Newsletter Fall 2020: Clinician Investigator Trainee Association of Canada (CITAC).
Abstract Message from the CITAC president To say that 2020 has been an unprecedented year is an understatement. The coronavirus disease 2019 (COVID-19) global pandemic and the major societal awakening on racial equity and justice have led us to reflect on our direction, goals and mission. Thanks to our talented and dedicated executive team, we were able to pivot our efforts and adapt to the changing landscape of research and advocacy. In April, we provided our members with a list of resources to help facilitate a smooth transition to working from home. In June, we published Clinician Investigator Trainee Associati...
Source: Clinical and Investigative Medicine - September 24, 2020 Category: Biomedical Science Authors: Castanov V, Zeng A, Behrouzi B, Macklin J, Hu S, Pietrobon A, Marvasti TB Tags: Clin Invest Med Source Type: research

Overview of the Canadian Clinician Investigator Trainees' research presented at the 2019 CSCI-CITAC Joint Meeting.
Abstract The 2019 Annual General Meeting and Young Investigators' Forum of the Canadian Society for Clinical Investigation / Société Canadienne de Recherche Clinique (CSCI/SCRC) and Clinician Investigator Trainee Association of Canada / Association des Cliniciens-Chercheurs en Formation du Canada (CITAC/ACCFC) was held in Banff, Alberta on November 8-10th, 2019. The theme was "Positioning Early Career Investigators for Success: Strategy and Resilience". Lectures and workshops provided knowledge and tools to facilitate the attendees' development as clinician investigators. Dr. Jason Berman (...
Source: Clinical and Investigative Medicine - September 24, 2020 Category: Biomedical Science Authors: Castanov V, Zhou TE, Balestrini CS, Lefebvre C, Cook EK, Whittaker HT, Macklin J, Briard JN, Lazarte J, Trinder M, Ware MA, Hu S, Pietrobon A, Marvasti TB Tags: Clin Invest Med Source Type: research

Challenges and opportunities for future Canadian physician-scientists: Perspectives of four experts.
Abstract In this series of interviews, the Clinical and Investigative Medicine editorial team gathered expert opinions on the future of physician-scientist training and career prospects in Canada. This was inspired by recent publications that voiced concerns over the diminishing support for the physician-scientist in Canada and the United States. For this editorial, the term physician-scientist was intentionally broad and inclusive; referring to individuals who identify both clinical work and biomedical or healthcare research as major components of their career. The following leaders in medical research or researc...
Source: Clinical and Investigative Medicine - September 24, 2020 Category: Biomedical Science Authors: Levit A, Bortolussi R Tags: Clin Invest Med Source Type: research

Physician-Scientist trainees: A "call to action" to confront future career challenges.
Physician-Scientist trainees: A "call to action" to confront future career challenges. Clin Invest Med. 2020 Sep 24;43(3):E25-26 Authors: Balestrini CS Abstract Throughout their careers, physician-scientists must adapt to the dynamic landscape of the medical research environment. As such, current physicianscientist trainees must overcome unique obstacles on the path to productive research careers. In the paper by Levit et al. in this month's Clinical and Investigative Medicine issue, Canadian research leaders describe the challenges and opportunities for the next generation of physician-scie...
Source: Clinical and Investigative Medicine - September 24, 2020 Category: Biomedical Science Authors: Balestrini CS Tags: Clin Invest Med Source Type: research

Effective mobilization with etoposide and cyclophosphamide for collection of peripheral blood stem cell in patients with multiple myeloma.
CONCLUSION: The etoposide and cyclophosphamide regimen could be an effective and safe method for mobilization in patients with multiple myeloma. PMID: 32971582 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - September 24, 2020 Category: Biomedical Science Authors: Wang X, Zhang Y, Fan T, Liu H, Wang M, Liu H, Zhang M, He P Tags: Clin Invest Med Source Type: research

Pulmonary hypertension in end-stage renal disease patients on dialysis and predialysis patients.
CONCLUSION: Incidence of PH was not statistically different in ESRD patients on dialysis and pre-dialysis patients. Uremia may play a major role in the pathogenesis of PH in patients. PMID: 32971584 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - September 24, 2020 Category: Biomedical Science Authors: Li Y, Zhang Y, Wang J, Chen W, Cai Y, Yang M, Li X Tags: Clin Invest Med Source Type: research

