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Total 27990 results found since Jan 2013.

MCPIP-1 knockdown enhances endothelial colony-forming cell angiogenesis via the TFRC/AKT/mTOR signaling pathway in the ischemic penumbra of MCAO mice
In this study, we performed Proteome Profiler™ Human Angiogenesis Antibody arrays and tandem mass tag protein profiling to investigate the effect of MCPIP-1 on ECFCs. We demonstrated that MCPIP-1 knockdown enhanced the proliferation, migration, and in vivo and in vitro angiogenic capacity of ECFCs by upregulating the transferrin receptor-activated AKT/m-TOR signaling pathway to promote cellular trophic factor secretion. Furthermore, we found that the lateral ventricular transplantation of ECFCs with lentiviral MCPIP-1 knockdown into mice with middle cerebral artery occlusion increased serum vacular endothelial growth fac...
Source: Experimental Neurology - September 9, 2023 Category: Neurology Authors: Xiaoxiong Zou Yu Xie Zhongfei Zhang Zhiming Feng Jianbang Han Qian Ouyang Shiting Hua Sixian Huang Cong Li Zhizheng Liu Yingqian Cai Yuxi Zou Yanping Tang Haijia Chen Xiaodan Jiang Source Type: research

The emerging role of the gut microbiome in posttraumatic stress disorder
Brain Behav Immun. 2023 Sep 7:S0889-1591(23)00269-6. doi: 10.1016/j.bbi.2023.09.005. Online ahead of print.ABSTRACTPosttraumatic stress disorder (PTSD) occurs in some people following exposure to a terrifying or catastrophic event involving actual/threatened death, serious injury, or sexual violence. PTSD is a common and debilitating mental disorder that imposes a significant burden on individuals, their families, health services, and society. Moreover, PTSD is a risk factor for chronic diseases such as coronary heart disease, stroke, diabetes, as well as premature mortality. Furthermore, PTSD is associated with dysregulat...
Source: Brain, Behavior, and Immunity - September 9, 2023 Category: Neurology Authors: Shanlin Ke Jakob Hartmann Kerry J Ressler Yang-Yu Liu Karestan C Koenen Source Type: research

Diffusion-Restricted Lesions of the Splenium: Clinical Presentation, Radiographic Patterns, and Patient Outcomes
Discussion Vascular DR lesions of the splenium were more common than CLOCCs and other etiologies in this cohort. While splenial DR lesions can present a clinical challenge, their associated clinical and radiographic characteristics may predict outcome and guide prognosis.
Source: Neurology Clinical Practice - September 8, 2023 Category: Neurology Authors: Stamm, B., Lineback, C. M., Tang, M., Jia, D. T., Chrenka, E., Sorond, F., Sabayan, B. Tags: MRI, DWI, All Cerebrovascular disease/Stroke Research Article Source Type: research

Pay attention: you can fall! The Mini-BESTest scale and the turning duration of the TUG test provide valid balance measures in neurological patients: a prospective study with falls as the balance criterion
ConclusionThe TUG turning duration and the Mini-BESTest predict the chance of being a faller. Their criterion validity as balance measures in neurological patients is substantial.
Source: Frontiers in Neurology - September 8, 2023 Category: Neurology Source Type: research

Association of Ferroptosis with Severity and Outcomes in Acute Ischemic Stroke Patients Undergoing Endovascular Thrombectomy: A Case-control Study
AbstractFerroptosis, an iron-dependent form of cell death, is characterized by intracellular accumulation of iron and reactive oxygen species-induced lipid peroxidation. Animal experiments have shown the important roles of ferroptosis in ischemic stroke, but the evidence in human stroke is insufficient. This prospective study evaluated the associations between plasma ferroptosis biomarkers at hyperacute stage and long-term outcomes in patients with acute ischemic stroke undergoing endovascular thrombectomy (EVT). The plasma samples were collected immediately before and after EVT (T1 and T2) and at 24  h (T3) for the 126 s...
Source: Molecular Neurobiology - September 7, 2023 Category: Neurology Source Type: research

SLC26A11 Inhibition Reduces Oncotic Neuronal Death and Attenuates Stroke Reperfusion Injury
In this study, electrophysiological properties of chloride current in primary cultured neurons were characterized using low chloride solution, 4,4 ′-diisothiocyano-2,2′-stilbenedisulfonic acid, and SLC26A11-specific siRNA under physiological conditions or ATP-depleted conditions. In vivo effect of SLC26A11 was evaluated on a rat stroke reperfusion model. We found that SLC26A11 mRNA in primary cultured neurons was upregulated as early as 6  h after oxygen glucose deprivation, and later, the protein level was elevated accordingly. Blockade of SLC26A11 activity could reduce chloride entry and attenuate hypoxia-induced ne...
Source: Molecular Neurobiology - September 7, 2023 Category: Neurology Source Type: research

