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Condition: Brain Tumor
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Total 780 results found since Jan 2013.
Web-based psychoeducational interventions for managing cognitive impairment –a systematic review
ConclusionWeb-based cognitive intervention programs are a new approach to rehabilitation and patient education. The evidence, although scarce, shows that web-based interventions are feasible and support subjective cognitive functioning. However, the literature to date is extremely limited and the quality of the studies is weak. More research with high-quality study designs is needed.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=257315, identifier: CRD42021257315.
Source: Frontiers in Neurology - September 13, 2023 Category: Neurology Source Type: research
Sensory hypersensitivity after acquired brain injury: the patient perspective
CONCLUSIONS: Sensory hypersensitivity can have a major impact on patients' physical well-being, return to work and (social) participation after ABI. Characteristics of sensory hypersensitivity vary between patients with ABI. To develop treatments for sensory hypersensitivity, future studies should focus on cognitive (e.g., filtering information) and psychological factors (e.g., coping) in relation to sensory hypersensitivity.PMID:37649314 | DOI:10.1080/09638288.2023.2251401
Source: Disability and Rehabilitation - August 31, 2023 Category: Rehabilitation Authors: A M de Sain L W M Pellikaan J van Voskuilen M Migdis M P J Sommers-Spijkerman J M A Visser-Meily I M C Huenges Wajer Source Type: research
Detection of Ferroptosis in Models of Brain Diseases
Methods Mol Biol. 2023;2712:233-251. doi: 10.1007/978-1-0716-3433-2_21.ABSTRACTFerroptosis is a regulated form of non-apoptotic cell death driven by iron-dependent lipid peroxidation. In the past decade, ferroptosis has been reported to be involved in the pathological role in the central nervous system degenerative diseases (e.g., Alzheimer's disease, Huntington's disease, and Parkinson's disease), stroke, traumatic brain injury, and brain tumor. However, how to reliably detect and classify ferroptosis from other cell death in pathological conditions remains a great challenge, especially in primary brain cells and brain ti...
Source: Mol Biol Cell - August 14, 2023 Category: Molecular Biology Authors: Danmin Shen Fei Yang Qian Li Source Type: research
Mechanosensitive Piezo1 Channel in Physiology and Pathophysiology of the Central Nervous System
Ageing Res Rev. 2023 Jul 31:102026. doi: 10.1016/j.arr.2023.102026. Online ahead of print.ABSTRACTSince the discovery of the mechanosensitive Piezo1 channel in 2010, there has been a significant amount of research conducted to explore its regulatory role in the physiology and pathology of various organ systems. Recently, a growing body of compelling evidence has emerged linking the activity of the mechanosensitive Piezo1 channel to health and disease of the central nervous system. However, the exact mechanisms underlying these associations remain inadequately comprehended. This review systematically summarizes the current ...
Source: Ageing Research Reviews - August 2, 2023 Category: Genetics & Stem Cells Authors: Boyi Zong Fengzhi Yu Xiaoyou Zhang Yige Pang Wenrui Zhao Peng Sun Lin Li Source Type: research
Mechanosensitive Piezo1 channel in physiology and pathophysiology of the central nervous system
Ageing Res Rev. 2023 Jul 31;90:102026. doi: 10.1016/j.arr.2023.102026. Online ahead of print.ABSTRACTSince the discovery of the mechanosensitive Piezo1 channel in 2010, there has been a significant amount of research conducted to explore its regulatory role in the physiology and pathology of various organ systems. Recently, a growing body of compelling evidence has emerged linking the activity of the mechanosensitive Piezo1 channel to health and disease of the central nervous system. However, the exact mechanisms underlying these associations remain inadequately comprehended. This review systematically summarizes the curre...
