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Specialty: Cytology

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Total 1150 results found since Jan 2013.

Expression of Tie2 (angiopoietin receptor) on the monocyte subpopulations from ischemic stroke patients: Histological and flowcytometric studies
CONCLUSIONS: The results of this study demonstrate dysregulation of angiogenesis in monocyte subsets in ischemic stroke patients, which could be used as an early diagnostic marker of neurovascular damage and may need angiogenic therapy or improved medications to prevent further damage of blood vessels.PMID:36876965 | DOI:10.14670/HH-18-601
Source: Histology and Histopathology - March 6, 2023 Category: Cytology Authors: Aziza R Alrafiah Source Type: research

The Involvement of Immune Cells Between Ischemic Stroke and Gut Microbiota
Transl Stroke Res. 2023 May 4. doi: 10.1007/s12975-023-01151-7. Online ahead of print.ABSTRACTIschemic stroke, a disease with high mortality and disability rate worldwide, currently has no effective treatment. The systemic inflammation response to the ischemic stroke, followed by immunosuppression in focal neurologic deficits and other inflammatory damage, reduces the circulating immune cell counts and multiorgan infectious complications such as intestinal and gut dysfunction dysbiosis. Evidence showed that microbiota dysbiosis plays a role in neuroinflammation and peripheral immune response after stroke, changing the lymp...
Source: Cell Research - May 4, 2023 Category: Cytology Authors: Bei Pu Hua Zhu Liang Wei Lijuan Gu Shenqi Zhang Zhihong Jian Xiaoxing Xiong Source Type: research

Scientific Landscape of Oxidative Stress in Stroke: From a Bibliometric Analysis to an in-Depth Review
Neurochem Res. 2023 Jul 28. doi: 10.1007/s11064-023-03999-5. Online ahead of print.ABSTRACTStroke is an acute cerebrovascular disease resulting from either obstruction or rupture of a blood vessel in the brain. Oxidative stress (OS), referred to a status where cellular oxidative capacities overwhelm antioxidative defenses, is involved in the pathophysiology of stroke. The bibliometric analysis and in-depth review aim to depict the research trend of OS in stroke. Relevant scientific publications were acquired from the Web of Science Core Collection database. Scientific landscape of OS in stroke was illustrated by general qu...
Source: Cell Research - July 28, 2023 Category: Cytology Authors: Minqi Zhou Jiayu Xin Jinyu Chen Caiyun Sun Bingyue Huo Wenting Zhang Xiangqian Liu Source Type: research

Multiple Cell Transplant for Stroke Patients Multiple Cell Transplantation Based on an Intraparenchymal Approach for Patients with Chronic Phase Stroke.
Abstract Stroke is the third leading cause of death worldwide and a huge perpetrator in adult disability. This pilot clinical study investigates the possible benefits of transplanting multiple cells in chronic stroke. A total of ten consecutive stroke patients were treated by combination cell transplantation on the basis of an intraparenchymal approach from November 2003 to April 2011. There were 6 males and 4 females. Their age ranged from 42 to 87 years and course of disease varied from 6 months to 20 years. Six patients suffered cerebral infarction, and 4 patients suffered a brain hemorrhage. The olfactory ensh...
Source: Cell Transplantation - August 29, 2013 Category: Cytology Authors: Chen L, Xi H, Huang H, Zhang F, Liu Y, Chen D, Xiao J Tags: Cell Transplant Source Type: research

Effects of Rat Anti-mouse Interleukin-6 Receptor Antibody on the Recovery of Cognitive Function in Stroke Mice.
This study aimed to investigate the effects of rat anti-mouse interleukin (IL)-6 receptor antibody (MR16-1) on the recovery of cognitive function in stroke mice. Adult male C57BL/6 mice were subjected to middle cerebral artery occlusion (MCAO). Mice were randomly assigned into three groups: sham group, model group, and MR16-1 group. After the treatment of MR16-1, spatial learning and memory performance of mice were evaluated by the Morris water maze (MWM) and Y-maze tests. Then, brain slices were obtained and infarct volume and neuronal apoptosis were assessed by 2,3,5-triphenyltetrazolium chloride (TTC) staining and Termi...
Source: Cellular and Molecular Neurobiology - May 9, 2017 Category: Cytology Authors: Wei J, Sun C, Liu C, Zhang Q Tags: Cell Mol Neurobiol Source Type: research

