A-series agent A-234: initial in vitro and in vivo characterization
This study is the first to provide essential experimental preclinical data on the A-234 compound.PMID:38446233 | DOI:10.1007/s00204-024-03689-3 (Source: Archives of Toxicology)
Source: Archives of Toxicology - March 6, 2024 Category: Toxicology Authors: Martina Hrabinova Jaroslav Pejchal Vendula Hepnarova Lubica Muckova Lucie Junova Jakub Opravil Jana Zdarova Karasova Tomas Rozsypal Alzbeta Dlabkova Helena Rehulkova Tomas Kucera Zbyn ěk Vecera Filip Caisberger Monika Schmidt Ondrej Soukup Daniel Jun Source Type: research
A-series agent A-234: initial in vitro and in vivo characterization
This study is the first to provide essential experimental preclinical data on the A-234 compound.PMID:38446233 | DOI:10.1007/s00204-024-03689-3 (Source: Archives of Toxicology)
Source: Archives of Toxicology - March 6, 2024 Category: Toxicology Authors: Martina Hrabinova Jaroslav Pejchal Vendula Hepnarova Lubica Muckova Lucie Junova Jakub Opravil Jana Zdarova Karasova Tomas Rozsypal Alzbeta Dlabkova Helena Rehulkova Tomas Kucera Zbyn ěk Vecera Filip Caisberger Monika Schmidt Ondrej Soukup Daniel Jun Source Type: research
A-series agent A-234: initial in vitro and in vivo characterization
This study is the first to provide essential experimental preclinical data on the A-234 compound.PMID:38446233 | DOI:10.1007/s00204-024-03689-3 (Source: Archives of Toxicology)
Source: Archives of Toxicology - March 6, 2024 Category: Toxicology Authors: Martina Hrabinova Jaroslav Pejchal Vendula Hepnarova Lubica Muckova Lucie Junova Jakub Opravil Jana Zdarova Karasova Tomas Rozsypal Alzbeta Dlabkova Helena Rehulkova Tomas Kucera Zbyn ěk Vecera Filip Caisberger Monika Schmidt Ondrej Soukup Daniel Jun Source Type: research
A-series agent A-234: initial in vitro and in vivo characterization
This study is the first to provide essential experimental preclinical data on the A-234 compound.PMID:38446233 | DOI:10.1007/s00204-024-03689-3 (Source: Archives of Toxicology)
Source: Archives of Toxicology - March 6, 2024 Category: Toxicology Authors: Martina Hrabinova Jaroslav Pejchal Vendula Hepnarova Lubica Muckova Lucie Junova Jakub Opravil Jana Zdarova Karasova Tomas Rozsypal Alzbeta Dlabkova Helena Rehulkova Tomas Kucera Zbyn ěk Vecera Filip Caisberger Monika Schmidt Ondrej Soukup Daniel Jun Source Type: research
The effects of diazepam on fear extinction in nulliparous and primiparous female rats
Horm Behav. 2024 Feb 28;161:105518. doi: 10.1016/j.yhbeh.2024.105518. Online ahead of print.ABSTRACTBenzodiazepines undermine the success of exposure therapy in humans with anxiety disorders, and impair the long-term memory of fear extinction (the laboratory basis of exposure therapy) in rodents. However, most rodent studies on fear extinction and benzodiazepines have been conducted in male rodents. In female rodents, the estrous cycle influences the consolidation of fear extinction memories and sensitivity to benzodiazepines. In addition, pregnancy leads to long-term changes in the neurobiological, hormonal, and behaviour...
Source: Hormones and Behavior - February 29, 2024 Category: Endocrinology Authors: Jodie E Pestana Tasfia Kabir Bronwyn M Graham Source Type: research
The effects of diazepam on fear extinction in nulliparous and primiparous female rats
Horm Behav. 2024 Feb 28;161:105518. doi: 10.1016/j.yhbeh.2024.105518. Online ahead of print.ABSTRACTBenzodiazepines undermine the success of exposure therapy in humans with anxiety disorders, and impair the long-term memory of fear extinction (the laboratory basis of exposure therapy) in rodents. However, most rodent studies on fear extinction and benzodiazepines have been conducted in male rodents. In female rodents, the estrous cycle influences the consolidation of fear extinction memories and sensitivity to benzodiazepines. In addition, pregnancy leads to long-term changes in the neurobiological, hormonal, and behaviour...
