Activity in grafted human iPS cell-derived cortical neurons integrated in stroke-inȷured rat brain regulates motor behavior [Neuroscience]
Stem cell transplantation can improve behavioral recovery after stroke in animal models but whether stem cell–derived neurons become functionally integrated into stroke-injured brain circuitry is poorly understood. Here we show that intracortically grafted human induced pluripotent stem (iPS) cell–derived cortical neurons send widespread axonal projections to both hemispheres of rats...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Sara Palma–Tortosa, Daniel Tornero, Marita Gronning Hansen, Emanuela Monni, Mazin Haȷy, Sopiko Kartsivadze, Sibel Aktay, Oleg Tsupykov, Malin Parmar, Karl Deisseroth, Galyna Skibo, Olle Lindvall, Zaal Kokaia Tags: Biological Sciences Source Type: research
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