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Total 2301 results found since Jan 2013.

The potential role of inflammation in cryptogenic stroke.
CONCLUSIONS: Endothelial dysfunction assessed by increased level of ADMA affects the inflammatory state in patients with cryptogenic stroke. Increase in the inflammatory cytokine IL-6 by 1 pg/ml almost doubles the risk of stroke. PMID: 31260841 [PubMed - as supplied by publisher]
Source: Advances in Medical Sciences - June 27, 2019 Category: Biomedical Science Authors: Gąsiorek P, Banach M, Sakowicz A, Głąbiński A, Sosnowska B, Maciejewski M, Bielecka-Dabrowa A Tags: Adv Med Sci Source Type: research

Impact of the Dedicated Neurointensivists on the Outcome in Patients with Ischemic Stroke Based on the Linked Big Data for Stroke in Korea.
CONCLUSION: Treatment by dedicated neurointensivists is associated with lower in-hospital and 3-month mortality using the linked big datasets for stroke in Korea. This finding stresses the importance of neurointensivists in treating patients with severe ischemic stroke. PMID: 32476299 [PubMed - in process]
Source: Journal of Korean Medical Science - June 3, 2020 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Prior ischemic stroke is not associated with worse clinical outcomes in patients undergoing percutaneous coronary intervention.
Conclusions: This study demonstrates that, in daily clinical practice, PCI can be provided safely and with good results to patients with a prior ischemic stroke (≥3 months). PMID: 25090258 [PubMed - as supplied by publisher]
Source: Clinical and Investigative Medicine - August 5, 2014 Category: Biomedical Science Authors: Zhang M, Guddeti RR, Wang SP, Wang J, Xin MK, Chen SJ, Kang JP, Lv Q, Ma CS, Liu JH Tags: Clin Invest Med Source Type: research

Clinical Manifestation of Depression after Stroke: Is It Different from Depression in Other Patient Populations?
Conclusions The findings suggest that depression after stroke is not a different type of depression. This finding indicates that all depressive symptoms should be evaluated in stroke patients, including somatic symptoms.
Source: PLoS One - December 4, 2015 Category: Biomedical Science Authors: Janneke M. de Man-van Ginkel et al. Source Type: research

Ischemic stroke in paediatrics - narrative review of the literature and two cases.
CONCLUSION: Despite advances in paediatric stroke research and clinical care, questions remain unanswered regarding acute treatment, secondary prevention and rehabilitation. The treatment recommendations are mainly extrapolated from studies on adult populations. We have summarized the clinical characteristics and diagnostic steps for stroke in children/adolescents based on the most recent international guidelines and practical directions for recognising and managing the child/adolescent with stroke in paediatric emergency. In the two case reports, we described the clinical course in both stroke patients. PMID: 27833170...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - November 13, 2016 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Adipose tissue and metabolic and inflammatory responses to stroke are altered in obese mice RESEARCH ARTICLE
ABSTRACT Obesity is an independent risk factor for stroke, although several clinical studies have reported that obesity improves stroke outcome. Obesity is hypothesised to aid recovery by protecting against post-stroke catabolism. We therefore assessed whether obese mice had an altered metabolic and inflammatory response to stroke. Obese ob/ob mice underwent a 20-min middle cerebral artery occlusion and 24-h reperfusion. Lipid metabolism and expression of inflammatory cytokines were assessed in the plasma, liver and adipose tissue. The obese-specific metabolic response to stroke was assessed in plasma using non-targeted ul...
Source: DMM Disease Models and Mechanisms - October 9, 2017 Category: Biomedical Science Authors: Haley, M. J., Mullard, G., Hollywood, K. A., Cooper, G. J., Dunn, W. B., Lawrence, C. B. Tags: RESEARCH ARTICLE Source Type: research

Combined Biomarkers Composed of Environment and Genetic Factors in Stroke.
In this study, we proposed a framework to identify the targeting or indicating role each factor played in the combined stroke biomarkers. A combined set of 36 biomarkers were identified based on evaluation and importance scores. Validations on three independent microarray data sets justified that the obtained markers were pervasively effective in discriminating stroke patients of different stages from healthy people on genetic levels. 8 and 3 genetic factors were identified as biomarkers in the acute and recovery phases of stroke, respectively. For example, the expression changing of SERPINH1 only appeared in the acute pha...
Source: BioScience Trends - August 31, 2018 Category: Biomedical Science Tags: Biosci Trends Source Type: research

The Epidemiology of Fracture in Patients with Acute Ischemic Stroke in Korea.
CONCLUSION: The CIFs of fractures are about 8% at 2 years and 13% at 4 years after acute ischemic stroke in Korea. Older age, women, pre-stroke fracture and osteoporosis raised the risk of post-stroke fractures. PMID: 31172697 [PubMed - in process]
Source: Journal of Korean Medical Science - June 8, 2019 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

The potential role of inflammation in cryptogenic stroke
ConclusionsEndothelial dysfunction assessed by increased level of ADMA affects the inflammatory state in patients with cryptogenic stroke. Increase in the inflammatory cytokine IL-6 by 1 pg/ml almost doubles the risk of stroke.
Source: Advances in Medical Sciences - June 30, 2019 Category: Biomedical Science Source Type: research

