Mpox: The Reemergence of an Old Disease and Inequities
We describe the demographics and clinical spectrum of classical and novel mpox, outlining the potential complications and management. Expected final online publication date for the Annual Review of Medicine, Volume 75 is January 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.PMID:37788486 | DOI:10.1146/annurev-med-080122-030714 (Source: Annual Review of Medicine)
Source: Annual Review of Medicine - October 3, 2023 Category: General Medicine Authors: J P Thornhill M Gandhi C Orkin Source Type: research
Cross-reactive antibody response to Monkeypox virus surface proteins in a small proportion of individuals with and without Chinese smallpox vaccination history
After the eradication of smallpox in China in 1979, vaccination with the vaccinia virus (VACV) Tiantan strain for the general population was stopped in 1980. As the monkeypox virus (MPXV) is rapidly spreading ... (Source: BMC Biology)
Source: BMC Biology - October 2, 2023 Category: Biology Authors: Anqi Xia, Xiaojie Wang, Jiaying He, Wei Wu, Weiyu Jiang, Song Xue, Qianqian Zhang, Yidan Gao, Yuru Han, Yaming Li, Xiaofang Peng, Minxiang Xie, Christian T. Mayer, Jie Liu, Chen Hua, Yiou Sha & hellip; Tags: Research article Source Type: research
Permafrost can imprison dangerous microbes for centuries. Will the Arctic thaw release them?
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Source: Science of Aging Knowledge Environment - September 27, 2023 Category: Geriatrics Source Type: research
A risk science perspective on vaccines
AbstractVaccines can be seen as one of the greatest successes in modern medicine. Good examples are the vaccines against smallpox, polio, and measles. Unfortunately, vaccines can have side effects, but the risks are considered by the health authorities and experts to be small compared to their benefits. Nevertheless, there are many who are skeptical of vaccination, something which has been very clearly demonstrated in relation to the COVID-19 disease. Risk is the key concept when evaluating a vaccine, in relation to both its ability to protect against the disease and its side effects. However, risk is a challenging concept...
Source: Risk Analysis - September 26, 2023 Category: International Medicine & Public Health Authors: Ingrid Glette ‐Iversen,
Terje Aven,
Roger Flage Tags: ORIGINAL ARTICLE Source Type: research
British Royalty and Aristocracy: Their Skin Maladies Part II: Queen Mary II's Death from Hemorrhagic Smallpox
In 1694, Queen Mary II (1662-1694) died, at age 32, from hemorrhagic smallpox, a rare and fatal form of this viral infection. This contribution presents the clinical features of Queen Mary II's smallpox infection. It also reviews, from a modern day perspective, the disseminated intravascular coagulopathy involved in the pathophysiology of hemorrhagic smallpox, which is characterized by thrombocytopenia, coagulation factor deficiency, and hypofibrinogenemia. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - September 22, 2023 Category: Dermatology Authors: Gerald A. Soff, Nick J. Levell, Lawrence Charles Parish, Leonard J. Hoenig Source Type: research
British Royalty and Aristocracy: Their skin maladies Part II. Queen Mary II's death from hemorrhagic smallpox
In 1694, Queen Mary II (1662-1694) died at age 32 of hemorrhagic smallpox, a rare and fatal form of the viral infection. This contribution presents the clinical features of Queen Mary II's smallpox infection. It also reviews, from a modern-day perspective, the disseminated intravascular coagulopathy involved in the pathophysiology of hemorrhagic smallpox, which is characterized by thrombocytopenia, coagulation factor deficiency, and hypofibrinogenemia. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - September 22, 2023 Category: Dermatology Authors: Gerald A. Soff, Nick J. Levell, Lawrence Charles Parish, Leonard J. Hoenig Tags: Reflections on Dermatology: Past, Present, and Future Source Type: research
Baseline immune states (BIS) associated with vaccine responsiveness and factors that shape the BIS
Semin Immunol. 2023 Sep 15;70:101842. doi: 10.1016/j.smim.2023.101842. Online ahead of print.ABSTRACTVaccines are among the greatest inventions in medicine, leading to the elimination or control of numerous diseases, including smallpox, polio, measles, rubella, and, most recently, COVID-19. Yet, the effectiveness of vaccines varies among individuals. In fact, while some recipients mount a robust response to vaccination that protects them from the disease, others fail to respond. Multiple clinical and epidemiological factors contribute to this heterogeneity in responsiveness. Systems immunology studies fueled by advances in...
Source: Seminars in Immunology - September 17, 2023 Category: Allergy & Immunology Authors: Djamel Nehar-Belaid Mark Sokolowski Sathyabaarathi Ravichandran Jacques Banchereau Damien Chaussabel Duygu Ucar Source Type: research
Baseline immune states (BIS) associated with vaccine responsiveness and factors that shape the BIS
Semin Immunol. 2023 Sep 15;70:101842. doi: 10.1016/j.smim.2023.101842. Online ahead of print.ABSTRACTVaccines are among the greatest inventions in medicine, leading to the elimination or control of numerous diseases, including smallpox, polio, measles, rubella, and, most recently, COVID-19. Yet, the effectiveness of vaccines varies among individuals. In fact, while some recipients mount a robust response to vaccination that protects them from the disease, others fail to respond. Multiple clinical and epidemiological factors contribute to this heterogeneity in responsiveness. Systems immunology studies fueled by advances in...
Source: Seminars in Immunology - September 17, 2023 Category: Allergy & Immunology Authors: Djamel Nehar-Belaid Mark Sokolowski Sathyabaarathi Ravichandran Jacques Banchereau Damien Chaussabel Duygu Ucar Source Type: research
Baseline immune states (BIS) associated with vaccine responsiveness and factors that shape the BIS
Semin Immunol. 2023 Sep 15;70:101842. doi: 10.1016/j.smim.2023.101842. Online ahead of print.ABSTRACTVaccines are among the greatest inventions in medicine, leading to the elimination or control of numerous diseases, including smallpox, polio, measles, rubella, and, most recently, COVID-19. Yet, the effectiveness of vaccines varies among individuals. In fact, while some recipients mount a robust response to vaccination that protects them from the disease, others fail to respond. Multiple clinical and epidemiological factors contribute to this heterogeneity in responsiveness. Systems immunology studies fueled by advances in...
Source: Seminars in Immunology - September 17, 2023 Category: Allergy & Immunology Authors: Djamel Nehar-Belaid Mark Sokolowski Sathyabaarathi Ravichandran Jacques Banchereau Damien Chaussabel Duygu Ucar Source Type: research
Human mpox: global trends, molecular epidemiology and options for vaccination
Pathog Glob Health. 2023 Sep 16:1-8. doi: 10.1080/20477724.2023.2258641. Online ahead of print.ABSTRACTThe eradication of smallpox and the cessation of vaccination have led to the growth of the susceptible human population to poxviruses. This has led to the increasing detection of zoonotic orthopoxviruses. Among those viruses, monkeypox virus (MPV) is the most commonly detected in Western and Central African regions. Since 2022, MPV is causing local transmission in newly affected countries all over the world. While the virus causing the current outbreak remains part of clade II (historically referred to as West African cla...
Source: Pathogens and Global Health - September 16, 2023 Category: International Medicine & Public Health Authors: Lorenzo Subissi Paola Stefanelli Giovanni Rezza Source Type: research
