PIP2 corrects cerebral blood flow deficits in small vessel disease by rescuing capillary Kir2.1 activity [Neuroscience]
Cerebral small vessel diseases (SVDs) are a central link between stroke and dementia—two comorbidities without specific treatments. Despite the emerging consensus that SVDs are initiated in the endothelium, the early mechanisms remain largely unknown. Deficits in on-demand delivery of blood to active brain regions (functional hyperemia) are early manifestations of...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Fabrice Dabertrand, Osama F. Harraz, Masayo Koide, Thomas A. Longden, Amanda C. Rosehart, David C. Hill-Eubanks, Anne Joutel, Mark T. Nelson Tags: Neuroscience Biological Sciences Source Type: research