Proceedings from the 8th Annual University of Calgary Leaders in Medicine Research Symposium.
Abstract On November 14, 2016, the Leaders in Medicine (LIM) program at the Cumming School of Medicine, University of Calgary hosted its 8th Annual Research Symposium. Professor Stephen Sawcer, Professor of Neurological Genetics at the University of Cambridge and an Honorary Consultant Neurologist at Addenbrooke's Hospital, was the keynote speaker and presented a lecture entitled, "Multiple sclerosis genetics - prospects and pitfalls". This was not only a cutting edge address on genetics but also a thoughtful overview on Dr. Sawcer's career and career choices. We were extremely grateful for the opportuni...
Source: Clinical and Investigative Medicine - January 30, 2019 Category: Biomedical Science Authors: Logan LM, Jensen SK, Singh N, Peplowski MA, Rabi D, Yipp BG, Hollenberg MD, Beck PL Tags: Clin Invest Med Source Type: research

Enabled homolog shown to be a potential biomarker and prognostic indicator for breast cancer by bioinformatics analysis.
CONCLUSION: ENAH is a potential biomarker and important prognostic factor in BC. PMID: 30737978 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - January 30, 2019 Category: Biomedical Science Authors: Li QL, Su YL, Zeng M, Shen WX Tags: Clin Invest Med Source Type: research

Characterizing inpatient care for adults with schizophrenia using the Health Quality Ontario indices: A single-centre retrospective cohort study.
This study examined all admissions for adults diagnosed with schizophrenia over a 6-month period in 2017 to an inpatient psychiatric unit situated in a nonprofit general hospital in Kingston, Ontario, Canada. The Health Quality Ontario standards for the inpatient care of adults with schizophrenia were used to assess the quality of care provided in hospital. Standards were determined to have been met by doing a thorough chart review for each patient, reviewing all documentation in progress notes, admission notes, discharge notes and emergency room notes for quality standard completion. RESULTS: The average length of st...
Source: Clinical and Investigative Medicine - January 30, 2019 Category: Biomedical Science Authors: Bahji A, Pikard JL, Mauer-Vakil D, Munsh T, Naeem F Tags: Clin Invest Med Source Type: research

Routine use of post-bronchodilator testing in pulmonary function testing labs.
CONCLUSIONS: Lab policies surrounding post-BD testing were found to be heterogeneous in Alberta. Low response rates, despite the use of a systems approach and requests in writing and in person from FP labs, were notable. Development of a standardized policy across the province would be beneficial. Further higher-level review of the appropriateness of post-BD use in both FP and NFP PFT labs is needed. PMID: 30737980 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - January 30, 2019 Category: Biomedical Science Authors: Agarwal J, Saad E, Fontaine G, Pagliardini S, Dafoe W, Killian K, Gibney RTN, Huston J, Vethanayagam D Tags: Clin Invest Med Source Type: research

The Women and Children's Infectious Diseases Center: An integrated approach to congenital infectious diseases.
Abstract Congenital infectious diseases, transmitted during the course of pregnancy, are estimated to affect nearly one in every hundred births worldwide. These infections may be associated with fetal and infant adverse health outcomes, due to congenital malformations caused by in utero transmission of the infectious organism itself (as is the case with cytomegalovirus, toxoplasmosis, syphilis and Zika virus), or due to chronic infection in the infant (as is the case with human immunodeficiency virus [HIV] and hepatitis B and C). In addition, children who are exposed, yet uninfected, may still suffer from the cons...
Source: Clinical and Investigative Medicine - January 30, 2019 Category: Biomedical Science Authors: Kakkar F, Boucoiran I Tags: Clin Invest Med Source Type: research

1978: Forty years later.
Abstract Think back; think wayyy back: before laptops, internet and smartphones. Bank machines didn't exist, tele-phones were permanently plugged into the wall, airport security meant only checking that you paid for your ticket and medical journals came in the mail (as did the bills for the journals). As it turned out, the 1970s was not a kind decade for medical journals, and several were struggling financially. Even the New England Journal of Medicine (NEJM), desperate for cash, was forced to offer a lifetime subscription to anyone who could pay the princely sum of $350! (A colleague of ours, now retired, still r...
Source: Clinical and Investigative Medicine - November 3, 2018 Category: Biomedical Science Authors: Bortolussi R, MacLeod S, Bevan D, Angel J Tags: Clin Invest Med Source Type: research

"I am a part of all that I have met".
"I am a part of all that I have met". Clin Invest Med. 2018 Nov 03;41:5-8 Authors: Friesen HG Abstract Dr. Friesen received his MD from the University of Manitoba in 1958. He began his career in research in endocrinology with a fellowship at the New England Medical Center, Boston. His initial academic appointment was at McGill University (1965-1973), followed by appointment as Professor and Head of the Department of Phys-iology and Professor of Medicine at the University of Manitoba (1973-1992). His re-search resulted in the discovery of the human pituitary hormone prolactin, defining its ro...
Source: Clinical and Investigative Medicine - November 3, 2018 Category: Biomedical Science Authors: Friesen HG Tags: Clin Invest Med Source Type: research