Source: Ageing Research Reviews - August 2, 2023 Category: Genetics & Stem Cells Authors: Boyi Zong Fengzhi Yu Xiaoyou Zhang Yige Pang Wenrui Zhao Peng Sun Lin Li Source Type: research
Mechanosensitive Piezo1 Channel in Physiology and Pathophysiology of the Central Nervous System
Ageing Res Rev. 2023 Jul 31:102026. doi: 10.1016/j.arr.2023.102026. Online ahead of print.ABSTRACTSince the discovery of the mechanosensitive Piezo1 channel in 2010, there has been a significant amount of research conducted to explore its regulatory role in the physiology and pathology of various organ systems. Recently, a growing body of compelling evidence has emerged linking the activity of the mechanosensitive Piezo1 channel to health and disease of the central nervous system. However, the exact mechanisms underlying these associations remain inadequately comprehended. This review systematically summarizes the current ...
Source: Ageing Research Reviews - August 2, 2023 Category: Genetics & Stem Cells Authors: Boyi Zong Fengzhi Yu Xiaoyou Zhang Yige Pang Wenrui Zhao Peng Sun Lin Li Source Type: research
The broad-spectrum activity of perampanel: state of the art and future perspective of AMPA antagonism beyond epilepsy
Glutamate is the brain’s main excitatory neurotransmitter. Glutamatergic neurons primarily compose basic neuronal networks, especially in the cortex. An imbalance of excitatory and inhibitory activities may result in epilepsy or other neurological and psychiatric conditions. Among glutamate receptors, AMPA receptors are the predominant mediator of glutamate-induced excitatory neurotransmission and dictate synaptic efficiency and plasticity by their numbers and/or properties. Therefore, they appear to be a major drug target for modulating several brain functions. Perampanel (PER) is a highly selective, noncompetitive AMPA...
Source: Frontiers in Neurology - July 6, 2023 Category: Neurology Source Type: research
Risk of intracranial hemorrhage with direct oral anticoagulation versus low molecular weight heparin in the treatment of brain tumor-associated venous thromboembolism: A meta-analysis
Direct oral anticoagulants (DOACs) are effective in treating cancer-related thrombosis and are superior to low molecular weight heparin (LMWH) in terms of efficacy. The effects of DOACs or LMWH on intracranial hemorrhage (ICH) remain uncertain in individuals with brain tumors. We conducted a meta-analysis to compare the frequency of ICH in individuals with brain tumors treated with DOACs or LMWH.
Source: Journal of Stroke and Cerebrovascular Diseases - July 4, 2023 Category: Neurology Authors: Jun Yang, Zesong He, Meihua Li, Tao Hong, Taohui Ouyang Source Type: research
Perspectives and new aspects of histone deacetylase inhibitors in the therapy of CNS diseases
Eur J Med Chem. 2023 Jun 29;258:115613. doi: 10.1016/j.ejmech.2023.115613. Online ahead of print.ABSTRACTMany populations worldwide are suffering from central nervous system (CNS) diseases such as brain tumors, neurodegenerative diseases (Alzheimer's disease, Parkinson's disease and Huntington's disease) and stroke. There is a shortage of effective drugs for most CNS diseases. As one of the regulatory mechanisms of epigenetics, the particular role and therapeutic benefits of histone deacetylases (HDACs) in the CNS have been extensively studied. In recent years, HDACs have attracted increasing attention as potential drug ta...
Source: European Journal of Medicinal Chemistry - July 3, 2023 Category: Chemistry Authors: Bo Han Mengfei Wang Jiayi Li Qiushi Chen Niubing Sun Xuezhi Yang Qingwei Zhang Source Type: research
Reframing Lesional Epilepsy as a Network Disease
The question why some brain lesions cause epilepsy whereas other do not has remained unanswered for the past century. Lesions are the leading identifiable cause of epilepsy in adults, especially in individuals older than 55 years. But, only 6% of those with stroke, 9% of those with intracerebral hemorrhage, and approximately 40% of those with brain tumors have lesional epilepsy. Why do some develop epilepsy whereas others do not?
Source: JAMA Neurology - July 3, 2023 Category: Neurology Source Type: research
