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Total 1260 results found since Jan 2013.
Bioinformatic analysis for potential biological processes and key targets of heart failure-related stroke
This study aimed to uncover underlying mechanisms and promising intervention targets of heart failure (HF)-related stroke. HF-related dataset GSE42955 and stroke-related dataset GSE58294 were obtained from the Gene Expression Omnibus (GEO) database. Weighted gene co-expression network analysis (WGCNA) was conducted to identify key modules and hub genes. Gene Ontology (GO) and pathway enrichment analyses were performed on genes in the key modules. Genes in HF- and stroke-related key modules were intersected to obtain common genes for HF-related stroke, which were further intersected with hub genes of stroke-related key modu...
Source: J Zhejiang Univ Sci ... - September 13, 2021 Category: Science Authors: Chiyu Liu Sixu Chen Haifeng Zhang Yangxin Chen Qingyuan Gao Zhiteng Chen Zhaoyu Liu Jingfeng Wang Source Type: research
‘Gamechanging’ heart disease drug approved for use in England
Doctors say inclisiran will prevent tens of thousands of deaths from heart attack and strokePatients in England are to start receiving a “gamechanger” drug that doctors say will protect tens of thousands of lives by cutting the number of people who have a heart attack or stroke.The treatment, inclisiran, works by boosting the liver ’s ability to reduce the body’s level of “bad” cholesterol, even in those who have already tried using statins.Continue reading...
Source: Guardian Unlimited Science - August 31, 2021 Category: Science Authors: Denis Campbell Health policy editor Tags: Drugs Health Heart attack Stroke UK news NHS National Institute for Health and Care Excellence Source Type: news
Streamwise and lateral maneuvers of a fish-inspired hydrofoil
Fish are highly maneuverable compared to human-made underwater vehicles. Maneuvers are inherently
transient, so they are often studied via observations of fish and fish-like robots, where their
dynamics cannot be recorded directly. To study maneuvers in isolation, we designed a new kind of
wireless carriage whose air bushings allow a hydrofoil to maneuver semi-autonomously in a water
channel. We show that modulating the hydrofoil's frequency, amplitude, pitch bias, and stroke speed
ratio (pitching speed of left vs right stroke) produces streamwise and lateral maneuvers with mixed
effectiveness. Modulating pitch bias,...
Source: Bioinspiration and Biomimetics - August 24, 2021 Category: Science Authors: Qiang Zhong and Daniel B Quinn Source Type: research
An outer-pore gate modulates the pharmacology of the TMEM16A channel Pharmacology
TMEM16A Ca2+-activated chloride channels are involved in multiple cellular functions and are proposed targets for diseases such as hypertension, stroke, and cystic fibrosis. This therapeutic endeavor, however, suffers from paucity of selective and potent modulators. Here, exploiting a synthetic small molecule with a biphasic effect on the TMEM16A channel, anthracene-9-carboxylic...
Source: Proceedings of the National Academy of Sciences - August 19, 2021 Category: Science Authors: Ria L. Dinsdale, Tanadet Pipatpolkai, Emilio Agostinelli, Angela J. Russell, Phillip J. Stansfeld, Paolo Tammaro Tags: Pharmacology Biological Sciences Source Type: research
Ras-like Gem GTPase induced by Npas4 promotes activity-dependent neuronal tolerance for ischemic stroke Neuroscience
Ischemic stroke, which results in loss of neurological function, initiates a complex cascade of pathological events in the brain, largely driven by excitotoxic Ca2+ influx in neurons. This leads to cortical spreading depolarization, which induces expression of genes involved in both neuronal death and survival; yet, the functions of these...
Source: Proceedings of the National Academy of Sciences - August 4, 2021 Category: Science Authors: Hiroo Takahashi, Ryo Asahina, Masayuki Fujioka, Takeshi K. Matsui, Shigeki Kato, Eiichiro Mori, Hiroyuki Hioki, Tohru Yamamoto, Kazuto Kobayashi, Akio Tsuboi Tags: Neuroscience Biological Sciences Source Type: research
Flu jab may reduce severe effects of Covid, suggests study
Analysis of 75,000 coronavirus patients found fewer major health problems among people with flu jabCoronavirus – latest updatesSee all our coronavirus coveragePeople who are vaccinated against influenza may be partly protected against some of the severe effects of coronavirus, and be less likely to need emergency care, according to a major study.The analysis of nearly 75,000 Covid patients found significant reductions in stroke, deep vein thrombosis (DVT) and sepsis, and fewer admissions to emergency departments and intensive care units, among those who had been given the flu jab.Continue reading...
Source: Guardian Unlimited Science - July 12, 2021 Category: Science Authors: Ian Sample Science editor Tags: Medical research Coronavirus Vaccines and immunisation Health UK news Source Type: news
City Heat is Worse if You ’re Not Rich or White. The World’s First Heat Officer Wants to Change That
Jane Gilbert knows she doesn’t get the worst of the sticky heat and humidity that stifles Miami each summer. She lives in Morningside, a coastal suburb of historically preserved art deco and Mediterranean-style single-family homes. Abundant trees shade the streets and a bay breeze cools residents when they leave their air conditioned cars and homes. “I live in a place of privilege and it’s a beautiful area,” says Gilbert, 58, over Zoom in early June, shortly after beginning her job as the world’s first chief heat officer, in Miami Dade county. “But you don’t have to go far to see t...
