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Total 2301 results found since Jan 2013.

Does normobaric hyperoxia increase oxidative stress in acute ischemic stroke? A critical review of the literature
AbstractStroke, one of the most debilitating cerebrovascular and nuerological diseases, is a serious life-threatening condition and a leading cause of long-term adult disability and brain damage, either directly or by secondary complications. Most effective treatments for stroke are time dependent such as the only FDA-approved therapy, reperfusion with tissue-type plasminogen activator; thus, improving tissue oxygenation with normobaric hyperoxia (NBO) has been considered a logical and potential important therapy. NBO is considered a good approach because of its potential clinical advantages, and many studies suggest that ...
Source: Medical Gas Research - August 25, 2015 Category: Biomedical Science Source Type: research

Functional differences in upper limb movement after early and chronic stroke based on kinematic motion indicators.
CONCLUSION: The variables used in the study showed applicability in assessing kinematic parameters in both the early and chronic period after stroke. PMID: 30338767 [PubMed - as supplied by publisher]
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - October 20, 2018 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

A high neutrophil-to-lymphocyte ratio predicts hemorrhagic transformation of large atherosclerotic infarction in patients with acute ischemic stroke.
Abstract Increasing evidence suggests that inflammation is associated with the development of acute ischemic stroke (AIS). The neutrophil-to-lymphocyte ratio (N/L) is an important marker of inflammation and is highly correlated with mortality in stroke patients in recent studies. The N/L of patients who experience hemorrhagic transformation (HT) after AIS is know, but any relationship between N/L and large artery atherosclerosis (LAA) remains unclear, this is our present topic. We enrolled 185 patients with LAA-type HT in the development cohort from a prospective, consecutive, hospital-based stroke registry to thi...
Source: Aging - February 5, 2020 Category: Biomedical Science Authors: Zhang WB, Zeng YY, Wang F, Cheng L, Tang WJ, Wang XQ Tags: Aging (Albany NY) Source Type: research

Endothelium-targeted deletion of the miR-15a/16-1 cluster ameliorates blood-brain barrier dysfunction in ischemic stroke.
Abstract The blood-brain barrier (BBB) maintains a stable brain microenvironment. Breakdown of BBB integrity during cerebral ischemia initiates a devastating cascade of events that eventually leads to neuronal loss. MicroRNAs are small noncoding RNAs that suppress protein expression, and we previously showed that the miR-15a/16-1 cluster is involved in the pathogenesis of ischemic brain injury. Here, we demonstrated that when subjected to experimentally induced stroke, mice with an endothelial cell (EC)-selective deletion of miR-15a/16-1 had smaller brain infarcts, reduced BBB leakage, and decreased infiltration o...
Source: Science Signaling - April 6, 2020 Category: Biomedical Science Authors: Ma F, Sun P, Zhang X, Hamblin MH, Yin KJ Tags: Sci Signal Source Type: research

Walking ability and functional status after post-acute care for stroke rehabilitation in different age groups: a prospective study based on propensity score matching.
Abstract Few studies have compared how rehabilitative post-acute care affects recovery of walking ability and other functions after stroke in different age groups. After propensity score matching (1:1), 316 stroke patients were separated into an aged group (age ≥65 years, n=158) and a non-aged group (age <65 years, n=158). Both groups significantly improved in Barthel index, EuroQol-5 dimension, Berg balance scale, 6-minute walking distance and 5-meter walking speed (P<0.001). The non-aged group had significantly larger improvements in Berg balance scale, instrumental activities of daily living, EuroQol-5 ...
Source: Aging - May 31, 2020 Category: Biomedical Science Authors: Wang CY, Miyoshi S, Chen CH, Lee KC, Chang LC, Chung JH, Shi HY Tags: Aging (Albany NY) Source Type: research

miR-137 prevents inflammatory response, oxidative stress, neuronal injury and cognitive impairment via blockade of Src-mediated MAPK signaling pathway in ischemic stroke.
In conclusion, our work suggests that, in mice, miR-137 confers neuroprotective effects against ischemic stroke via attenuation of oxidative, apoptotic, and inflammatory pathways through inhibiting Src-dependent MAPK signaling pathway. PMID: 32496209 [PubMed - as supplied by publisher]
Source: Aging - June 3, 2020 Category: Biomedical Science Authors: Tian R, Wu B, Fu C, Guo K Tags: Aging (Albany NY) Source Type: research

Potential mechanisms of hemorrhagic stroke in elderly COVID-19 patients.
Abstract The novel severe acute respiratory syndrome coronavirus 2 is the causative agent of coronavirus disease 2019, a new human infectious disease. While fever, cough, and respiratory distress are typical first symptoms, a fraction of those affected present instead with neurological symptoms suggestive of central nervous system compromise. This review summarizes the potential contribution of coronavirus disease 2019 to hemorrhagic stroke in the elderly and proposes possible mechanisms. Reports show that the most affected patients have underlying chronic diseases such as hypertension and diabetes, which are two ...
Source: Aging - June 10, 2020 Category: Biomedical Science Authors: Wang H, Tang X, Fan H, Luo Y, Song Y, Xu Y, Chen Y Tags: Aging (Albany NY) Source Type: research