EMMPRIN/CD147 plays a detrimental role in clinical and experimental ischemic stroke.
CONCLUSIONS: Acute inhibition of CD147 decreases levels of MMP-9, limits tissue loss, and improves long-term cognitive outcomes following experimental stroke in aged mice. High serum CD147 correlates with poor outcomes in stroke patients. This study identifies CD147 as a novel, clinically relevant target in ischemic stroke. PMID: 32191628 [PubMed - as supplied by publisher]
Source: Aging - March 18, 2020 Category: Biomedical Science Authors: Patrizz A, Doran SJ, Chauhan A, Ahnstedt H, Roy-O'Reilly M, Lai YJ, Weston G, Tarabishy S, Patel AR, Verma R, Staff I, Kofler JK, Li J, Liu F, Ritzel RM, McCullough LD Tags: Aging (Albany NY) Source Type: research

Research Articles An MD2-perturbing peptide has therapeutic effects in rodent and rhesus monkey models of stroke
Studies have failed to translate more than 1000 experimental treatments from bench to bedside, leaving stroke as the second leading cause of death in the world. Thrombolysis within 4.5 hours is the recommended therapy for stroke and cannot be performed until neuroimaging is used to distinguish ischemic stroke from hemorrhagic stroke. Therefore, finding a common and critical therapeutic target for both ischemic and hemorrhagic stroke is appealing. Here, we report that the expression of myeloid differentiation protein 2 (MD2), which is traditionally regarded to be expressed only in microglia in the normal brain, was markedly...
Source: Science Translational Medicine - June 9, 2021 Category: Biomedical Science Authors: Fang, Z., Wu, D., Deng, J., Yang, Q., Zhang, X., Chen, J., Wang, S., Hu, S., Hou, W., Ning, S., Ding, Y., Fan, Z., Jiang, Z., Kang, J., Liu, Y., Miao, J., Ji, X., Dong, H., Xiong, L. Tags: Research Articles Source Type: research

Characterization of familial hypercholesterolemia in Taiwanese ischemic stroke patients
Aging (Albany NY). 2021 Jul 27;13(undefined). doi: 10.18632/aging.203320. Online ahead of print.ABSTRACTFamilial hypercholesterolemia (FH) is a common genetic disorder characterized by a lifelong elevated low-density lipoprotein cholesterol (LDL-C) level. The relationship between FH and ischemic stroke is still controversial. We enrolled ischemic stroke patients prospectively in our neurological ward, and divided them into two groups according to LDL-C levels with a threshold of 130 mg/dl. Targeted sequencing was performed in all stroke patients for LDLR, APOB, and PCSK9 genes. The fifty-eight high-LDL subjects were older,...
Source: Aging - July 27, 2021 Category: Biomedical Science Authors: Hsin Tung Hsueh-Ju Lin Po-Lin Chen Tsai-Jung Lu Pei-Pei Jhan Jun-Peng Chen Yi-Ming Chen Chen-Chin Wu Yung-Yang Lin Tzu-Hung Hsiao Source Type: research

The COVID-19 pandemic effect on the prehospital Madrid stroke code metrics and diagnostic accuracy
by Nicol ás Riera-López, Andrea Gaetano-Gil, José Martínez-Gómez, Nuria Rodríguez-Rodil, Borja M. Fernández-Félix, Jorge Rodríguez-Pardo, Carmen Cuadrado-Hernández, Emmanuel Pelayo Martínez-González, Alicia Villar-Arias, Fátima Gutiérrez-Sánchez, Pablo Busca-Ostolaza, Eduardo Montero-Ruiz, Exu perio Díez-Tejedor, Javier Zamora, Blanca Fuentes-Gimeno, on behalf of the Madrid Stroke Network BackgroundOnly very few studies have investigated the effect of the COVID-19 pandemic on the pre-hospital stroke code protocol. During the first wave, Spain was one of the most affected countries by the SARS-CoV-2 coronavi...
Source: PLoS One - October 10, 2022 Category: Biomedical Science Authors: Nicol ás Riera-López Source Type: research

Exploring the experiences of people who had a stroke and therapists who managed people with stroke during the COVID-19 pandemic: An exploratory qualitative study
ConclusionThe findings of this study explored the impact of the pandemic on stroke care from the perspective of the patients and therapists and provides suggestions for improved delivery of care in similar situations. Future research is warranted to examine the long-term effects on people who had inadequate post-stroke rehabilitation during covid pandemic and urgent measures taken to reduce the impact the pandemic has had on the physical and mental issues for these patients.
Source: PLoS One - February 28, 2023 Category: Biomedical Science Authors: Ahmad Sahely Source Type: research

Integrative identification of hub genes in development of atrial fibrillation related stroke
ConclusionsHub genesEIF4E3,ZNF595,ZNF700,MATR3,ACKR4,ANXA3,SEPSECS-AS1, andRNF166 have potential as novel biomarkers and therapeutic targets in AF-related stroke. Thehsa_circ_0018657/hsa-miR-198/EIF4E3 axis could play an important role regulating the development of AF-related stroke.
Source: PLoS One - March 23, 2023 Category: Biomedical Science Authors: Kai Huang Source Type: research