Mechanism and site of action of big dynorphin on ASIC1a [Pharmacology]

Acid-sensing ion channels (ASICs) are proton-gated cation channels that contribute to neurotransmission, as well as initiation of pain and neuronal death following ischemic stroke. As such, there is a great interest in understanding the in vivo regulation of ASICs, especially by endogenous neuropeptides that potently modulate ASICs. The most potent...

Source: Proceedings of the National Academy of Sciences - March 30, 2020 Category: Science Authors: Christian B. Borg, Nina Braun, Stephanie A. Heusser, Yasmin Bay, Daniel Weis, Iacopo Galleano, Camilla Lund, Weihua Tian, Linda M. Haugaard–Kedstrom, Eric P. Bennett, Timothy Lynagh, Kristian Stromgaard, Jacob Andersen, Stephan A. Pless Tags: Biological Sciences Source Type: research