KIF4A: A potential biomarker for prediction and prognostic of prostate cancer.
We examined 1) the relationship between the expression of KIF4A and clinico-pathological characteristics of PCa patients using a tissue microarray and the Cancer Genome Atlas database, 2) the prognostic value of KIF4A expression in patients using Kaplan-Meier plots and 3) the functions of KIF4A in LNCaP and DU145 cells, such as cell proliferation, cell cycle and cell apoptosis. RESULTS: Compared with normal prostate, the mRNA and protein expressions of KIF4A were up-regulated in PCa. The up-regulation expression rates of KIF4A in PCa were significantly related to the Gleason score (P. PMID: 32971585 [PubMed - in ...
Source: Clinical and Investigative Medicine - September 24, 2020 Category: Biomedical Science Authors: Chen J, Li M, Fang S, Zhou X, Liao J, Yang S, Zhu J, He R, Lu J, Jiang F, Xu X, Zhong W Tags: Clin Invest Med Source Type: research

Association of TBXA2R, P2Y12 and ADD1 genes polymorphisms with ischemic stroke susceptibility: A metaanalysis.
Abstract BACKGROUND: Ischemic stroke is a common cause of death and disability throughout the world. We aimed to evaluate the association between polymorphisms in TBXA2R (rs4523, rs768963, rs1131882), P2Y12 (rs204693), ADD1 (rs4961) and risk of ischemic stroke. METHODS: A comprehensive retrieval with the databases of Pubmed, Embase, CENTRAL, CNKI and Wan fang data was conducted. The deadline was February 1, 2019. Pooled ORs and 95% CIs were calculated by using the Z-test. Heterogeneity between the included studies was tested using the I2 method. Begg's funnel plot and Egger's linear regression were used to ev...
Source: Clinical and Investigative Medicine - August 29, 2020 Category: Biomedical Science Authors: Liang X, Zhou Y, Li S Tags: Clin Invest Med Source Type: research

Performance report for a 10-year-old MD/PhD Program: A survey of trainees at the University of Ottawa.
CONCLUSION: Our report contributes to the body of knowledge on concrete obstacles experienced by students within MD/PhD programs and key areas that can be improved upon-locally, provincially and nationally-to further advance student success. PMID: 32593271 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - June 28, 2020 Category: Biomedical Science Authors: Pietrobon A, Chehadé L, Beaudry-Richard A, Keller BA, Schlossmacher MG Tags: Clin Invest Med Source Type: research

Optimizing childhood oncology care transition from pediatric to adult settings: A survey of primary care physicians' and residents' perspectives.
CONCLUSION: The PCPs and residents rarely provide care for childhood cancer adult survivors. On an individual basis, there is a clear need for increased awareness, education and collaboration regarding long-term care of childhood cancer adult survivors during medical training. On a more global basis, structural, organizational and cultural changes are also needed to ensure adequate care transition. PMID: 32593272 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - June 28, 2020 Category: Biomedical Science Authors: Marcoux SMMP, Laverdière C Tags: Clin Invest Med Source Type: research

Role of spleen-derived CD11b+Gr-1+ cells in sepsis-induced acute kidney injury.
CONCLUSION: Splenic CD11b+Gr-1+ cells migrated to the kidney in sepsis, which led to acute kidney injury via the inhibition of mTOR/HIF-1α. PMID: 32593273 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - June 28, 2020 Category: Biomedical Science Authors: Cao Y, Xu QXM, Liu C, Fu C Tags: Clin Invest Med Source Type: research

Why USB-endoscope laryngoscopy is as effective as video laryngoscopy.
CONCLUSION: Our study showed that USB endoscope laryngoscope provided similar intubation time to video laryngoscopy at a fraction of the cost; and both had superior times in comparison with direct laryngoscopy. PMID: 32593274 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - June 28, 2020 Category: Biomedical Science Authors: Findik M, Kayipmaz AE, Kavalci C, Sencelikel TS, Muratoglu M, Akcebe A, Gungorer B, Kavalci G Tags: Clin Invest Med Source Type: research

