Effect of prostaglandins and beta blockers on progression of hypertensive and normotensive glaucomas.
CONCLUSION: Treatment of glaucoma with prostaglandins and beta blockers has a significant importance in HTG. However, beta blockers have a higher protective effect on the visual field. This is not true in NTG, where we demonstrated this effect only following the administration of beta blockers. PMID: 32225997 [PubMed - as supplied by publisher] (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - April 2, 2020 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Ultraviolet A protective potential of plant extracts and phytochemicals.
This article includes 17 well standardized plant extracts (Camellia sinensis (L.) Kuntze, Silybum marianum L. Gaertn., Punica granatum L., Polypodium aureum L., Vaccinium myrtillus L., Lonicera caerulea L., Thymus vulgaris L., Opuntia ficus-indica (L.) Mill., Morinda citrifolia L., Aloe vera (L.) Burm.f., Oenothera paradoxa Hudziok, Galinsoga parviflora Cav., Galinsoga quadriradiata Ruiz et Pavón, Hippophae rhamnoides L., Cola acuminata Schott & Endl., Theobroma cacao L. and Amaranthus cruentus L.) and 26 phytochemicals. PMID: 32188958 [PubMed - as supplied by publisher] (Source: Biomedical Papers of the Med...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - March 20, 2020 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

General and oral health status of preterm one-year-old very low and extremely low birthweight infants (a cross - sectional study).
Authors: Merglova V, Hauer L, Broukal Z, Dort J, Koberova Ivancakova R Abstract AIMS: The aim of the present study was to evaluate the general and oral health status of a group of preterm one-year-old very low (VLBW) and extremely low birthweight (ELBW) infants and make a comparison with full-term one-year-old normal birthweight infants (NBW). METHODS: A cross-sectional study was conducted in 102 one-year-old preterm VLBW and ELBW infants, and the data obtained were compared to 87 one-year-old full-term NBW infants. The infants' medical histories were obtained from hospital records and interviews with the mothe...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - March 20, 2020 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Comparative immunohistochemical study of deep infiltrating endometriosis, lymph node endometriosis and atypical ovarian endometriosis including description of a perineural invasion.
Authors: Lenz J, Chvatal R, Fiala L, Konecna P, Lenz D Abstract AIM: Endometriosis is an inflammatory condition that shares a number of similarities with malignant diseases, such as an abnormal morphology, migration along the nerve bundles and metastatic spread to lymph nodes and distant organs. Endometriotic lesions are associated with oestrogen and progesterone imbalance which seems to play a key role in the pathogenesis of endometriosis. The aim of this study was to compare the status of both oestrogen and progesterone receptors in tissue of deep infiltrating endometriosis, lymph node endometriosis and atypical ...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - March 13, 2020 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Change in sagittal profile after implantation of anchored interbody cage in the surgical procedure for degenerative cervical spine disease.
CONCLUSION: SSP change after 1- or 2-level ACDF correlates mostly weakly with GSP change. Male gender and osteoporosis were identified as risk factors for global lordotisation following ACDF. PMID: 32158016 [PubMed - as supplied by publisher] (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - March 13, 2020 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Efficacy and analgesic use during the therapy of iatrogenic pneumothorax using Pleuralvent ™ and Chest Tube (ASPIRATE): A randomised controlled trial protocol.
DISCUSSION: Preliminary results showed similar effectivity of the Pleuralvent™ system compared to large bore chest tube insertion. This randomized clinical trial should confirm these results and prove that the Pleuralvent™ system is an effective way of treatment of patients with iatrogenic pneumothorax. If Pleuralvent™ proves to have the same level of efficacy, it may become the standard of care of patients with iatrogenic pneumothorax. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03700554. PMID: 32153301 [PubMed - as supplied by publisher] (Source: Biomedical Papers of the Medical Facult...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - March 12, 2020 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Atypical carcinoma detected after regression of a "benign" oral white lesion. A case report.
CONCLUSION: We would like to point out that apparent spontaneous regressions of oral white lesions following smoking cessation still need attention and close follow-up to make sure that a developing squamous cell carcinoma cannot pass undetected. PMID: 32116310 [PubMed - as supplied by publisher] (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - March 3, 2020 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Association between negative preoperative axillary node staging and surgical sentinel node biopsy in patients with newly diagnosed breast cancer: A retrospective analysis.
