PIP2 corrects cerebral blood flow deficits in small vessel disease by rescuing capillary Kir2.1 activity [Neuroscience]

Cerebral small vessel diseases (SVDs) are a central link between stroke and dementia—two comorbidities without specific treatments. Despite the emerging consensus that SVDs are initiated in the endothelium, the early mechanisms remain largely unknown. Deficits in on-demand delivery of blood to active brain regions (functional hyperemia) are early manifestations of...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Neuroscience Biological Sciences Source Type: research