The efficacy and safety of Montelukast sodium in the prevention of bronchopulmonary dysplasia.
CONCLUSION: Montelukast was not effective in reducing moderate or severe BPD. There were no significant adverse drug events associated with Montelukast treatment.
PMID: 26512261 [PubMed] (Source: Korean Journal of Pediatrics)
Source: Korean Journal of Pediatrics - November 19, 2015 Category: Pediatrics Tags: Korean J Pediatr Source Type: research
Prevention of Capsular Contracture Using Leukotriene Antagonists
Conclusion: The prophylactic use of Singulair was, in this sample, shown to be effective in helping to reduce the incidence of capsular contracture.
CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III. (Source: Plastic and Reconstructive Surgery)
Source: Plastic and Reconstructive Surgery - October 30, 2015 Category: Cosmetic Surgery Tags: Cosmetic: Original Articles Source Type: research
Is montelukast as effective as N-acetylcysteine in hepatic injury due to acetaminophen intoxication in rats?
This study aims to investigate the acute protective effect of montelukast sodium in hepatic injury secondary to acetaminophen (APAP) intoxication. This study used 60 rats. The rats were grouped into 6 groups. The control group was administered oral distilled water 10ml/kg, the APAP group oral APAP 1g/kg, the montelukast sodium (MK) group oral MK 30mg/kg, the acetaminophen+N-acetylcysteine (APAP+NAC) group oral APAP 1g/kg, followed by a single dose of intraperitoneal NAC 1.5g/kg three hours later, the acetaminophen+montelukast sodium (APAP+MK) group oral APAP 1g/kg, followed by oral MK 30mg/kg 3h later, the acetaminophen+N-...
Source: Experimental and Toxicologic Pathology - October 10, 2015 Category: Pathology Authors: İçer M, Zengin Y, Gunduz E, Dursun R, Durgun HM, Turkcu G, Yuksel H, Üstündağ M, Guloglu C Tags: Exp Toxicol Pathol Source Type: research
Beneficial effects montelukast, cysteinyl-leukotriene receptor antagonist, on renal damage after unilateral ureteral obstruction in rats
Introductıon Ureteral obstruction is a common pathology and caused kidney fibrosis and dysfunction at late period. In this present, we investigated the antifibrotic and antiinflammatory effects of montelukast which is cysteinyl leukotriene receptor antagonist, on kidney damage after unilateral ureteral obstruction(UUO) in rats. Mateirıals and Methods 32 rats divided four groups. Group 1 was control, group 2 was sham, group 3 was rats with UUO and group 4 was rats with UUO which were given montelukast sodium (oral 10 mg/kg/day). After 14 days, rats were killed and their kidneys were taken and blood analysis was performed....
Source: International Braz J Urol - June 9, 2015 Category: Urology & Nephrology Source Type: research
Development of Montelukast Sodium Loaded Niosomal Carriers by Film Hydration Technique
(Source: Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry)
Source: Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry - May 31, 2015 Category: Allergy & Immunology Authors: Kumar, SumitAwasthi, Rajendra Tags: Articles Source Type: research
The Effect of Introduction of Generic Drugs on Patients’ Access To Pharmaceuticals In Hungary
The aim of our study was to analyze the generic competition of medicaments containing the active substance montelukast sodium and to examine the cost-containment methods of the Hungarian National Health Insurance Fund Administration. (Source: Value in Health)
Source: Value in Health - May 1, 2015 Category: Global & Universal Authors: B. Répásy, D. Endrei, T. Csákvári, R. Vajda, N. Danku, I. Boncz Source Type: research
An Enantioselective
Formal Synthesis of Montelukast
Sodium
The Journal of Organic ChemistryDOI: 10.1021/acs.joc.5b00197 (Source: The Journal of Organic Chemistry)
Source: The Journal of Organic Chemistry - April 6, 2015 Category: Chemistry Authors: Satyanarayana Bollikonda, Saravanan Mohanarangam, Rajender Reddy Jinna, Venkata Kiran Kumar Kandirelli, Laxman Makthala, Saikat Sen, David A. Chaplin, Richard C. Lloyd, Thomas Mahoney, Vilas Hareshwar Dahanukar, Srinivas Oruganti and Martin E. Fox Source Type: research
Do Montelukast Sodium and N-Acetylcysteine Have a Nephroprotective Effect on Unilateral Ureteral Obstruction: A Placebo Controlled Trial in a Rat Model
We assessed the nephroprotective effects of montelukast sodium and N-acetylcysteine on secondary renal damage due to unilateral ureteral obstruction in a rat model. (Source: The Journal of Urology)
Source: The Journal of Urology - March 14, 2015 Category: Urology & Nephrology Authors: Melih Sunay, Tolga Karakan, Arif Aydın, Gökhan Koca, Pınar Börcek, Elmas Öğüş Tags: Investigative Urology Source Type: research
Do Montelukast Sodium and N-Acetylcysteine Have Nephroprotective Effect on Unilateral Ureteral Obstruction: Placebo-Controlled Trial in A Rat Model
To assess nephroprotective effects of Montelukast Sodium and N-Acetylcysteine (NAC) on seconder renal damage due to unilateral ureteral obstruction in a rat model. (Source: The Journal of Urology)
Source: The Journal of Urology - March 14, 2015 Category: Urology & Nephrology Authors: Melih Sunay, Tolga Karakan, Arif Aydın, Gökhan Koca, Pınar Börcek, Elmas Öğüş Source Type: research
Is montelukast effective in regression of endometrial implants in an experimentally induced endometriosis model in rats?