Interpretable machine learning for prediction of clinical outcomes in acute ischemic stroke
ConclusionML algorithms demonstrated proficient prediction for the 3-month functional outcome in AIS patients. With the aid of the SHAP method, we can attain an in-depth understanding of how critical features contribute to model predictions and how changes in these features influence such predictions.
Source: Frontiers in Neurology - September 7, 2023 Category: Neurology Source Type: research

Treatment of In-stent Restenosis of the Internal Carotid Artery Using Drug-eluting Balloons
ConclusionThe use of DEB angioplasty is a  safe and effective treatment of ICA ISR lesions, yielding significantly better results compared to other modalities. Randomized multicenter studies are warranted.
Source: Clinical Neuroradiology - September 7, 2023 Category: Neurology Source Type: research

Statins may Decrease Aneurysm wall Enhancement of Unruptured Fusiform Intracranial Aneurysms: A high-resolution 3T MRI Study
AbstractInflammation plays an integral role in the formation, growth, and progression to rupture of unruptured intracranial aneurysms. Aneurysm wall enhancement (AWE) in high-resolution magnetic resonance imaging (HR-MRI) has emerged as a surrogate biomarker of vessel wall inflammation and unruptured intracranial aneurysm instability. We investigated the correlation between anti-inflammatory drug use and three-dimensional AWE of fusiform intracranial aneurysms (FIAs). We retrospectively analyzed consecutive patients with FIAs in our database who underwent 3T HR-MRI at three Chinese centers. FIAs were classified as fusiform...
Source: Translational Stroke Research - September 7, 2023 Category: Neurology Source Type: research

Impact of e-ASPECTS software on the performance of physicians compared to a consensus ground truth: a multi-reader, multi-case study
ConclusionDecision support with the e-ASPECTS software significantly improves the accuracy of ASPECTS scoring, even by expert US neurologists and neuroradiologists.
Source: Frontiers in Neurology - September 7, 2023 Category: Neurology Source Type: research

The experiences of young women living post-stroke in Jordan: a descriptive phenomenological study
CONCLUSION: After their stroke, Jordanian women have experienced profound, interrelated, and multifaceted difficulties in all aspects of their life and relationships inside and outside the family. Whilst healthcare providers recognize these stressful symptoms; however, there is a lack of attention and care to meet these needs.PMID:37671993 | DOI:10.1080/10749357.2023.2254049
Source: Topics in Stroke Rehabilitation - September 6, 2023 Category: Neurology Authors: Marwa Nayef Alhalabi Inaam Abdallah Khalaf Ruqayya Sayed Zeilani Hala Ahmad Bawadi Ahmad S Musa Abdulqadir J Nashwan Source Type: research

Do we need to consider head-on-body position, starting roll position and presence of visuospatial neglect when assessing perception of verticality after stroke?
CONCLUSIONS: HOB position and the presence of SRP and VSN are important factors to consider during SVV and SPV measurements. Assessment with a neutral HOB position leads to more accurate results. HOB position and SRP influence the results of SVV and SPV differently in individuals with and without VSN, which highlights the relevance of VSN assessment.PMID:37671676 | DOI:10.1080/10749357.2023.2253622
Source: Topics in Stroke Rehabilitation - September 6, 2023 Category: Neurology Authors: Charlotte van der Waal Elissa Embrechts Steven Truijen Wim Saeys Source Type: research

Phenothiazines reduced autophagy in ischemic stroke through endoplasmic reticulum (ER) stress-associated PERK-eIF2 α pathway
CONCLUSION: The combined treatment of C + P plays a crucial role in stroke therapy by inhibiting ER stress-mediated autophagy, thereby leading to reduced apoptosis and increased neuroprotection. Our findings highlight the PERK-eIF2α pathway as a central mechanism through which C + P exerts its beneficial effects. The results from this study may pave the way for the development of more targeted and effective treatments for stroke patients.PMID:37673390 | DOI:10.1016/j.expneurol.2023.114524
Source: Experimental Neurology - September 6, 2023 Category: Neurology Authors: Shuyu Lv Xiaokun Geng Ho Jun Yun Yuchuan Ding Source Type: research