The Revolution in Health Research.
Abstract After PhD studies at the University of Toronto, and postdoctoral work in London, Alan worked at the Ontario Cancer Institute and then the Samuel Lunenfeld Research Institute (eventually as Director of Research). As inaugural president of the Canadian Institutes of Health Research (CIHR; 2000-2007), he led the transformation of health research in Canada and an almost tripling of the budget for health research. He then was named executive director of the Global HIV Vaccine Enterprise (2008-2012). Since 2012, Alan has been president of CIFAR, Canada's global research institute, where he has led major initiat...
Source: Clinical and Investigative Medicine - November 3, 2018 Category: Biomedical Science Authors: Bernstein A Tags: Clin Invest Med Source Type: research

On mindset, mental preparation and chasing breakthroughs: A physician-scientist trainee's perspective.
Abstract Karan ("Josh") Abraham is a physician-scientist trainee in the University of Toronto MD-PhD program. He is a Vanier Scholar, Ruggle's Innovation Award winner, Adel S. Sedra Distinguished Graduate Award recipient, and is currently president of the Clinician-Investigator Trainee Association of Canada (CITAC). In his PhD work, he uses molecular, genetic and cell biological approaches to uncover mechanisms that preserve the integrity of the genetic code and sustain the protein synthesis capacity of cells. He hopes to lead a basic research program that will advance scientific knowledge to better unde...
Source: Clinical and Investigative Medicine - November 3, 2018 Category: Biomedical Science Authors: Abraham KJ Tags: Clin Invest Med Source Type: research

HIV Cure Research: An example of successful advocacy by scientists for science.
Abstract Following medical school and an internal medicine residency in Toronto, and infec-tious diseases training at the New England Medical Center/Tufts University in Boston, Jonathan joined the Division of Infectious Diseases, Department of Medicine at the Ottawa General Hospital in 1995. His research focuses on understanding how HIV damages the immune system and how these insights may lead to new therapies. Jon-athan is currently Professor of Medicine, University of Ottawa and Senior Scientist, Ottawa Hospital Research Institute. He was Editor-in-Chief of CIM from 2010-2015. PMID: 30394273 [PubMed - in pr...
Source: Clinical and Investigative Medicine - November 3, 2018 Category: Biomedical Science Authors: Angel JB Tags: Clin Invest Med Source Type: research

Curare: from laboratory to law court.
Abstract Dr. David Bevan held the Wesley-Bourne Chair of Anesthesia at McGill University, Chair of Anesthesia at UBC, Anesthetist-in-Chief at the University Health Network/Mount Sinai Hospital and subsequently Chair of the Department of Anesthesia at University of Toronto until his retirement in 2006. Dr. Bevan's research contributions included seminal work in neuromuscular blockade and this work, in addition to his expertise as a reviewer, led to several editorial appointments, including Editor-in-Chief for CIM (2003-2010). Dr. Bevan played a role in the introduction of the Anesthesia Care Team concept in Ontario...
Source: Clinical and Investigative Medicine - November 3, 2018 Category: Biomedical Science Authors: Bevan DR Tags: Clin Invest Med Source Type: research

Model organisms-the critical link between gene discovery and therapeutic intervention.
Abstract Jason graduated from the University of Toronto Medical School in 1997 followed by a pediatric residency at the Hospital for Sick Children, a fellowship in pediatric hematology/oncology at Boston Children's Hospital and post-doctoral training at the Dana-Farber Cancer Institute. He is a professor at Dalhousie University in the Departments of Pediatrics, Microbiology and Immunology and Pathology, was appointed as the director of the Clinician Investigator Program (CIP) and the Graduate Program in Medical Research at Dalhousie (2014), elected president of the Canadian Society for Clinical Investigation (CSCI...
Source: Clinical and Investigative Medicine - November 3, 2018 Category: Biomedical Science Authors: Berman J Tags: Clin Invest Med Source Type: research

My brief but spectacular career in hockey: A life lesson.
Abstract Bob is a pediatric infectious disease specialist at Dalhousie University, where he did research on the ontogeny of the immune system in neonates. He was VP Research at the IWK Health Centre (1992-2007). He developed the curriculum for a CIHR train-ing program and edited "Handbook for Clinician Scientists". In 2008, he cofounded MicroResearch, which helps clinicians in Africa do research that will improve health programs there. He is also a Professor Emeritus at Dalhousie University and current Editor-in-Chief of CIM. PMID: 30394276 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - November 3, 2018 Category: Biomedical Science Authors: Bortolussi R Tags: Clin Invest Med Source Type: research

