An outer-pore gate modulates the pharmacology of the TMEM16A channel [Pharmacology]

TMEM16A Ca2+-activated chloride channels are involved in multiple cellular functions and are proposed targets for diseases such as hypertension, stroke, and cystic fibrosis. This therapeutic endeavor, however, suffers from paucity of selective and potent modulators. Here, exploiting a synthetic small molecule with a biphasic effect on the TMEM16A channel, anthracene-9-carboxylic...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Pharmacology Biological Sciences Source Type: research