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Total 1260 results found since Jan 2013.

Modeling the neuro-protection of theaflavic acid from black tea and its synergy with nimodipine via mitochondria apoptotic pathway
J Zhejiang Univ Sci B. 2021 Feb 15;22(2):123-135. doi: 10.1631/jzus.B2000540.ABSTRACTIschemic stroke presents a leading cause of mortality and morbidity worldwide. Theaflavic acid (TFA) is a theaflavin isolated from black tea that exerts a potentially neuro-protective effect. However, the dynamic properties of TFA-mediated protection remain largely unknown. In the current study, we evaluated the function of TFA in the mitochondria apoptotic pathway using mathematical modeling. We found that TFA-enhanced B-cell lymphoma 2 (Bcl-2) overexpression can theoretically give rise to bistability. The bistability is highly robust aga...
Source: J Zhejiang Univ Sci ... - February 22, 2021 Category: Science Authors: Dan Mu Huaguang Qin Mengjie Jiao Shaogui Hua Tingzhe Sun Source Type: research

Modeling the neuro-protection of theaflavic acid from black tea and its synergy with nimodipine via mitochondria apoptotic pathway.
Abstract Ischemic stroke presents a leading cause of mortality and morbidity worldwide. Theaflavic acid (TFA) is a theaflavin isolated from black tea that exerts a potentially neuro-protective effect. However, the dynamic properties of TFA-mediated protection remain largely unknown. In the current study, we evaluated the function of TFA in the mitochondria apoptotic pathway using mathematical modeling. We found that TFA-enhanced B-cell lymphoma 2 (Bcl-2) overexpression can theoretically give rise to bistability. The bistability is highly robust against parametric stochasticity while also conferring considerable va...
Source: J Zhejiang Univ Sci ... - February 15, 2021 Category: Science Authors: Mu D, Qin H, Jiao M, Hua S, Sun T Tags: J Zhejiang Univ Sci B Source Type: research

Developmental synaptic regulator, TWEAK/Fn14 signaling, is a determinant of synaptic function in models of stroke and neurodegeneration Neuroscience
Identifying molecular mediators of neural circuit development and/or function that contribute to circuit dysfunction when aberrantly reengaged in neurological disorders is of high importance. The role of the TWEAK/Fn14 pathway, which was recently reported to be a microglial/neuronal axis mediating synaptic refinement in experience-dependent visual development, has not been explored...
Source: Proceedings of the National Academy of Sciences - February 1, 2021 Category: Science Authors: David Nagy, Katelin A. Ennis, Ru Wei, Susan C. Su, Christopher A. Hinckley, Rong–Fang Gu, Benbo Gao, Ramiro H. Massol, Chris Ehrenfels, Luke Jandreski, Ankur M. Thomas, Ashley Nelson, Stefka Gyoneva, Mihaly Haȷos, Linda C. Burkly Tags: Neuroscience Biological Sciences Source Type: research

Unipolar stroke, electroosmotic pump carbon nanotube yarn muscles
Success in making artificial muscles that are faster and more powerful and that provide larger strokes would expand their applications. Electrochemical carbon nanotube yarn muscles are of special interest because of their relatively high energy conversion efficiencies. However, they are bipolar, meaning that they do not monotonically expand or contract over the available potential range. This limits muscle stroke and work capacity. Here, we describe unipolar stroke carbon nanotube yarn muscles in which muscle stroke changes between extreme potentials are additive and muscle stroke substantially increases with increasing po...
Source: ScienceNOW - January 28, 2021 Category: Science Authors: Chu, H., Hu, X., Wang, Z., Mu, J., Li, N., Zhou, X., Fang, S., Haines, C. S., Park, J. W., Qin, S., Yuan, N., Xu, J., Tawfick, S., Kim, H., Conlin, P., Cho, M., Cho, K., Oh, J., Nielsen, S., Alberto, K. A., Razal, J. M., Foroughi, J., Spinks, G. M., Kim, Tags: Materials Science reports Source Type: news

