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Total 451 results found since Jan 2013.

Hypothalamic-Pituitary Disorders in Childhood Cancer Survivors: Prevalence, Risk Factors and Long-Term Health Outcomes.
CONCLUSIONS: HP radiotherapy, CNS injury and, to a lesser extent, chemotherapy are associated with HP disorders, which are associated with adverse health outcomes. PMID: 31373627 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - August 1, 2019 Category: Endocrinology Authors: van Iersel L, Li Z, Srivastava DK, Brinkman TM, Bjornard KL, Wilson CL, Green DM, Merchant TE, Pui CH, Howell RM, Smith SA, Armstrong GT, Hudson MM, Robison LL, Ness KK, Gajjar A, Krull KR, Sklar CA, van Santen HM, Chemaitilly W Tags: J Clin Endocrinol Metab Source Type: research

Nonbacterial Thrombotic Endocarditis Due to Primary Gallbladder Malignancy with Recurrent Stroke Despite Anticoagulation: Case Report and Literature Review
AbstractNonbacterial thrombotic endocarditis (NBTE) associated with malignancy is rare; its infrequency and similarity to other diagnoses make it a significant diagnostic challenge. A 63-year-old woman on rivaroxaban for prior deep vein thrombosis presented with left upper extremity weakness and left facial droop with imaging demonstrating multiple strokes. Echocardiograms revealed mitral and aortic valve vegetations. The patient was switched to apixaban and started on vancomycin and ceftriaxone for presumed culture-negative endocarditis. Despite continuing apixaban, her hospital course was complicated by new acute embolic...
Source: Journal of General Internal Medicine - July 15, 2019 Category: Internal Medicine Source Type: research

Persistent Impairment in Cardiopulmonary Fitness after Breast Cancer Chemotherapy
Purpose Anthracycline chemotherapy (AC) is associated with acute reductions in cardiopulmonary fitness (V˙O2peak). We sought to determine whether changes in V˙O2peak and cardiac function persisted at 12 months post-AC completion, and whether changes in cardiac function explain the heightened long-term heart failure risk. Methods Women with breast cancer scheduled for AC (n = 28) who participated in a nonrandomized trial of exercise training (ET; n = 14) or usual care (UC; n = 14) during AC completed a follow-up evaluation 12 months post-AC completion (16 months from baseline). At baseline, 4 months, and 16 months, p...
Source: Medicine and Science in Sports and Exercise - July 12, 2019 Category: Sports Medicine Tags: CLINICAL SCIENCES Source Type: research

5-HT3 Receptor Antagonists in Neurologic and Neuropsychiatric Disorders: The Iceberg Still Lies beneath the Surface.
Abstract 5-HT3 receptor antagonists, first introduced to the market in the mid-1980s, are proven efficient agents to counteract chemotherapy-induced emesis. Nonetheless, recent investigations have shed light on unappreciated dimensions of this class of compounds in conditions with an immunoinflammatory component as well as in neurologic and psychiatric disorders. The promising findings from multiple studies have unveiled several beneficial effects of these compounds in multiple sclerosis, stroke, Alzheimer disease, and Parkinson disease. Reports continue to uncover important roles for 5-HT3 receptors in the physio...
Source: Pharmacological Reviews - June 28, 2019 Category: Drugs & Pharmacology Authors: Fakhfouri G, Rahimian R, Dyhrfjeld-Johnsen J, Zirak MR, Beaulieu JM Tags: Pharmacol Rev Source Type: research

Adjuvant radiotherapy-induced cardiac changes among patients with early breast cancer: a three-year follow-up study.
Conclusion: During the 3-year follow-up after RT, negative subclinical changes in cardiac biomarkers and in LV systolic and diastolic function were observed. The measured changes were more pronounced in left-sided patients. In addition, AI use was associated with impaired cardiac systolic function. PMID: 31219359 [PubMed - as supplied by publisher]
Source: Acta Oncologica - June 19, 2019 Category: Cancer & Oncology Authors: Skyttä T, Tuohinen S, Luukkaala T, Virtanen V, Raatikainen P, Kellokumpu-Lehtinen PL Tags: Acta Oncol Source Type: research

One of Britain's youngest stroke victims at just 19 months 'stands up' for the first time
Ronnie Kerman, of Bransholme, was found lifeless in his cot in March 2018 by his father. He is receiving chemotherapy for a brain tumour which caused the stroke and left him unable to use his legs.
Source: the Mail online | Health - June 14, 2019 Category: Consumer Health News Source Type: news

Delayed radiation-induced stroke mimics recurrent tumor in and adolescent with remote history of low-grade brainstem glioma
A 13-year-old female was diagnosed with a ponto- medullary brainstem glioma and following unsuccessful treatment with chemotherapy, underwent focal photon intensity modulated radiation therapy that resulted in a favorable response. Ten years later, the patient presented with acute onset left-sided hemiplegia and headaches. Magnetic resonance imaging (MRI) at presentation showed a large contrast- enhancing lesion with surrounding vasogenic edema and reduced diffusivity on diffusion- weighted imaging most concerning for a high grade secondary malignancy (Figure 1).
Source: Pediatric Neurology - June 4, 2019 Category: Neurology Authors: Lianne Q. Chau, Michael L. Levy, John Ross Crawford Tags: Short Communication Source Type: research

Delayed Radiation-Induced Stroke Mimics Recurrent Tumor in an Adolescent With Remote History of Low-Grade Brainstem Glioma
This 13-year-old girl was diagnosed with a ponto-medullary brainstem glioma, and following unsuccessful treatment with chemotherapy, she underwent focal photon intensity-modulated radiation therapy that resulted in a favorable response. Ten years later, she presented with acute left hemiplegia and headaches. Magnetic resonance imaging (MRI) at presentation showed a large contrast-enhancing lesion with surrounding vasogenic edema and reduced diffusivity on diffusion-weighted imaging, most concerning for a high-grade secondary malignancy (Fig 1).
Source: Pediatric Neurology - June 4, 2019 Category: Neurology Authors: Lianne Q. Chau, Michael L. Levy, John R. Crawford Tags: Clinical Letter Source Type: research

