira Marques Source Type: research
Effects of chronic diazepam exposure on the behaviors and oxidative stress homeostasis in the eyes and brains of female Japanese medaka
In this study, we exposed female Japanese medaka (Oryzias latipes) to environmentally relevant doses of DZP (800 and 8000 ng/L) for 4 weeks, aimed to investigate their behavioral responses and possible links with ocular and brain oxidative stress homeostasis. As a result, DZP exposure could significantly reduce swimming activity (800 ng/L) and anxiety (800 and 8000 ng/L), indicating a sedative effect on medaka. The DZP exposure also significantly increased the social interaction in medaka at 8000 ng/L. Furthermore, exposure to DZP could alter the ocular and brain oxidative stress homeostasis in medaka. The ocular CAT activ...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - December 6, 2023 Category: Biochemistry Authors: Sijing Wang Jiao Dong Kun Chen Yanhong Shi Xuchun Qiu Source Type: research
Corrigendum to "Diazepam enhances melanogenesis, melanocyte dendricity and melanosome transport via the PBR/cAMP/PKA pathway" [Int. J. Biochem. Cell Biol. 116 (2019) 105620]
Int J Biochem Cell Biol. 2023 Dec 5:106505. doi: 10.1016/j.biocel.2023.106505. Online ahead of print.NO ABSTRACTPMID:38057196 | DOI:10.1016/j.biocel.2023.106505 (Source: The International Journal of Biochemistry and Cell Biology)
Source: The International Journal of Biochemistry and Cell Biology - December 6, 2023 Category: Biochemistry Authors: Jinpeng Lv Ying Fu Rongyin Gao Jiawen Li Maofan Kang Guoqiang Song Changjun Yun Source Type: research
When the fever will not stop, stop the pills! A case report
CONCLUSION: Antipsychotic agents are commonly employed to manage behavioral changes linked to various disorders. However, their severe side effects necessitate a high degree of vigilance, the cessation of all medications, and the implementation of supportive care measures. A prompt and accurate diagnosis of NMS is crucial to alleviating the severe, prolonged morbidity and potential mortality associated with this syndrome.PMID:38055420 | PMC:PMC10703491 | DOI:10.1590/1516-3180.2022.0401.R1.13032023 (Source: Sao Paulo Medical Journal)
Source: Sao Paulo Medical Journal - December 6, 2023 Category: General Medicine Authors: C ésar Ricardo Coimbra de Matos Eduarda Maria da Concei ção Sério Pereira Beirão Rafael Sim ões Neves Ant ónio José Assunção Rui Moreira Marques Source Type: research
Corrigendum to "Diazepam enhances melanogenesis, melanocyte dendricity and melanosome transport via the PBR/cAMP/PKA pathway" [Int. J. Biochem. Cell Biol. 116 (2019) 105620]
Int J Biochem Cell Biol. 2023 Dec 5:106505. doi: 10.1016/j.biocel.2023.106505. Online ahead of print.NO ABSTRACTPMID:38057196 | DOI:10.1016/j.biocel.2023.106505 (Source: The International Journal of Biochemistry and Cell Biology)
Source: The International Journal of Biochemistry and Cell Biology - December 6, 2023 Category: Biochemistry Authors: Jinpeng Lv Ying Fu Rongyin Gao Jiawen Li Maofan Kang Guoqiang Song Changjun Yun Source Type: research
When the fever will not stop, stop the pills! A case report
CONCLUSION: Antipsychotic agents are commonly employed to manage behavioral changes linked to various disorders. However, their severe side effects necessitate a high degree of vigilance, the cessation of all medications, and the implementation of supportive care measures. A prompt and accurate diagnosis of NMS is crucial to alleviating the severe, prolonged morbidity and potential mortality associated with this syndrome.PMID:38055420 | PMC:PMC10703491 | DOI:10.1590/1516-3180.2022.0401.R1.13032023 (Source: Sao Paulo Medical Journal)
Source: Sao Paulo Medical Journal - December 6, 2023 Category: General Medicine Authors: C ésar Ricardo Coimbra de Matos Eduarda Maria da Concei ção Sério Pereira Beirão Rafael Sim ões Neves Ant ónio José Assunção Rui Moreira Marques Source Type: research
Corrigendum to "Diazepam enhances melanogenesis, melanocyte dendricity and melanosome transport via the PBR/cAMP/PKA pathway" [Int. J. Biochem. Cell Biol. 116 (2019) 105620]
Int J Biochem Cell Biol. 2023 Dec 5:106505. doi: 10.1016/j.biocel.2023.106505. Online ahead of print.NO ABSTRACTPMID:38057196 | DOI:10.1016/j.biocel.2023.106505 (Source: The International Journal of Biochemistry and Cell Biology)
Source: The International Journal of Biochemistry and Cell Biology - December 6, 2023 Category: Biochemistry Authors: Jinpeng Lv Ying Fu Rongyin Gao Jiawen Li Maofan Kang Guoqiang Song Changjun Yun Source Type: research
When the fever will not stop, stop the pills! A case report
CONCLUSION: Antipsychotic agents are commonly employed to manage behavioral changes linked to various disorders. However, their severe side effects necessitate a high degree of vigilance, the cessation of all medications, and the implementation of supportive care measures. A prompt and accurate diagnosis of NMS is crucial to alleviating the severe, prolonged morbidity and potential mortality associated with this syndrome.PMID:38055420 | PMC:PMC10703491 | DOI:10.1590/1516-3180.2022.0401.R1.13032023 (Source: Sao Paulo Medical Journal)
Source: Sao Paulo Medical Journal - December 6, 2023 Category: General Medicine Authors: C ésar Ricardo Coimbra de Matos Eduarda Maria da Concei ção Sério Pereira Beirão Rafael Sim ões Neves Ant ónio José Assunção Rui Moreira Marques Source Type: research