The making of a lipid biochemist.
Abstract Patrick obtained his undergraduate degree at McGill University, and received his graduate training in Medicine and Biochemistry at the University of North Dakota. His postdoctoral work was conducted at the University of British Columbia. He joined the Faculty of Medicine, University of Manitoba as an Assistant Professor of Biochemistry in 1979. He was the recipient of a New Investigator Award (1979-85) from the Heart and Stroke Foundation of Canada, followed by a Scientist Award (1985-90) from the MRC/CIHR. These career awards allowed him to devote the majority of his time to research. He was promoted to ...
Source: Clinical and Investigative Medicine - November 3, 2018 Category: Biomedical Science Authors: Choy PC Tags: Clin Invest Med Source Type: research

The pyramids of Gizeh, reductionist research-based progress, unintended consequences and the complexity of medicine.
Abstract Bing graduated from the Medical Faculty at Erasmus University in Rotterdam, The Netherlands in 1988. He then completed a PhD in Medical Sciences (University of Calgary), internship (University of Regina) and surgical residency (University of Western Ontario) and post-residency clinical fellowships (University of Toronto and Harvard University) followed by a research post-doctoral fellowship (Department of Cell Biology, University of Toronto). Bing has been with the Roth | McFarlane Hand and Upper Limb Centre at St. Joseph's Health Centre since 1998. He is a Professor of Surgery and Medical Biophysics at W...
Source: Clinical and Investigative Medicine - November 3, 2018 Category: Biomedical Science Authors: Gan BS Tags: Clin Invest Med Source Type: research

A woman in a man's world.
Abstract Graduating from the University of Alberta in Chemistry (1963) and Medicine (1967), Jean was the founding Head of the Dalhousie Division of General Medicine, Associate Dean of Postgraduate Medical Education (1988-1996) and Associate Dean of Continuing Medical Education (1996-2002). She has served as President, Vice-President and Chair of numerous societies and as a member of several other national and international committees and boards. She is a Member of the Order of Canada and has two honorary doctorates. PMID: 30394279 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - November 3, 2018 Category: Biomedical Science Authors: Gray J Tags: Clin Invest Med Source Type: research

When science meets Google: Reflections on research and evidence in the age of science deniers.
Abstract Noni is a former Dean of Medicine at Dalhousie University. Her two current major areas of interest are 1) Vaccines, including vaccine safety, hesitancy, demand, pain mitigation, education and policy especially through her work with the World Health Organization as a member of Strategic Advisory Group of Experts on Immunization and 2) MicroResearch, building capacity in community-focused research in developing countries and now also in Canada to help interdisciplinary health professionals find local solutions for community health problems that fit the context, culture and resources. Noni has long been inte...
Source: Clinical and Investigative Medicine - November 3, 2018 Category: Biomedical Science Authors: MacDonald NE Tags: Clin Invest Med Source Type: research

CSCI and the future of clinical health science research in Canada.
Abstract In 2003, Dr. MacLeod became Professor (emeritus since 2014) in the Department of Pediatrics, University of British Columbia and Director of the BC Children's Hospital Research Institute. Previously, he had spent 14 years as a clinical pharmacologist at the University of Toronto and The Hospital for Sick Children and was Dean of the Faculty of Health Sciences, McMaster University 1987-1992. His research interests include pediatric clinical pharmacology, treatments for rare disorders, global health and medical education. From 1984-85, he was President of the Canadian Society for Clinical Investigation. ...
Source: Clinical and Investigative Medicine - November 3, 2018 Category: Biomedical Science Authors: MacLeod SM Tags: Clin Invest Med Source Type: research

On becoming a clinician-scientist: The importance of mentorship and role models.
Abstract Brent graduated from medicine (with distinction) from the University of Alberta in 1984, and subsequently trained in Internal Medicine at the University of Toronto and in Critical Care at the University of Manitoba. He later did a post-doctoral fellowship in molecular/cellular biology at National Jewish Center (Denver, CO). His research interests now focus on examining diseases of the critically ill using metabolomics. When he finished training in 1996, Brent was recruited to the University of Calgary in Critical Care Medicine and is now a Professor of Medicine. In Calgary, he helped to establish the grad...
Source: Clinical and Investigative Medicine - November 3, 2018 Category: Biomedical Science Authors: Winston BW Tags: Clin Invest Med Source Type: research