Crush is superior to Culotte in two-stent strategy for treatment of left main coronary artery bifurcations: A systematic review and meta-analysis.
CONCLUSION: Crush was superior to Culotte for treatment of left main coronary artery bifurcation lesions with a trend of lower incidence of long-term major adverse cardiac events, mainly derived from decreased myocardial infarction, stent thrombosis and cardiac death. PMID: 32593275 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - June 28, 2020 Category: Biomedical Science Authors: Chen XCM, Cui DY, Chen YCMP, Niu TS Tags: Clin Invest Med Source Type: research

Rituximab treatment for lupus nephritis: A systematic review.
CONCLUSION: The study systematically analyzed the effectiveness and safety of rituximab for lupus nephritis, which suggested that the complete remission rate of rituximab in the treatment of lupus nephritis was a significantly higher than that of cyclophosphamide group, while the effectiveness and safety was of no difference compared with cyclophosphamide and mycophenolate mofetil. PMID: 32593276 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - June 28, 2020 Category: Biomedical Science Authors: Yuan Z, Xie Q, Wu X, Tan B, Zhang X Tags: Clin Invest Med Source Type: research

Newsletter Spring 2020: Clinician Investigator Trainee Association of Canada (CITAC).
Abstract Message from Tina Marvasti, President of the Clinician Investigator Trainee Association of Canada: National and international collaborations and evidence based advocacy for the Canadian MD/PhD and MD+ trainees The overarching goals of the Clinician Investigator Trainee Association of Canada (CITAC) for 2020 are to expand its reach to increase membership and to continue to build strong relationships with our national and international partners. These goals will be achieved by applying the following three strategies: • Continue to develop and strengthen our relationships with national and international...
Source: Clinical and Investigative Medicine - April 5, 2020 Category: Biomedical Science Authors: Marvasti TB, Pietrobon A Tags: Clin Invest Med Source Type: research

Piloting a long distance clinician scientist trainee mentorship match in Canada.
Abstract Clinician scientists are physicians who are uniquely trained to bridge the gap between scientific discovery and clinical practice. However, the challenges of integrating research and medicine are often not directly addressed in the clinician scientist training programs. Furthermore, the demanding training path is financially and personally daunting. Previous studies have shown that MD/PhD trainees value the advice and expertise of senior mentors in navigating their academic career path. Despite this demand for mentors, there is a lack of formal mentorship initiatives at the institutional level across Cana...
Source: Clinical and Investigative Medicine - April 5, 2020 Category: Biomedical Science Authors: Mirali S, Fan K, Cook EK, Marvasti TB Tags: Clin Invest Med Source Type: research

Effects of dexmedetomidine and esmolol on otoacoustic emissions during controlled hypotensive anesthesia: randomized clinical trial.
CONCLUSIONS: Infusion of dexmedetomidine and esmolol decreased DPOAE levels during the operations, but DPOAE levels returned to normal in the postoperative period, and had no effect on stapes reflexes. Studies with larger groups of patients are needed to confirm these results in tympanoplasty and other surgeries. PMID: 32247297 [PubMed - as supplied by publisher] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - April 5, 2020 Category: Biomedical Science Authors: Gökahmetoğlu G, Pehlivan S, Aksu R, Biçer C Tags: Clin Invest Med Source Type: research

Impact of trainee involvement on patient radiation exposure and contrast volumes during invasive cardiac procedures.
Abstract PURPOSE: The impact of cardiology fellows (CFs) and interventional cardiology fellows (ICFs) on patient radiation and contrast exposure during diagnostic coronary angiography and percutaneous coronary intervention is unknown. METHODS: Between 2011 and 2014, 16,175 cases were retrospectively assessed involving 27 CFs, 22 ICFs and 24 staff as primary operators. RESULTS: During diagnostic coronary angiography, ICFs administered the lowest radiation dose (5,648±5,523 cGy*cm2; 1.30 ± 1.27 mSv)-achieving 22% less radiation than the staff (6,889±4,294 cGy*cm2; 1.58 ± 0.99 mS...
Source: Clinical and Investigative Medicine - April 5, 2020 Category: Biomedical Science Authors: Kansal V, Simard T, Di Santo P, Chong AY, So D, Hossain A, Small G, Chow BJW, Hibbert B Tags: Clin Invest Med Source Type: research

