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Total 1260 results found since Jan 2013.
Voltage-dependent structural models of the human Hv1 proton channel from long-timescale molecular dynamics simulations Biophysics and Computational Biology
The voltage-gated Hv1 proton channel is a ubiquitous membrane protein that has roles in a variety of cellular processes, including proton extrusion, pH regulation, production of reactive oxygen species, proliferation of cancer cells, and increased brain damage during ischemic stroke. A crystal structure of an Hv1 construct in a putative...
Source: Proceedings of the National Academy of Sciences - June 15, 2020 Category: Science Authors: Andrew D. Geragotelis, Mona L. Wood, Hendrik Goddeke, Liang Hong, Parker D. Webster, Eric K. Wong, J. Alfredo Freites, Francesco Tombola, Douglas J. Tobias Tags: Biological Sciences Source Type: research
Activity in grafted human iPS cell-derived cortical neurons integrated in stroke-inȷured rat brain regulates motor behavior Neuroscience
Stem cell transplantation can improve behavioral recovery after stroke in animal models but whether stem cell–derived neurons become functionally integrated into stroke-injured brain circuitry is poorly understood. Here we show that intracortically grafted human induced pluripotent stem (iPS) cell–derived cortical neurons send widespread axonal projections to both hemispheres of rats...
Source: Proceedings of the National Academy of Sciences - April 20, 2020 Category: Science Authors: Sara Palma–Tortosa, Daniel Tornero, Marita Gronning Hansen, Emanuela Monni, Mazin Haȷy, Sopiko Kartsivadze, Sibel Aktay, Oleg Tsupykov, Malin Parmar, Karl Deisseroth, Galyna Skibo, Olle Lindvall, Zaal Kokaia Tags: Biological Sciences Source Type: research
I am an eye surgeon but could soon be your doctor in the ICU. I'm terrified
I am fearful for the future, uncertain for how my skills will hold up when put to testCoronavirus – latest updatesSee all our coronavirus coverageI am an ophthalmologist. I am the doctor you see for your cataract surgery, the doctor your grandmother sees to have her age-related macular degeneration checked, the one who prescribed the bedtime drops to slow down your grandfather ’s glaucoma. In the next few weeks I will be the doctor your father sees for his stroke, the doctor who treats your grandmother’s heart failure, the doctor you see in A&E to treat your asthma. Potentially the doctor you meet in intensive ca...
Source: Guardian Unlimited Science - April 20, 2020 Category: Science Authors: Selina Khan Tags: Coronavirus outbreak Doctors Society Health Society Professionals Infectious diseases Science NHS Work & careers Guardian Careers Source Type: news
Concern as heart attack and stroke patients delay seeking help
Consultants report drop in admissions of people with non-coronavirus related conditionsCoronavirus – latest updatesSee all our coronavirus coverageFurther evidence is emerging of dramatic falls in numbers of hospital patients presenting with serious medical conditions such as strokes and heart attacks since the beginning of the coronavirus pandemic.AUS study found that interventions for serious heart attacks have fallen 38% since 1 March. Similar reductions were reported in Spain, while inLombardy, the worst affected region of Italy, the figure was 70%.Continue reading...
Source: Guardian Unlimited Science - April 16, 2020 Category: Science Authors: Laura Spinney Tags: Coronavirus outbreak Hospitals Doctors Health Medical research Science Society Heart disease Heart attack Stroke World news UK news Source Type: news
Nasally delivered VEGFD mimetics mitigate stroke-induced dendrite loss and brain damage Neuroscience
In the adult brain, vascular endothelial growth factor D (VEGFD) is required for structural integrity of dendrites and cognitive abilities. Alterations of dendritic architectures are hallmarks of many neurologic disorders, including stroke-induced damage caused by toxic extrasynaptic NMDA receptor (eNMDAR) signaling. Here we show that stimulation of eNMDARs causes a...