Scientific overview on CSCI-CITAC Annual General Meeting and 2017 Young Investigators' Forum.
Abstract The 2017 Annual General Meeting of the Canadian Society of Clinician Investigators (CSCI) and Clinician Investigator Trainee Association of Canada/Association des Cliniciens-Chercheurs en Formation du Canada (CITAC/ACCFC) was a national Annual General Meeting (AGM) held in Toronto, Ontario November 20-22, 2017, in conjunction with the University of Toronto Clinician Investigator Program Research Day. The theme for this year's meeting was "Roll up your sleeves-How to manage your physician scientist career", emphasizing lectures and workshops that were designed to provide tools for being proactive...
Source: Clinical and Investigative Medicine - October 5, 2018 Category: Biomedical Science Authors: Barton KI, Ma X, Babadagli ME, Zhou E, Tonial N, Newell C, Ishaque A, Leduc-Pessah H, Marvasti TB, Mirali S, Levit A, Kumar S, Steadman PE, Cook EK, Abraham J Tags: Clin Invest Med Source Type: research

Intermittent inhaled tobramycin and systemic cytokines response in CF patients with Pseudomonas aeruginosa.
CONCLUSIONS: The results of lung function parameters support the relative stability of CF patients during the month off therapy; however, the difference in serum IL-6 raises the possibility of ongoing higher degrees of inflammation during the month off therapy with TIP. The small sample size and the multiple parameters evaluated preclude firm conclusions; therefore, larger multicenter studies are needed to assess the on/off treatment strategy. PMID: 30315749 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - September 30, 2018 Category: Biomedical Science Authors: Toukan Y, Gur M, Hakim FH, Geffen Y, Bar-Yoseph R, Nir V, Bentur L Tags: Clin Invest Med Source Type: research

The Need for an Executive Leadership Curriculum in Scientist-Clinician Training Programs.
Abstract The health of Canadians depends on effective leadership among health care providers to facilitate the translation of new health discoveries into clinical practice. Clinician-scientists play an important role in bridging the gap between research and clinical practice, and require effective leadership skills to advance clinical practice successfully. To accelerate the leadership development in clinician scientist trainees, with the aim of developing strong leaders in administration and health advocacy, the Leaders in Medicine (LIM) training program at the University of Calgary created an Executive Leadershi...
Source: Clinical and Investigative Medicine - September 30, 2018 Category: Biomedical Science Authors: Barton KI, Capozzi LC, Aker G, Yipp BG, Hollenberg MD, Rabi DM, Beck PL Tags: Clin Invest Med Source Type: research

Validation of abdominal aortic aneurysm repair codes in Ontario administrative data.
CONCLUSIONS: Diagnostic, procedure and billing code combinations allow identification of eOSR, eEVAR, rOSR and rEVAR patients in Ontario administrative data with a high degree of certainty. PMID: 30315751 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - September 30, 2018 Category: Biomedical Science Authors: Salata K, Hussain MA, De Mestral C, Greco E, Mamdani M, Tu JV, Forbes TL, Verma S, Al-Omran M Tags: Clin Invest Med Source Type: research

Mean platelet volume/count and mortality in extremely low birth weight infants of preeclamptic mothers.
CONCLUSION: Hemoglobin and platelet counts were statistically different in ELBW infants born to preeclamptic mothers compared with non-preeclamptic mothers. Although the survival was not different between the two groups, platelet count and MPV/platelet count ratio were significantly correlated with overall mortality and mortality in the first 7 days of life in infants of preeclamptic mothers. PMID: 30315748 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - September 22, 2018 Category: Biomedical Science Authors: Aksoy HT, Güzoğlu N, Eras Z, Canpolat FE, Uraş N Tags: Clin Invest Med Source Type: research

Newsletter Fall 2018:   Clinician Investigator Trainee Association of Canada (CITAC).
Newsletter Fall 2018:  Clinician Investigator Trainee Association of Canada (CITAC). Clin Invest Med. 2018 Sep 18;41(3):E127-E129 Authors: Barton KI, Ma X, Pietrobon A, Capozzi LC, Joshua Abraham K Abstract Message from the President: Optimism for the Future The Clinician-Investigator Trainee Association of Canada (CITAC) was established in 2006 to address issues relevant to Canadian trainees seeking dual training in medicine and research. As clinician-investigator (CI) trainees, we comprise but a fraction (less than 5%) of all medical trainees. Our 'bilingual' careers render our individual paths...
Source: Clinical and Investigative Medicine - September 18, 2018 Category: Biomedical Science Authors: Barton KI, Ma X, Pietrobon A, Capozzi LC, Joshua Abraham K Tags: Clin Invest Med Source Type: research

Predicting Pre-transplant Abstinence in Patients with Alcohol-Induced Liver Disease.
CONCLUSIONS: A self-reported period of abstinence in excess of six months was associated with an increased risk of subsequent relapse following a hepatologist's instructions to remain abstinent. These counter-intuitive findings should be confirmed by larger, prospective studies. PMID: 29959881 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - June 30, 2018 Category: Biomedical Science Authors: Gong A, Leitold S, Uhanova J, Dolovich C, Medd P, Peretz D, Minuk G Tags: Clin Invest Med Source Type: research

