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Condition: Brain Tumor
Therapy: Chemotherapy

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Total 27 results found since Jan 2013.

Diffuse low-grade glioma misdiagnosed as acute cerebral infarction: A case report
We report a case of DLGG detected by computed tomography and magnetic resonance imaging (MRI). Patient concerns: A 58-year-old man suddenly phantom smells for half an hour and was previously healthy. Diagnoses: Computed tomography findings showed a leaf-shaped slightly hypodense shadow in the right temporal lobe with no obvious mass effect and an unclear boundary. MRI findings showed diffuse and slightly longer T1-weighted imaging (T1WI)/T2-weighted imaging (T2WI)signal in the right temporal lobe and hippocampus, slight hyperintensity on diffusion-weighted imaging, diffuse swelling in the right temporal lobe ...
Source: Medicine - September 2, 2022 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Recent Synergy of Nanodiamonds: Role in Brain-Targeted Drug Delivery for the Management of Neurological Disorders
AbstractThe aim of the present review article is to summarize the role of nanodiamonds in various neurological diseases. We have taken related literature of making this review article from ScienceDirect, springer, Research gate, PubMed, Sci-finder, etc. The current approaches for treating neurological conditions such as glioblastoma includes chemotherapy or combination anti-retro viral therapy for HIV (human immunodeficiency virus) or use of anti-Alzheimer drugs during cognitive impairment. These approaches can provide only symptomatic relief as they do not target the cause of the disease due to their inability to penetrat...
Source: Molecular Neurobiology - May 27, 2022 Category: Neurology Source Type: research

Ischemic Stroke Risk Among Adult Brain Tumor Survivors: Evidence to Guide Practice
CONCLUSION: Nurses play a key role in the assessment, prevention, and identifying individuals who are at risk of AIS during brain tumor survivorship. Engaging patients and their caregivers on minimizing their risks of AIS is crucial in the outpatient setting. Annual surveillance visits that include intracranial artery imaging should be used to identify individuals considered most at risk for developing AIS symptoms.
Source: Journal of Neuroscience Nursing - September 9, 2021 Category: Neuroscience Tags: Clinical Nursing Focus Source Type: research

Clinical Importance of the Posterior Inferior Cerebellar Artery: A Review of the Literature.
In conclusion, PICA is very important in clinical practice. PMID: 33173421 [PubMed - in process]
Source: International Journal of Medical Sciences - November 13, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

RFDCR: Automated brain lesion segmentation using cascaded random forests with dense conditional random fields
Publication date: Available online 11 February 2020Source: NeuroImageAuthor(s): Gaoxiang Chen, Qun Li, Fuqian Shi, Islem Rekik, Li Wang, Zhifang PanSegmentation of brain lesions from magnetic resonance images (MRI) is an important step for disease diagnosis, surgical planning, radiotherapy and chemotherapy. However, due to noise, motion, and partial volume effects, automated segmentation of lesions from MRI is still a challenging task. In this paper, we propose a two-stage supervised learning framework for automatic brain lesion segmentation. Specifically, in the first stage, intensity-based statistical features, template-...
Source: NeuroImage - February 11, 2020 Category: Neuroscience Source Type: research

One of Britain's youngest stroke victims at just 19 months 'stands up' for the first time
Ronnie Kerman, of Bransholme, was found lifeless in his cot in March 2018 by his father. He is receiving chemotherapy for a brain tumour which caused the stroke and left him unable to use his legs.
Source: the Mail online | Health - June 14, 2019 Category: Consumer Health News Source Type: news

Delayed radiation-induced stroke mimics recurrent tumor in and adolescent with remote history of low-grade brainstem glioma
A 13-year-old female was diagnosed with a ponto- medullary brainstem glioma and following unsuccessful treatment with chemotherapy, underwent focal photon intensity modulated radiation therapy that resulted in a favorable response. Ten years later, the patient presented with acute onset left-sided hemiplegia and headaches. Magnetic resonance imaging (MRI) at presentation showed a large contrast- enhancing lesion with surrounding vasogenic edema and reduced diffusivity on diffusion- weighted imaging most concerning for a high grade secondary malignancy (Figure 1).
Source: Pediatric Neurology - June 4, 2019 Category: Neurology Authors: Lianne Q. Chau, Michael L. Levy, John Ross Crawford Tags: Short Communication Source Type: research

Delayed Radiation-Induced Stroke Mimics Recurrent Tumor in an Adolescent With Remote History of Low-Grade Brainstem Glioma
This 13-year-old girl was diagnosed with a ponto-medullary brainstem glioma, and following unsuccessful treatment with chemotherapy, she underwent focal photon intensity-modulated radiation therapy that resulted in a favorable response. Ten years later, she presented with acute left hemiplegia and headaches. Magnetic resonance imaging (MRI) at presentation showed a large contrast-enhancing lesion with surrounding vasogenic edema and reduced diffusivity on diffusion-weighted imaging, most concerning for a high-grade secondary malignancy (Fig 1).
Source: Pediatric Neurology - June 4, 2019 Category: Neurology Authors: Lianne Q. Chau, Michael L. Levy, John R. Crawford Tags: Clinical Letter Source Type: research