Combined impact of body mass index and glycemic control on the efficacy of clopidogrel-aspirin therapy in patients with minor stroke or transient ischemic attack.
CONCLUSIONS: Compared with aspirin alone, efficacy of clopidogrel-aspirin therapy for stroke still exists in overweight/obesity patients with normal glycemic control. METHODS: In Clopidogrel in High-Risk Patients with Acute Nondisabling Cerebrovascular Events trial, 3044 patients with available baseline GA were recruited. Low/normal weight and overweight/obesity were defined as BMI < 25 kg/m2 and ≥ 25 kg/m2, respectively. Elevated and low GA levels were defined as GA levels > 15.5 % and ≤ 15.5 %, respectively. The primary outcome was stroke recurrence during the 90-day follow-up. PMID: 32544082 [PubMed ...
Source: Aging - June 15, 2020 Category: Biomedical Science Authors: Chen Z, Mo J, Xu J, Wang A, Qin H, Zheng H, Liu L, Meng X, Li H, Wang Y Tags: Aging (Albany NY) Source Type: research

Inactive bowel movement and stroke are associated with increased risks of mild cognitive impairment among community-living Singapore elderly.
Abstract Mild cognitive impairment (MCI), as a preclinical phase of dementia, provides an invaluable time window for intervention. Besides several proposed modifiable risk factors, the associations of MCI with dietary habits and bowel movement are not well clarified. We thus conducted a cross-sectional study of community-living Singapore elderly and focused on the relationship of clinically diagnosed MCI with dietary habits and bowel movement frequencies. The multiple logistic regression results showed that frequent (≥4 days per week) fruit consumption (P = 0.004), active (≥4 days per week) bowel movement with...
Source: Aging - September 8, 2020 Category: Biomedical Science Authors: Huang KY, Tang XY, Yang L, Zhang ZY, Ye KX, Shen QF, Wang X, Zhu XH, Huang XW, Lu GD, Feng L Tags: Aging (Albany NY) Source Type: research

High incidence of stroke in COVID-19 patients.
Abstract A retrospective analysis of 11 COVID-19 patients complicated with stroke was performed. It was found that the incidence of stroke in patients with COVID-19 was significantly higher than the average level of the general population (P=0.003), and the D-dimer levels of 11 stroke patients were significantly higher than other patients (P=0.004). The significant increase of D-dimer can be used as an early warning indicator of cerebral infarction. It is critical to have a response plan for treating acute stroke in COVID-19 patients. PMID: 33221756 [PubMed - as supplied by publisher]
Source: Aging - November 20, 2020 Category: Biomedical Science Authors: Chen J, Wu Y, Chen Z, Yi B, Zhang L, Yin C, Feng H Tags: Aging (Albany NY) Source Type: research

Time course of the upper limb motor recovery in subacute stroke patients undergoing conventional or robotic rehabilitation. A preliminary report.
In this study, the time course of the upper limb motor recovery of 24 subacute stroke patients undergoing a 30-session robotic or conventional treatment was analyzed through the upper extremity portion of the Fugl-Meyer Assessment scale (FMA-UE). The FMA-UE was administered before the treatment, and after 10, 20, and 30 rehabilitation sessions. Statistical analysis showed that, according to the FMA-UE, the time course in the two groups was similar: patients did not change between the baseline and the 10-session assessment, while they improved between 10 and 20 sessions, and between 20 and 30 sessions, with most of the gain...
Source: Journal of Biological Regulators and Homeostatic Agents - January 4, 2021 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Human umbilical cord mesenchymal stem cell-derived exosomal miR-146a-5p reduces microglial-mediated neuroinflammation via suppression of the IRAK1/TRAF6 signaling pathway after ischemic stroke.
Abstract To investigate the therapeutic mechanism of action of transplanted stem cells and develop exosome-based nanotherapeutics for ischemic stroke, we assessed the effect of exosomes (Exos) produced by human umbilical cord mesenchymal stem cells (hUMSCs) on microglia-mediated neuroinflammation after ischemic stroke. Our results found that injected hUMSC-Exos were able to access the site of ischemic damage and could be internalized by cells both in vivo and in vitro. In vitro, treatment with hUMSC-Exos attenuated microglia-mediated inflammation after oxygen-glucose deprivation (OGD). In vivo results demonstrated...
Source: Aging - January 21, 2021 Category: Biomedical Science Authors: Zhang Z, Zou X, Zhang R, Xie Y, Feng Z, Li F, Han J, Sun H, Ouyang Q, Hua S, Lv B, Hua T, Liu Z, Cai Y, Zou Y, Tang Y, Jiang X Tags: Aging (Albany NY) Source Type: research

The serum galectin-3 levels are associated with the severity and prognosis of ischemic stroke
This study shows that higher serum levels of galectin-3 are associated with stroke severity at admission and stroke prognosis at discharge in ischemic stroke.PMID:33686023 | DOI:10.18632/aging.202610
Source: Aging - March 9, 2021 Category: Biomedical Science Authors: Jia-Jun Zhuang Li Zhou Yan-Hua Zheng Yan-Sheng Ding Source Type: research

Design and validation of a recognition instrument-the stroke aid for emergency scale-to predict large vessel occlusion stroke
CONCLUSIONS: The SAFE scale can accurately recognize LVOS at a rate comparable to those of other, similar scales.PMID:33902003 | DOI:10.18632/aging.202910
Source: Aging - April 26, 2021 Category: Biomedical Science Authors: Baorui Zhang Xiaochuan Huo Fei Yuan Guangrong Song Lang Liu Gaoting Ma Dapeng Mo Zhongxue Wu Zhongrong Miao Aihua Liu Source Type: research