The Role of Montelukast Sodium in Children with Adenoid Hypertrophy - A Comparative Study
Conclusion Oral Montelukast therapy is seen to be effective not only in the reduction of the size of adenoids but also in improvement of the overall symptoms and can thus be considered as a viable alternative . (Source: Indian Journal of Otolaryngology and Head and Neck Surgery)
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - November 5, 2022 Category: ENT & OMF Source Type: research
Characterization of interactions of montelukast sodium with human serum albumin: Multi-spectroscopic techniques and computer simulation studies
New J. Chem., 2022, Accepted Manuscript DOI: 10.1039/D2NJ00419D, PaperShoujun Zheng, Xinyi Fang, Fan Li, Qiaomei Sun, Mu Zhao, Huiping Wei, Wanyu Xu, Hui Li Montelukast sodium (MLS) is a leukotriene receptor antagonist and widely used to treat asthma in clinical treatment. To further understand the pharmacological mechanism of MLS in the human body, detailed... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - October 26, 2022 Category: Chemistry Authors: Shoujun Zheng Source Type: research
Exploration of Parteck ® SRP 80 and Hypromellose for Chronomodulated Release of LTD4 Receptor Antagonist and Statistical Optimization Using Central Composite Design
AAPS PharmSciTech. 2022 Sep 23;23(7):263. doi: 10.1208/s12249-022-02415-5.ABSTRACTTo manage early morning symptoms of nocturnal bronchial asthma, a chronotherapeutic drug delivery system (ChrDDS) of montelukast sodium was designed and developed utilizing non-saccharide, fully synthetic Parteck® SRP 80, and hydrophilic cellulose derivative hydroxypropyl methylcellulose (HPMC). Recurrent lag phase, each followed by the release of a fraction of the drug dose, can be achieved by formulating a "tablets in a capsule" system containing more than one compressed coated tablet encapsulated in an enteric-coated capsule. Lag time in ...
Source: AAPS PharmSciTech - September 23, 2022 Category: Drugs & Pharmacology Authors: Saniya Jawed Satish Cs Source Type: research
Exploration of Parteck ® SRP 80 and Hypromellose for Chronomodulated Release of LTD4 Receptor Antagonist and Statistical Optimization Using Central Composite Design
AAPS PharmSciTech. 2022 Sep 23;23(7):263. doi: 10.1208/s12249-022-02415-5.ABSTRACTTo manage early morning symptoms of nocturnal bronchial asthma, a chronotherapeutic drug delivery system (ChrDDS) of montelukast sodium was designed and developed utilizing non-saccharide, fully synthetic Parteck® SRP 80, and hydrophilic cellulose derivative hydroxypropyl methylcellulose (HPMC). Recurrent lag phase, each followed by the release of a fraction of the drug dose, can be achieved by formulating a "tablets in a capsule" system containing more than one compressed coated tablet encapsulated in an enteric-coated capsule. Lag time in ...
Source: AAPS PharmSciTech - September 23, 2022 Category: Drugs & Pharmacology Authors: Saniya Jawed Satish Cs Source Type: research
Exploration of Parteck ® SRP 80 and Hypromellose for Chronomodulated Release of LTD4 Receptor Antagonist and Statistical Optimization Using Central Composite Design
AAPS PharmSciTech. 2022 Sep 23;23(7):263. doi: 10.1208/s12249-022-02415-5.ABSTRACTTo manage early morning symptoms of nocturnal bronchial asthma, a chronotherapeutic drug delivery system (ChrDDS) of montelukast sodium was designed and developed utilizing non-saccharide, fully synthetic Parteck® SRP 80, and hydrophilic cellulose derivative hydroxypropyl methylcellulose (HPMC). Recurrent lag phase, each followed by the release of a fraction of the drug dose, can be achieved by formulating a "tablets in a capsule" system containing more than one compressed coated tablet encapsulated in an enteric-coated capsule. Lag time in ...
Source: AAPS PharmSciTech - September 23, 2022 Category: Drugs & Pharmacology Authors: Saniya Jawed Satish Cs Source Type: research
Study on the Effect of Self-Made Lifei Dingchuan Decoction Combined with Western Medicine on Cough Variant Asthma
CONCLUSION: The study on the clinical efficacy and low hospitalization cost of the self-prepared lung and asthma-restorative soup in patients with cough variant asthma significantly improved the patients' arterial oxygen saturation, acid-base value, arterial partial pressure of oxygen, and partial pressure of carbon dioxide and effectively controlled the heart rate and respiratory rate with high safety, which is worth further promotion.PMID:36132547 | PMC:PMC9484939 | DOI:10.1155/2022/9803552 (Source: Computational and Mathematical Methods in Medicine)
Source: Computational and Mathematical Methods in Medicine - September 22, 2022 Category: Statistics Authors: Jiachun Li Ziliang Huang Keying Li Xiaoyun Jian Binghui Liang Source Type: research
Biosynthesized poly(3-hydroxybutyrate-co-3-hydroxyvalerate) as biocompatible microcapsules with extended release for busulfan and montelukast
Int J Biol Macromol. 2022 Jun 4:S0141-8130(22)01172-2. doi: 10.1016/j.ijbiomac.2022.05.181. Online ahead of print.ABSTRACTAn extended release dosage form based on encapsulating the challenging drug busulfan within microspheres of the biodegradable, biocompatible and biosynthesized poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) polyester was achieved. The used (PHBV) polymer was biosynthesized by the halophilic archaeon Haloferax mediterranei from date waste biomass as feed-stock. PHBV microspheres of 1.2-2.1 μm diameter were successfully fabricated and loaded with busulfan with encapsulation efficiency of 29.2 ± 0.2...