Source: TIME: Science - July 7, 2021 Category: Science Authors: Ciara Nugent Tags: Uncategorized climate change feature Londontime Source Type: news
Serial sarcomere number is substantially decreased within the paretic biceps brachii in individuals with chronic hemiparetic stroke Applied Biological Sciences
A muscle’s structure, or architecture, is indicative of its function and is plastic; changes in input to or use of the muscle alter its architecture. Stroke-induced neural deficits substantially alter both input to and usage of individual muscles. We combined in vivo imaging methods (second-harmonic generation microendoscopy, extended field-of-view ultrasound,...
Source: Proceedings of the National Academy of Sciences - June 25, 2021 Category: Science Authors: Amy N. Adkins, Julius P. A. Dewald, Lindsay P. Garmirian, Christa M. Nelson, Wendy M. Murray Tags: Applied Biological Sciences Source Type: research
Common genetic variation influencing human white matter microstructure
Brain regions communicate with each other through tracts of myelinated axons, commonly referred to as white matter. We identified common genetic variants influencing white matter microstructure using diffusion magnetic resonance imaging of 43,802 individuals. Genome-wide association analysis identified 109 associated loci, 30 of which were detected by tract-specific functional principal components analysis. A number of loci colocalized with brain diseases, such as glioma and stroke. Genetic correlations were observed between white matter microstructure and 57 complex traits and diseases. Common variants associated with whi...
Source: Science: Current Issue - June 17, 2021 Category: Science Authors: Zhao, B., Li, T., Yang, Y., Wang, X., Luo, T., Shan, Y., Zhu, Z., Xiong, D., Hauberg, M. E., Bendl, J., Fullard, J. F., Roussos, P., Li, Y., Stein, J. L., Zhu, H. Tags: Genetics, Online Only r-articles Source Type: research
A reverse stroke characterizes the force generation of cardiac myofilaments, leading to an understanding of heart function Biophysics and Computational Biology
Changes in the molecular properties of cardiac myosin strongly affect the interactions of myosin with actin that result in cardiac contraction and relaxation. However, it remains unclear how myosin molecules work together in cardiac myofilaments and which properties of the individual myosin molecules impact force production to drive cardiac contractility....
Source: Proceedings of the National Academy of Sciences - June 4, 2021 Category: Science Authors: Yongtae Hwang, Takumi Washio, Toshiaki Hisada, Hideo Higuchi, Motoshi Kaya Tags: Biophysics and Computational Biology Biological Sciences Source Type: research
Evolutionary design of magnetic soft continuum robots Engineering
Worldwide cardiovascular diseases such as stroke and heart disease are the leading cause of mortality. While guidewire/catheter-based minimally invasive surgery is used to treat a variety of cardiovascular disorders, existing passive guidewires and catheters suffer from several limitations such as low steerability and vessel access through complex geometry of vasculatures...
Source: Proceedings of the National Academy of Sciences - May 20, 2021 Category: Science Authors: Liu Wang, Dongchang Zheng, Pablo Harker, Aman B. Patel, Chuan Fei Guo, Xuanhe Zhao Tags: Engineering Physical Sciences Source Type: research
Astrotherapy for stroke
Source: ScienceNOW - April 22, 2021 Category: Science Authors: Maroso, M. Tags: twis Source Type: news
PIP2 corrects cerebral blood flow deficits in small vessel disease by rescuing capillary Kir2.1 activity Neuroscience
Cerebral small vessel diseases (SVDs) are a central link between stroke and dementia—two comorbidities without specific treatments. Despite the emerging consensus that SVDs are initiated in the endothelium, the early mechanisms remain largely unknown. Deficits in on-demand delivery of blood to active brain regions (functional hyperemia) are early manifestations of...
Source: Proceedings of the National Academy of Sciences - April 19, 2021 Category: Science Authors: Fabrice Dabertrand, Osama F. Harraz, Masayo Koide, Thomas A. Longden, Amanda C. Rosehart, David C. Hill-Eubanks, Anne Joutel, Mark T. Nelson Tags: Neuroscience Biological Sciences Source Type: research
Space Can Take a Nasty Toll On An Astronaut ’s Heart, Study Finds
It’s perfectly fine that human beings want to travel in space. But we have to reckon with the fact that space doesn’t want anything to do with us. The exterior environment of space, of course, represents instantaneous death, what with the killing cold and the absence of any atmosphere. But even inside a spacecraft or a space station—cozy, pressurized, temperature-controlled, with food supplies, comfortable sleep pods, and a zero-g privy to take care of unavoidable essentials—the body doesn’t care for space.
Space radiation, which makes it through the walls of even the sturdiest ship, raises an...
Source: TIME: Science - April 2, 2021 Category: Science Authors: Jeffrey Kluger Tags: Uncategorized Source Type: news