Short and Long Term Mortality Predictors in Octogenarians with Acute Coronary Syndromes.
CONCLUSION: It would be reasonable to pay further attention to octogenarians with acute coronary syndrome if they are presenting with ST-segment-elevation myocardial infarction, and have hypotension, impaired left ventricular function, hyponatremia, atrial fibrillation or renal dysfunction, which are associated with increased mortality. PMID: 29959882 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - June 30, 2018 Category: Biomedical Science Authors: Atas H, Tigen K, Ozben B, Kartal F, Gurel E, Atas DB, Sari İ, Basaran Y Tags: Clin Invest Med Source Type: research

Combining the Love of Art, Science, Business and Medicine to Innovate and Enhance Patient Health. Highlights from the 7th Annual Leaders in Medicine Symposium of the Cummings School of Medicine, Calgary, AB.
Abstract The Leader in Medicine (LIM) Program of the Cumming School of Medicine, University of Calgary, hosted its 7th Annual LIM Research Symposium on October 30, 2015 and participation grew once again, with a total of six oral and 99 posters presentations! Over 45 of our Faculty members also participated in the symposium. This year's LIM Symposium theme was "Innovations in Medicine" and the invited guest speaker was our own Dr. Breanne Everett (MD/MBA). She completed her residency in plastic surgery at University of Calgary and holds both a medical degree and an MBA from the University of Calgary. In h...
Source: Clinical and Investigative Medicine - June 30, 2018 Category: Biomedical Science Authors: Beatty J, Peplowski M, Singh N, Beers C, Beck EM, Hollenberg M, Yipp B, Beck PL Tags: Clin Invest Med Source Type: research

Proceedings from the 7th Annual University of Calgary Leaders in Medicine Research Symposium.
Abstract TOn October 30th, 2015, the Leaders in Medicine (LIM) program at the Cumming School of Medicine, University of Calgary hosted its 7th Annual Research Symposium. Dr. Breanne Everett, President and CEO of Orpyx Medical Technologies and holder both of medical and MBA degrees from the University of Calgary, presented a lecture entitled "Marrying Business and Medicine: Toe-ing a Fine Line". The LIM symposium also provides a forum for both LIM and non-LIM medical students to present their research work in oral and poster presentation formats. This year over 100 students submitted their work and six or...
Source: Clinical and Investigative Medicine - June 30, 2018 Category: Biomedical Science Authors: Frolkis A, Beatty J, Peplowski M, Singh N, Beers C, Beck EM, Hollenberg M, Yipp B, Beck PL Tags: Clin Invest Med Source Type: research

Newsletter Spring 2018: Clinician Investigator Trainee Association of Canada (CITAC).
Abstract A decade of CITAC Annual General Meetings: 2007-2017 In 2007, the Clinician Investigator Trainee Association of Canada (CITAC) launched its inaugural Annual General Meeting (AGM). The AGM has since become a major annual event, jointly organized by CITAC and leaders from the Canadian Society for Clinical Investigation (CSCI), and continues to provide a forum for clinician investigator (CI) trainees to exchange ideas, advance career prospects and engage with the broader community. Indeed, since its inception, all Canadian institutions with medical doctor and clinician investigator (MD+CI) training programs ...
Source: Clinical and Investigative Medicine - March 27, 2018 Category: Biomedical Science Authors: Zhou TE, Zaslavsky K, Barton K, Abraham KJ, Bortolussi R Tags: Clin Invest Med Source Type: research

Dose adjustment of immunosuppressants during co-administration of posaconazole: a systematic review.
CONCLUSION: Our findings indicate that, when posaconazole is co-administered, the dosage of sirolimus and tacrolimus should be reduced by 60%-70% and for cyclosporine and by 30%-40% following allogeneic hematopoietic stem cell and solid-organ transplantation. PMID: 29603686 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - March 27, 2018 Category: Biomedical Science Authors: Fu C, Chen J, Xu Y, Wu D Tags: Clin Invest Med Source Type: research

MiR-7, miR-9 and miR-375 contribute to effect of Exendin-4 on pancreatic β-cells in high-fat-diet-fed mice.
MiR-7, miR-9 and miR-375 contribute to effect of Exendin-4 on pancreatic β-cells in high-fat-diet-fed mice. Clin Invest Med. 2018 Mar 27;41(1):E16-E24 Authors: Guo C, Sun YQ, Li Q, Zhang JC Abstract PURPOSE: The purpose of this study was to test whether glucagon-like peptide-1 (GLP-1) receptor activation preserved pancreatic β-cells via the regulation of microRNAs and target genes in high-fat-diet-fed mice. METHODS: C57BL/6 male mice were simultaneously treated with high-fat-diet (HFD) and GLP-1 analogue, Exendin-4 (Ex-4) (3 μg/kg/day or 30 μg/kg/day), i.p. or vehicle, for consecu...
Source: Clinical and Investigative Medicine - March 27, 2018 Category: Biomedical Science Authors: Guo C, Sun YQ, Li Q, Zhang JC Tags: Clin Invest Med Source Type: research

