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Specialty: Cytology

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Total 1150 results found since Jan 2013.

Electrical Stimulation Enhances Migratory Ability of Transplanted Bone Marrow Stromal Cells in a Rodent Ischemic Stroke Model
Conclusions: These results suggest that electrical stimulation enhances migratory ability of transplanted BMSCs in ischemic stroke model of rats. If we can direct the implanted BMSCs to the site of interest, it may lead to a greater therapeutic effect.Cell Physiol Biochem 2018;46:57 –68
Source: Cellular Physiology and Biochemistry - March 23, 2018 Category: Cytology Source Type: research

Angiopoietin-1 Mimetic Peptide Promotes Neuroprotection after Stroke in Type 1 Diabetic Rats.
CONCLUSION: Decreased neuroinflammation and reduced BBB leakage may contribute, at least in part, to vasculotide-induced neuroprotective effects after stroke in T1DM rats. PMID: 30124060 [PubMed - as supplied by publisher]
Source: Cell Transplantation - August 20, 2018 Category: Cytology Authors: Venkat P, Yan T, Chopp M, Zacharek A, Ning R, Van Slyke P, Dumont D, Landschoot-Ward J, Liang L, Chen J Tags: Cell Transplant Source Type: research

Non-Coding RNA in Acute Ischemic Stroke: Mechanisms, Biomarkers and Therapeutic Targets.
Abstract Non-coding RNAs (ncRNAs) are a class of functional RNAs that regulate gene expression in a post-transcriptional manner. NcRNAs include microRNAs, long non-coding RNAs and circular RNAs. They are highly expressed in the brain and are involved in the regulation of physiological and pathophysiological processes, including cerebral ischemic injury, neurodegeneration, neural development, and plasticity. Stroke is one of the leading causes of death and physical disability worldwide. Acute ischemic stroke (AIS) occurs when brain blood flow stops, and that stoppage results in reduced oxygen and glucose supply to ...
Source: Cell Transplantation - October 26, 2018 Category: Cytology Authors: Wang SW, Liu Z, Shi ZS Tags: Cell Transplant Source Type: research

The regulatory role of Toll-like receptors after ischemic stroke: neurosteroids as TLR modulators with the focus on TLR2/4.
Abstract Ischemic stroke is the most common cerebrovascular disease and considered as a worldwide leading cause of death. After cerebral ischemia, different pathophysiological processes including neuroinflammation, invasion and aggregation of inflammatory cells and up-regulation of cytokines occur simultaneously. In this respect, Toll-like receptors (TLRs) are the first identified important mediators for the activation of the innate immune system and are widely expressed in glial cells and neurons following brain trauma. TLRs are also able to interact with endogenous and exogenous molecules released during ischemi...
Source: Cellular and Molecular Life Sciences : CMLS - October 30, 2018 Category: Cytology Authors: Tajalli-Nezhad S, Karimian M, Beyer C, Atlasi MA, Azami Tameh A Tags: Cell Mol Life Sci Source Type: research

MALAT1 Up-Regulator Polydatin Protects Brain Microvascular Integrity and Ameliorates Stroke Through C/EBP β/MALAT1/CREB/PGC-1α/PPARγ Pathway.
MALAT1 Up-Regulator Polydatin Protects Brain Microvascular Integrity and Ameliorates Stroke Through C/EBPβ/MALAT1/CREB/PGC-1α/PPARγ Pathway. Cell Mol Neurobiol. 2019 Jan 03;: Authors: Ruan W, Li J, Xu Y, Wang Y, Zhao F, Yang X, Jiang H, Zhang L, Saavedra JM, Shi L, Pang T Abstract Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long non-coding RNA contributing to protect the blood-brain barrier (BBB) after stroke. We searched for small molecules that may up-regulate MALAT1 and focused on polydatin (PD), a natural product, as a possible candidate. PD enhanced MALAT1 gene express...
Source: Cellular and Molecular Neurobiology - January 3, 2019 Category: Cytology Authors: Ruan W, Li J, Xu Y, Wang Y, Zhao F, Yang X, Jiang H, Zhang L, Saavedra JM, Shi L, Pang T Tags: Cell Mol Neurobiol Source Type: research

Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke
Publication date: Available online 2 May 2019Source: CellAuthor(s): Ishraq Alim, Joseph T. Caulfield, Yingxin Chen, Vivek Swarup, Daniel H. Geschwind, Elena Ivanova, Javier Seravalli, Youxi Ai, Lauren H. Sansing, Emma J. Ste.Marie, Robert J. Hondal, Sushmita Mukherjee, John W. Cave, Botir T. Sagdullaev, Saravanan S. Karuppagounder, Rajiv R. RatanSummaryFerroptosis, a non-apoptotic form of programmed cell death, is triggered by oxidative stress in cancer, heat stress in plants, and hemorrhagic stroke. A homeostatic transcriptional response to ferroptotic stimuli is unknown. We show that neurons respond to ferroptotic stimul...
Source: Cell - May 3, 2019 Category: Cytology Source Type: research

A Hallmark Clinical Study of Cord Blood Therapy in Adults with Ischemic Stroke.
Abstract The therapeutic application of human umbilical cord blood cells has been an area of great interest for at least the last 25 years. Currently, cord blood cells are approved for reconstitution of the bone marrow following myeloablation in both young and old patients with myeloid malignancies and other blood cancers. Translational studies investigating alternative uses of cord blood have also shown that these cells not only stimulate neurogenesis in the aged brain but are also potentially therapeutic in the treatment of adult neurodegenerative disorders including amyotrophic lateral sclerosis, Alzheimer's di...
Source: Cell Transplantation - June 10, 2019 Category: Cytology Authors: Sanberg PR, Ehrhart J Tags: Cell Transplant Source Type: research

Astrocyte-derived exosomes suppress autophagy and ameliorate neuronal damage in experimental ischemic stroke.
Abstract The aim of this study was to investigate the role of astrocyte-derived exosomes (AS-Exo) on neuronal damage in ischemic stroke. We isolated astrocytes from 3- to 4-day-old C57BL/6 mice and astrocytes were identified by GFAP immunostaining. Exosomes were obtained from astrocyte supernatant by overspeed centrifugation. For investigating the effect of AS-Exo on the apoptosis of neurons after oxygen and glucose deprivation (OGD), the exosome labeling and uptake by neurons were observed by confocal laser microscopy, then HT-22 cell vitality and apoptosis were determined by Cell Counting Kit-8 (CCK-8) assay a...
Source: Experimental Cell Research - June 19, 2019 Category: Cytology Authors: Pei X, Li Y, Zhu L, Zhou Z Tags: Exp Cell Res Source Type: research

Structural Disconnections Explain Brain Network Dysfunction after Stroke
Publication date: 3 September 2019Source: Cell Reports, Volume 28, Issue 10Author(s): Joseph C. Griffis, Nicholas V. Metcalf, Maurizio Corbetta, Gordon L. ShulmanSummaryStroke causes focal brain lesions that disrupt functional connectivity (FC), a measure of activity synchronization, throughout distributed brain networks. It is often assumed that FC disruptions reflect damage to specific cortical regions. However, an alternative explanation is that they reflect the structural disconnection (SDC) of white matter pathways. Here, we compare these explanations using data from 114 stroke patients. Across multiple analyses, we f...
Source: Cell Reports - September 5, 2019 Category: Cytology Source Type: research

Combined Rehabilitation Promotes the Recovery of Structural and Functional Features of Healthy Neuronal Networks after Stroke
Publication date: 24 September 2019Source: Cell Reports, Volume 28, Issue 13Author(s): Anna Letizia Allegra Mascaro, Emilia Conti, Stefano Lai, Antonino Paolo Di Giovanna, Cristina Spalletti, Claudia Alia, Alessandro Panarese, Alessandro Scaglione, Leonardo Sacconi, Silvestro Micera, Matteo Caleo, Francesco Saverio PavoneSummaryRehabilitation is considered the most effective treatment for promoting the recovery of motor deficits after stroke. One of the most challenging experimental goals is to unambiguously link brain rewiring to motor improvement prompted by rehabilitative therapy. Previous work showed that robotic train...
Source: Cell Reports - September 26, 2019 Category: Cytology Source Type: research