Source: International Journal of Biological Macromolecules - June 7, 2022 Category: Biochemistry Authors: Mohammad I Ibrahim Diya Alsafadi Eyad Safi Eid Alenazi Mohamed Aboulsoud Mahmoud A Hussein Khalid A Alamry Source Type: research
Biosynthesized poly(3-hydroxybutyrate-co-3-hydroxyvalerate) as biocompatible microcapsules with extended release for busulfan and montelukast
Int J Biol Macromol. 2022 Jun 4:S0141-8130(22)01172-2. doi: 10.1016/j.ijbiomac.2022.05.181. Online ahead of print.ABSTRACTAn extended release dosage form based on encapsulating the challenging drug busulfan within microspheres of the biodegradable, biocompatible and biosynthesized poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) polyester was achieved. The used (PHBV) polymer was biosynthesized by the halophilic archaeon Haloferax mediterranei from date waste biomass as feed-stock. PHBV microspheres of 1.2-2.1 μm diameter were successfully fabricated and loaded with busulfan with encapsulation efficiency of 29.2 ± 0.2...
Source: International Journal of Biological Macromolecules - June 7, 2022 Category: Biochemistry Authors: Mohammad I Ibrahim Diya Alsafadi Eyad Safi Eid Alenazi Mohamed Aboulsoud Mahmoud A Hussein Khalid A Alamry Source Type: research
Cross linked alginate beads of montelukast sodium coated with eudragit for chronotherapy: statistical optimization, in vitro and in vivo evaluation
The objective of the current investigation is to prepare delayed-release beads (DRBs) containing montelukast sodium (MKS) for chronotherapy of asthma.METHODS: Delayed-release beads of alginate were prepared using a simple method, i.e., ionotropic gelation. The effect of cross-linking agents (zinc or calcium ions) and the concentration of chitosan on the properties of the beads were investigated. The prepared beads were coated by a polymer having pH-independent solubility, i.e., Eudragit RSPO and Eudragit RLPO in different ratios to achieve the desired lag time of 4-5 h. Beads were evaluated for surface morphology, practica...
Source: Current Drug Delivery - February 22, 2022 Category: Drugs & Pharmacology Authors: Om Prakash Ranjan Nitesh Kumar Vivek Dave Source Type: research
Cross linked alginate beads of montelukast sodium coated with eudragit for chronotherapy: statistical optimization, in vitro and in vivo evaluation
The objective of the current investigation is to prepare delayed-release beads (DRBs) containing montelukast sodium (MKS) for chronotherapy of asthma.METHODS: Delayed-release beads of alginate were prepared using a simple method, i.e., ionotropic gelation. The effect of cross-linking agents (zinc or calcium ions) and the concentration of chitosan on the properties of the beads were investigated. The prepared beads were coated by a polymer having pH-independent solubility, i.e., Eudragit RSPO and Eudragit RLPO in different ratios to achieve the desired lag time of 4-5 h. Beads were evaluated for surface morphology, practica...
Source: Current Drug Delivery - February 22, 2022 Category: Drugs & Pharmacology Authors: Om Prakash Ranjan Nitesh Kumar Vivek Dave Source Type: research
Cross linked alginate beads of montelukast sodium coated with eudragit for chronotherapy: statistical optimization, in vitro and in vivo evaluation
The objective of the current investigation is to prepare delayed-release beads (DRBs) containing montelukast sodium (MKS) for chronotherapy of asthma.METHODS: Delayed-release beads of alginate were prepared using a simple method, i.e., ionotropic gelation. The effect of cross-linking agents (zinc or calcium ions) and the concentration of chitosan on the properties of the beads were investigated. The prepared beads were coated by a polymer having pH-independent solubility, i.e., Eudragit RSPO and Eudragit RLPO in different ratios to achieve the desired lag time of 4-5 h. Beads were evaluated for surface morphology, practica...
Source: Current Drug Delivery - February 22, 2022 Category: Drugs & Pharmacology Authors: Om Prakash Ranjan Nitesh Kumar Vivek Dave Source Type: research
Cross linked alginate beads of montelukast sodium coated with eudragit for chronotherapy: statistical optimization, in vitro and in vivo evaluation
The objective of the current investigation is to prepare delayed-release beads (DRBs) containing montelukast sodium (MKS) for chronotherapy of asthma.METHODS: Delayed-release beads of alginate were prepared using a simple method, i.e., ionotropic gelation. The effect of cross-linking agents (zinc or calcium ions) and the concentration of chitosan on the properties of the beads were investigated. The prepared beads were coated by a polymer having pH-independent solubility, i.e., Eudragit RSPO and Eudragit RLPO in different ratios to achieve the desired lag time of 4-5 h. Beads were evaluated for surface morphology, practica...
Source: Current Drug Delivery - February 22, 2022 Category: Drugs & Pharmacology Authors: Om Prakash Ranjan Nitesh Kumar Vivek Dave Source Type: research
Cross linked alginate beads of montelukast sodium coated with eudragit for chronotherapy: statistical optimization, in vitro and in vivo evaluation
The objective of the current investigation is to prepare delayed-release beads (DRBs) containing montelukast sodium (MKS) for chronotherapy of asthma.METHODS: Delayed-release beads of alginate were prepared using a simple method, i.e., ionotropic gelation. The effect of cross-linking agents (zinc or calcium ions) and the concentration of chitosan on the properties of the beads were investigated. The prepared beads were coated by a polymer having pH-independent solubility, i.e., Eudragit RSPO and Eudragit RLPO in different ratios to achieve the desired lag time of 4-5 h. Beads were evaluated for surface morphology, practica...
Source: Current Drug Delivery - February 22, 2022 Category: Drugs & Pharmacology Authors: Om Prakash Ranjan Nitesh Kumar Vivek Dave Source Type: research