Genetic Variations of Oxidative Stress Related Genes ALOX5, ALOX5AP and MPO Modulate Ischemic Stroke Susceptibility Through Main Effects and Epistatic Interactions in a Chinese Population
Conclusion: Our study revealed that epistatic interaction among theALOX5, ALOX5AP andMPO genes played a significant role in vulnerability to ischemic stroke. Furthermore, these results also suggest that the rs2107545 ofMPO gene can be used as a biomarker for the susceptibility and prognosis of ischemic stroke patients.Cell Physiol Biochem 2017;43:1588 –1602
Source: Cellular Physiology and Biochemistry - October 17, 2017 Category: Cytology Source Type: research

Upregulated Serum MiR-146b Serves as a Biomarker for Acute Ischemic Stroke
Conclusion: Our preliminary findings suggested that upregulated serum miR-146b in acute ischemic stroke might be a potential biomarker for AIS evaluation.Cell Physiol Biochem 2018;45:397 –405
Source: Cellular Physiology and Biochemistry - January 26, 2018 Category: Cytology Source Type: research

Effects of Xiaoshuan Enteric-Coated Capsule on White and Gray Matter Injury Evaluated by Diffusion Tensor Imaging in Ischemic Stroke.
This study was to investigate the effects of XSECC on white and gray matter injury in a rat model of ischemic stroke by diffusion tensor imaging (DTI) and histopathological analyses. The ischemia was induced by middle cerebral artery occlusion (MCAO). The cerebral blood flow measured by arterial spin labeling was improved by treatment with XSECC on the 3rd, 7th, 14th and 30th days after MCAO. Spatiotemporal white and gray matter changes in MCAO rats were examined with DTI-derived parameters (fractional anisotropy, FA; apparent diffusion coefficient, ADC; axial diffusivity, λ//; radial diffusivity, λ⊥). The increased FA...
Source: Cell Transplantation - October 4, 2018 Category: Cytology Authors: Zhang J, Chen S, Shi W, Li M, Zhan Y, Yang L, Zou H, Lei J, Chai X, Gao K, Liu J, Wang W, Wang Y, Zhao H Tags: Cell Transplant Source Type: research

The role of P2Y12 receptor in ischemic stroke of atherosclerotic origin.
Abstract Atherosclerosis is a chronic and progressive disease of the arterial walls and a leading cause of non-cardioembolic ischemic stroke. P2Y12 is a well-recognized receptor that is expressed on platelets and is a target of thienopyridine-type antiplatelet drugs. In the last few decades, P2Y12 receptor inhibitors, such as clopidogrel, have been applied for the secondary prevention of non-cardioembolic ischemic stroke. Recent clinical studies have suggested that these P2Y12 receptor inhibitors may be more effective than other antiplatelet drugs in patients with ischemic stroke/transient ischemic attack of ather...
Source: Cellular and Molecular Life Sciences : CMLS - October 9, 2018 Category: Cytology Authors: Gao Y, Yu C, Pi S, Mao L, Hu B Tags: Cell Mol Life Sci Source Type: research

CCR5 Is a Therapeutic Target for Recovery after Stroke and Traumatic Brain Injury
Publication date: 21 February 2019Source: Cell, Volume 176, Issue 5Author(s): Mary T. Joy, Einor Ben Assayag, Dalia Shabashov-Stone, Sigal Liraz-Zaltsman, Jose Mazzitelli, Marcela Arenas, Nora Abduljawad, Efrat Kliper, Amos D. Korczyn, Nikita S. Thareja, Efrat L. Kesner, Miou Zhou, Shan Huang, Tawnie K. Silva, Noomi Katz, Natan M. Bornstein, Alcino J. Silva, Esther Shohami, S. Thomas CarmichaelSummaryWe tested a newly described molecular memory system, CCR5 signaling, for its role in recovery after stroke and traumatic brain injury (TBI). CCR5 is uniquely expressed in cortical neurons after stroke. Post-stroke neuronal kno...
Source: Cell - February 22, 2019 Category: Cytology Source Type: research

