Valerenic acid reduces anxiety-like behavior in young adult, female (C57BL/6J) mice
Behav Brain Res. 2023 Oct 16:114717. doi: 10.1016/j.bbr.2023.114717. Online ahead of print.ABSTRACTExtracts from the plant Valeriana officinalis are marketed as an herbal remedy to treat anxiety and insomnia. Valerenic acid (VA) is a major chemical component of Valeriana extracts. To date, there is relatively little information about how VA affects behavior. The purpose of these experiments was to (1) test whether administration of VA induces measurable changes in anxiety-like, depression-like, or locomotor behaviors; (2) determine whether the effects of VA on behavior are dose-dependent; and (3) compare the effects of VA ...
Source: Brain Research - October 18, 2023 Category: Neurology Authors: Natalie E Pinder Isaac Y Ligocki Brent M Horton John E Hoover Source Type: research

Valerenic acid reduces anxiety-like behavior in young adult, female (C57BL/6J) mice
Behav Brain Res. 2023 Oct 16:114717. doi: 10.1016/j.bbr.2023.114717. Online ahead of print.ABSTRACTExtracts from the plant Valeriana officinalis are marketed as an herbal remedy to treat anxiety and insomnia. Valerenic acid (VA) is a major chemical component of Valeriana extracts. To date, there is relatively little information about how VA affects behavior. The purpose of these experiments was to (1) test whether administration of VA induces measurable changes in anxiety-like, depression-like, or locomotor behaviors; (2) determine whether the effects of VA on behavior are dose-dependent; and (3) compare the effects of VA ...
Source: Behavioural Brain Research - October 18, 2023 Category: Neurology Authors: Natalie E Pinder Isaac Y Ligocki Brent M Horton John E Hoover Source Type: research

The real-world effectiveness of intravenous brivaracetam as a second-line treatment in status epilepticus
CONCLUSION: The present study highlights the potential of BRV when used as an early add-on therapy in SE, further confirming its good safety profile.PMID:37839249 | DOI:10.1016/j.yebeh.2023.109464 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - October 15, 2023 Category: Neurology Authors: Chiara Martellino Angelina Lagan à Giorgia Atanasio Fabio Lamanna Silvia Attardo Simona Cascino Marcella De Luca Orazio Pardeo Giuseppa Giacobbe Giovanni Tripepi Roberta Roberti Francesca Granata Carmela Morace Emilio Russo Angelo Labate Source Type: research

The real-world effectiveness of intravenous brivaracetam as a second-line treatment in status epilepticus
CONCLUSION: The present study highlights the potential of BRV when used as an early add-on therapy in SE, further confirming its good safety profile.PMID:37839249 | DOI:10.1016/j.yebeh.2023.109464 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - October 15, 2023 Category: Neurology Authors: Chiara Martellino Angelina Lagan à Giorgia Atanasio Fabio Lamanna Silvia Attardo Simona Cascino Marcella De Luca Orazio Pardeo Giuseppa Giacobbe Giovanni Tripepi Roberta Roberti Francesca Granata Carmela Morace Emilio Russo Angelo Labate Source Type: research

Therapeutic Efficacy of Head Gusha Combined with Kaitianmen in the Management of Insomnia
CONCLUSIONS: The combination of specialized head scraping and Kaitianmen therapy has demonstrated effectiveness in the treatment of insomnia and offers a valid means of alleviating patients' negative emotions. These findings suggest promising prospects for clinical applications.PMID:37820682 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - October 11, 2023 Category: Complementary Medicine Authors: Lanting Yan Liying Jiang Yue Liu Yun Chen Jiayan Zhong Dingtian Luo Source Type: research

Therapeutic Efficacy of Head Gusha Combined with Kaitianmen in the Management of Insomnia
CONCLUSIONS: The combination of specialized head scraping and Kaitianmen therapy has demonstrated effectiveness in the treatment of insomnia and offers a valid means of alleviating patients' negative emotions. These findings suggest promising prospects for clinical applications.PMID:37820682 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - October 11, 2023 Category: Complementary Medicine Authors: Lanting Yan Liying Jiang Yue Liu Yun Chen Jiayan Zhong Dingtian Luo Source Type: research

Therapeutic Efficacy of Head Gusha Combined with Kaitianmen in the Management of Insomnia
CONCLUSIONS: The combination of specialized head scraping and Kaitianmen therapy has demonstrated effectiveness in the treatment of insomnia and offers a valid means of alleviating patients' negative emotions. These findings suggest promising prospects for clinical applications.PMID:37820682 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - October 11, 2023 Category: Complementary Medicine Authors: Lanting Yan Liying Jiang Yue Liu Yun Chen Jiayan Zhong Dingtian Luo Source Type: research

