IL-1 β augments TGF-β inducing epithelial-mesenchymal transition of epithelial cells and associates with poor pulmonary function improvement in neutrophilic asthmatics
CONCLUSIONS: IL-1β level in baseline sputum predicts the poor lung function improvement in NA. The potential mechanism may be related to IL-1β augmenting TGF-β1-induced steroid-resistant EMT through MAPK signaling pathways.TRIAL REGISTRATION: This study was approved by the Ethics Committee of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (IRB ID: 20150406).PMID:34344357 | DOI:10.1186/s12931-021-01808-7 (Source: Respiratory Care)
Source: Respiratory Care - August 4, 2021 Category: Respiratory Medicine Authors: Shengding Zhang Yu Fan Lu Qin Xiaoyu Fang Cong Zhang Junqing Yue Wenxue Bai Gang Wang Zhihong Chen Harld Renz Chrysanthi Skevaki Xiansheng Liu Min Xie Source Type: research
IL-1 β augments TGF-β inducing epithelial-mesenchymal transition of epithelial cells and associates with poor pulmonary function improvement in neutrophilic asthmatics
CONCLUSIONS: IL-1β level in baseline sputum predicts the poor lung function improvement in NA. The potential mechanism may be related to IL-1β augmenting TGF-β1-induced steroid-resistant EMT through MAPK signaling pathways.TRIAL REGISTRATION: This study was approved by the Ethics Committee of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (IRB ID: 20150406).PMID:34344357 | DOI:10.1186/s12931-021-01808-7 (Source: Respiratory Care)
Source: Respiratory Care - August 4, 2021 Category: Respiratory Medicine Authors: Shengding Zhang Yu Fan Lu Qin Xiaoyu Fang Cong Zhang Junqing Yue Wenxue Bai Gang Wang Zhihong Chen Harld Renz Chrysanthi Skevaki Xiansheng Liu Min Xie Source Type: research
Ecotoxicity and photodegradation of Montelukast (a drug to treat asthma) in water
In this study, solar-simulated irradiation of the drug in water was investigated. The drug was quickly converted into a series of photoproducts that were spectroscopically characterized. The possible photoreaction pathways were proposed. Ecotoxicity tests were performed on parent compound and mixture of photoproducts towards two bioindicators (Raphidocelis subcapitata and Daphnia magna). Results evidenced that effects of MTL on D. magna (EC50 = 16.4 mg/L) were greater than effects on R. subcapitata (EC50 = 195.7 mg/L). Microscopy observations revealed that MTL had mainly accumulated in the gut of daphnia. Toxicity data on ...
Source: Environmental Research - July 13, 2021 Category: Environmental Health Authors: Antonietta Siciliano Marco Guida Maria Rosaria Iesce Giovanni Libralato Fabio Temussi Emilia Galdiero Federica Carraturo Flavio Cermola Marina DellaGreca Source Type: research
Ecotoxicity and photodegradation of Montelukast (a drug to treat asthma) in water
In this study, solar-simulated irradiation of the drug in water was investigated. The drug was quickly converted into a series of photoproducts that were spectroscopically characterized. The possible photoreaction pathways were proposed. Ecotoxicity tests were performed on parent compound and mixture of photoproducts towards two bioindicators (Raphidocelis subcapitata and Daphnia magna). Results evidenced that effects of MTL on D. magna (EC50 = 16.4 mg/L) were greater than effects on R. subcapitata (EC50 = 195.7 mg/L). Microscopy observations revealed that MTL had mainly accumulated in the gut of daphnia. Toxicity data on ...
Source: Environmental Research - July 13, 2021 Category: Environmental Health Authors: Antonietta Siciliano Marco Guida Maria Rosaria Iesce Giovanni Libralato Fabio Temussi Emilia Galdiero Federica Carraturo Flavio Cermola Marina DellaGreca Source Type: research
Evaluation of efficiency and safety of combined montelukast sodium and budesonide in children with cough variant asthma: A protocol for systematic review and meta-analysis
Conclusion:
Our findings will provide vigorous evidence to judge whether montelukast sodium and budesonide therapy is an efficient form of therapy for CVA patients.
Ethics and dissemination:
Ethics approval is not needed for the present meta-analysis.
OSF registration number:
May 17, 2021.osf.io/cuvjz (https://osf.io/cuvjz/). (Source: Medicine)
Source: Medicine - June 25, 2021 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research
Huanglong Antitussive Granule Relieves Acute Asthma Through Regulating Pulmonary Lipid Homeostasis
Conclusion: HL Granule might improve pulmonary lipid homeostasis and could be used as an alternative or supplementary therapy in clinical for the treatment of asthma. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - April 23, 2021 Category: Drugs & Pharmacology Source Type: research
Dipyridamole, chloroquine, montelukast sodium, candesartan, oxytetracycline, and atazanavir are not SARS-CoV-2 main protease inhibitors [Biological Sciences]
Li et al. (1) recently report the discovery of 16 Food and Drug Administration–approved drugs as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro) inhibitors. They were identified from a computational virtual screening approach using the Mpro as the drug target, and their enzymatic inhibition against SARS-CoV-2 Mpro... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 10, 2021 Category: Science Authors: Chunlong Ma, Jun Wang Tags: Biophysics and Computational Biology, Letters, Letters and Replies, Coronavirus (COVID-19) Source Type: research
Efficacy and safety of montelukast sodium combined with fluticasone in the treatment of adult bronchial asthma: A protocol for systematic review and meta-analysis
Conclusion:
This study will provide reliable evidence-based evidence for the clinical application of montelukast sodium combined with fluticasone in the treatment of adult BA.
OSF Registration number:
DOI 10.17605/OSF.IO/CKQFM (Source: Medicine)
Source: Medicine - December 24, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research
Antiviral activity against Middle East Respiratory Syndrome Coronavirus by Montelukast, an anti-asthma drug.
Abstract
Middle East respiratory syndrome (MERS) is a respiratory disease caused by a coronavirus (MERS-CoV). Since its emergence in 2012, nosocomial amplifications have led to its high epidemic potential and mortality rate of 34.5 %. To date, there is an unmet need for vaccines and specific therapeutics for this disease. Available treatments are either supportive medications in use for other diseases or those lacking specificity requiring higher doses. The viral infection mode is initiated by the attachment of the viral Spike glycoprotein to the human Dipeptidyl Peptidase IV (DPP4). Our attempts to screen...
Source: Antiviral Research - December 9, 2020 Category: Virology Authors: Gan HJ, Harikishore A, Lee J, Jeon S, Rajan S, Chen MW, Neo JL, Kim S, Yoon HS Tags: Antiviral Res Source Type: research