Plasma metanephrins are associated with myocardial hypertrophy and cardiac diastolic function in patients with essential hypertension.
CONCLUSIONS: In patients with essential hypertension, high level of plasma MNs associates with left ventricular hypertrophy and impaired diastolic function. PMID: 32247299 [PubMed - as supplied by publisher] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - April 5, 2020 Category: Biomedical Science Authors: Zhou Y, Yuan J, Wang Y, Qiao S Tags: Clin Invest Med Source Type: research

A new suicide risk assessment tool in Nova Scotia, Canada.
Abstract Suicide is a major public health concern. In Canada, suicide is the ninth leading cause of death in all ages, with a rate of 10.3 deaths per 100,000 people. In Nova Scotia, Canada, 137 suicides were reported in 2016 [1]. Suicide risk assessment (SRA) and management are clinical competencies required for patient care. Strategies used for SRA include the use of formal self-report measures [2], personalized clinical interview however vital information about suicide risk may be missed during that unstructured assessment [3] and structured tool to supplement the clinical interview. PMID: 32247300 [PubMed ...
Source: Clinical and Investigative Medicine - April 5, 2020 Category: Biomedical Science Authors: Sadek J, Pyche M, Theriault S, Delva N, Chehil S, Pilon D Tags: Clin Invest Med Source Type: research

An exercise in scientific writing for physicians in training.
Abstract It is important to strengthen critical thinking and scientific writing abilities during medical training to support trainees in their research endeavors and prepare students for careers in academic medicine. This commentary describes an interactive workshop to encourage student engagement with scientific literature and contribution to scholarly discourse by writing letters to the editor (LTEs). Students in the MD-PhD program at McGill University were asked to identify an article from a high-impact journal and think about ways in which they could address its scientific content. Students completed this prep...
Source: Clinical and Investigative Medicine - April 5, 2020 Category: Biomedical Science Authors: Whittaker HT, Skerritt L, Dankner M, Eisenberg MJ Tags: Clin Invest Med Source Type: research

Can a virtual on-line nation-wide mentorship-matching process meet the need?
Abstract In Homer's 8th century BC Greek epic poem "Odyssey", Odysseus, upon leaving town to do battle for an extended period, could not have done better than to leave his son, Telemachus, in the care of a trusted friend, Mentor. Thus, "mentorship" can be seen as a key process, whereby a more experienced individual takes on an advisor role for a less-experienced colleague. PMID: 32247302 [PubMed - as supplied by publisher] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - April 5, 2020 Category: Biomedical Science Authors: Hollenberg MD Tags: Clin Invest Med Source Type: research

Exposing HIV-1 Env: Implications for therapeutic strategies.
Abstract The human immunodeficiency virus (HIV-1) envelope glycoprotein trimer (Env) is exposed on the surfaces of both virions and infected cells. Thus, Env is the principal target for neutralizing antibodies and antibodies able to mediate antibodydependent cellular cytotoxicity (ADCC). The HIV-1 Env is a flexible molecule known to exist in at least three different conformational states: states 1, 2 and 3. Before interacting with the primary receptor, CD4, Env preferentially adopts a compact, "closed" conformation (state 1) that is largely antibody-resistant. The CD4 binding "opens" Env increa...
Source: Clinical and Investigative Medicine - December 29, 2019 Category: Biomedical Science Authors: Finzi A Tags: Clin Invest Med Source Type: research

Cancer genetics-one family at a time.
This article is a distillation and extension of some of themes I presented as a lecture to the Canadian Society of Clinical Investigation meeting in Banff in 2019. I emphasize the important role that investigation of a few key families seen in our clinic (sometimes as few as one) can play in cancer genetic discovery. I present the work both thematically and chronologically, demonstrating how clinical observation, combined with laboratory work and extensive collaboration can lead to novel insights. I will focus on families possessing germline pathogenic variants in PALB2, DICER1, SMARCA4, FGFR1 and RAD51D as examples of how...
Source: Clinical and Investigative Medicine - December 29, 2019 Category: Biomedical Science Authors: Foulkes W Tags: Clin Invest Med Source Type: research