Source: Proceedings of the National Academy of Sciences - April 13, 2020 Category: Science Authors: Daniela Mauceri, Bettina Buchthal, Thekla J. Hemstedt, Ursula Weiss, Christian D. Klein, Hilmar Bading Tags: Biological Sciences Source Type: research
Endothelium-targeted deletion of the miR-15a/16-1 cluster ameliorates blood-brain barrier dysfunction in ischemic stroke
The blood-brain barrier (BBB) maintains a stable brain microenvironment. Breakdown of BBB integrity during cerebral ischemia initiates a devastating cascade of events that eventually leads to neuronal loss. MicroRNAs are small noncoding RNAs that suppress protein expression, and we previously showed that the miR-15a/16-1 cluster is involved in the pathogenesis of ischemic brain injury. Here, we demonstrated that when subjected to experimentally induced stroke, mice with an endothelial cell (EC)–selective deletion of miR-15a/16-1 had smaller brain infarcts, reduced BBB leakage, and decreased infiltration of peripheral...
Source: Signal Transduction Knowledge Environment - April 6, 2020 Category: Science Authors: Ma, F., Sun, P., Zhang, X., Hamblin, M. H., Yin, K.-J. Tags: STKE Research Articles Source Type: news
This way for brain tingles: ASMR gets a shiver-inducing exhibition
From cucumber-crunchers to cranial exams, YouTube is full of ASMRtists provoking the strangely pleasurable autonomous sensory meridian response. Now they ’ve got their own euphoric museum showSome whisper gently into the microphone, while tapping their nails along the spine of a book. Others take a bar of soap andslice it methodically into tiny cubes, letting the pieces clatter into a plastic tray. There are those who dress up as doctors and pretend toperform a cranial nerve exam, and the ones who eat food as noisily as they can, recording every crunch and slurp in 3D stereo sound.To an outsider, the world of ASMR videos...
Source: Guardian Unlimited Science - March 31, 2020 Category: Science Authors: Oliver Wainwright Tags: Art Psychology Health & wellbeing Social trends Art and design Culture Technology Exhibitions Museums Installation Video art Sweden Painting Anxiety Alternative medicine Animal behaviour Science Life and style World Source Type: news
Mechanism and site of action of big dynorphin on ASIC1a Pharmacology
Acid-sensing ion channels (ASICs) are proton-gated cation channels that contribute to neurotransmission, as well as initiation of pain and neuronal death following ischemic stroke. As such, there is a great interest in understanding the in vivo regulation of ASICs, especially by endogenous neuropeptides that potently modulate ASICs. The most potent...
Source: Proceedings of the National Academy of Sciences - March 30, 2020 Category: Science Authors: Christian B. Borg, Nina Braun, Stephanie A. Heusser, Yasmin Bay, Daniel Weis, Iacopo Galleano, Camilla Lund, Weihua Tian, Linda M. Haugaard–Kedstrom, Eric P. Bennett, Timothy Lynagh, Kristian Stromgaard, Jacob Andersen, Stephan A. Pless Tags: Biological Sciences Source Type: research
Spreading edema after stroke
Source: ScienceNOW - March 11, 2020 Category: Science Authors: Hurtley, S. M. Tags: Medicine, Diseases, Neuroscience twis Source Type: news
Cerebrospinal fluid influx drives acute ischemic tissue swelling
Stroke affects millions each year. Poststroke brain edema predicts the severity of eventual stroke damage, yet our concept of how edema develops is incomplete and treatment options remain limited. In early stages, fluid accumulation occurs owing to a net gain of ions, widely thought to enter from the vascular compartment. Here, we used magnetic resonance imaging, radiolabeled tracers, and multiphoton imaging in rodents to show instead that cerebrospinal fluid surrounding the brain enters the tissue within minutes of an ischemic insult along perivascular flow channels. This process was initiated by ischemic spreading depola...
Source: ScienceNOW - March 11, 2020 Category: Science Authors: Mestre, H., Du, T., Sweeney, A. M., Liu, G., Samson, A. J., Peng, W., Mortensen, K. N., Staeger, F. F., Bork, P. A. R., Bashford, L., Toro, E. R., Tithof, J., Kelley, D. H., Thomas, J. H., Hjorth, P. G., Martens, E. A., Mehta, R. I., Solis, O., Blinder, P Tags: Medicine, Diseases, Neuroscience, Online Only r-articles Source Type: news
Sequential activation of necroptosis and apoptosis cooperates to mediate vascular and neural pathology in stroke Neuroscience
Apoptosis and necroptosis are two regulated cell death mechanisms; however, the interaction between these cell death pathways in vivo is unclear. Here we used cerebral ischemia/reperfusion as a model to investigate the interaction between apoptosis and necroptosis. We show that the activation of RIPK1 sequentially promotes necroptosis followed by apoptosis...
