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Specialty: Biomedical Science

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Total 2301 results found since Jan 2013.

Association between hand grip strength and stroke in China: a prospective cohort study
CONCLUSIONS: HGS weakness and decline of HGS were associated with stroke incidence for adults aged 45 years and older in China.PMID:33686964 | DOI:10.18632/aging.202630
Source: Aging - March 9, 2021 Category: Biomedical Science Authors: Guihao Liu Yunlian Xue Sheng Wang Yuhu Zhang Qingshan Geng Source Type: research

Stress hyperglycemia may have higher risk of stroke recurrence than previously diagnosed diabetes mellitus
Aging (Albany NY). 2021 Mar 22;13. doi: 10.18632/aging.202797. Online ahead of print.ABSTRACTWe aim to evaluate the risk of stroke recurrence among non-diabetes mellitus (non-DM), previously diagnosed diabetes mellitus (PDDM), newly diagnosed diabetes mellitus-related hyperglycemia (NDDM-RH) and stress hyperglycemia after minor stroke or TIA. Totally, 3026 patients with baseline fasting glucose and glycated albumin from the CHANCE trial (Clopidogrel in High-Risk Patients with Acute Nondisabling Cerebrovascular Events) were included. Patients were classified as non-DM, PDDM, NDDM-RH and stress hyperglycemia according to the...
Source: Aging - March 22, 2021 Category: Biomedical Science Authors: Yuzhou Guo Guangyao Wang Jing Jing Anxin Wang Xiaoli Zhang Xia Meng Xingquan Zhao Liping Liu Hao Li David Wang Yongjun Wang Yilong Wang Source Type: research

Associations between cerebral magnetic resonance imaging infarct volume and acute ischemic stroke etiology
ConclusionsIn this study, larger volume infarcts were significantly associated with both cardioembolic and large-artery atherosclerotic strokes (no difference in the degree of association) and decreased odds of lacunar stroke. A single, large-volume stroke was associated with large-artery atherosclerosis, while multiple infarcts were associated with cardioembolism. Given the differential associations between volume, number of lesions, and stroke etiology, defining stroke subtypes in light of infarct volume might aid in clinical practice.
Source: PLoS One - August 23, 2021 Category: Biomedical Science Authors: Nicholas Omid Daneshvari Source Type: research

Exogenous inter-α inhibitor proteins prevent cell death and improve ischemic stroke outcomes in mice
In this study, we first assessed the clinical relevance of IAIPs in stroke and then tested the therapeutic efficacy of exogenous IAIPs in several experimental stroke models. IAIP levels were reduced in both ischemic stroke patients and in mice subjected to experimental ischemic stroke when compared with controls. Post-stroke administration of IAIP significantly improved stroke outcomes across multiple stroke models, even when given 6 hours after stroke onset. Importantly, the beneficial effects of delayed IAIP treatment were observed in both young and aged mice. Using targeted gene expression analysis, we identified a rece...
Source: Journal of Clinical Investigation - September 2, 2021 Category: Biomedical Science Authors: Louise D. McCullough, Meaghan Roy-O’Reilly, Yun-Ju Lai, Anthony Patrizz, Yan Xu, Juneyoung Lee, Aleah Holmes, Daniel C. Kraushaar, Anjali Chauhan, Lauren H. Sansing, Barbara S. Stonestreet, Liang Zhu, Julia Kofler, Yow-Pin Lim, Venugopal Reddy Venna Source Type: research

Risk factors of dysphagia in patients with ischemic stroke: A meta-analysis and systematic review
ConclusionsElder age, hypertension, diabetes and brainstem stroke are associated with the development of dysphagia in patients with ischemic stroke. Attention should be paid to the assessment and early intervention of those risk factors for dysphagia to improve the prognosis of stroke patients.
Source: PLoS One - June 16, 2022 Category: Biomedical Science Authors: Cui Yang Source Type: research