CONCLUSIONS: Preoperative ultrasonography is very accurate in the detecting of axillary LN metastases. Patients with primary tumour size ≥ 1 cm, with grade ≥ 2 no special type carcinomas (NST - no special type, also known as invasive ductal carcinoma) or multicentric lobular invasive cancer should undergo a more thorough ultrasound evaluation. PMID: 32116311 [PubMed - as supplied by publisher] (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - March 3, 2020 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Is endovascular treatment of aorto-iliac aneurysms with simultaneous unilateral revascularization of internal iliac artery by branched iliac stentgraft sufficient?
CONCLUSION: Unilateral flow preservation in the IIA territory using IBDI is associated with a lesser, but a certain risk of ischemic complications. Bilateral IBDI with bilateral flow preservation of IIAs increases the complexity, procedure -/ fluoroscopy times, contrast agent volume and cost, however, may further reduce these ischemic complications. PMID: 32116312 [PubMed - as supplied by publisher] (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - March 3, 2020 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Granulation tissue enriched by aspirin and omega-3 fatty acids in healing experimental periodontal lesion.
Authors: Hromcik F, Vokurka J, Gopfert E, Faldyna M, Hermanova M, Kyr M, Vicenova M, Izakovicova Holla L Abstract AIMS: Granulation tissue (GT) and specialized pro‑resolving mediators such as lipoxins and resolvins are key elements in the successful resolution of periodontitis. Aspirin‑triggered lipoxins and resolvins are even more powerful than their natural analogues. Their biosynthesis can be accelerated by omega-3 fatty acids. The aim of this study was to evaluate the use of GT enriched by aspirin and omega-3 fatty acids during the surgical treatment of periodontitis in an experimental animal model (rabbit)...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - February 25, 2020 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Acute myocardial infarction, intraventricular thrombus and risk of systemic embolism.
Authors: Hudec S, Hutyra M, Precek J, Latal J, Nykl R, Spacek M, Sluka M, Sanak D, Tudos Z, Navratil K, Pavlu L, Taborsky M Abstract The development of left ventricular thrombus (LVT) is a well-known and serious complication of acute myocardial infarction (AMI) due to the risk of systemic arterial embolism (SE), which is variable in its clinical picture and has potentially serious consequences depending on the extent of target organ damage. SE results in an increase in mortality and morbidity in these patients. LVT is one of the main causes of the development of ischaemic cardio-embolic cardiovascular events (CVE) ...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - February 14, 2020 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Out-of-hospital cardiac arrest in the Pilsen Region in 2018.
CONCLUSION: The study has provided valuable epidemiological data on OHCA and prehospital CPR in the area of the Pilsen Region in 2018. The collected data, compared to international results, show a higher survival rate with good neurological score in 12.6% of cases. PMID: 31974532 [PubMed - as supplied by publisher] (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - January 26, 2020 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

The impact of riociguat on clinical parameters and quality of life in patients with chronic thromboembolic pulmonary hypertension - results of a retrospective clinical registry.
CONCLUSION: Riociguat improves functional NYHA class, distance in the 6MWD test and quality of life in a real-world patient population. PMID: 31974533 [PubMed - as supplied by publisher] (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - January 26, 2020 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Preparation of PLGA microspheres loaded with 10-hydroxycamptothecin and arsenic trioxide and their treatment for rabbit hepatocellular carcinoma.
CONCLUSION: The combination of As2O3 and HCPT PLGA microspheres as embolization for VX2 hepatocellular carcinoma in rabbits has significant therapeutic effect. PMID: 31907490 [PubMed - as supplied by publisher] (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - January 9, 2020 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Treatments for enhancing the biocompatibility of titanium implants. A review.
Authors: Stepanovska J, Matejka R, Rosina J, Bacakova L, Kolarova H Abstract Titanium surface treatment is a crucial process for achieving sufficient osseointegration of an implant into the bone. If the implant does not heal sufficiently, serious complications may occur, e.g. infection, inflammation, aseptic loosening of the implant, or the stress-shielding effect, as a result of which the implant may need to be reoperated. After a titanium graft has been implanted, several interactions are crucial in order to create a strong bone-implant connection. It is essential that cells adhere to the surface of the implant. ...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - January 9, 2020 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Therapeutic significance of hormone receptor positivity in patients with HER-2 positive breast cancer.
