Cortical stimulation in aphasia following ischemic stroke: toward model-guided electrical neuromodulation.

Cortical stimulation in aphasia following ischemic stroke: toward model-guided electrical neuromodulation. Biol Cybern. 2020 Feb 04;: Authors: Beuter A, Balossier A, Vassal F, Hemm S, Volpert V Abstract The aim of this paper is to integrate different bodies of research including brain traveling waves, brain neuromodulation, neural field modeling and post-stroke language disorders in order to explore the opportunity of implementing model-guided, cortical neuromodulation for the treatment of post-stroke aphasia. Worldwide according to WHO, strokes are the second leading cause of death and the third leading cause of disability. In ischemic stroke, there is not enough blood supply to provide enough oxygen and nutrients to parts of the brain, while in hemorrhagic stroke, there is bleeding within the enclosed cranial cavity. The present paper focuses on ischemic stroke. We first review accumulating observations of traveling waves occurring spontaneously or triggered by external stimuli in healthy subjects as well as in patients with brain disorders. We examine the putative functions of these waves and focus on post-stroke aphasia observed when brain language networks become fragmented and/or partly silent, thus perturbing the progression of traveling waves across perilesional areas. Secondly, we focus on a simplified model based on the current literature in the field and describe cortical traveling wave dynamics and their modulation. This ...
Source: Biological Cybernetics - Category: Science Authors: Tags: Biol Cybern Source Type: research