Difelikefalin (Korsuva) for Chronic Kidney Disease-Associated Pruritus
Date: February 7, 2022
Issue #:
1643Summary:
Difelikefalin (Korsuva– Vifor), an IV kappa opioid
receptor (KOR) agonist, has been approved by the
FDA for treatment of moderate to severe pruritus
associated with chronic kidney disease (CKD) in
adults on hemodialysis. It is the first drug to be
approved for this indication and the first KOR agonist
to become availab le in the US. Difelikefalin has not
been studied in patients on peritoneal dialysis. (Source: The Medical Letter)
Source: The Medical Letter - January 11, 2022 Category: Drugs & Pharmacology Authors: admin Tags: Antihistamines chronic kidney disease difelikefalin Gabapentin Korsuva Lyrica Montelukast Neurontin Phototherapy Pregabalin sertraline Singulair Zoloft Source Type: research
Performance Evaluation of Montelukast Pediatric Formulations: Part II — a PBPK Modelling Approach
This study aimed to build a physiologically based pharmacokinetic (PBPK) model coupled with age-appropriatein vitro dissolution data to describe drug performance in adults and pediatric patients. Montelukast sodium was chosen as a model drug. Two case studies were investigated: case study 1 focused on the description of formulation performance from adults to children; case study 2 focused on the description of the impact of medicine co-administration with vehicles on drug exposure in infants. The PBPK model for adults and pediatric patients was developed in Simcyp® v18.2 informed by age-appropriatein vitro dissolution res...
Source: The AAPS Journal - January 10, 2022 Category: Drugs & Pharmacology Source Type: research
Stability-indicating Liquid Chromatography Method Development and Validation for Impurity Profiling of Montelukast Sodium in Bulk Drug and Tablet Dosage Form
Biomed Chromatogr. 2022 Jan 7:e5330. doi: 10.1002/bmc.5330. Online ahead of print.ABSTRACTMontelukast sodium (MLS) is a leukotriene receptor antagonist drug used in the treatment of asthma, bronchospasm, allergic rhinitis and urticaria. A reversed-phase high performance liquid chromatography method was developed to separate, identify and quantitative determination of MLS and its eight known organic impurities in tablet dosage form using C18 column and mobile phases consisting of gradient mixture of pH 2.5 phosphate buffer and acetonitrile. Stability-indicating character of the developed method was proven using stress testi...
Source: Biomedical Chromatography : BMC - January 7, 2022 Category: Biomedical Science Authors: Mohan Pasham Sharath Babu Haridasyam N V V D Praveen Boppy Muvvala Venkatanarayana Ashok Kumar Palakurthi Source Type: research
Therapeutic effect of acupuncture combined montelukast sodium on cough variant asthma in children: A protocol for systematic review and meta-analysis
Conclusion:
This systematic review will provide evidence to determine whether acupuncture combined with montelukast sodium is an effective and safe intervention for patients with cough variant asthma in children.
INPLASY Registration number:
INPLASY2021110006. (Source: Medicine)
Source: Medicine - December 23, 2021 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research
Effect of azelastine hydrochloride combined with montelukast sodium in the treatment of patients with allergic rhinitis
CONCLUSION: Azelastine hydrochloride combined with montelukast sodium can effectively improve clinical symptoms and inflammatory reactions in patients with allergic rhinitis; furthermore, this research provides ideas for clinical practice.PMID:34540080 | PMC:PMC8430178 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - September 20, 2021 Category: Research Authors: Qiling Zheng Dijiang Ma Qi Zhu Shenjun Tang Chengbo Chen Source Type: research