Authors: Kolarova I, Vanasek J, Odrazka K, Melichar B, Ryska A, Petera J, Vosmik M, Dolezel M Abstract Breast cancer with high expression of human epidermal growth factor receptor (HER)-2 represents a biologically and clinically heterogeneous group of neoplastic disorders. Importantly, hormone receptor expression has an effect on biological properties and affects the selection of therapies. On the basis of molecular genetics, four principal subtypes, including luminal A, luminal B, HER2-enriched (HER-2-E), and basal-like can be distinguished. Breast tumors characterized by HER-2 positivity and simultaneous expressi...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - December 15, 2019 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Assessment of visual sensation, psychiatric profile and quality of life following vestibular schwannoma surgery in patients prehabituated by chemical vestibular ablation.
Authors: Balatkova Z, Cada Z, Hruba S, Komarc M, Cerny R Abstract AIMS: Preoperative chemical vestibular ablation can reduce vestibular symptoms in patients who have gone through vestibular schwannoma resection. The goal of this study was to determine whether chemical vestibular prehabituation influences the patients' post-operative perception of visual stimulation, mental status and quality of life. We also tried to find out whether increases of optokinetic nystagmus, measured by routine electronystagmography, correlate with subjective symptoms. METHODS: We preoperatively administered (2 months prior to surger...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - December 6, 2019 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

SNPs within CHRNA5-A3-B4 and CYP2A6/B6, nicotine metabolite concentrations and nicotine dependence treatment success in smokers.
Authors: Hubacek JA, Kurcova I, Maresova V, Pankova A, Stepankova L, Zvolska K, Lanska V, Kralikova E Abstract AIM: Plasma values of nicotine and its metabolites are highly variable, and this variability has a strong genetic influence. In our study, we analysed the impact of common polymorphisms associated with smoking on the plasma values of nicotine, nicotine metabolites and their ratios and investigated the potential effect of these polymorphisms and nicotine metabolite ratios on the successful treatment of tobacco dependence. METHODS: Five variants (rs16969968, rs6474412, rs578776, rs4105144 and rs3733829) ...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - December 6, 2019 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Has the time come for de-escalation in the management of oropharyngeal carcinoma?
Authors: Durkova J, Boldis M, Kovacova S Abstract Over the course of the last two decades, there has been a decrease in the incidence of head and neck cancers thanks to a decreasing prevalence of smoking. However, a new risk factor has been coming to the fore: human papillomavirus infection (HPV). HPV-positive oropharyngeal squamous cell carcinoma (HPV+OPC) is more sensitive to chemotherapy and radiotherapy, which translates to a much better prognosis with conventional treatment protocols than tumours that are HPV-negative. Traditional therapeutic interventions are associated with substantial morbidity and have a g...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - December 6, 2019 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Effects of dexmedetomidine versus remifentanil on mothers and neonates during cesarean section under general anesthesia.
This study aimed to compare the effects of remifentanil and dexmedetomidine on mothers and neonates during cesarean section under general anesthesia. METHODS: A total of 120 patients scheduled for elective cesarean section under general anesthesia were randomly allocated to dexmedetomidine (D), remifentanil (R), and control (C) groups. Anesthesia was induced with propofol and muscle relaxants in all groups. Anesthesia in groups D and R was induced with dexmedetomidine (induction, 0.5 µg/kg; maintenance, 0.5 µg/kg.h) and remifentanil (induction, 0.5 µg/kg; maintenance, 2 µg/kg.h), respectively, u...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - November 26, 2019 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Cardiac papillary fibroelastomas: A 10-year single-center surgical experience and long-term echocardiographic follow-up study.
CONCLUSION: CPF can be safely and effectively treated surgically. TEE is superior to the TTE option in CPF post-operative recurrence detection. There is a clear need for a prospective study to determine criteria for embolization risk stratification and optimum management in patients with CPF. PMID: 31748759 [PubMed - as supplied by publisher] (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - November 23, 2019 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

The influence of central corneal thickness on progression of normotensive glaucoma.
CONCLUSION: We found no relationship between progression of changes in the visual fields in CCT. Progression of changes in the visual fields was higher in patients who had more advanced changes at the beginning of observation. The untreated patients had progression of changes in the visual fields both in PD and OD in contrast to those who were taking prostaglandins and presented changes only in PD. PMID: 31748760 [PubMed - as supplied by publisher] (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - November 23, 2019 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Multiparametric flow cytometry analysis of peripheral blood B cell trafficking differences among Epstein-Barr virus infected and uninfected subpopulations.