Therapeutic Efficacy of Head Gusha Combined with Kaitianmen in the Management of Insomnia
CONCLUSIONS: The combination of specialized head scraping and Kaitianmen therapy has demonstrated effectiveness in the treatment of insomnia and offers a valid means of alleviating patients' negative emotions. These findings suggest promising prospects for clinical applications.PMID:37820682 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - October 11, 2023 Category: Complementary Medicine Authors: Lanting Yan Liying Jiang Yue Liu Yun Chen Jiayan Zhong Dingtian Luo Source Type: research

Therapeutic Efficacy of Head Gusha Combined with Kaitianmen in the Management of Insomnia
CONCLUSIONS: The combination of specialized head scraping and Kaitianmen therapy has demonstrated effectiveness in the treatment of insomnia and offers a valid means of alleviating patients' negative emotions. These findings suggest promising prospects for clinical applications.PMID:37820682 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - October 11, 2023 Category: Complementary Medicine Authors: Lanting Yan Liying Jiang Yue Liu Yun Chen Jiayan Zhong Dingtian Luo Source Type: research

Therapeutic Efficacy of Head Gusha Combined with Kaitianmen in the Management of Insomnia
CONCLUSIONS: The combination of specialized head scraping and Kaitianmen therapy has demonstrated effectiveness in the treatment of insomnia and offers a valid means of alleviating patients' negative emotions. These findings suggest promising prospects for clinical applications.PMID:37820682 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - October 11, 2023 Category: Complementary Medicine Authors: Lanting Yan Liying Jiang Yue Liu Yun Chen Jiayan Zhong Dingtian Luo Source Type: research

Effects of N-acetylcysteine and acetyl-L-carnitine on acute PTZ-induced seizures in larval and adult zebrafish
CONCLUSION: Consequently, we conclude that, under the conditions employed in this study, NAC and ALC do not exhibit any significant effects on acute seizures in zebrafish.PMID:37814098 | DOI:10.1007/s43440-023-00536-7 (Source: Pharmacological Reports)
Source: Pharmacological Reports - October 9, 2023 Category: Drugs & Pharmacology Authors: Rafael Chitolina Carlos G Reis Thailana Stahlhofer-Buss Amanda Linazzi Radharani Benvenutti Matheus Marcon Ana P Herrmann Angelo Piato Source Type: research

Effects of N-acetylcysteine and acetyl-L-carnitine on acute PTZ-induced seizures in larval and adult zebrafish
CONCLUSION: Consequently, we conclude that, under the conditions employed in this study, NAC and ALC do not exhibit any significant effects on acute seizures in zebrafish.PMID:37814098 | DOI:10.1007/s43440-023-00536-7 (Source: Pharmacological Reports)
Source: Pharmacological Reports - October 9, 2023 Category: Drugs & Pharmacology Authors: Rafael Chitolina Carlos G Reis Thailana Stahlhofer-Buss Amanda Linazzi Radharani Benvenutti Matheus Marcon Ana P Herrmann Angelo Piato Source Type: research

Effects of N-acetylcysteine and acetyl-L-carnitine on acute PTZ-induced seizures in larval and adult zebrafish
CONCLUSION: Consequently, we conclude that, under the conditions employed in this study, NAC and ALC do not exhibit any significant effects on acute seizures in zebrafish.PMID:37814098 | DOI:10.1007/s43440-023-00536-7 (Source: Pharmacological Reports)
Source: Pharmacological Reports - October 9, 2023 Category: Drugs & Pharmacology Authors: Rafael Chitolina Carlos G Reis Thailana Stahlhofer-Buss Amanda Linazzi Radharani Benvenutti Matheus Marcon Ana P Herrmann Angelo Piato Source Type: research

Administration of α-lipoic acid and silymarin attenuates aggression by modulating endocrine, oxidative stress and inflammatory pathways in mice
In conclusion, ALA is more effective than silymarin in attenuating aggression in mice.Graphical abstract (Source: Metabolic Brain Disease)
Source: Metabolic Brain Disease - October 1, 2023 Category: Neurology Source Type: research

Presumed first episode of nonconvulsive status epilepticus as the cause of postoperative disorder of consciousness following the completion of general anesthesia: A case report
Head computed tomography: There was no evidence of intracranial hemorrhage. Key Clinical MessageDisorder of consciousness can lead to irreversible sequelae without proper intervention. Consequently, early diagnosis and treatment are of paramount importance in patients with disorder of consciousness.AbstractDisorder of consciousness (DOC) has various etiologies. Here, we report a case in which DOC following general anesthesia was suspected as being due to the first episode of nonconvulsive status epilepticus (NCSE). An elderly man in his 80s underwent uneventful tumor resection surgery under general anesthesia for extramamm...
Source: Clinical Case Reports - September 28, 2023 Category: General Medicine Authors: Yumi Tsuzuki, Yusuke Ishida, Mikiko Tomino Tags: CASE REPORT Source Type: research