Correlation analysis of preoperative magnetic resonance cholangiopancreatography and prognosis in hilar cholangiocarcinoma.
CONCLUSIONS: The presence and extent of preoperative biliary obstruction, measured by MRCP, was associated with aggressive clinicopathological features and indicated poor prognosis in HC patients. PMID: 31922704 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - December 29, 2019 Category: Biomedical Science Authors: Xu X, Li L, Zhang XN Tags: Clin Invest Med Source Type: research

Psychiatric co-morbidity and asthma: A pilot study utilizing a free use tool to improve asthma care.
CONCLUSIONS: Psychiatric co-morbidity was confirmed to be common in patients with moderate-severe asthma. In individuals with asthma, the MINI screen appeared to be a simple and useful clinical tool to screen for untreated/sub-optimally-managed psychiatric co-morbidities that may impact management. PMID: 31922705 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - December 29, 2019 Category: Biomedical Science Authors: Paquet J, Mah D, Saad E, Beach J, Vethanayagam D Tags: Clin Invest Med Source Type: research

Moderate hyperoxia plays a protective role in lung bronchial epithelial cells.
CONCLUSION: These results suggest that moderate hyperoxia promotes proliferation in NHBE cells and activates TNF-α and downstream ASK1. Then TNF-α activates NF-κB and SC to play a protective role. PMID: 31922706 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - December 29, 2019 Category: Biomedical Science Authors: Tang S, Sun S, Zhang D, Liu D Tags: Clin Invest Med Source Type: research

Glycated hemoglobin measurements at three, 12 and 24 months postpartum after gestational diabetes.
Abstract PURPOSE: To determine the associations between glycated hemoglobin (A1C) values at three, 12 and 24 months postpartum taken during the Families Defeating Diabetes trial. METHODS: The Families Defeating Diabetes trial was a randomized 12 month lifestyle intervention delivered in the first year postpartum. Women were reviewed at three, 6 12 and 24 months for body habitus, diet and lifestyle choices. Glycated hemoglobin levels were measured at three, 12 and 24 months. RESULTS: There were 170 randomization participants: 89 interventional (INT); and 81 control (CON). Of these 170 participants, 50 INT...
Source: Clinical and Investigative Medicine - December 29, 2019 Category: Biomedical Science Authors: Barton K, Donovan L, Giroux I, Miller D, Mottola M, McManus R Tags: Clin Invest Med Source Type: research

The Vision Health Research Network and its commitment to the scholarly development of its trainees.
Abstract The Vision Health Research Network (VHRN) is a provincial scientific organization that aims to improve the ocular health of patients across Quebec by supporting local research endeavors in vision health. The VHRN Student Committee, composed of 288 trainees with diverse backgrounds, has demonstrated its commitment to the scholarly development of its members by providing leadership opportunities, creating networking events, increasing visibility of researchers-in-training and encouraging professional advancement through educational workshops and funding programs. In this article, we review the contributions...
Source: Clinical and Investigative Medicine - December 29, 2019 Category: Biomedical Science Authors: Anchouche S, Liu J, Vucetic S, Santerre K, Zhou T Tags: Clin Invest Med Source Type: research

Fourth Annual Clinician Scientist Trainee Symposium at the Schulich School of Medicine and Dentistry.
Abstract The Annual Clinician Scientist Trainee Symposium (CSTS) gathers the local medical research community at the Schulich School of Medicine and Dentistry, including research trainees at the medical student, resident and fellow levels. Trainees showcase their current and upcoming work, and leaders in the community impart their perspectives on the importance and future of research in medicine. At the 4th Annual CSTS, perseverance and cautious optimism emerged as the characteristics that trainees should foster through their future careers as clinician scientists. This was echoed by the challenges and encouraging...
Source: Clinical and Investigative Medicine - December 29, 2019 Category: Biomedical Science Authors: Levit A, Yin C, Lewis J Tags: Clin Invest Med Source Type: research

