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Specialty: Cytology

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Total 1150 results found since Jan 2013.

Brain Maturation as a Fundamental Factor in Immune-Neurovascular Interactions in Stroke
Transl Stroke Res. 2023 Jan 27. doi: 10.1007/s12975-022-01111-7. Online ahead of print.ABSTRACTInjuries in the developing brain cause significant long-term neurological deficits. Emerging clinical and preclinical data have demonstrated that the pathophysiology of neonatal and childhood stroke share similar mechanisms that regulate brain damage, but also have distinct molecular signatures and cellular pathways. The focus of this review is on two different diseases-neonatal and childhood stroke-with emphasis on similarities and distinctions identified thus far in rodent models of these diseases. This includes the susceptibil...
Source: Cell Research - January 27, 2023 Category: Cytology Authors: Elena Di Martino Aditya Rayasam Zinaida S Vexler Source Type: research

Epigenetics and stroke: role of DNA methylation and effect of aging on blood-brain barrier recovery
This study aimed to evaluate the epigenetic and transcriptional profile of cerebral microvessels after thromboembolic (TE) stroke to define potential causes of limited BBB recovery. RNA-sequencing and reduced representation bisulfite sequencing (RRBS) analyses were performed using microvessels isolated from young (6 months) and old (18 months) mice seven days poststroke compared to age-matched sham controls. DNA methylation profiling of poststroke brain microvessels revealed 11287 differentially methylated regions (DMR) in old and 9818 DMR in young mice, corresponding to annotated genes. These DMR were enriched in genes en...
Source: Cell Research - January 30, 2023 Category: Cytology Authors: Chelsea Phillips Svetlana Stamatovic Richard Keep Anuska Andjelkovic Source Type: research

Cyclo (MQCNS) has the potential to treat ischemic stroke
In this study, we established a rat model of ischemic stroke by occluding the middle cerebral artery and then administered LZ-3 (2 or 4 mg/kg) via the tail vein for 7 consecutive days. Our results showed that LZ-3 (2 or 4 mg/kg) substantially decreased infarct volume, reduced cortical nerve cell death, improved neurological function, reduced cortical and hippocampal injury, and decreased the levels of inflammatory factors in the blood and brain tissues. In a well-differentiated, oxygen-glucose deprivation/reoxygenation-induced BV2 cell model of post-stroke, LZ-3 (100 μM) inhibited the JAK1-STAT6 signaling pathway. LZ-3 re...
Source: Cell Research - June 7, 2023 Category: Cytology Authors: Zhibing Song Xinyu Li Mengting Lv Yuchen Guo Shanshan Deng Yuefan Zhang Tiejun Li Source Type: research

Functional reconstruction of the impaired cortex and motor function by hMGEOs transplantation in stroke
Biochem Biophys Res Commun. 2023 Jun 3;671:87-95. doi: 10.1016/j.bbrc.2023.06.010. Online ahead of print.ABSTRACTStroke is the leading cause of death and long-term disability worldwide. But treatments are not available to promote functional recovery, and efficient therapies need to be investigated. Stem cell-based therapies hold great promise as potential technologies to restore function in brain disorders. Loss of GABAergic interneurons after stroke may result in sensorimotor defects. Here, by transplanting human brain organoids resembling the MGE domain (human MGE organoids, hMGEOs) derived from human induced pluripotent...
Source: Cell Research - June 10, 2023 Category: Cytology Authors: Shi-Ying Cao Meng-Dan Tao Shu-Ning Lou Di Yang Yu-Hui Lin Hai-Yin Wu Lei Chang Chun-Xia Luo Yun Xu Yan Liu Dong-Ya Zhu Source Type: research

Activation of endothelial TRPM2 exacerbates blood-brain barrier degradation in ischemic stroke
CONCLUSIONS: In conclusion, our data reveals a novel molecular mechanism in which TRPM2 and CD36 promote the activation of each other, which exacerbates endothelial dysfunction during ischemic stroke. Our study suggests that TRPM2 in endothelial cells is a promising target for developing more effective and safer therapies for ischemic stroke.PMID:37595268 | DOI:10.1093/cvr/cvad126
Source: Cell Research - August 18, 2023 Category: Cytology Authors: Pengyu Zong Jianlin Feng Cindy X Li Evan R Jellison Zhichao Yue Barbara Miller Lixia Yue Source Type: research

Effects of Ischemic Stroke on Interstitial Fluid Clearance in Mouse Brain: a Bead Study
In conclusion, we report that the physiological clearance of ISF and beads mainly passes through the cleft between the CC/EC and striatum into the LV, or alternatively through the cortex into the subarachnoid space. Stroke delays the main route but enhances the minor route, and microglia/macrophages engulf the beads in the infarction. Ischemic stroke impairs the clearance of brain interstitial fluid/beads. Under physiological conditions, the main route ( ① ) of interstitial fluid clearance is to the lateral ventricle, and the minor one ( ② ) is to the subarachnoid space. Ischemic stroke weakens the main route ( ① ), ...
Source: Cellular and Molecular Neurobiology - August 27, 2023 Category: Cytology Authors: Tuo Yang Yang Sun Qianqian Li Nour Alraqmany Feng Zhang Source Type: research

Intracerebral Implantation of Autologous Peripheral Blood Stem Cells in Stroke Patients: a Randomized Phase II Study.
Abstract In our previous study, intracerebral implantation of peripheral blood stem cells (PBSC) improved functional outcome in rats with chronic cerebral infarction. Based on this findings, a randomized, single blind controlled study was conducted in 30 patients [PBSC group (n=15) and control group (n=15)] with middle cerebral artery infarction confirmed on T2?weighted MRI 6 months to 5 years after a stroke. Only subjects with neurological deficits of intermediate severity based on the National Institute of Health Stroke Scale (NIHSS) (range: 9?20) that had been stable for at least 3 months were enrolled. Those i...
Source: Cell Transplantation - January 29, 2014 Category: Cytology Authors: Chen DC, Lin SZ, Fan JR, Lin CH, Lee W, Lin CC, Liu YJ, Tsai CH, Chen JC, Cho DY, Lee CC, Shyu WC Tags: Cell Transplant Source Type: research

A two-year follow-up study of co-transplantation with neural stem/precursor cells and mesenchymal stromal cells in ischemic stroke patients.
Abstract Stem cell therapy is an emerging therapeutic modality in the treatment of stroke. We assessed the safety and feasibility of the co-transplantation of neural stem/precursor cells (NSPCs) and mesenchymal stromal cells (MSCs) in patients with ischemic stroke. Eight patients were enrolled in this study. All patients had a hemisphere with infarct lesions located on one side of the territories of the cerebral middle or anterior arteries as revealed with cranial magnetic resonance imaging (MRI). The patients received one of the following two types of treatment: the first treatment involved 4 intravenous injectio...
Source: Cell Transplantation - October 20, 2014 Category: Cytology Authors: Qiao LY, Huang FJ, Zhao M, Xie JH, Shi J, Wang J, Lin XZ, Zuo H, Wang YL, Geng TC Tags: Cell Transplant Source Type: research