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Specialty: Neurology
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Total 27990 results found since Jan 2013.

Caveolin-1 aggravates neurological deficits by activating neuroinflammation following experimental intracerebral hemorrhage in rats
CONCLUSIONS: Our research revealed CAV1 aggravated neurological dysfunction in a rat ICH model. CAV1 knockdown exerted neuroprotective effect by suppressing microglia activation and neuroinflammation after ICH might via the C-Src/CAV1/IKK-β/NF-κB signaling pathway.PMID:37598879 | DOI:10.1016/j.expneurol.2023.114508
Source: Experimental Neurology - August 20, 2023 Category: Neurology Authors: Demao Cao Bing Li Cheng Cao Juyi Zhang Xiang Li Haiying Li Zhengquan Yu Haitao Shen Ming Ye Source Type: research

Association of remnant cholesterol with intracranial atherosclerosis in community-based population: The ARIC study
Intracranial atherosclerotic stenosis (ICAS) is one of the main prevalent causes of ischemic stroke globally.1,2 However, even with aggressive medical management, the annual rate of stroke recurrence remains high among individuals with multiple risk factors and severe stenosis.2 Moreover, ICAS has been connected to an elevated risk of mild cognitive impairment and dementia3, which confers an extra necessity for the identification of risk factors associated with ICAS.
Source: Journal of Stroke and Cerebrovascular Diseases - August 19, 2023 Category: Neurology Authors: Peng Zhang, Ziheng Zhang, Daojing Li, Rongrong Han, Hongfang Li, Jinfeng Ma, Peng Xu, Ziyou Qi, Lixia Liu, Aimei Zhang Source Type: research

Thrombolysis and thrombectomy for stroke in octogenarians and nonagenarians: A regional observational study
DISCUSSION: IVT and MT improve early neurological recovery and functional outcome at discharge of both octogenarians and nonagenarians in current practice. Despite a poorer outcome for nonagenarians than octogenarians, these reperfusion treatments should not be withheld on the basis of age only.PMID:37596186 | DOI:10.1016/j.neurol.2023.03.023
Source: Revue Neurologique - August 18, 2023 Category: Neurology Authors: M Michelard O Detante O Heck S Marcel W Vadot G Gavazzi J Papassin Source Type: research

Surgery for Malignant Acute Ischemic Stroke: A Narrative Review of the Knowns and Unknowns
Semin Neurol 2023; 43: 370-387 DOI: 10.1055/s-0043-1771208Malignant acute ischemic stroke (AIS) is characterized by acute neurological deterioration caused by progressive space-occupying brain edema, often occurring in the first hours to days after symptom onset. Without any treatment, the result is often fatal. Despite advances in treatment for AIS, up to 80% of patients with a large hemispheric stroke or cerebellar stroke are at risk of poor outcome. Decompressive surgery can be life-saving in a subgroup of patients with malignant AIS, but uncertainties exist on patient selection, predictors of malignant infarction, peri...
Source: Seminars in Neurology - August 18, 2023 Category: Neurology Authors: Krishnan, Kailash Hollingworth, Milo Nguyen, Thanh N. Kumaria, Ashwin Kirkman, Matthew A. Basu, Surajit Tolias, Christos Bath, Philip M. Sprigg, Nikola Tags: Review Article Source Type: research

The influence of COVID-19 on the treatment of patients with acute ischemic stroke: a  retrospective observational study
CONCLUSIONS: The pandemic situation of COVID-19 significantly reduced the number of patients with AIS and prolonged the travel time to the hospital whereas most of the stroke treatment services were maintained.PMID:37587891 | DOI:10.5114/fn.2023.124565
Source: Folia Neuropathologica - August 17, 2023 Category: Neurology Authors: Wei Chen Fangju Lin Wei Zhao Baoling Yang Weihua Jia Source Type: research