An overview of the adverse effects of cannabis use for Canadian physicians.
CONCLUSION: Overall, evidence for direct and long-term adverse effects of cannabis use is minimal and additional longitudinal studies will be required to better delineate unidentified effects. PMID: 31563157 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - September 29, 2019 Category: Biomedical Science Authors: Leduc-Pessah H, Jensen SK, Newell C Tags: Clin Invest Med Source Type: research

A Clinician-Researcher Training Program for Family Medicine Residents.
CONCLUSIONS: With the aim of developing clinician-researchers in the field of family medicine, this novel program will help change the research climate in a large organization, where community-based family practitioners were not typically involved in research. PMID: 31563158 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - September 29, 2019 Category: Biomedical Science Authors: Koren G, Gabay L, Kuchnir J Tags: Clin Invest Med Source Type: research

Energy spectrum computed tomography improves the differentiation between benign and malignant solitary pulmonary nodules.
Abstract PURPOSE: To evaluate the diagnostic efficiency of computed tomography (CT) values at the 40~140 keV monochromatic level for the differential diagnosis of solitary pulmonary nodules (SPNs). METHODS: Energy spectrum CT data of 44 patients with SPNs were analyzed retrospectively; 24 patients with malignant SPNs served as the malignant group and 20 patients with benign SPNs served as the benign group. The basic material concentration and the enhancement degree differences in double-phase enhanced scans were compared between the two groups. The sensitivity and specificity were calculated to determine diag...
Source: Clinical and Investigative Medicine - September 29, 2019 Category: Biomedical Science Authors: Zhao J, Chai Y, Zhou J, Zhang Z, Wang Z Tags: Clin Invest Med Source Type: research

Relationship between blood lipid and arterial stiffness in hypertension.
CONCLUSION: Hypertension and/or dyslipidemia may be risk factors for arterial stiffness. In hypertension patients, TC, HDL-C, AIP, AI and TC/HDL-C might correlate to arterial stiffness and pathological increases in these levels may indicate risk factors for arterial stiffness. PMID: 31563160 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - September 29, 2019 Category: Biomedical Science Authors: Si XB, Liu W Tags: Clin Invest Med Source Type: research

Obstetrical and neonatal factors associated with optimal public banking of umbilical cord blood in the context of delayed cord clamping.
Abstract PURPOSE: To assess the association of specific newborn and maternal factors with indicators of increased blood-forming capacity in umbilical cord blood to inform strategic collection strategies that could augment the quality of units in public cord blood banks. METHODS: Data regarding 268 consecutive cord blood units (CBUs) banked by Canadian Blood Services were analyzed. Multivariate analysis was performed to identify factors associated with markers of hematopoietic potency and likelihood of utilization. RESULTS: Delayed clamping of the cord beyond 60 s was associated with reduced volume collec...
Source: Clinical and Investigative Medicine - September 29, 2019 Category: Biomedical Science Authors: Munro A, Corsi DJ, Martin L, Halpenny M, Dibdin N, Elmoazzen HE, Walker M, Allan DS Tags: Clin Invest Med Source Type: research

Clinical relevance of semaphorin-3F in patients with prostate cancer.
Abstract PURPOSE: To identify prognosis predictors for patients with prostate cancer (PCa). METHODS: Four independent PCa microarray datasets (GSE32448, GSE16560, GSE79957 and GSE17951) were reanalyzed to characterize the expression of semaphorin-3F (SEMA3F) gene between PCa patients and normal prostate tissues and the correlation between SEMA3F expression and the age, tumor/nodes/metastasis (TNM) staging, Gleason Grade Group, prostate-specific antigen level and overall survival of PCa patients. Gene set enrichment analysis was applied to investigate the potential relevant mechanisms regarding the expression ...
Source: Clinical and Investigative Medicine - September 29, 2019 Category: Biomedical Science Authors: Wu G Tags: Clin Invest Med Source Type: research

Proceedings from the 9th Annual University of Calgary Leaders in Medicine Research Symposium.
Abstract On November 3, 2017 the Leaders in Medicine (LIM) program at the University of Calgary's Cumming School of Medicine hosted the 9th Annual Leaders in Medicine (LIM) Symposium. This year's event commemorated 20 years of the LIM program and its dedication to the training of clinician- scientists. PMID: 31228961 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - June 23, 2019 Category: Biomedical Science Authors: Ward R, Delaloye N, Logan L, Jenkins S, Hollenberg MD, Rabi DM Tags: Clin Invest Med Source Type: research