CONCLUSION: Although EBV-infected B cells represent only a minor subpopulation, their atypical functions could contribute in predisposed person to development abnormities such as some autoimmune diseases or tumors. Using multi-parameter flow cytometry we characterized differences in migration of EBV-positive and -negative B cells of various maturation stage and isotype of produced antibodies particularly different targeting to mucosal tissues of gastrointestinal and respiratory tracts. PMID: 31723302 [PubMed - as supplied by publisher] (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - November 16, 2019 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

ABCB4 disease mimicking morbus Wilson: A potential diagnostic pitfall.
CONCLUSION: PFIC3 and WD display pleomorphic and sometimes overlapping clinical and laboratory features, which may pose a differential diagnostic problem. Since the patient management in WD and PFIC3 differs significantly, an early and accurate diagnosis is crucial for optimising of therapeutic approach and prevention of possible complications. PMID: 31728073 [PubMed - as supplied by publisher] (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - November 16, 2019 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Tumor infiltrating lymphocytes in malignant melanoma - allies or foes?
Authors: Zidlik V, Bezdekova M, Brychtova S Abstract This is an overview of current problematics regarding the role of tumor infiltrating lymphocytes (TILs) in malignant melanomas. Various and often conflicting data have been published, correlating tumor type, stage, prognosis, as well as sex and age of patients. This is partly due to heterogeneity in scaling systems and unstandardized TILs grading but also due to changes of tumor-host interactions. Melanomas are an immunologically heterogeneous group with variability of TILs, where distinct gene expression patterns were found in tumors with absent, and/or non- bri...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - October 28, 2019 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Comparison of atrial fibrillation ablation efficacy using remote magnetic navigation vs. manual navigation with contact-force control.
This study aims to compare procedural parameters and clinical efficacy of remote magnetic navigation (RMN) vs. manual navigation (MAN) approach for radiofrequency ablation (RFA) in patients with atrial fibrillation (AF). METHODS: 146 patients with AF were enrolled in the study. In the RMN group (n=57), patients were treated with the CARTO® 3 in combination with the Niobe ES system. In the MAN group (n=89), ablation was performed with the EnSite Velocity and TactiCath™ Quartz catheter with direct contact force measurement. Procedural time, ablation time, fluoroscopy time, radiation dose and ablation counts wer...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - October 26, 2019 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Cancer detection rates and inter-examiner variability of MRI/TRUS fusion targeted biopsy and systematic transrectal biopsy.
CONCLUSION: MRI/TRUS TG in combination with SB had significantly higher detection rates than SB in the RB group only. Differences in detection rates between examiners were dependent on the level of previous experience with TRUS guided biopsy. PMID: 31602045 [PubMed - as supplied by publisher] (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - October 13, 2019 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Audio-visual navigation reduces treatment time in deep-inspiration breath hold radiotherapy.
CONCLUSION: Audio-visual navigation enables to significantly reduce the treatment time in comparison with DIBH without A-V feedback. PMID: 31602046 [PubMed - as supplied by publisher] (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - October 13, 2019 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Bioinformatics analysis of genes associated with the patchy-type alopecia areata: CD2 may be a new therapeutic target.
CONCLUSION: Our data suggest that the CD2 may be a new therapeutic target for AAP. Further study is needed to explore the value of CD2 in the treatment of alopecia areata. PMID: 31558844 [PubMed - as supplied by publisher] (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - September 29, 2019 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Profiling of biological and environmental risk factors in immunogenetic subgroups of chronic lymphocytic leukemia - Czech national study.
CONCLUSION: To the best of our knowledge, this study is the first to investigate CLL immunogenetic features and clonality in the context of epidemiological data. We reported statistically significant associations suggesting the influence of certain health and social conditions on a number of clonal populations expanding in CLL and also on characteristic BCR features, especially stereotypy. PMID: 31558845 [PubMed - as supplied by publisher] (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - September 29, 2019 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Chronic calcified subdural hematoma - case report of a rare diagnosis.
We present a case report of 81-year-old woman with calcified chronic subdural hematoma. Patient underwent an osteoplastic left craniotomy, evacuation of chronic subdural mass with careful dissection andsuccessful removal of inner and outer membrane. Postoperative CT scan showed removal of subdural hematoma, decrease of left shift of median line and good brain re-expansion. Postoperative period was without any serious complications. RESULTS: Subdural hematoma was successfully removed, resulting in a good recovery with complete resolution of patients symptoms. From our experience, we highly recommend surgical treatment i...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - September 29, 2019 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Functional magnetic resonance imaging following epimacular and internal limiting membrane peeling - ipsilateral and contralateral findings.
