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Total 2301 results found since Jan 2013.

Neuroplasticity of peripheral axonal properties after ischemic stroke
ConclusionUpper motor neuron injury after stroke can alter nerve excitability in lower motor neurons, and the changes are more obvious in severely paretic limbs. The accommodative changes of axons progress from the subacute to the chronic stage after stroke. Further investigation is necessary to explore the downstream effects of an upper motor neuron insult in the peripheral nerve system.
Source: PLoS One - October 4, 2022 Category: Biomedical Science Authors: Hung-Ju Chen Source Type: research

Information, involvement, self-care and support —The needs of caregivers of people with stroke: A grounded theory approach
ConclusionsThere is a need to create a caregiver-centered approach in stroke recovery to ensure limited obstruction to care and reduced uncertainty in stroke recovery. Moreover, through the inclusion of caregivers in stroke recovery, it may be possible to reduce the burden of care to the caregiver and ensure the satisfaction of the healthcare system throughout stroke recovery.
Source: PLoS One - January 31, 2023 Category: Biomedical Science Authors: Elton H. Lobo Source Type: research

Effect of alteplase, benzodiazepines and beta-blocker on post-stroke pneumonia: Exploration of VISTA-Acute
by Thanh G. Phan, Richard Beare, Philip M. Bath, Svitlana Ievlieva, Stella Ho, John Ly, Amanda G. Thrift, Velandai K. Srikanth, Henry Ma, on behalf of the VISTA-Acute Collaborators BackgroundPost-stroke pneumonia is a frequent complication of stroke and is associated with high mortality. Investigators have described its associations with beta-blocker. However, there has been no evaluation of the role of recombinant tissue plasminogen activator (RTPA). We postulate that RTPA may modify the effect of stroke on pneumonia by reducing stroke disability. We explore this using data from neuroprotection trials in Virtual Internati...
Source: PLoS One - May 1, 2023 Category: Biomedical Science Authors: Thanh G. Phan Source Type: research

Motor network reorganization in stroke patients with dyskinesias during a shoulder-touching task: A fNIRS study
This study aimed to explore the brain activation and network reorganization of the motor cortex (MC) with functional near-infrared spectroscopy (fNIRS). T he MC hemodynamic signals were gained from 22 stroke patients and 14 healthy subjects during a shoulder-touching task with the right hand. The MC activation pattern and network attributes analyzed with the graph theory were compared between the two groups. The results revealed that healthy controls presented dominant activation in the left MC while stroke patients exhibited dominant activation in the bilateral hemispheres MC. The MC networks for the two groups had small-...
Source: Journal of Innovative Optical Health Sciences - June 19, 2023 Category: Biomedical Science Authors: Yizheng Zhang Dan Wang Dongyang Wang Kecheng Yan Li Yi Shuoshu Lin Guangjian Shao Zhiyong Shao Jinyan Sun Aoran Yang Source Type: research

Environmental enrichment enhanced neurogenesis and behavioral recovery after stroke in aged rats
CONCLUSIONS: EE improved post-stroke recovery on the basis of enhancing neurogenesis in aged rats.PMID:37688770 | DOI:10.18632/aging.205010
Source: Aging - September 9, 2023 Category: Biomedical Science Authors: Ji Yan Yan Liu Fangda Zheng Dan Lv Di Jin Source Type: research

Association between electronic nicotine delivery systems use and risk of stroke: a meta-analysis of 1,024,401 participants
CONCLUSIONS: The ENDS usage appears to be associated with a higher risk of stroke compared to non-use, whereas there was no association between former ENDS use and the risk of stroke.PMID:37732043 | PMC:PMC10507757 | DOI:10.5114/aoms/171473
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Kamal Awad Maged Mohammed Seth S Martin Maciej Banach Source Type: research

Evaluation of lower limb cross planar kinetic connectivity signatures post-stroke
This study supports the idea that coupled cross-planar kinetic outflow between the lower limb joints uniquely emerges during pathological control of frontal plane degrees of freedom resulting in a generalized extension of the limb. It remains to be seen if a pattern of lower limb motor outflow that is centrally mediated contributes to abnormal hemiparetic gait.
Source: Journal of Biomechanics - February 19, 2014 Category: Biomedical Science Authors: Andrew Q. Tan, Yasin Y. Dhaher Tags: Papers Source Type: research

