British Royalty and Aristocracy: Their Skin Maladies Part II: Queen Mary II's Death from Hemorrhagic Smallpox

In 1694, Queen Mary II (1662-1694) died, at age 32, from hemorrhagic smallpox, a rare and fatal form of this viral infection. This contribution presents the clinical features of Queen Mary II's smallpox infection. It also reviews, from a modern day perspective, the disseminated intravascular coagulopathy involved in the pathophysiology of hemorrhagic smallpox, which is characterized by thrombocytopenia, coagulation factor deficiency, and hypofibrinogenemia.
Source: Clinics in Dermatology - Category: Dermatology Authors: Source Type: research