Source: Proceedings of the National Academy of Sciences - March 2, 2020 Category: Science Authors: Masanori Gomi Naito, Daichao Xu, Palak Amin, Jinwoo Lee, Huibing Wang, Wanjin Li, Michelle Kelliher, Manolis Pasparakis, Junying Yuan Tags: Biological Sciences Source Type: research
B cells migrate into remote brain areas and support neurogenesis and functional recovery after focal stroke in mice Neuroscience
Lymphocytes infiltrate the stroke core and penumbra and often exacerbate cellular injury. B cells, however, are lymphocytes that do not contribute to acute pathology but can support recovery. B cell adoptive transfer to mice reduced infarct volumes 3 and 7 d after transient middle cerebral artery occlusion (tMCAo), independent of...
Source: Proceedings of the National Academy of Sciences - March 2, 2020 Category: Science Authors: Sterling B. Ortega, Vanessa O. Torres, Sarah E. Latchney, Cody W. Whoolery, Ibrahim Z. Noorbhai, Katie Poinsatte, Uma M. Selvaraj, Monica A. Benson, Anouk J. M. Meeuwissen, Erik J. Plautz, Xiangmei Kong, Denise M. Ramirez, Apoorva D. Ajay, Julian P. Meeks Tags: Biological Sciences Source Type: research
Selective targeting of nanomedicine to inflamed cerebral vasculature to enhance the blood-brain barrier Chemistry
Drug targeting to inflammatory brain pathologies such as stroke and traumatic brain injury remains an elusive goal. Using a mouse model of acute brain inflammation induced by local tumor necrosis factor alpha (TNFα), we found that uptake of intravenously injected antibody to vascular cell adhesion molecule 1 (anti-VCAM) in the...
Source: Proceedings of the National Academy of Sciences - February 17, 2020 Category: Science Authors: Oscar A. Marcos-Contreras, Colin F. Greineder, Raisa Yu Kiseleva, Hamideh Parhiz, Landis R. Walsh, Viviana Zuluaga-Ramirez, Jacob W. Myerson, Elizabeth D. Hood, Carlos H. Villa, Istvan Tombacz, Norbert Pardi, Alecia Seliga, Barbara L. Mui, Ying K. Tam, Pa Tags: Physical Sciences Source Type: research
Cortical stimulation in aphasia following ischemic stroke: toward model-guided electrical neuromodulation.
Abstract
The aim of this paper is to integrate different bodies of research including brain traveling waves, brain neuromodulation, neural field modeling and post-stroke language disorders in order to explore the opportunity of implementing model-guided, cortical neuromodulation for the treatment of post-stroke aphasia. Worldwide according to WHO, strokes are the second leading cause of death and the third leading cause of disability. In ischemic stroke, there is not enough blood supply to provide enough oxygen and nutrients to parts of the brain, while in hemorrhagic stroke, there is bleeding within the enclosed ...
Source: Biological Cybernetics - February 3, 2020 Category: Science Authors: Beuter A, Balossier A, Vassal F, Hemm S, Volpert V Tags: Biol Cybern Source Type: research
Do public and private hospitals differ in quality? Evidence from Italy
Publication date: Available online 30 January 2020Source: Regional Science and Urban EconomicsAuthor(s): Francesco Moscone, Luigi Siciliani, Elisa Tosetti, Giorgio VittadiniAbstractWe investigate whether public and private providers differ in quality in Lombardy, a large Italian region. This region has adopted an “internal market”model where public and private providers are paid by DRG and compete for publicly-funded patients for both elective and emergency treatments. Using a large administrative sample in 2012–14, we measure clinical quality with 30-day mortality for the following emergency conditions: heart attack...
Source: Regional Science and Urban Economics - January 31, 2020 Category: Science Source Type: research