Risk of peripheral artery disease and stroke in migraineurs with or without aura: a nationwide population-based cohort study
Conclusion: Migraineurs without established cardiovascular disease had a significantly increased risk of PAD and stroke, and the risk of stroke persists in migraineurs with or without aura, with an increased trend of PAD in migraineurs with aura. Our study result should remind clinical physicians of the risk of PAD in the future among migraineurs even without established cardiovascular disease currently, and screening for PAD and stroke may be needed in caring patients with migraine.PMID:35919822 | PMC:PMC9339415 | DOI:10.7150/ijms.72119
Source: International Journal of Medical Sciences - August 3, 2022 Category: Biomedical Science Authors: Wun-Zhih Siao Chun-Hung Su Yu-Hsiang Kuan Tung-Han Tsai Kuang-Hua Huan Chien-Ying Lee Source Type: research

Correlation of the middle cerebral artery atherosclerotic plaque characteristics with ischemic stroke recurrence: a vessel wall magnetic resonance imaging study
This study aims to analyze the imaging features of atherosclerotic plaques in the middle cerebral artery (MCA) of patients with recurrent ischemic stroke using vessel wall magnetic resonance imaging (VWMRI) and investigate the correlation between these imaging features and the recurrence of ischemic stroke. Consecutive patients with ischemic stroke caused by atherosclerotic stenosis of the MCA were collected. The patients were divided into recurrent and non-recurrent ischemic stroke groups. We obtained VWMRI images of MCA plaques using 3.0T MRI by black-blood sequences, and the differences in VWMRI characteristics and clin...
Source: Aging - August 11, 2023 Category: Biomedical Science Authors: Fangbing Li Yilin Wang Ying Du Tianxiang Hu Yejun Wu Source Type: research

Dyslipidemia and outcome in patients with acute ischemic stroke.
CONCLUSION: Serum levels of TC, LDL-C, and HDL-C are positively related with the outcome in patients with acute ischemic stroke. PMID: 24625400 [PubMed - in process]
Source: Biomedical and Environmental Sciences : BES - February 1, 2014 Category: Biomedical Science Authors: Xu T, Zhang JT, Yang M, Zhang H, Liu WQ, Kong Y, Xu T, Zhang YH Tags: Biomed Environ Sci Source Type: research

Language-specific Dysgraphia in Korean Patients with Right Brain Stroke: Influence of Unilateral Spatial Neglect.
In conclusion, unilateral spatial neglect influences copy writing system of Korean language in patients with right brain stroke. PMID: 25729257 [PubMed - in process]
Source: Journal of Korean Medical Science - March 3, 2015 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Development-assistance Strategies for Stroke in Low- and Middle-income Countries.
Authors: Lee H, Nam YS, Lee KM Abstract While communicable diseases still pose a serious health threat in developing countries, previously neglected health issues caused by non-communicable diseases such as stroke are rapidly becoming a major burden to these countries. In this review we will discuss the features and current status of stroke in low- and middle-income countries (LMICs). Overall the global burden of hemorrhagic stroke is larger than ischemic stroke, with a disproportionately greater burden, measured in incidence and disability-adjusted life-years, regionally localized in LMICs. Patients in poorer coun...
Source: Journal of Korean Medical Science - December 1, 2015 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Ischemic stroke induces gut permeability and enhances bacterial translocation leading to sepsis in aged mice.
Abstract Aging is an important risk factor for post-stroke infection, which accounts for a large proportion of stroke-associated mortality. Despite this, studies evaluating post-stroke infection rates in aged animal models are limited. In addition, few studies have assessed gut microbes as a potential source of infection following stroke. Therefore we investigated the effects of age and the role of bacterial translocation from the gut in post-stroke infection in young (8-12 weeks) and aged (18-20 months) C57Bl/6 male mice following transient middle cerebral artery occlusion (MCAO) or sham surgery. Gut permeability...
Source: Aging - April 24, 2016 Category: Biomedical Science Authors: Crapser J, Ritzel R, Verma R, Venna VR, Liu F, Chauhan A, Koellhoffer E, Patel A, Ricker A, Maas K, Graf J, McCullough LD Tags: Aging (Albany NY) Source Type: research