Cyclic nucleotide phosphodiesterases (PDEs) and endothelial function in ischaemic stroke. A review.
CONCLUSION: This review demonstrates that non-selective and selective PDEi of PDE3, PDE4 and PDE5 modulated endothelial function in cerebral ischemic stroke by regulating processes involved in vascular repair and neuroprotection and thus reduced cell death and inflammation. Of note, they promoted angiogenesis, microcirculation and improved functional recovery; all are important in stroke prevention and recovery, and effects should be further evaluated in humans. PMID: 31132399 [PubMed - as supplied by publisher]
Source: Cellular Signalling - May 23, 2019 Category: Cytology Authors: Yasmeen S, Akram BH, Hainsworth AH, Kruuse C Tags: Cell Signal Source Type: research

Inhibition of Reactive Astrocytes with Fluorocitrate Ameliorates Learning and Memory Impairment Through Upregulating CRTC1 and Synaptophysin in Ischemic Stroke Rats.
Abstract Ischemic stroke often causes motor and cognitive deficits. Deregulated glia gap junction communication, which is reflected by increased protein levels of glial fibrillary acidic protein (GFAP) and connexin 43 (Cx43), has been observed in ischemic hippocampus and has been associated with cognitive impairment in animal stroke models. Here, we tested the hypothesis that reactive astrocytes-mediated loss of synaptophysin (SYP) and CREB-regulated transcription coactivator 1 (CRTC1) contribute to dysfunction in glia gap junction communication and memory impairment after ischemic stroke. Male Sprague-Dawley rats...
Source: Cellular and Molecular Neurobiology - July 2, 2019 Category: Cytology Authors: Zhang X, Shen X, Dong J, Liu WC, Song M, Sun Y, Shu H, Towse CL, Liu W, Liu CF, Jin X Tags: Cell Mol Neurobiol Source Type: research

microRNA-381-3p Confers Protection Against Ischemic Stroke Through Promoting Angiogenesis and Inhibiting Inflammation by Suppressing Cebpb and Map3k8.
This study aims to explore the potential role of miR-381-3p in ischemic stroke, along with its underlying mechanism. A mouse model of ischemic stroke was developed using middle cerebral artery occlusion. Next, the expression of mitogen-activated protein kinase kinase kinase 8 (Map3k8) and CCAAT enhancer binding protein beta (Cebpb) was determined by RT-qPCR. Gain- and loss-of-function approaches were applied to analyze the effects of miR-381-3p, Cebpb and Map3k8 on the biological functions of endothelial progenitor cells (EPCs) with the involvement of the tumor necrosis factor-α (TNF-α) signaling pathway. In addition, du...
Source: Cellular and Molecular Neurobiology - April 14, 2020 Category: Cytology Authors: Li J, Lv H, Che Y Tags: Cell Mol Neurobiol Source Type: research

MiR-665 Participates in the Protective Effect of Dexmedetomidine in Ischemic Stroke by ROCK2/NF- κB Axis
Neurochem Res. 2022 May 10. doi: 10.1007/s11064-022-03597-x. Online ahead of print.ABSTRACTIschemic stroke is a grievous intimidation to the healthiness of sufferers. Previous studies have reported that dexmedetomidine (DEX) has a protective effect on a variety of organs. This paper aimed to explore the regulatory mechanism of DEX in ischemic stroke through miR-665/ROCK2 axis. The mice model of ischemic stroke was constructed by middle cerebral artery occlusion (MCAO). The cell model of ischemic stroke was constructed by oxygen-glucose deprivation (OGD). Cell viability and apoptosis were assessed by CCK-8 assay and flow cy...
Source: Cell Research - May 10, 2022 Category: Cytology Authors: QiongHua Liu JianE Wu ShangShu Lai Gan Li Source Type: research