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Total 27990 results found since Jan 2013.

20  kDa isoform of connexin-43 augments spatial reorganization of the brain endothelial junctional complex and lesion leakage in cerebral cavernous malformation type-3
This study highlights generation of potential defects at the CCM3-affected brain endothelial barrier which may underlie prolonged vascular leakiness.PMID:37652184 | DOI:10.1016/j.nbd.2023.106277
Source: Neurobiology of Disease - August 31, 2023 Category: Neurology Authors: Chelsea M Phillips Allison M Johnson Svetlana M Stamatovic Richard F Keep Anuska V Andjelkovic Source Type: research

Effect of using an 8-figure shoulder brace on arm swing angle and gait parameters in chronic stroke patients: a pilot randomized controlled study
CONCLUSIONS: This study demonstrated that 8-FSBTT training, combined with standard physiotherapy, improved Arm swing angle, gait speed, cadence, and both side stride lengths in the chronic stroke patients.PMID:37651200 | DOI:10.1080/10749357.2023.2253626
Source: Topics in Stroke Rehabilitation - August 31, 2023 Category: Neurology Authors: Donghwan Park Source Type: research

A right convergence area of the prefrontal lobe is involved in the improvement of semantic fluency in patients with post-stroke aphasia
CONCLUSION: The improvement of semantic fluency in subacute PSA patients may require the participation of the right convergence area of the prefrontal lobe.PMID:37651207 | DOI:10.1080/10749357.2023.2253632
Source: Topics in Stroke Rehabilitation - August 31, 2023 Category: Neurology Authors: Tao Feng Chao Zhang Siwei Xu Lingmin Wang Kai Xu Zhiyuan Xie Jie Xiang Weiwei Chen Source Type: research

Healthcare expenditure trends among adult stroke patients in the United States, 2011-2020
In the US, between 2018 and 2019, approximately $57 billion were expended on stroke and related conditions. The aim of this study was to understand trends in direct healthcare expenditures among stroke patients using novel cost estimation methods and a nationally representative database.
Source: Journal of Stroke and Cerebrovascular Diseases - August 31, 2023 Category: Neurology Authors: Venkataraghavan Ramamoorthy, Kelvin Chan, Mukesh Roy, Anshul Saxena, Md Ashfaq Ahmed, Zhenwei Zhang, Sandeep Appunni, Ronnie Thomas, Peter McGranaghan, Michael McDermott, Felipe De Los Rios La Rosa, Muni Rubens Source Type: research

Transradial versus transfemoral access for mechanical thrombectomy in acute ischemic stroke: A retrospective cohort study
The objective of this study was to compare procedural and clinical outcomes in patients with acute ischemic stroke (AIS) treated via transradial access (TRA) mechanical thrombectomy (MT) versus conventional transfemoral access (TFA).
Source: Journal of Stroke and Cerebrovascular Diseases - August 31, 2023 Category: Neurology Authors: Leonard H. Verhey, Andres Restrepo Orozco, Marion Oliver, Leah Lyons, Andrea P. Sewell, Jenny P-C Tsai, Paul Mazaris, Muhib Khan, Justin A. Singer Source Type: research

Prediction models for post-thrombectomy brain edema in patients with acute ischemic stroke: a systematic review and meta-analysis
ConclusionDespite the promising discriminative ability shown by studies on prediction models for post-thrombectomy brain edema in AIS patients, concerns related to a high risk of bias and limited external validation remain. Future research should prioritize the external validation and optimization of these models. There is an urgent need for large-scale, multicenter studies to develop robust, user-friendly models for real-world clinical application.Systematic review registrationhttps://www.crd.york.ac.uk, unique Identifier: CRD42022382790.
Source: Frontiers in Neurology - August 31, 2023 Category: Neurology Source Type: research

Inflammasome Activation Mediates Apoptotic and Pyroptotic Death in Astrocytes Under Ischemic Conditions
In this study, we investigated the expression and activati on of inflammasome components in protoplasmic and fibrous astrocytes under ischemic conditions. We found that both protoplasmic and fibrous astrocytes expressed a differential increase in inflammasome protein components, and that their activation promoted maturation of IL-1β and IL-18, and secretio n of IL-1β, as well as initiating apoptotic and pyroptotic cell death. Pharmacological inhibition of caspase-1 decreased expression of cleaved caspase-1 and production of mature IL-1β, and protected against inflammasome-mediated apoptotic and pyroptotic cell death. Ov...
Source: NeuroMolecular Medicine - August 30, 2023 Category: Neurology Source Type: research

Comparison of three measures for insomnia in ischemic stroke patients: Pittsburgh sleep quality index, insomnia severity index, and Athens insomnia scale
ConclusionEach of the three questionnaires has advantages and disadvantages when assessing insomnia. In the evaluation of insomnia in IS patients, the best questionnaire selection should be made according to the purpose of clinical evaluation and considering the sensitivity and specificity.
Source: Frontiers in Neurology - August 30, 2023 Category: Neurology Source Type: research

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