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Specialty: Cytology
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Total 1150 results found since Jan 2013.
Mice and Rats Exhibit Striking Inter-species Differences in Gene Response to Acute Stroke
Cell Mol Neurobiol. 2021 Aug 5. doi: 10.1007/s10571-021-01138-8. Online ahead of print.ABSTRACTNeuroprotection in acute stroke has not been successfully translated from animals to humans. Animal research on promising agents continues largely in rats and mice which are commonly available to researchers. However, controversies continue on the most suitable species to model the human situation. Generally, putative agents seem less effective in mice as compared with rats. We hypothesized that this may be due to inter-species differences in stroke response and that this might be manifest at a genetic level. Here we used whole-g...
Source: Cellular and Molecular Neurobiology - August 5, 2021 Category: Cytology Authors: Qiu Jing Wu Xiujun Sun Lucy Teves Diana Mayor Michael Tymianski Source Type: research
Mesenchymal stem cell-derived exosomes for treatment of ischemic stroke
Curr Stem Cell Res Ther. 2021 Aug 12. doi: 10.2174/1574888X16666210812151003. Online ahead of print.ABSTRACTStroke is a life-threatening disease and one of the leading causes of death and physical disability worldwide. Currently, no drugs on the market promote neural recovery after stroke insult, and spontaneous remodeling processes are limited to induce recovery in the ischemic regions. Therefore, promoting a cell-based therapy has been needed to elevate the endogenous recovery process. Mesenchymal stem cells (MSCs) have been regarded as candidate cell sources for therapeutic purposes of ischemic stroke, which their thera...
Source: Cell Research - August 13, 2021 Category: Cytology Authors: Rucheng Liu Yi Zhang Yundi Zhang Maryam Farzaneh Seyed Esmaeil Khoshnam Source Type: research
Recent advances in nanomedicines for the treatment of ischemic stroke
Acta Pharm Sin B. 2021 Jul;11(7):1767-1788. doi: 10.1016/j.apsb.2020.11.019. Epub 2020 Nov 28.ABSTRACTIschemic stroke is a cerebrovascular disease normally caused by interrupted blood supply to the brain. Ischemia would initiate the cascade reaction consisted of multiple biochemical events in the damaged areas of the brain, where the ischemic cascade eventually leads to cell death and brain infarction. Extensive researches focusing on different stages of the cascade reaction have been conducted with the aim of curing ischemic stroke. However, traditional treatment methods based on antithrombotic therapy and neuroprotective...
Source: Cell Research - August 13, 2021 Category: Cytology Authors: Chao Li Tao Sun Chen Jiang Source Type: research
Nuclear receptor coactivator 4-mediated ferritinophagy contributes to cerebral ischemia-induced ferroptosis in ischemic stroke
Pharmacol Res. 2021 Oct 8:105933. doi: 10.1016/j.phrs.2021.105933. Online ahead of print.ABSTRACTIschemic stroke poses a significant health risk due to its high rate of disability and mortality. To address this problem, several therapeutic approaches have been proposed, including interruption targeting programmed cell death (PCD). Ferroptosis is a newly defined PCD characterized by iron-dependent accumulation of lipid peroxidation, and is becoming a promising target for treating numerous diseases. To explore the underlying mechanisms of the initiation and execution of ferroptosis in ischemic stroke, we established stroke m...
Source: Cell Research - October 11, 2021 Category: Cytology Authors: Chong Li Guangchi Sun Binglin Chen Lei Xu Yangfan Ye Jinyan He Zhongyuan Bao Pengzhan Zhao Zong Miao Lin Zhao Jingming Hu Yongping You Ning Liu Honglu Chao Jing Ji Source Type: research
Post-treatment with apocynin at a lower dose regulates the UPR branch of eIF2 α and XBP-1 pathways after stroke
Brain Res Bull. 2022 Feb 7:S0361-9230(22)00036-3. doi: 10.1016/j.brainresbull.2022.02.003. Online ahead of print.ABSTRACTStroke leads to disturbance in the physiology of the ER (Endoplasmic Reticulum) that triggers UPR (Unfolded Protein Response) pathways aimed to compensate neuronal cell damage. However, sustained UPR causes stressful conditions in the ER lumen forming abnormal protein aggregates. Stroke-induced oxidative stress also amalgamates with UPR to safeguard and ensure the proper functioning of brain cells. Thus we tested the effect of apocynin (a potent antioxidant) post-treatment in experimental stroke on the o...
Source: Cell Research - February 10, 2022 Category: Cytology Authors: Venkata Prasuja Nakka Raghu Gogada Praveen Kumar Simhadri Mohammed Abdul Qadeer Prakash Babu Phanithi Source Type: research
Final Results of Allogeneic Adipose Tissue-Derived Mesenchymal Stem Cells in Acute Ischemic Stroke (AMASCIS): A Phase II, Randomized, Double-Blind, Placebo-Controlled, Single-Center, Pilot Clinical Trial
We report the final trial results after 24 months of follow-up. Recruitment began in December 2014 and stopped in December 2017 after 19 of 20 planned patients were included. Six patients did not receive study treatment: two due to technical issues and four for acquiring exclusion criteria after randomization. The final study sample was composed of 13 patients (4 receiving AD-MSCs and 9 placebo). One patient in the placebo group died within the first week after study treatment delivery due to sepsis. Two non-treatment-related serious AEs occurred in the AD-MSC group and nine in the placebo group. The total number of AEs an...