Activation of CRHR1 contributes to cerebral endothelial barrier impairment via cPLA2 phosphorylation in experimental ischemic stroke.
Abstract The activation of corticotrophin-releasing hormone receptor (CRHR) 1 is implicated in neuronal injury in experimental stroke. However, little is known about the relationship between CRHR1 activation and brain endothelial barrier impairment after ischemia and reperfusion (I/R). Recently we have demonstrated that the activation of extracellular signal-regulated kinase (Erk) 1/2 as well as p38 is required for hydrogen peroxide (H2O2)-increased cytosolic phospholipase A2 (cPLA2) phosphorylation in bEnd3 cells. Using this in vitro ischemic-like model, we found that both blockade and interference of CRHR1 inhib...
Source: Cellular Signalling - November 8, 2019 Category: Cytology Authors: Cao C, Zhou J, Wu X, Qian Y, Hong Y, Mu J, Jin L, Zhu C, Li S Tags: Cell Signal Source Type: research

Exogenous recombinant Hsp70 mediates neuroprotection after photothrombotic stroke.
Abstract Ischaemic stroke is an acute interruption of the blood supply to the brain, which leads to rapid irreversible damage to nerve tissue. Ischaemic stroke is accompanied by the development of neuroinflammation and neurodegeneration observed around the affected brain area. Heat shock protein 70 (Hsp70) facilitates cell survival under a variety of different stress conditions. Hsp70 may be secreted from cells and exhibits cytoprotective activity. This activity most likely occurs by decreasing the levels of several proinflammatory cytokines through interaction with a few receptors specific to the innate immune sy...
Source: Cell Stress and Chaperones - August 31, 2020 Category: Cytology Authors: Demyanenko S, Nikul V, Rodkin S, Davletshin A, Evgen'ev MB, Garbuz DG Tags: Cell Stress Chaperones Source Type: research

Role of DAMPs and of Leukocytes Infiltration in Ischemic Stroke: Insights from Animal Models and Translation to the Human Disease.
Abstract Stroke is a leading cause of death and disability worldwide. Several mechanisms are involved in the pathogenesis of ischemic stroke (IS). The contributory role of the inflammatory and immunity processes was demonstrated both in vitro and in animal models, and was confirmed in humans. IS evokes an immediate inflammatory response that involves complex cellular and molecular mechanisms. All components of the innate and adaptive immunity systems are involved in several steps of the ischemic cascade. In the early phase, inflammatory and immune mechanisms contribute to the brain tissue damage, whereas, in the l...
Source: Cellular and Molecular Neurobiology - September 28, 2020 Category: Cytology Authors: Stanzione R, Forte M, Cotugno M, Bianchi F, Marchitti S, Rubattu S Tags: Cell Mol Neurobiol Source Type: research

Pericytes Regulate Cerebral Perfusion through VEGFR1 in Ischemic Stroke
Cell Mol Neurobiol. 2021 Mar 13. doi: 10.1007/s10571-021-01071-w. Online ahead of print.ABSTRACTNeurons in the penumbra (the area surrounding ischemic tissue that consists of still viable tissue but with reduced blood flow and oxygen transport) may be rescued following stroke if adequate perfusion is restored in time. It has been speculated that post-stroke angiogenesis in the penumbra can reduce damage caused by ischemia. However, the mechanism for neovasculature formation in the brain remains unclear and vascular-targeted therapies for brain ischemia remain suboptimal. Here, we show that VEGFR1 was highly upregulated in ...
Source: Cellular and Molecular Neurobiology - March 13, 2021 Category: Cytology Authors: Chang-Xiong Gong Qin Zhang Xiao-Yi Xiong Jun-Jie Yuan Guo-Qiang Yang Jia-Cheng Huang Juan Liu Chun-Mei Duan None Rui-Xu Zhong-Ming Qiu Zhao-You Meng Kai Zhou Fa-Xiang Wang Chen-Hao Zhao Fangfei Li Qing-Wu Yang Source Type: research