IL-1 β augments TGF-β inducing epithelial-mesenchymal transition of epithelial cells and associates with poor pulmonary function improvement in neutrophilic asthmatics

CONCLUSIONS: IL-1β level in baseline sputum predicts the poor lung function improvement in NA. The potential mechanism may be related to IL-1β augmenting TGF-β1-induced steroid-resistant EMT through MAPK signaling pathways.TRIAL REGISTRATION: This study was approved by the Ethics Committee of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (IRB ID: 20150406).PMID:34344357 | DOI:10.1186/s12931-021-01808-7

Source: Respiratory Care - August 4, 2021 Category: Respiratory Medicine Authors: Shengding Zhang Yu Fan Lu Qin Xiaoyu Fang Cong Zhang Junqing Yue Wenxue Bai Gang Wang Zhihong Chen Harld Renz Chrysanthi Skevaki Xiansheng Liu Min Xie Source Type: research