Validation of endovascular and open thoracoabdominal aortic aneurysm repair in Ontario health administrative databases.
CONCLUSIONS: Endovascular TAAA repair may be identified using a single CCI code (1ID80GQNRN). Open TAAA repair may be identified using a combination of CCI and OHIP codes. Researchers may therefore use administrative data to conduct population-based studies of endovascular and open repair of TAAA. PMID: 31228962 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - June 23, 2019 Category: Biomedical Science Authors: Rocha RV, Al-Omran M, Hussain MA, Lee DS, Forbes TL, Lindsay TF, Ouzounian M Tags: Clin Invest Med Source Type: research

Effect of adrenalectomy on pulmonary edema resolution.
CONCLUSIONS: These experiments demonstrated that resolution of thioureainduced pulmonary edema can occur in the absence of hormonal secretion by the adrenal glands. PMID: 31228963 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - June 23, 2019 Category: Biomedical Science Authors: Massé C, Berthiaume Y Tags: Clin Invest Med Source Type: research

Golgi phosphoprotein-3 promotes invasiveness of gastric cancer cells through the mTOR signalling pathway.
CONCLUSIONS: In conclusion, GOLPH3 increased in poorly-differentiated gastric cancer cells, activating the mTOR-70S6K/4EBP1-RhoA signalling pathway to promote the migration and metastasis of gastric cancer cells. PMID: 31228964 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - June 23, 2019 Category: Biomedical Science Authors: Liu J, Wei H, Lai L, Wang Y, Han X, Zhang Z Tags: Clin Invest Med Source Type: research

Efficacy of milrinone and dobutamine in low cardiac output states: Systematic review and meta-analysis.
CONCLUSIONS: Currently available data comparing milrinone to dobutamine in patients requiring inotropic support is limited. Dobutamine may be associated with a shorter LOS in the ICU, with a worrisome signal of increased risk of allcause mortality. Randomized data are needed to guide inotrope selection in patients with LCOS and/or CS. PMID: 31228965 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - June 23, 2019 Category: Biomedical Science Authors: Mathew R, Visintini SM, Ramirez FD, DiSanto P, Simard T, Labinaz M, Hibbert BM Tags: Clin Invest Med Source Type: research

Newsletter Spring 2019: Clinician Investigator Trainee Association of Canada (CITAC).
Abstract Message from the President: Demystifying and promoting the MD-PhD/MD+ world Since its inception in 2006, the Clinician-Investigator Trainee Association of Canada (CITAC) has investigated, supported and promoted the needs of Canadian trainees on track to building a career in research and medicine. Membership in CITAC signals interest in such a career as a physician/clinician/surgeon-scientist. MD+ trainees (e.g., those in Clinician Investigator Programs (CIP), MD-PhD and MD-MSc programs) are involved in discussions surrounding this dual career often enough to have a sense of what it entails. Trainees assum...
Source: Clinical and Investigative Medicine - March 23, 2019 Category: Biomedical Science Authors: Cook E, Ma X, Castanov V, Hutchinson N Tags: Clin Invest Med Source Type: research

Comorbidity in multiple sclerosis: Past, present and future.
CONCLUSION: Comorbidity is highly prevalent in MS throughout the disease course. Comorbid conditions, including depression, anxiety, hypertension, hyperlipidemia, diabetes and chronic lung disease, adversely affect a broad range of outcomes. Less is known about the effects of MS on outcomes related to these comorbid conditions. These findings highlight an urgent need to determine how to best prevent and treat comorbidity in MS. PMID: 30904030 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - March 23, 2019 Category: Biomedical Science Authors: Marrie RA Tags: Clin Invest Med Source Type: research

Cardio-Oncology: A Tale of Two Cities: The art of preventing broken hearts in women with breast cancer.
Abstract 2018 CSCI Henry Friesen Award recipient. PMID: 30904031 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - March 23, 2019 Category: Biomedical Science Authors: Jassal DS Tags: Clin Invest Med Source Type: research