Conclusion(s) Montelukast may effectively cause a significant decrease in the area of endometriotic implants. (Source: European Journal of Obstetrics and Gynecology and Reproductive Biology)
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - November 27, 2014 Category: OBGYN Source Type: research
Simulation of In Vitro Dissolution Behavior Using DDDPlus™
The objective of this study was to evaluate if computer simulations can predict the in vitro dissolution of two model drugs for which different dissolution data were available. Published montelukast sodium and glyburide dissolution data was used for the simulations. Different pharmacopeial and biorelevant buffers, volumes, and rotations speeds were evaluated. Additionally, a pH change protocol was evaluated using these buffers. DDDPlus™ 3, Beta version (Simulation Plus, Inc.), was used to simulate the in vitro dissolution data. The simulated data were compared with the in vitro data. A regression coefficient between pred...
Source: AAPS PharmSciTech - November 20, 2014 Category: Drugs & Pharmacology Authors: Almukainzi M, Okumu A, Wei H, Löbenberg R Tags: AAPS PharmSciTech Source Type: research
Osmotically controlled pulsatile release capsule of montelukast sodium for chronotherapy: Statistical optimization, in vitro and in vivo evaluation
Drug Delivery, Volume 21, Issue 7, Page 509-518, November 2014. (Source: Drug Delivery)
Source: Drug Delivery - November 5, 2014 Category: Drugs & Pharmacology Tags: article Source Type: research
Bioequivalence of two formulations of montelukast sodium 4 mg oral granules in healthy adults
Abstract
Montelukast is an effective and well-tolerated treatment for the prophylaxis and chronic treatment of asthma, acute prevention of exercise-induced bronchoconstriction and symptomatic relief of seasonal allergic rhinitis and perennial allergic rhinitis. The aim of the study was to compare bioavailability, and characterise the pharmacokinetic profile and safety of Sandoz generic montelukast 4 mg oral granules relative to Singulair® mini (Merck, Sharp & Dohme). An open-label, randomised, single-dose, two-treatment, two-period, two-sequence, two-way crossover bioequivalence study was conducted...
Source: Clinical and Translational Allergy - September 18, 2014 Category: Allergy & Immunology Source Type: research
Development and validation of rp-hplc method for the simultaneous estimation of montelukast sodium and ebastine in tablet dosage form
NS Rana, KS Rajesh, Nikita N Patel, PR Patel, U Limbachiya, TY PashaIndian Journal of Pharmaceutical Sciences 2013 75(5):599-602A rapid and sensitive RP-HPLC method with UV detection (244 nm) for routine analysis of montelukast sodium and ebastine in a pharmaceutical formulation (Ebast-M) was developed. Chromatography was performed with mobile phase containing a mixture of methanol:acetonitrile:ammonium acetate (80:10:10, % v/v/v), pH of mobile phase was adjusted 5.5 using glacial acetic acid and flow rate was 1.2 ml/min. The method was validated for linearity, accuracy, robustness and intermediate precision. The li...
Source: Indian Journal of Pharmaceutical Sciences - December 11, 2013 Category: Drugs & Pharmacology Authors: NS RanaKS RajeshNikita N PatelPR PatelU LimbachiyaTY Pasha Source Type: research
Effects of montelukast sodium on tendon healing: An experimental study
Conclusion: MS decreased tendon healing, apparently by inhibiting the early inflammatory phase of nonsynovial tendon healing. (Source: Table of Contents : Indian Journal of Orthopaedics : 2007 - 41(1))
Source: Table of Contents : Indian Journal of Orthopaedics : 2007 - 41(1) - September 17, 2013 Category: Orthopaedics Authors: Atilla PolatMehmet Kerem CanboraDilek AkakinFaruk Aykanat Source Type: research