Source: Hormones and Behavior - February 29, 2024 Category: Endocrinology Authors: Jodie E Pestana Tasfia Kabir Bronwyn M Graham Source Type: research
GABA < sub > A < /sub > receptor subunit M2-M3 linkers have asymmetric roles in pore gating and diazepam modulation
Biophys J. 2024 Feb 22:S0006-3495(24)00136-X. doi: 10.1016/j.bpj.2024.02.016. Online ahead of print.ABSTRACTGABAA receptors (GABAARs) are neurotransmitter-gated ion channels critical for inhibitory synaptic transmission as well as the molecular target for benzodiazepines (BZDs), one of the most widely prescribed class of psychotropic drugs today. Despite structural insight into the conformations underlying functional channel states, the detailed molecular interactions involved in conformational transitions and the physical basis for their modulation by BZDs are not fully understood. We previously identified that alanine su...
Source: Biophysical Journal - February 24, 2024 Category: Physics Authors: Joseph W Nors Zachary Endres Marcel P Goldschen-Ohm Source Type: research
GABA < sub > A < /sub > receptor subunit M2-M3 linkers have asymmetric roles in pore gating and diazepam modulation
Biophys J. 2024 Feb 22:S0006-3495(24)00136-X. doi: 10.1016/j.bpj.2024.02.016. Online ahead of print.ABSTRACTGABAA receptors (GABAARs) are neurotransmitter-gated ion channels critical for inhibitory synaptic transmission as well as the molecular target for benzodiazepines (BZDs), one of the most widely prescribed class of psychotropic drugs today. Despite structural insight into the conformations underlying functional channel states, the detailed molecular interactions involved in conformational transitions and the physical basis for their modulation by BZDs are not fully understood. We previously identified that alanine su...
Source: Biophysical Journal - February 24, 2024 Category: Physics Authors: Joseph W Nors Zachary Endres Marcel P Goldschen-Ohm Source Type: research
Correlation between serum galanin and neuron-specific enolase levels with EEG abnormalities in pediatric convulsive status epilepticus and the efficacy of triple drug therapy
CONCLUSIONS: The study concludes that serum GAL and NSE levels in children with convulsive status epilepticus are positively correlated with the degree of EEG abnormalities. The combination therapy involving midazolam, diazepam, and phenobarbital is effective in treating children with convulsive status epilepticus, significantly improving clinical symptoms, reducing brain damage, and ensuring safety.PMID:38375724 | DOI:10.26355/eurrev_202402_35358 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - February 20, 2024 Category: Drugs & Pharmacology Authors: M A Ansari R Syed M Shahid J Yin Source Type: research
Correlation between serum galanin and neuron-specific enolase levels with EEG abnormalities in pediatric convulsive status epilepticus and the efficacy of triple drug therapy
CONCLUSIONS: The study concludes that serum GAL and NSE levels in children with convulsive status epilepticus are positively correlated with the degree of EEG abnormalities. The combination therapy involving midazolam, diazepam, and phenobarbital is effective in treating children with convulsive status epilepticus, significantly improving clinical symptoms, reducing brain damage, and ensuring safety.PMID:38375724 | DOI:10.26355/eurrev_202402_35358 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 20, 2024 Category: Drugs & Pharmacology Authors: M A Ansari R Syed M Shahid J Yin Source Type: research
Correlation between serum galanin and neuron-specific enolase levels with EEG abnormalities in pediatric convulsive status epilepticus and the efficacy of triple drug therapy
CONCLUSIONS: The study concludes that serum GAL and NSE levels in children with convulsive status epilepticus are positively correlated with the degree of EEG abnormalities. The combination therapy involving midazolam, diazepam, and phenobarbital is effective in treating children with convulsive status epilepticus, significantly improving clinical symptoms, reducing brain damage, and ensuring safety.PMID:38375724 | DOI:10.26355/eurrev_202402_35358 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - February 20, 2024 Category: Drugs & Pharmacology Authors: M A Ansari R Syed M Shahid J Yin Source Type: research
Correlation between serum galanin and neuron-specific enolase levels with EEG abnormalities in pediatric convulsive status epilepticus and the efficacy of triple drug therapy
CONCLUSIONS: The study concludes that serum GAL and NSE levels in children with convulsive status epilepticus are positively correlated with the degree of EEG abnormalities. The combination therapy involving midazolam, diazepam, and phenobarbital is effective in treating children with convulsive status epilepticus, significantly improving clinical symptoms, reducing brain damage, and ensuring safety.PMID:38375724 | DOI:10.26355/eurrev_202402_35358 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - February 20, 2024 Category: Drugs & Pharmacology Authors: M A Ansari R Syed M Shahid J Yin Source Type: research
