Cortical stimulation in aphasia following ischemic stroke: toward model-guided electrical neuromodulation.

Cortical stimulation in aphasia following ischemic stroke: toward model-guided electrical neuromodulation. Biol Cybern. 2020 Feb 04;: Authors: Beuter A, Balossier A, Vassal F, Hemm S, Volpert V Abstract The aim of this paper is to integrate different bodies of research including brain traveling waves, brain neuromodulation, neural field modeling and post-stroke language disorders in order to explore the opportunity of implementing model-guided, cortical neuromodulation for the treatment of post-stroke aphasia. Worldwide according to WHO, strokes are the second leading cause of death and the third leading cause of disability. In ischemic stroke, there is not enough blood supply to provide enough oxygen and nutrients to parts of the brain, while in hemorrhagic stroke, there is bleeding within the enclosed cranial cavity. The present paper focuses on ischemic stroke. We first review accumulating observations of traveling waves occurring spontaneously or triggered by external stimuli in healthy subjects as well as in patients with brain disorders. We examine the putative functions of these waves and focus on post-stroke aphasia observed when brain language networks become fragmented and/or partly silent, thus perturbing the progression of traveling waves across perilesional areas. Secondly, we focus on a simplified model based on the current literature in the field and describe cortical traveling wave dynamics and their modulation. This model uses a biophysi...
Source: Biological Cybernetics - Category: Science Authors: Tags: Biol Cybern Source Type: research

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Authors: Feres M, Retamal-Valdes B, Faveri M, Duarte P, Shibli J, Soares GMS, Miranda T, Teles F, Goodson M, Hasturk H, Van Dyke T, Ehmke B, Eickholz P, Schlagenhauf U, Meyle J, Koch R, Kocher T, Hoffmann T, Kim TS, Kaner D, Figueiredo LC, Doyle H Abstract OBJECTIVE: The selection of proper outcome measures is a critical step in clinical research. Most randomized clinical trials (RCTs) assessing the effects of initial anti-infective periodontal therapies use surrogate outcomes as primary outcome variables, such as mean changes in probing depth (PD) or in clinical attachment. However, these parameters do not reflect...
Source: Journal of the International Academy of Periodontology - Category: Dentistry Tags: J Int Acad Periodontol Source Type: research
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Source: Journal of the International Academy of Periodontology - Category: Dentistry Tags: J Int Acad Periodontol Source Type: research
Authors: Teng F, Yin Y, Guo J, Jiang M Abstract Calpain activation may have an important role in early brain injury (EBI) following subarachnoid hemorrhage (SAH). The present study investigated the effects of the calpastatin peptide, a cell-permeable peptide that functions as a potent inhibitor of calpain, on EBI in a rat SAH model. It was revealed that calpastatin peptide treatment significantly reduced SAH-induced body weight loss and neurological deficit at 72 h when compared with untreated SAH controls. Furthermore, the quantification of brain water content and the extravasation of Evans blue dye revealed a sig...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
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Source: Journal of Sound and Vibration - Category: Physics Source Type: research
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Source: Surgical Endoscopy - Category: Surgery Source Type: research
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Source: Surgical Endoscopy - Category: Surgery Source Type: research
Authors: Matsumura E, Nohara K, Tanaka N, Fujii N, Sakai T Abstract Polypharmacy in elderly persons living at home or in a nursing home is an issue. In the field of dentistry, strategies to reduce polypharmacy must be promoted; however, there is insufficient basic data on medications received by elderly persons with dysphagia living at home or in a nursing home. The subjects were 106 elderly persons with dysphagia living at home or in a nursing home. Based on their medical records, the presence of disease and number/type of drugs being administered were investigated. Stroke, dementia, and hypertension were common. ...
Source: Journal of oral science - Category: Dentistry Tags: J Oral Sci Source Type: research
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Source: Oral health and Preventive dentistry - Category: Dentistry Source Type: research
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Source: NYT Health - Category: Consumer Health News Authors: Tags: your-feed-science Seizures (Medical) Coronavirus (2019-nCoV) Fever Senses and Sensation Nerves and Nervous System Smell (Olfaction) Boca Raton (Fla) China Europe Germany France Wuhan (China) United States your-feed-health Source Type: news
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