Source: Cell Transplantation - March 18, 2022 Category: Cytology Authors: Elena de Celis-Ruiz Blanca Fuentes Mar ía Alonso de Leciñana Mar ía Gutiérrez-Fernández Alberto M Borobia Raquel Guti érrez-Zúñiga Gerardo Ruiz-Ares Laura Otero-Ortega Fernando Laso-Garc ía Mari Carmen G ómez-de Frutos Exuperio D íez-Tejedor Source Type: research
Poly (ADP-ribose) polymerase: An Overview of Mechanistic Approaches and Therapeutic Opportunities in the Management of Stroke
Neurochem Res. 2022 Apr 18. doi: 10.1007/s11064-022-03595-z. Online ahead of print.ABSTRACTStroke is one of the leading causes of morbidity and mortality accompanied by blood supply loss to a particular brain area. Several mechanistic approaches such as inhibition of poly (ADP-ribose) polymerase, therapies against tissue thrombosis, and neutrophils lead to stroke's therapeutic intervention. Evidence obtained with the poly (ADP-ribose) polymerase (PARP) inhibition and animals having a deficiency of PARP enzymes; represented the role of PARP in cerebral stroke, ischemia/reperfusion, and neurotrauma. PARP is a nuclear enzyme ...
Source: Cell Research - April 19, 2022 Category: Cytology Authors: Palak Tiwari Heena Khan Thakur Gurjeet Singh Amarjot Kaur Grewal Source Type: research
Multiplexed mRNA analysis of brain-derived extracellular vesicles upon experimental stroke in mice reveals increased mRNA content with potential relevance to inflammation and recovery processes
Cell Mol Life Sci. 2022 May 31;79(6):329. doi: 10.1007/s00018-022-04357-4.ABSTRACTExtracellular vesicles (EVs) are lipid bilayer-enclosed structures that represent newly discovered means for cell-to-cell communication as well as promising disease biomarkers and therapeutic tools. Apart from proteins, lipids, and metabolites, EVs can deliver genetic information such as mRNA, eliciting a response in the recipient cells. In the present study, we have analyzed the mRNA content of brain-derived EVs (BDEVs) isolated 72 h after experimental stroke in mice and compared them to controls (shams) using nCounter® Nanostring panels, w...
Source: Cellular and Molecular Life Sciences : CMLS - May 31, 2022 Category: Cytology Authors: Annika Bub Santra Brenna Malik Alawi Paul K ügler Yuqi Gui Oliver Kretz Hermann Altmeppen Tim Magnus Berta Puig Source Type: research
Vascular perfusion differs in two distinct PDGFR β-positive zones within the ischemic core of male mice 2 weeks following photothrombotic stroke
J Neurosci Res. 2022 Nov 22. doi: 10.1002/jnr.25146. Online ahead of print.ABSTRACTStroke therapy has largely focused on preventing damage and encouraging repair outside the ischemic core, as the core is considered irreparable. Recently, several studies have suggested endogenous responses within the core are important for limiting the spread of damage and enhancing recovery, but the role of blood flow and capillary pericytes in this process is unknown. Using the Rose Bengal photothrombotic model of stroke, we illustrate blood vessels are present in the ischemic core and peri-lesional regions 2 weeks post stroke in male mic...
Source: Cell Research - November 22, 2022 Category: Cytology Authors: Gary P Morris Emma K Gowing Jo-Maree Courtney Hannah E Coombe Natalie E King Sarah S J Rewell David W Howells Andrew N Clarkson Brad A Sutherland Source Type: research
Overexpression of vascular endothelial growth factor enhances the neuroprotective effects of bone marrow mesenchymal stem cell transplantation in ischemic stroke
Neural Regen Res. 2023 Jun;18(6):1286-1292. doi: 10.4103/1673-5374.358609.ABSTRACTAlthough bone marrow mesenchymal stem cells (BMSCs) might have therapeutic potency in ischemic stroke, the benefits are limited. The current study investigated the effects of BMSCs engineered to overexpress vascular endothelial growth factor (VEGF) on behavioral defects in a rat model of transient cerebral ischemia, which was induced by middle cerebral artery occlusion. VEGF-BMSCs or control grafts were injected into the left striatum of the infarcted hemisphere 24 hours after stroke. We found that compared with the stroke-only group and the ...
Source: Cell Research - December 1, 2022 Category: Cytology Authors: Cui Liu Zhi-Xiang Yang Si-Qi Zhou Ding Ding Yu-Ting Hu Hong-Ning Yang Dong Han Shu-Qun Hu Xue-Mei Zong Source Type: research
Exosome therapies improve outcome in rodents with ischemic stroke; Meta-analysis
This study systematically evaluated the efficacy of exosome therapy in ischemic stroke based on preclinical studies in rodent models.METHODS: We reviewed existing literature on exosome therapy in rodent stroke models from various databases, and reviewed the interventional measures, and outcome measures systematically, with changes in the infarct volume and functional scores as outcome parameters. Seventeen homogeneous studies were found qualitatively acceptable for meta-analysis. The study used software RevMan 5.3 to conduct the meta-analysis (PROSPERO Register Number: CRD42022314138) RESULTS: Compared to placebo, exosomes...
Source: Cell Research - January 2, 2023 Category: Cytology Authors: Simy Grace Cherian Sunil K Narayan Murugesan Arumugam Source Type: research
