Asthma diagnosis and severity monitoring in primary school children: Essential role of sequential testing of exhaled nitric oxide.
CONCLUSION: FeNO is an easy, used non-invasive tool for the diagnosis of allergic asthma. Sequential FeNO testing can accurately reflect asthma severity and provide for successful stepwise therapy for asthmatic children.
PMID: 23830305 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - July 2, 2013 Category: Allergy & Immunology Authors: Wan KS, Chiu WH, Yang W Tags: Allergol Immunopathol (Madr) Source Type: research
Combination therapy of fexofenadine and montelukast is effective in prurigo nodularis and pemphigoid nodularis
This study revealed that combination therapy of fexofenadine and montelukast was effective for some patients with conventional therapy‐resistant prurigo nodularis and pemphigoid nodularis. (Source: Dermatologic Therapy)
Source: Dermatologic Therapy - July 1, 2013 Category: Dermatology Authors: Takako Shintani, Chika Ohata, Hiroshi Koga, Bungo Ohyama, Takahiro Hamada, Takekuni Nakama, Minao Furumura, Daisuke Tsuruta, Norito Ishii, Takashi Hashimoto Tags: Therapeutic Hotline Source Type: research
Effects of montelukast on the healing of ischemic colon anastomoses
Conclusions: Montelukast prevented ischemia/reperfusion-induced damage in a rat model of colonic anastomotic wound healing. (Source: American Journal of Surgery)
Source: American Journal of Surgery - June 27, 2013 Category: Surgery Authors: Atilla Celik, Ersin Ergun, Neset Koksal, Aysun Simsek Celik, Ediz Altinli, Mehmet Ali Uzun, Ersan Eroglu, Ahu Kemik Tags: Clinical Science Source Type: research
Assessment of absorption potential of poorly water-soluble drugs by using the dissolution/permeation system.
This study aims to assess the absorption potential of oral absorption of poorly water-soluble drugs by using the dissolution/permeation system (D/P system). The D/P system can be used to perform analysis of drug permeation under dissolution process and can predict the fraction of absorbed dose in humans. When celecoxib at 1/100 of a clinical dose was applied to the D/P system,% of dose dissolved and permeated significantly decreased with an increase in the applied amount, resulting in the oral absorption being predicted to be 22-55%. Whereas similar dissolution and permeation profiles of montelukast sodium was observed, es...
Source: European Journal of Pharmaceutics and Biopharmaceutics - June 25, 2013 Category: Drugs & Pharmacology Authors: Kataoka M, Yano K, Hamatsu Y, Masaoka Y, Sakuma S, Yamashita S Tags: Eur J Pharm Biopharm Source Type: research
Chemopreventive effect of montelukast in n-nitroso n-methyl urea induced mammary carcinogenesis in female Sprague-Dawley rats
Conclusion: The results revealed that montelukast sodium prevent the mammary carcinogenesis and confirms the role of cysteinyl leukotriene D 4 -receptor in mammary gland neoplasia. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - May 15, 2013 Category: Drugs & Pharmacology Authors: Manonmani Alvin JoseRamakrishna AmathiDuraiswami SathyamurthyBalasubramanian Nandha Kumar Source Type: research
[Psychiatric disorders associated with montelukast: Data from the National Pharmacovigilance Database.]
The objective of this study was to take stock of the adverse events (AEs) related to montelukast reported in France. Cases of psychiatric disorders reported to regional pharmacovigilance centers (CRPV) and the literature data were analyzed. The 56psychiatric AEs account for 20% of all AEs reported in the montelukast CRPV: essentially sleep disorders, behavioral disorders and depression. This risk is also found in pharmacovigilance databases in other countries, especially in the North American database, which recorded a significant number of cases of "suicidality", including suicidal ideation, suicide attempts, and suicides...
Source: Archives de Pediatrie - January 31, 2013 Category: Pediatrics Authors: Marchand MS, Jonville-Béra AP, Autret-Leca E, Association française des centres régionaux de pharmacovigilance Tags: Arch Pediatr Source Type: research