Serum level of fetuin B is associated with osteoporosis: a 4-year prospective study in China.
Abstract PURPOSE: As a novel hepatokine, fetuin B involves in various functions of energy metabolism. Recent advance reveals a complex interaction between bone and liver via the secretion of hepatokines. The association between serum fetuin B and osteoporosis was evaluated in a 4-year hospital-based prospective study of 1,370 Chinese postmenopausal women. METHODS: Bone mineral densities (BMDs) were obtained on femoral neck and lumbar spines by dual energy X-ray absorptiometry. Serum fetuin B level was tested by enzyme-linked immunosorbent assay. RESULTS: Of the 1,370 participants in the baseline study (2...
Source: Clinical and Investigative Medicine - March 27, 2018 Category: Biomedical Science Authors: Xu ZH, He J, Zhang X, Xie H, Zhou ZH, Sun YW, Luo X Tags: Clin Invest Med Source Type: research

CIM Journal Club: Gene therapy for spinal muscular atrophy Comment on Mendell et al. N Engl J Med 2017;377:1713-22.
Abstract In their landmark paper, Mendell et al. show that infants with spinal muscular atrophy (SMA) reached important motor milestones and survived longer when treated with AVXS-101 (AveXis), a viral vector containing DNA encoding the survival of motor neuron protein (SMN). Patients not only crawled, stood and walked independently, but learned to speak. These results are very encouraging for patients with SMA and offer hope for pediatric and adult patients with other types of motor neuron diseases. PMID: 29603689 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - March 27, 2018 Category: Biomedical Science Authors: Schneider R Tags: Clin Invest Med Source Type: research

The 2nd Annual Clinical Scientist Trainee Symposium, August 22, 2017, London, Canada.
Abstract Clinician scientists play a critical role in bridging research and clinical practice. Unfortunately, the neglect of research training in medical schools has created clinicians who are unable to translate evidence from literature to practice. Furthermore, the erosion of research training in medical education has resulted in clinicians who lack the skills required for successful scientific investigation. To counteract this, the Schulich School of Medicine & Dentistry has made an effort to engage trainees, at all levels, in the research process. The 2nd Annual Clinician Scientist Trainee Symposium was he...
Source: Clinical and Investigative Medicine - March 27, 2018 Category: Biomedical Science Authors: Yin C, Blom JN, Lewis JF Tags: Clin Invest Med Source Type: research

Editor's Comment and Announcement.
Abstract It is hard to believe but Clinical and Investigative Medicine (CIM), the official journal of Canadian Society for Clinical Investigation (CSCI), will soon celebrate its 40th birthday!  Over these past four decades, CIM has been the premier journal for Canadian clinician scientists; publishing over 1,000 articles on breakthroughs and major advances from Canada and around the world.  We are listed on Medline, PubMed and the Library of Science. We have been, and will continue to be, an independent journal. To celebrate this auspicious occasion, we have plans ...
Source: Clinical and Investigative Medicine - December 17, 2017 Category: Biomedical Science Authors: Bortolussi R Tags: Clin Invest Med Source Type: research

Association among tenascin-C and NT-proBNP levels and arrhythmia prevalence in heart failure.
i M Abstract PURPOSE: Tenascin-C (TN-C) and amino-terminal fragment of the B-type natriuretic peptide (NT-proBNP) are the important predictors in prognosis of heart failure (HF). The aim of this study was to analyze the relationship of TN-C and NT-proBNP levels with the frequency and severity of ventricular arrhythmia. MATERIALS AND METHODS: Our study included 107 HF patients with EF
Source: Clinical and Investigative Medicine - December 17, 2017 Category: Biomedical Science Authors: Ozmen C, Deniz A, Deveci OS, Cagliyan CE, Celik AI, Yildiz İ, Yildiz PÖ, Demir M, Kanadasi M Tags: Clin Invest Med Source Type: research

Plaque distribution in common femoral artery bifurcations, based on multi-slice computed tomography assessment.
Abstract PURPOSE: The aim of this study was to observe the exact plaque distribution at the common femoral artery bifurcation by multi-slice computed tomography angiography and to examine the relationship between plaque distribution and carina location. METHODS: Symptomatic outpatients who underwent multi-slice computed tomography angiography between May 2013 and February 2015 were enrolled in this study. The presence and distribution of atherosclerotic plaques were assessed in cross section views of vessel lumen. Each vessel lumen cross section was divided into four equal quadrants for the common femoral, su...
Source: Clinical and Investigative Medicine - December 17, 2017 Category: Biomedical Science Authors: Zhang B, Yang M, Zou Y Tags: Clin Invest Med Source Type: research

