TWiV 981: Tastes like chikungunya
TWiV explains the recent meeting of the National Science Advisory Board for Biosecurity (NSABB) where stricter guidelines for research involving human, animal, and plant pathogens were considered, and how the consumption of viruses by small protists returns energy to food chains. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode •Research assistant position at FDA (pdf) •Register for ASV 2023 •MicrobeTV Discord Server •NSABB proposed oversight framework (pdf) ...
Source: This Week in Virology - MP3 Edition - February 5, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 959: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses effectiveness of influenza vaccination of pregnant women for prevention of maternal and early infant Influenza-associated hospitalizations in South Africa, a multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes, single and 2-dose vaccinations with modified vaccinia Ankara-Bavarian Nordic induce durable B cell memory responses comparable to replicating smallpox vaccines, whether the risk of still and preterm birth is affected by the timing of symptomatic SARS-CoV-2 infection during pregnancy, medical masks versus N95 respirators for...
Source: This Week in Virology - MP3 Edition - December 3, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 938: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin reviews the public health response to poliovirus in New York, impact of mandatory influenza vaccination, monkeypox in a young infant, health care worker exposure to monkeypox virus, monkeypox testing delays, transmission potential of monkeypox virus, TPOXX trial for monkeypox, detection of SARS-CoV-2 subgenomic mRNA, mucosal IgA against SARS-CoV-2, BNT262b2 against Omicron, awareness and use of SARS-CoV-2 antivirals, comparable outcomes for Bebtelovimab and Nirmatrelvir, and COVID-19 and Alzheimer's disease. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a...
Source: This Week in Virology - MP3 Edition - September 24, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 927: Merchlinsky vs monkeypox
Michael Merchlinsky joins TWiV to discuss the development of two smallpox antiviral drugs and two smallpox vaccines and their uses during the monkeypox outbreak. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler Guest: Michael Merchlinsky Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Michael on Anything but academic (TWiM 145) Development of Tecoviromat (TPOXX) (Antiviral Res) Use of Jynneos vaccine (MMWR) Limitations of Tecoviromat (NEJM) Poliovirus in NYC wastewater (NY Times) Letters read on TWiV 927 Timestamps by Jolene...
Source: This Week in Virology - MP3 Edition - August 14, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 900: Burning down the mouse
TWiV celebrates 900 episodes, Vincent gives the Richard R. Ernst lecture, and we discuss why inflammasome activation in infected macrophages drives severe COVID-19. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Richard R. Ernst Lecture Infected macrophages drives severe COVID-19 (Nature) Timestamps by Jolene. Thanks! Weekly Picks Brianne – The Milky Way’s Black Hole Comes to Light Kathy – River dolphins playing with anaconda Rich – Smallpox vaccination techniq...
Source: This Week in Virology - MP3 Edition - May 15, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 898: Immunity is skin deep
TWiV explains why the concept of herd immunity might not apply to COVID-19, and the observation that smallpox vaccination causes an increase in skin bacteria that promote pathology and influence the immune response. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Herd immunity may not apply to COVID-19 (J Inf Dis) Smallpox vaccination increases skin bacteria (PLoS Path) The invinceable TWiV (TWiV 145) By the pricking of my thumbs… (TWiV 284) Letters read on TWiV 898 Timestamps b...
Source: This Week in Virology - MP3 Edition - May 8, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 878: Shape matters sometimes
TWiV revisits chronic wasting disease of cervids and the ability of the prions to infect meadow voles and raccoons, and the suggestion that stochastic assembly of influenza virus particles may play a role in phenotypic diversity. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode CWD in meadow voles and raccoons (Emerg Inf Dis) Unusual infectious agents (Virology Live) Low fidelity influenza virus assembly (Cell) Shape-shifting viruses (TWiV 743) From variolous effluvia to VLPs (T...
Source: This Week in Virology - MP3 Edition - March 20, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 832: Heavy metal flu fighters
TWiV reviews the vials labeled smallpox that were not, re-emergence of enterovirus D68 in Europe, efficacy of inactivated SARS-CoV-2 vaccine, and cellular correlates of protection for an oral influenza virus vaccine. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Smallpox vials contain vaccinia virus (6abc.com) European re-emergence of enterovirus D68 (Eurosurveill) Efficacy of inactivated SARS-CoV-2 vaccine (Lancet) Cellular correlates of protection for oral flu vaccine (Cell Host M...
Source: This Week in Virology - MP3 Edition - November 21, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 827: A shot to save the world with Greg Zuckerman
Greg Zuckerman joins TWiV to discuss his book that explores the race to produce COVID-19 vaccines, with insights into the companies, scientists, and executives involved and the rivalries, ambitions, ego, and a desire to save the world. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler Guest: Greg Zuckerman Click arrow to play Download TWiV 824 (76 MB .mp3, 127 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode A Shot to Save the World (Hardcover, Kindle) Letters read on TWiV 827 Timestamps by Jolene. Thanks! Weekly Picks Dickson ...
Source: This Week in Virology - MP3 Edition - November 7, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 824: Immunogoblins in the nose and lungs
TWiV explores the properties of the spike glycoproteins of an influenza B virus discovered in the Wuhan spiny eel, and protection against SARS-CoV-2 infection one year after mRNA-1273 vaccination of nonhuman primates. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode HA and NA of Wuhan spiny eel influenza virus (Nat Comm) Protection one year after mRNA-1273 vaccination (bioRxiv) Letters read on TWiV 824 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Best of Gilda Radner Brianne ...
Source: This Week in Virology - MP3 Edition - October 31, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 822: Viking variola variants
Rich reviews the history of smallpox and the discovery of variola viral genomes in ancient DNA from human remains throughout Northern Europe, which pushes back the earliest date of smallpox virus infection to ~600–1050 CE, overlapping the Viking Age. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Variola virus genomes from Viking era (Science) Hidden history of ancient plagues (Nature) Was smallpox a mild disease? (Science) Smallpox: Ten years gone (Am J Pub Health) Myth of ...
Source: This Week in Virology - MP3 Edition - October 28, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 756: Precluding problematic polio prophylaxis
TWiV returns to the 2012 brouhaha over transmission experiments with avian H5N1 influenza virus, re-examines the claim of SARS-CoV-2 RNA integration into human DNA, and reviews the engineering and testing of a genetically stable version of the attenuated type 2 Sabin poliovirus vaccine. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Amy Rosenfeld Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV vaccine town halls 3:16 First smallpox vaccine day Revised masking and distancing (CDC) Science vs Spin (Sandman) Artifactual SARS-CoV-2 in...
Source: This Week in Virology - MP3 Edition - May 16, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts