Nasally delivered VEGFD mimetics mitigate stroke-induced dendrite loss and brain damage [Neuroscience]

In the adult brain, vascular endothelial growth factor D (VEGFD) is required for structural integrity of dendrites and cognitive abilities. Alterations of dendritic architectures are hallmarks of many neurologic disorders, including stroke-induced damage caused by toxic extrasynaptic NMDA receptor (eNMDAR) signaling. Here we show that stimulation of eNMDARs causes a...

http://www.pnas.org/content/117/15/8616.short?rss=1

Source: Proceedings of the National Academy of Sciences - April 13, 2020 Category: Science Authors: Daniela Mauceri, Bettina Buchthal, Thekla J. Hemstedt, Ursula Weiss, Christian D. Klein, Hilmar Bading Tags: Biological Sciences Source Type: research