Authors: Lestak J, Kalvodova B, Karel I, Tintera J Abstract PURPOSE: The purpose of this study was to find out whether peeling of the epimacular membrane (EMM) and internal limiting membrane (ILM) for symptomatic lamellar macular hole (LMH), causes impairment of the visual cortex. PATIENTS AND METHODS: This pilot study consisted of 8 eyes of 4 patients (2 females and 2 males), mean age 69.25 years (60-83 years), who underwent pars plana vitrectomy and EMM and ILM peeling in one eye for lamellar macular hole The second eye remained intact. The patients had no other ophthalmological or neurological disease. The c...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - September 29, 2019 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Monitoring of fibrinolytic system activity with plasminogen, D-dimers and FDP in primary total knee arthroplasty (TKA) after topical, intravenous or combined administration of tranexamic acid.
Authors: Lostak J, Gallo J, Slavik L, Zapletalova J, Balaz L Abstract AIM: We assessed various ways of tranexamic acid (TXA) administration on the fibrinolytic system. Blood loss, transfusions, drainage and haematoma were secondary outcomes. METHODS: In this prospective study, we examined 100 patients undergoing primary total knee arthroplasty (TKA) between June and November 2018. Patients were randomly assigned to 4 groups according to the following TXA regimens: 1) loading dose 15 mg TXA/kg single intravenous administration applied at initiation of anesthesia (IV1); 2) loading dose 15 mg TXA/kg + additional d...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - September 27, 2019 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Complications of the surgical treatment of esophageal cancer and microbiological analysis of the respiratory tract.
Authors: Vrba R, Neoral C, Vomackova K, Vrana D, Melichar B, Lubuska L, Loveckova Y, Aujesky R Abstract AIM: The aim of this study was to reduce the severe respiratory complications of esophageal cancer surgery.often leading to death. METHODS: Two groups of patients operated on for esophageal cancer were evaluated in this retrospective analysis. The first group was operated between 2006-2011, prior to the implementation of preoperative microbiological examination while the second group had surgery between 2012-2017 after implementation of this examination. RESULTS: In total, 260 patients, 220 males and 40 f...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - September 27, 2019 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Prediction Score for persisting perfusion defects after pulmonary embolism.
Authors: Mrozek J, Necasova T, Svoboda M, Simkova I, Jansa P Abstract AIMS: Long-term persistence of perfusion defect after pulmonary embolism (PE) may lead to the development of chronic thromboembolic pulmonary hypertension. Identification of patients at risk of such a complication using a scoring system would be beneficial in clinical practice. Here, we aimed to derive a score for predicting persistence of perfusion defects after PE. METHODS: 83 patients after PE were re-examined 6, 12 and 24 months after the PE episode. Data collected at the time of PE and perfusion status during follow-ups were used for mod...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - September 27, 2019 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Congenital fetal heart defect - an agreement between fetal echocardiography and autopsy findings.
CONCLUSION: Altogether, the results indicated that FECHO is a highly sensitive method for the prenatal detection of CHD but is incapable of detecting the complete spectrum of cardiac defects. Autopsies verified the diagnosis, confirmed the overall impairment in the fetus, and provided data for further counselling of the affected family. PMID: 31548732 [PubMed - as supplied by publisher] (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - September 26, 2019 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Characteristic CT features of pheochromocytomas - probability model calculation tool based on a multicentric study.
CONCLUSION: This study confirms the value of anatomical features in the assessment of adrenal masses with the ability to significantly improve the identification of pheochromocytomas. Advanced assessment of the tumor shape was defined and a original comprehensive calculating tool of the pheochromocytoma probability was created on the basis of the results presented here and could be used in clinical routine. PMID: 31544898 [PubMed - as supplied by publisher] (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - September 24, 2019 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Relationship between epicardial adipose tissue thickness and coronary thrombus burden in patients with ST-elevation myocardial infarction.
CONCLUSIONS: The present study showed that EAT was an independent predictor of coronary thrombus burden in STEMI. PMID: 31544899 [PubMed - as supplied by publisher] (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - September 24, 2019 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

In silico study of pseudoprogression in glioblastoma: collaboration of radiologists and radiation oncologists in the estimation of extent of high dose RT region.
CONCLUSION: Continuing effort to improve education on specific procedures in RT and in radiology as well as automatic tools for exporting RT targets is needed in order to increase specificity and sensitivity in response evaluation. PMID: 31544900 [PubMed - as supplied by publisher] (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - September 24, 2019 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Uveal melanoma - testing of abnormalities of chromosome 3 and 8 in the Czech Republic.