Adolescent obesity and the role of the fat mass and obesity-associated gene polymorphism.
Nacak M, Araz M Abstract PURPOSE: The association between fat mass and obesity-associated (FTO) gene and obesity is unclear in both adults and adolescents. The aim of this study was to examine the role of the FTO gene variant rs9939609 as a candidate gene for obesity and the relationship between insulin resistance (IR), metabolic syndrome (MetS), estimated glomerular filtration rate (eGFR) and neutrophil-to-lymphocyte ratio (NLR). METHODS: Obese adolescents (n=100) and healthy controls (n=100) were included. Rs9939609 polymorphism in the FTO gene was genotyped by PCR-SNaPshot. RESULTS: The prevalence of ...
Source: Clinical and Investigative Medicine - December 17, 2017 Category: Biomedical Science Authors: Çöl N, Demircioğlu-Kiliç B, Nacak M, Araz M Tags: Clin Invest Med Source Type: research

Predicting Acute Kidney Injury following Transcatheter Aortic Valve Replacement.
Abstract PURPOSE: Acute kidney injury occurs in up to a quarter of patients following transcatheter aortic valve replacement (TAVR) and has been associated with increased short and long-term mortality rates. A variety of patient characteristics predictive of post-TAVR acute kidney injury (AKI) have been identified, however discrepancies among studies exist almost uniformly. We investigated the hypothesis that the change in glomerular filtration rate (ΔGFR) in response to contrast administered during pre-TAVR coronary angiography is predictive of ΔGFR post-TAVR. METHODS: The study comprised 195 pat...
Source: Clinical and Investigative Medicine - December 17, 2017 Category: Biomedical Science Authors: Marbach JA, Feder J, Yousef A, Ramirez FD, Simard T, DiSanto P, Russo JJ, Boland P, Labinaz M, Glover C, Dick A, Hibbert B Tags: Clin Invest Med Source Type: research

Pattern reversal visual evoked potentials in adults: variability with age.
This study measured the changes in the latencies and amplitudes of the PRVEP with age and gender in normal subjects. METHODS: Healthy participants (n=81; 162 total eyes), between the ages of 20 and 92 years were recruited for the study. Stimulation was performed monocularly with a high-contrast (>50%) black-white checkerboard pattern with a check size of 30° at a reversal rate of 2 Hz, a band-pass of 1-100 Hz, a sweep of 250 msec and an average of 150 stimulations in a dark room. Mean and standard deviations for three latencies (N75, P100 and N145) and the amplitude (N75-P100) for each decade were measured. ...
Source: Clinical and Investigative Medicine - December 17, 2017 Category: Biomedical Science Authors: Sawaya R, Sawaya H, Youssef G Tags: Clin Invest Med Source Type: research

Association between donor and recipient Interleukin-18 gene polymorphisms and the risk of infection after liver transplantation.
CONCLUSIONS: These findings indicate that the IL-18 rs1946518 SNP in the donor liver is a risk factor for developing bacterial infection after liver transplantation. PMID: 29061223 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - October 19, 2017 Category: Biomedical Science Authors: Shi BJ, Yu XY, Li H, Xing TH, Fan JW, Wang PW, Peng ZH, Zhong L Tags: Clin Invest Med Source Type: research

Glucagon-like peptide-1 levels and dipeptidyl peptidase-4 activity in type 2 diabetes.
Abstract PURPOSE: Hyperglycemia is the major risk factor for microvascular complications in type 2 diabetes mellitus (T2DM) patients. This randomized controlled clinical trial aimed to investigate T2DM patients with microvascular complications with regard to possible relations among serum clusterin (CLU), amylin, secreted frizzled-related protein-4 (SFRP-4), glucagon-like peptide-1 (GLP-1) and dipeptidyl peptidase-4 (DPP-4) activities. METHODS: Subject groups were defined as follows: T2DM without complications (n=25, F/M=9/16, age 53.9±11.1 years); T2DM+Retinopathy (n=25, F/M=13/12, age 63.8±7.1...
Source: Clinical and Investigative Medicine - October 19, 2017 Category: Biomedical Science Authors: Senyigit A, Tabak O, Orhanoglu T, Karadag A, Ugurlu S, Uzun H, Konukoglu D Tags: Clin Invest Med Source Type: research

Combination of α-blocker and 5α-reductase inhibitor for treatment of benign prostatic hyperplasia.
This study compared the efficacy of an α-blocker monotherapy alone with a combination of α-blocker plus 5α-reductase in treatment of benign prostatic hyperplasia (BPH). METHODS: Medline (PubMed), EMBASE, CENTRAL (Cochrane databases) and Google Scholar were searched until May 2015 using the following search terms: ([α-blocker] AND 5α-reductase inhibitor) AND benign prostatic hyperplasia; and benign prostatic hyperplasia AND (adrenergic alpha blockers OR 5 alpha reductase inhibitor). Randomized controlled trials (RCTs) that included men with a clinical diagnosis of BPH were included. Eligib...
Source: Clinical and Investigative Medicine - October 19, 2017 Category: Biomedical Science Authors: Kang D, Hu C, Fu Y, Wang D Tags: Clin Invest Med Source Type: research

