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Specialty: Cytology

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Total 1150 results found since Jan 2013.

Sirt3 Protects Against Ischemic Stroke Injury by Regulating HIF-1 α/VEGF Signaling and Blood-Brain Barrier Integrity.
Sirt3 Protects Against Ischemic Stroke Injury by Regulating HIF-1α/VEGF Signaling and Blood-Brain Barrier Integrity. Cell Mol Neurobiol. 2020 Jun 04;: Authors: Yang X, Zhang Y, Geng K, Yang K, Shao J, Xia W Abstract Sirtuin 3 (Sirt3) is a member of the Sirtuin family proteins and known to regulate multiple physiological processes such as metabolism and aging. As stroke is an aging-related disease, in this work, we attempt to examine the role and potential mechanism of Sirt3 in regulating ischemic stroke by using a permanent middle cerebral artery occlusion (pMCAO) model in wild type (WT) and Sirt3 kn...
Source: Cellular and Molecular Neurobiology - June 3, 2020 Category: Cytology Authors: Yang X, Zhang Y, Geng K, Yang K, Shao J, Xia W Tags: Cell Mol Neurobiol Source Type: research

Improvement of Neurological Function in Rats with Ischemic Stroke by Adipose-derived Pericytes.
Abstract Pericytes possess high multipotent features and cell plasticity, and produce angiogenic and neurotrophic factors that indicate their high regenerative potential. The aim of this study was to investigate whether transplantation of adipose-derived pericytes can improve functional recovery and neurovascular plasticity after ischemic stroke in rats. Rat adipose-derived pericytes were isolated from subcutaneous adipose tissue by fluorescence-activated cell sorting. Adult male Wistar rats were subjected to 90 min of middle cerebral artery occlusion followed by intravenous injection of rat adipose-derived pericy...
Source: Cell Transplantation - December 31, 2019 Category: Cytology Authors: Ogay V, Kumasheva V, Li Y, Mukhlis S, Sekenova A, Olzhayev F, Tsoy A, Umbayev B, Askarova S, Shpekov A, Kaliyev A, Zhetpisbayev B, Makhambetov Y, Akshulakov S, Saparov A, Ramankulov Y Tags: Cell Transplant Source Type: research

Label-Free Quantitative Proteome Profiling of Cerebrospinal Fluid from a Rat Stroke Model with Stem Cell Therapy
We examined hAMSC-secreted proteins obtained from serum-free culture medium by liquid chromatography-tandem mass spectrometry (LC-MS/MS), which identified several extracellular matrix proteins, supporting the well-known active paracrine function of hAMSCs. Subsequently, we performed label-free quantitative proteomic analysis on CSF samples from rat stroke models intravenously injected with hAMSC (experimental) or phosphate buffered saline (control). In total, 524 proteins were identified; among them, 125 and 91 proteins were increased and decreased with hAMSC treatment, respectively. Furthermore, gene set enrichment analys...
Source: Cell Transplantation - June 28, 2021 Category: Cytology Authors: Junseok W Hur Min-Sik Kim Se-Yeon Oh Ho-Young Kang Jingi Bae Hokeun Kim Hangyeore Lee Sang-Won Lee Dong-Hyuk Park Source Type: research

The role of leukocytes in acute ischemic stroke-related thrombosis: a notable but neglected topic
Cell Mol Life Sci. 2021 Aug 16. doi: 10.1007/s00018-021-03897-5. Online ahead of print.ABSTRACTIschemic stroke is one of the most serious diseases today, and only a minority of patients are provided with effective clinical treatment. Importantly, leukocytes have gradually been discovered to play vital roles in stroke thrombosis, including promoting the activation of thrombin and the adhesion and aggregation of platelets. However, they have not received enough attention in the field of acute ischemic stroke. It is possible that we could not only prevent stroke-related thrombosis by inhibiting leukocyte activation, but also ...
Source: Cellular and Molecular Life Sciences : CMLS - August 16, 2021 Category: Cytology Authors: Rentang Bi Shengcai Chen Shaolin Chen Qiwei Peng Huijuan Jin Bo Hu Source Type: research

Recycled Translation: Repurposing Drugs for Stroke
Transl Stroke Res. 2022 Feb 26. doi: 10.1007/s12975-022-01000-z. Online ahead of print.ABSTRACTStroke, which continues to be a leading cause of death and long-term disability worldwide, has often been described as a clinical graveyard. While multiple small molecule therapeutics have undergone clinical trials in stroke, currently only one Food and Drug Administration (FDA)-approved medication exists for the treatment of stroke, the biological, recombinant tissue plasminogen activator (rt-PA). Repurposing of therapeutics which have previously gained FDA approval for alternative indications serves as a prospective option for ...
Source: Cell Research - February 26, 2022 Category: Cytology Authors: Samantha E Spellicy David C Hess Source Type: research

Novel contact-kinin inhibitor sylvestin targets thromboinflammation and ameliorates ischemic stroke
Cell Mol Life Sci. 2022 Apr 13;79(5):240. doi: 10.1007/s00018-022-04257-7.ABSTRACTIschemic stroke is a leading cause of death and disability worldwide. Increasing evidence indicates that ischemic stroke is a thromboinflammatory disease in which the contact-kinin pathway has a central role by activating pro-coagulant and pro-inflammatory processes. The blocking of distinct members of the contact-kinin pathway is a promising strategy to control ischemic stroke. Here, a plasma kallikrein and active FXII (FXIIa) inhibitor (sylvestin, contained 43 amino acids, with a molecular weight of 4790.4 Da) was first identified from fore...
Source: Cellular and Molecular Life Sciences : CMLS - April 13, 2022 Category: Cytology Authors: Zhiye Zhang Chuanbin Shen Mingqian Fang Yajun Han Chengbo Long Weihui Liu Min Yang Ming Liu Dengdeng Zhang Qiqi Cao Xue Chen Yaqun Fang Qiumin Lu Zongliu Hou Yaxiong Li Zhenze Liu Xi Lei Heyu Ni Ren Lai Source Type: research