CONCLUSIONS: Our data showed the association of progression-free survival with the presence of monosomy 3 in uveal melanomas. We provided a good prognostic value of monosomy 3 in uveal melanoma. PMID: 31544901 [PubMed - as supplied by publisher] (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - September 24, 2019 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

A case series on the value of tau and neurofilament protein levels to predict and detect delirium in cardiac surgery patients.
CONCLUSION: Tau and NfL might be of benefit to identify patients in cardiac surgery at risk for delirium and to detect patients with the postoperative emergence of delirium. PMID: 31530945 [PubMed - as supplied by publisher] (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - September 20, 2019 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Evaluation and management of toxicity of cytoreductive surgery/hyperthermic intraperitoneal chemotherapy: the initial experience of a single centre study.
CONCLUSION: CRS/HIPEC performed is a safe method with low perioperative mortality. PMID: 31435073 [PubMed - as supplied by publisher] (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - August 24, 2019 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Infectious uveitis in immunodeficient HIV-negative patients: A retrospective study.
CONCLUSION: Our experience shows that patients with diagnoses of acute retinal necrosis or progressive outer retinal necrosis have a poor visual prognosis. The occurrence of cytomegalovirus retinitis signifies a very unfavorable survival prognosis in patients who underwent hematopoietic stem cell transplantation; the patients in our study died within 1 year from cytomegalovirus retinitis diagnosis. PMID: 31435074 [PubMed - as supplied by publisher] (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - August 24, 2019 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Prognostic and predictive markers for perineural and bone invasion of oral squamous cell carcinoma.
Authors: Michalek J, Brychtova S, Pink R, Dvorak Z Abstract Oral squamous cell carcinoma (OSCC) is a growing problem worldwide. Several biological and molecular criteria have been established for making a prognosis of OSCC. One of the most important factors affecting the risk of tumor recurrence and overall prognosis is perineural invasion and bone invasion. Perineural invasion is defined as a tumor spreading and the ability of tumor cells to penetrate around or through the nerve tissue. Perineural invasion can cause the tumor to spread to distant areas from the primary tumor location. One possible explanation for ...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - August 24, 2019 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Downregulation of CIP2A inhibits cancer cell proliferation and vascularization in renal clear cell carcinoma.
CONCLUSION: Downregulation of CIP2A can inhibit cancer cell proliferation and vascularization in renal clear cell carcinoma through inactivation of the Akt pathway and its downstream VEGF. PMID: 31431792 [PubMed - as supplied by publisher] (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - August 23, 2019 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

The effect of quercetin on microRNA expression: A critical review.
Authors: Dostal Z, Modriansky M Abstract Quercetin, a flavonoid with multiple proven health benefits to both man and animals, displays a plethora of biological activities, collectively referred to as pleiotropic. The most studied of these are antioxidant and anti-inflammatory but modulation of signalling pathways is important as well. One of the lesser-known and recently discovered roles of quercetin, is modulation of microRNA (miRNA) expression. miRNAs are important posttranscriptional modulators that play a critical role in health and disease and many of these non-coding oligonucleotides are recognized as oncogen...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - July 4, 2019 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Diagnostic criteria for the determination of clinically significant internal carotid artery stenosis using duplex ultrasound.
CONCLUSION: These criteria allow for reliable determination of internal carotid artery stenosis ≥70% by duplex ultrasound. PMID: 31219103 [PubMed - as supplied by publisher] (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - June 22, 2019 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

HPV, protein p16 and squamous cell carcinoma of the oral cavity.
CONCLUSIONS: In summary, the data suggest that there is no effect of HPV status on the prognosis of OSCC patients compared to other HNSCC locations. PMID: 31219104 [PubMed - as supplied by publisher] (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - June 22, 2019 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Evaluation of spine structure stability at different locations during SBRT.
CONCLUSION: Positional tracking during spine SBRT treatments revealed low mean translational and rotational shifts. Patient immobilization did not improve spine shifts compared with our results for the Th and LS spine without immobilization. For the most precise spine SBRT, we recommend checking the patient's position during treatment. PMID: 31219105 [PubMed - as supplied by publisher] (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - June 22, 2019 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research

Percutaneous biopsy of retroperitoneal lesions - 10 year experience of a single centre.
CONCLUSION: Percutaneous CT-guided biopsy performed in patients with a suspected retroperitoneal tumorous process had a high accuracy in establishing the correct diagnosis including histological subtyping. Simultaneously, the complication rate was low. PMID: 31219106 [PubMed - as supplied by publisher] (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - June 22, 2019 Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research