Do we have to age?
The biologist Andrew Steele thinks ageing is a disease that can be treated. But if we had a cure for getting old, what would that mean for us?When the biologist Andrew Steele tells people his thoughts on ageing – that we might one day cure it as if it were any other disease – they are often incredulous and sometimes hostile. Once, at a friend’s wedding, he left a group of guests mildly incensed for suggesting that near-future humans might live well into their 100s. A similar thing happens at dinner p arties, where the responses are more polite but no less sceptical. He understands the reaction. We think of ageing as ...
Source: Guardian Unlimited Science - January 3, 2021 Category: Science Authors: Alex Moshakis Tags: Ageing Life and style Science Source Type: news

Amid 2020's gloom, there are reasons to be hopeful about the climate in 2021 | John Sauven
The concerted global response to the pandemic could be replicated for the fight against the climate crisisIn a world rife with disputes and divisions, there will be one emotion likely to unite most people at the stroke of midnight on 31 December: sheer relief that 2020 is finally over.There ’s no risk of overstating it: this past year has pushed our world right to the edge. A single virus leaping from animals to humans was enough tokill 1.6 million people, bring major economies to their knees, and cause untold anguish and suffering all over the world.Continue reading...
Source: Guardian Unlimited Science - December 31, 2020 Category: Science Authors: John Sauven Tags: Climate change Environment Coronavirus Science World news Source Type: news

Poststroke acute dysexecutive syndrome, a disorder resulting from minor stroke due to disruption of network dynamics Neuroscience
Stroke patients with small central nervous system infarcts often demonstrate an acute dysexecutive syndrome characterized by difficulty with attention, concentration, and processing speed, independent of lesion size or location. We use magnetoencephalography (MEG) to show that disruption of network dynamics may be responsible. Nine patients with recent minor strokes and...
Source: Proceedings of the National Academy of Sciences - December 29, 2020 Category: Science Authors: Elisabeth B. Marsh, Christian Brodbeck, Rafael H. Llinas, Dania Mallick, Joshua P. Kulasingham, Jonathan Z. Simon, Rodolfo R. Llinas Tags: Biological Sciences Source Type: research

IL-4/STAT6 signaling facilitates innate hematoma resolution and neurological recovery after hemorrhagic stroke in mice Neuroscience
Intracerebral hemorrhage (ICH) is a devastating form of stroke affecting millions of people worldwide. Parenchymal hematoma triggers a series of reactions leading to primary and secondary brain injuries and permanent neurological deficits. Microglia and macrophages carry out hematoma clearance, thereby facilitating functional recovery after ICH. Here, we elucidate a pivotal...
Source: Proceedings of the National Academy of Sciences - December 22, 2020 Category: Science Authors: Jing Xu, Zhouqing Chen, Fang Yu, Huan Liu, Cheng Ma, Di Xie, Xiaoming Hu, Rehana K. Leak, Sherry H. Y. Chou, R. Anne Stetler, Yejie Shi, Jun Chen, Michael V. L. Bennett, Gang Chen Tags: Biological Sciences Source Type: research

Transfer RNA fragments replace microRNA regulators of the cholinergic poststroke immune blockade Medical Sciences
Stroke is a leading cause of death and disability. Recovery depends on a delicate balance between inflammatory responses and immune suppression, tipping the scale between brain protection and susceptibility to infection. Peripheral cholinergic blockade of immune reactions fine-tunes this immune response, but its molecular regulators are unknown. Here, we report...
Source: Proceedings of the National Academy of Sciences - December 22, 2020 Category: Science Authors: Katarzyna Winek, Sebastian Lobentanzer, Bettina Nadorp, Serafima Dubnov, Claudia Dames, Sandra Jagdmann, Gilli Moshitzky, Benjamin Hotter, Christian Meisel, David S. Greenberg, Sagiv Shifman, Jochen Klein, Shani Shenhar-Tsarfaty, Andreas Meisel, Hermona S Tags: Biological Sciences Source Type: research