Sickle cell anemia: Intracranial stenosis and silent cerebral infarcts in children with low risk of stroke.
CONCLUSIONS: The prevalence of intracranial arterial stenosis in children with SCA classified as at low risk of stroke by TCD mean velocity <170cm/s is high. Children with stenosis are at higher risk of brain parenchymal injury as they have more silent cerebral infarcts. PMID: 24797985 [PubMed - in process]
Source: Advances in Medical Sciences - March 1, 2014 Category: Biomedical Science Authors: Arkuszewski M, Krejza J, Chen R, Ichord R, Kwiatkowski JL, Bilello M, Zimmerman R, Ohene-Frempong K, Melhem ER Tags: Adv Med Sci Source Type: research

Interleukin-21 Polymorphism Affects Gene Expression and is Associated with Risk of Ischemic Stroke
Abstract There has been more and more evidence to confirm the essential role of inflammatory processes in the development of ischemic stroke. Interleukin-21 (IL-21), the most recently discovered CD132-dependent cytokine, plays a key role in regulating inflammation. The aim of the study was to understand the association between IL-21 polymorphisms and ischemic stroke, and the effects of these polymorphisms on gene expression. Two polymorphisms in IL-21, rs907715G/A and rs4833837A/G, were identified in 278 ischemic stroke patients and 282 healthy controls. Results showed that frequencies of rs907715GA and AA genoty...
Source: Inflammation - November 10, 2014 Category: Biomedical Science Source Type: research

The influence of statin therapy on platelet activity markers in hyperlipidemic patients after ischemic stroke.
CONCLUSIONS: HMG-CoA reductase inhibitor therapy in stroke patients with hyperlipidemia may be useful not only due to the lipid-lowering effect but also because of a significant role in reduction of platelet activation and reactivity. PMID: 25861297 [PubMed]
Source: Archives of Medical Science - June 3, 2015 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Arginine-Vasopressin Receptor Blocker Conivaptan Reduces Brain Edema and Blood-Brain Barrier Disruption after Experimental Stroke in Mice
by Emil Zeynalov, Susan M. Jones, Jeong-Woo Seo, Lawrence D. Snell, J. Paul Elliott Background Stroke is a major cause of morbidity and mortality. Stroke is complicated by brain edema and blood-brain barrier (BBB) disruption, and is often accompanied by increased release of arginine-vasopressin (AVP). AVP acts through V1a and V2 receptors to trigger hyponatremia, vasospasm, and platelet aggregation which can exacerbate brain edema. The AVP receptor blockers conivaptan (V1a and V2) and tolvaptan (V2) are used to correct hyponatremia, but their effect on post-ischemic brain edema and BBB disruption remains to be elucidated. ...
Source: PLoS One - August 14, 2015 Category: Biomedical Science Authors: Emil Zeynalov et al. Source Type: research

Association of polymorphisms in the AGT gene(M235T, T174M) with ischemic stroke in the Chinese population
Conclusions: The meta-analysis indicated the significant association of AGT gene polymorphisms (M235T, T174M) with risk of ischemic stroke in the Chinese population.
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - September 7, 2015 Category: Biomedical Science Authors: Gao, T., Huang, L., Fu, Q., Bai, Y. Tags: Original Articles Source Type: research

The Effect of Emergency Medical Service Use and Inter-hospital Transfer on Prehospital Delay among Ischemic Stroke Patients: A Multicenter Observational Study.
Authors: Park HA, Ahn KO, Shin SD, Cha WC, Ro YS Abstract The time between symptom onset and arrival at an emergency department (ED) (S2D) is a crucial time for optimal intravenous reperfusion care for ischemic stroke. We aimed to analyze the effect of emergency medical services (EMS) utilization and inter-hospital transfer on S2D in Korea. Ischemic stroke patients were prospectively enrolled from November 2007 to December 2012 in 23 tertiary and teaching hospital EDs in Korea. Of 31,443 adult ischemic stroke patients, 20,780 were categorized into 4 groups based on modes of EMS utilization and inter-hospital transf...
Source: Journal of Korean Medical Science - January 16, 2016 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research