NAMPT as a Dedifferentiation-Inducer Gene: NAD+ as Core Axis for Glioma Cancer Stem-Like Cells Maintenance
Conclusion and Perspectives Gliomas are the most prevalent primary brain cancer in adults and include a broad category of tumors including astrocytoma, oligodendroglioma, and GBM. Regardless of tumor aggressiveness, malignancy, and infiltration, these glia-derived tumors rarely exceed a median survival time of 12–14 months. Driven by the infiltrative nature of these tumors, the clinical approach is difficult and relapses often occur with fatal consequences. These unsuccessful attempts to control glioma's fate have fostered research looking for more effective therapies. (GSCs) are a small subset of CD133&#...
Source: Frontiers in Oncology - May 2, 2019 Category: Cancer & Oncology Source Type: research

Therapeutic dormancy to delay postsurgical glioma recurrence: the past, present and promise of focal hypothermia
AbstractSurgery precedes both radiotherapy and chemotherapy as the first-line therapy for glioma. However, despite multimodal treatment, most glioma patients die from local recurrence in the resection margin. Glioma surgery is inherently lesional, and the response of brain tissue to surgery includes hemostasis, angiogenesis, reactive gliosis and inflammation. Unfortunately, these processes are also associated with tumorigenic side-effects. An increasing amount of evidence indicates that the response to a surgery-related brain injury is hijacked by residual glioma cells and participates in the local regeneration of tumor ti...
Source: Journal of Neuro-Oncology - May 17, 2017 Category: Cancer & Oncology Source Type: research

Stroke-like migraine attacks in long term survivors of high grade glioma. (P1.174)
Conclusions:Stroke-like migraine attacks are difficult to treat and the pathophysiology is unknown. With more sophisticated imaging techniques, a better understanding of this phenomenon will aid in the treatment and prophylaxis of the syndrome with a goal of improving quality of life for this small but slowly growing population.Disclosure: Dr. New has nothing to disclose. Dr. Mirza has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: New, P., Mirza, H. Tags: Neuro-oncology: Gliomas I Source Type: research

Tumor Treating Fields (TTF) with Triple Chemotherapy for Recurrent Glioblastoma (P1.177)
Conclusions:Therapies with TTF plus TBC demonstrates superior OS benefit for recurrent GBM with moderate, but manageable side effects. A prospective study of TTF plus TBC for recurrent GBM is warranted.Study Supported by: Dr. Marnie Rose FoundationDisclosure: Dr. Zhu has received personal compensation for activities with Novocure, and Prime Oncology. Dr. Zhu has received research support from Novocure, Inc., Five Prime Therapeutics, Immuno-Cellular Inc., DEKK-TEC. Dr. Lu has nothing to disclose. Dr. Rao has nothing to disclose. Dr. Zhu has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Zhu, J.-J., Lu, G., Rao, M., Zhu, P. Tags: Neuro-oncology: Gliomas I Source Type: research

Vascular complications in glioma patients.
Abstract Vascular complications in patients with glioma most commonly include venous and arterial thromboembolism; however, treatment-induced vasculopathies are also problematic, especially in long-term survivors. The interactions between treatment such as radiation and chemotherapy, the coagulation cascade, endothelium, and regulators of angiogenesis are complex, drive glioma growth and invasion, and create common management problems in the clinic. We review the incidence of thrombotic complications in glioma, the biology of the coagulome as related to glioma progression, prevention and treatment of thrombosis, t...
Source: Clinical Genitourinary Cancer - December 16, 2016 Category: Cancer & Oncology Authors: Le Rhun E, Perry JR Tags: Handb Clin Neurol Source Type: research

Ntox-08. safety of intra-arterial chemotherapy in the treatment of brain tumours
The treatment of brain tumors is greatly limited the delivery impediment caused by the blood-brain barrier and blood-tumor barrier. To circumvent this limitation, different approaches have been studied, including intra-arterial delivery. Because of a significant local increase in plasma-peak concentration, this strategy increases the local area under the curve, and translates into a 3 to 5.5 fold increase in intra-tumoral chemotherapy concentration. However, intra-arterial chemotherapy in the treatment of brain tumors has a notoriously bad name, thanks to prior trials led in past decades showing significant neurotoxicities...
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Fortin, D., Caux, S., Gahide, G. Tags: NEUROTOXICITY OF THERAPY Source Type: research

Atim-18. phase i dose escalation study of d2c7-it administered intratumorally via convection-enhanced delivery (ced) for recurrent malignant glioma (mg)
CONCLUSION:Infusion of D2C7-IT via CED is safe thus far and encouraging efficacy results are observed. Enrollment is ongoing.
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Desjardins, A., Randazzo, D., Chandramohan, V., Sampson, J., Peters, K., Vlahovic, G., Threatt, S., Herndon, J., Boulton, S., Lally-Goss, D., Healy, P., Lipp, E., Friedman, A., Friedman, H., Bigner, D. Tags: ADULT CLINICAL TRIALS (IMMUNOLOGICAL) Source Type: research