Occlusive radiation cerebral vasculopathy implies medical complexity: a case report
ConclusionLate-onset occlusive radiation vasculopathy is a potentially severe iatrogenic manifestation of radiotherapy that requires a high index of suspicion as an etiology of stroke in young population, especially those with coexistent meningioma that might be a strong indicator for occlusive radiation vasculopathy as the stroke culprit. We reviewed the available literature to better understand the pathogenesis, clinical presentation, and treatment options of occlusive radiation vasculopathy. Applying perfusion studies with acetazolamide measures the cerebrovascular reserve in patients with occlusive radiation vasculopat...
Source: Journal of Medical Case Reports - June 2, 2019 Category: General Medicine Source Type: research

A Serious Diagnosis Lacking Common Symptoms
​BY JENNIFER TUONG; IVAN KHARCHENKO; JEAN LUC AGARD; & AHMED RAZIUDDIN, MDA 65-year-old man who had HIV well-controlled with highly active antiretroviral therapy, hypertension, sciatica, and restless leg syndrome presented to the emergency department with left leg pain. He also had had chemotherapy and radiation for anal cancer. The patient said the pain had started 45 minutes earlier when he was sitting on the toilet.He described the pain as sore in quality and 10/10 on the pain scale. He reported that it had started in his lower back and radiated to his left leg. He said he had had no trauma or weakness to the regi...
Source: The Case Files - May 28, 2019 Category: Emergency Medicine Tags: Blog Posts Source Type: research

NAMPT as a Dedifferentiation-Inducer Gene: NAD+ as Core Axis for Glioma Cancer Stem-Like Cells Maintenance
Conclusion and Perspectives Gliomas are the most prevalent primary brain cancer in adults and include a broad category of tumors including astrocytoma, oligodendroglioma, and GBM. Regardless of tumor aggressiveness, malignancy, and infiltration, these glia-derived tumors rarely exceed a median survival time of 12–14 months. Driven by the infiltrative nature of these tumors, the clinical approach is difficult and relapses often occur with fatal consequences. These unsuccessful attempts to control glioma's fate have fostered research looking for more effective therapies. (GSCs) are a small subset of CD133&#...
Source: Frontiers in Oncology - May 2, 2019 Category: Cancer & Oncology Source Type: research

Sex Differences in Sex Hormone Profiles and Prediction of Consciousness Recovery After Severe Traumatic Brain Injury
Conclusion: These findings indicate that TBI differentially affects the levels of sex-steroid hormones in men and women patients. Plasma levels of testosterone could be a good candidate blood marker to predict recovery from unconsciousness after sTBI for male patients. Introduction Traumatic brain injury (TBI) is a major cause of death and disability worldwide and is increasing in incidence (1). Patients with acute severe TBI (sTBI) often develop severe disorders of consciousness, i.e., coma, minimally conscious state or vegetative state. Although many patients may regain consciousness during the 1-month post-TBI p...
Source: Frontiers in Endocrinology - April 25, 2019 Category: Endocrinology Source Type: research

Cancers, Vol. 11, Pages 571: Chronic Treatment with Multi-Kinase Inhibitors Causes Differential Toxicities on Skeletal and Cardiac Muscles
Andrea Bonetto Despite recent progress, chemotherapy remains the preferred treatment for cancer. We have shown a link between anticancer drugs and the development of cachexia, i.e., body wasting accompanied by muscle loss. The multi-kinase inhibitors (MKIs) regorafenib and sorafenib, used as second-line treatment for solid tumors, are frequently accompanied by several side effects, including loss of muscle mass and strength. In the present study we aimed to investigate the molecular mechanisms associated with the occurrence of muscle toxicities in in vivo conditions. Hence, we treated 8-week old healthy CD2F1 male mic...
Source: Cancers - April 22, 2019 Category: Cancer & Oncology Authors: Joshua R. Huot Alyson L. Essex Maya Gutierrez Rafael Barreto Meijing Wang David L. Waning Lilian I. Plotkin Andrea Bonetto Tags: Article Source Type: research

Role of TREK-1 in Health and Disease, Focus on the Central Nervous System
Conclusion and Perspectives Since their cloning 20 years ago, the physiological importance of TREK-1 channels has continued to grow (Figure 3). Today, TREK-1 channels have been shown to be important and their presence is essential in a number of physiopathological processes. Their involvement in these different processes demonstrate the necessity to design pharmacological modulators, activators or inhibitors, of these channels to correct any TREK-1-related dysfunctions. Despites a number of studies and many molecule screenings, only few putative new drugs were identified. The activators belonging to the ML and BL series ...
Source: Frontiers in Pharmacology - April 10, 2019 Category: Drugs & Pharmacology Source Type: research

Neuroimaging and Neurolaw: Drawing the Future of Aging
Vincenzo Tigano1, Giuseppe Lucio Cascini2, Cristina Sanchez-Castañeda3, Patrice Péran4 and Umberto Sabatini5* 1Department of Juridical, Historical, Economic and Social Sciences, University of Magna Graecia, Catanzaro, Italy 2Department of Experimental and Clinical Medicine, University of Magna Graecia, Catanzaro, Italy 3Department of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain 4ToNIC, Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, Toulouse, France 5Department of Medical and Surgical Sciences, University of Magna Graecia, Catanzaro, ...
Source: Frontiers in Endocrinology - April 7, 2019 Category: Endocrinology Source Type: research