Scientific Overview on CSCI-CITAC Annual General Meeting and 2016 Young Investigators' Forum.
Abstract The 2016 Annual General Meeting of the Canadian Society of Clinician Investigators (CSCI) and Clinician Investigator Trainee Association of Canada/Association des Cliniciens-Chercheurs en Formation du Canada (CITAC/ACCFC) was a national conference held in Toronto November 21-23, 2016, in conjunction with The University of Toronto Clinician Investigator Program Research Day. The theme for this year's meeting was "Mapping Your Career as a Clinician-Scientist"; emphasizing essential skills for developing a fruitful career as clinician-scientist. The meeting featured an opening presentation by Dr. A...
Source: Clinical and Investigative Medicine - October 19, 2017 Category: Biomedical Science Authors: Zhou TE, Barton KI, Cook E, Benesch MGK, Jette N, Moderie C, Ondrusova K, Lees C, Steadman PE, Marvasti TB, Mirali S, Liu PJ, Babadagli EM, Abraham KJ, Zaslavsky KJ Tags: Clin Invest Med Source Type: research

Ascending aortic diameter is associated with hypertension in Korean men.
Abstract PURPOSE: The purpose of this study was to evaluate the association between ascending aortic diameter (AAD) as measured with low-dose chest computed tomography (LDCT) and hypertension in Korean men. METHODS: Korean men (n=1,050) who were screened for lung cancer using LDCT imaging at a health promotion center in Seoul, Korea between January 1 and December 31were recruited for the study. AAD is the longest length of ascending aorta measured from approximately 15 mm above left main coronary ostium to the mid-slice level of the right pulmonary artery. RESULTS: AAD were divided into quartiles, and th...
Source: Clinical and Investigative Medicine - August 29, 2017 Category: Biomedical Science Authors: Suh E, Ryoo JH, Doo M, Lee HS, Lee SW, Shim KW, Lee JY, Byun AR, Chun H Tags: Clin Invest Med Source Type: research

The association of HLA-DQB1*0602 but not HLA-DRB1*15 with obstructive sleep apnea.
This study aimed to investigate the association between OSA and two human leukocyte antigens (HLA) alleles; DQB1*0602 and DRB1*15. METHODS: Forty patients with OSA and 40 control subjects were enrolled in the study. OSA diagnosis was made utilizing the Apnea-Hypopnea Index (AHI)≥5 in overnight polysomnography (PSG). AHI was also used to determine OSA severity. Controls were randomly selected from healthy volunteers who had a low risk for OSA, utilizing the Berlin Questionnaire. Polymerase chain reaction (PCR) using Sequence Specific Primers (PCR-SSPs) was used to determine the association between HLA (HLA-DQB1*0602...
Source: Clinical and Investigative Medicine - August 29, 2017 Category: Biomedical Science Authors: Momany SM, Al-Qatarneh TA, Khader YS, Abu-Harfeil NM, Daoud AK, Mahasneh AA Tags: Clin Invest Med Source Type: research

Interval versus external fixation for the treatment of pelvic fractures: a comparative study.
CONCLUSION: IF was found to be associated with shorter operation times, less blood loss and better postoperative rehabilitation in comparison with EF, suggesting that it is an effective therapy for the treatment of unstable PF and will lead to restoration of normal pelvis functions. PMID: 28653611 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - June 26, 2017 Category: Biomedical Science Authors: Ma X, Zheng X, Zhao W, Lu Z, Xu L, Liu Y, Liu Z Tags: Clin Invest Med Source Type: research

Addition of  dexmedetomidine to bupivacaine in supraclavicular brachial plexus block.
CONCLUSIONS: In the implementation of ultrasound-guided supraclavicular brachial plexus block, block success, sensory and motor block and analgesia duration were similar for patients anaesthetized with 30 ml of bupivacaine in comparison with dexmedetomidine+bupivacaine (when the bupivacaine dose was reduced by 50% by the addition of the adjuvant). PMID: 28653612 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - June 26, 2017 Category: Biomedical Science Authors: Aksu R, Bicer C Tags: Clin Invest Med Source Type: research

Myopia correction in children: a meta-analysis.
CONCLUSIONS: The effect of RGP lenses and SCL/spectacles on axial length elongation and spherical equivalent and of RGP and OK lenses on corneal curvature in children with myopia was similar. PMID: 28653613 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - June 26, 2017 Category: Biomedical Science Authors: Cui Y, Li L, Wu Q, Zhao J, Chu H, Yu G, Wei W Tags: Clin Invest Med Source Type: research