Ras-like Gem GTPase induced by Npas4 promotes activity-dependent neuronal tolerance for ischemic stroke [Neuroscience]

Ischemic stroke, which results in loss of neurological function, initiates a complex cascade of pathological events in the brain, largely driven by excitotoxic Ca2+ influx in neurons. This leads to cortical spreading depolarization, which induces expression of genes involved in both neuronal death and survival; yet, the functions of these...

http://www.pnas.org/content/118/32/e2018850118.short?rss=1

Source: Proceedings of the National Academy of Sciences - August 4, 2021 Category: Science Authors: Hiroo Takahashi, Ryo Asahina, Masayuki Fujioka, Takeshi K. Matsui, Shigeki Kato, Eiichiro Mori, Hiroyuki Hioki, Tohru Yamamoto, Kazuto Kobayashi, Akio Tsuboi Tags: Neuroscience Biological Sciences Source Type: research