Calling all Emerging Health Leaders: A unique professional development opportunity awaits you!
Abstract The Health Leadership Academy (HLA) is a joint venture between McMaster University's DeGroote School of Business and Faculty of Health Sciences. As part of a landmark gift from Michael G. DeGroote, the HLA strives to have a transformative impact on global healthcare by nurturing a community of future leaders through interdisciplinary and forwardthinking approaches to education, public events and research. Operating out of the Ron Joyce Centre in Burlington Ontario, the HLA creates transformative impact by developing tomorrow's health leaders at all levels of the health system with new ways to think and do...
Source: Clinical and Investigative Medicine - March 23, 2019 Category: Biomedical Science Authors: Fitzgerald K, Taws M, Calic A Tags: Clin Invest Med Source Type: research

Association between PRDM16, MEF2D, TRPM8, LRP1 gene polymorphisms and migraine susceptibility in the She ethnic population in China.
This study investigated four SNPs, identified in genome-wide association studies, within migraine-susceptible loci in Han Chinese for their association with migraine susceptibility in the She population. METHODS: Two-hundred unrelated migraine patients and 200 healthy controls were recruited. The SNPs examined included rs2651899 (PRDM16 ), rs2274316 (MEF2D ), rs7577262 (TRPM8) and rs11172113 (LRP1). Genotyping of the SNPs was performed by allele-specific polymerase chain reaction and direct sequencing. RESULTS: No significant differences between the participants with migraines and controls (participants without m...
Source: Clinical and Investigative Medicine - March 23, 2019 Category: Biomedical Science Authors: Fu X, Yang J, Wu X, Lin Q, Zeng Y, Xia Q, Cao L, Huang B, Huang G Tags: Clin Invest Med Source Type: research

RIPK3 expression as a potential predictive and prognostic marker in metastatic colon cancer.
CONCLUSIONS: This study suggests that expression of RIPK3 in primary tumors of metastatic colon cancer patients should be further investigated for its potential as a promising predictive and prognostic marker. PMID: 30904034 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - March 23, 2019 Category: Biomedical Science Authors: Conev NV, Dimitrova EG, Bogdanova MK, Kashlov YK, Chaushev BG, Radanova MA, Petrov DP, Georgiev KD, Bachvarov CH, Todorov GN, Kalchev KP, Popov HB, Manev RR, Donev IS Tags: Clin Invest Med Source Type: research

Blood pressure measurement and the prevalence of postprandial hypotension.
Abstract BACKGROUND: Postprandial hypotension (PPH) is a serious condition that has been shown to be an independent risk factor for falls, fractures and death. PURPOSE: The prevalence of this problem in older adults with a past history of falls has shown a wide variability in the literature; the present study seeks to examine how the frequency with which blood pressure is measured impacts the prevalence and severity of PPH. METHODS: Older adults were recruited sequentially from a geriatric medicine falls clinic for meal testing (n=95). All subjects (mean age 77.5±0.7 years, 61±5% female) we...
Source: Clinical and Investigative Medicine - March 23, 2019 Category: Biomedical Science Authors: Madden KM, Feldman B, Meneilly GS Tags: Clin Invest Med Source Type: research

Serum alkaline phosphatase level is correlated with the incidence of cerebral small vessel disease.
CONCLUSION: The circulating level of ALP was positively correlated with a high risk of silent lacunar infarct and white matter hyperintensity; important indicators of small vessel disease. PMID: 30904036 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - March 23, 2019 Category: Biomedical Science Authors: Xiangyu P, Zhao J, Wu Y Tags: Clin Invest Med Source Type: research

Safety and efficacy of active and passive immunotherapy in mild-to-moderate Alzheimer's disease: A systematic review and network meta-analysis.
CONCLUSION: In terms of efficacy, the review showed a statistically, but not clinically significant, improvement in favor of immunotherapy versus placebo. Further clinical trials are required to demonstrate any cognitive benefits of immunotherapies in mild-to-moderate AD. PMID: 30904037 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - March 23, 2019 Category: Biomedical Science Authors: Foroutan N, Hopkins RB, Tarride JE, Florez ID, Levine M Tags: Clin Invest Med Source Type: research