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Specialty: Cytology

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Total 1150 results found since Jan 2013.

NPD1 Plus RvD1 Mediated Ischemic Stroke Penumbra Protection Increases Expression of Pro-homeostatic Microglial and Astrocyte Genes
This study focuses on the neuroprotective bioactivity of docosanoid mediators: Neuroprotectin D1 (NPD1), Resolvin D1 (RvD1), and their combination in experimental stroke. Molecular targets of NPD1 and RvD1 are defined by following dose-response and therapeutic window. We demonstrated that treatment with NPD1, RvD1, and combination therapy provides high-grade neurobehavioral recovery and decreases ischemic core and penumbra volumes even when administered up to 6 h after stroke. The expression of the following genes was salient: (a) Cd163, an anti-inflammatory stroke-associated gene, was the most differentially expressed gen...
Source: Cellular and Molecular Neurobiology - June 4, 2023 Category: Cytology Authors: Madigan M Reid Marie-Audrey I Kautzmann Gethein Andrew Andre Obenaus Pranab K Mukherjee Larissa Khoutorova Jeff X Ji Cassia R Roque Reinaldo B Oria Bola F Habeb Ludmila Belayev Nicolas G Bazan Source Type: research

Treatment of Stroke at a Delayed Timepoint with a Repurposed Drug Targeting Sigma 1 Receptors
In this study, we hypothesized that oral oxeladin citrate would stimulate BDNF secretion and improve stroke outcomes when administered to male rats starting 48 h after transient middle cerebral artery occlusion. Oxeladin did not alter blood clotting and crossed the blood brain barrier within 30 min of oral administration. Rats underwent 90 min of transient middle cerebral artery occlusion. Forty-eight hours later rats began receiving daily oxeladin (135 mg/kg) for 11 days. Oxeladin significantly improved neurological function on days 3, 7, and 14 following MCAO. Infarct size was not altered by a single dose, but the final ...
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Derek A Schreihofer Dhwanil Dalwadi Seongcheol Kim Daniel Metzger Anthony Oppong-Gyebi Paromita Das-Earl John A Schetz Source Type: research

Notch Signaling-Mediated Neural Lineage Selection Facilitates Intrastriatal Transplantation Therapy for Ischemic Stroke by Promoting Endogenous Regeneration in Hippocampus.
This study described a simple 3-stage protocol to induce hES cells into neural lineage cells using a 2-week coculture with the murine bone marrow stromal cells (BMSC) PA6, followed by a 2-week propagation culture in PA6-conditioned medium and an additional 2-week selection culture in chemically defined neurobasal medium. This protocol generated a relatively high yield of neural lineage cells without mesodermal and endodermal lineage cell contamination. Notably, we demonstrated that PA6 coculture can significantly enhance the expression level of Notch signaling components and promote neural lineage entry of hES cell derivat...
Source: Cell Transplantation - January 2, 2013 Category: Cytology Authors: Yang T, Liu LY, Ma YY, Zhang W Tags: Cell Transplant Source Type: research

Vascular endothelial growth factors (VEGFs) and stroke.
Abstract Vascular endothelial growth factors (VEGFs) have been shown to participate in atherosclerosis, arteriogenesis, cerebral edema, neuroprotection, neurogenesis, angiogenesis, postischemic brain and vessel repair, and the effects of transplanted stem cells in experimental stroke. Most of these actions involve VEGF-A and the VEGFR-2 receptor, but VEGF-B, placental growth factor, and VEGFR-1 have been implicated in some cases as well. VEGF signaling pathways represent important potential targets for the acute and chronic treatment of stroke. PMID: 23475070 [PubMed - in process]
Source: Cellular and Molecular Life Sciences : CMLS - May 1, 2013 Category: Cytology Authors: Greenberg DA, Jin K Tags: Cell Mol Life Sci Source Type: research

The rationale of targeting mammalian target of rapamycin for ischemic stroke.
Abstract Given the current limitation of therapeutic approach for ischemic stroke, a leading cause of disability and mortality in the developed countries, to develop new therapeutic strategies for this devastating disease is urgently necessary. As a serine/threonine kinase, mammalian target of rapamycin (mTOR) activation can mediate broad biological activities that include protein synthesis, cytoskeleton organization, and cell survival. mTOR functions through mTORC1 and mTORC2 complexes and their multiple downstream substrates, such as eukaryotic initiation factor 4E-binding protein 1, p70 ribosomal S6 kinase, ste...
Source: Cellular Signalling - April 3, 2013 Category: Cytology Authors: Chong ZZ, Yao Q, Li HH Tags: Cell Signal Source Type: research

Intra-Arterial Transplantation of Low-Dose Stem Cells Provides Functional Recovery Without Adverse Effects After Stroke.
In conclusion, selective intra-arterial transplantation of low-dose MSCs has anti-inflammatory effects and reduces the adverse effects of embolic complication, resulting in sufficient functional recovery of the affected brain. PMID: 25398358 [PubMed - as supplied by publisher]
Source: Cellular and Molecular Neurobiology - November 15, 2014 Category: Cytology Authors: Fukuda Y, Horie N, Satoh K, Yamaguchi S, Morofuji Y, Hiu T, Izumo T, Hayashi K, Nishida N, Nagata I Tags: Cell Mol Neurobiol Source Type: research

Melatonin as an Antioxidant for Stroke Neuroprotection.
Abstract Melatonin (N-acetyl-5-methoxytryptamine) is a hormone derived from the pineal gland that has wide range of clinical application. While melatonin was originally assessed as a hormone specializing in regulation of the normal circadian rhythm in mammals, it now has been shown to be an effective free radical scavenger and antioxidant. Current research has focused on Central Nervous System (CNS) disorders, stroke in particular, for potential melatonin-based therapeutics. As of now, the realm of potential therapy regimens is focused on three main treatments: exogenously delivered melatonin, pineal gland graftin...
Source: Cell Transplantation - October 22, 2015 Category: Cytology Authors: Watson N, Diamandis T, Gonzales-Portillo C, Reyes S, Borlongan CV Tags: Cell Transplant Source Type: research

Effects of Estrogen and Phytoestrogen Treatment on an In Vitro Model of Recurrent Stroke on HT22 Neuronal Cell Line.
Abstract An increase of stroke incidence occurs in women with the decline of estrogen levels following menopause. This ischemic damage may recur, especially soon after the first insult has occurred. We evaluated the effects of estrogen and phytoestrogen treatment on an in vitro recurrent stroke model using the HT22 neuronal cell line. HT22 cells were treated with 17β-estradiol or genistein 1 h after the beginning of the first of two oxygen and glucose deprivation/reoxygenation (OGD/R) cycles. During the second OGD, there was a deterioration of some components of the electron transport chain, such as cytochrome c...
Source: Cellular and Molecular Neurobiology - April 7, 2016 Category: Cytology Authors: Morán J, Perez-Basterrechea M, Garrido P, Díaz E, Alonso A, Otero J, Colado E, González C Tags: Cell Mol Neurobiol Source Type: research

Intravenously infused F3.Olig2 improve memory deficit via restoring demyelination in the aged hippocampus following experimental ischemic stroke.
In this study, the effects of F3.Olig2 transplantation on memory and cognitive dysfunction, in the aged gerbil induced by ischemic stroke were investigated. To investigate the possible mechanisms, changes in the expression of myelin basic protein (MBP), oligodendrocytes specific protein (OSP) and brain-derived neurotrophic factor (BDNF) were examined. Experimental ischemic stroke was induced by occlusion of bilateral common carotid arteries in aged gerbils. Gerbils (n = 31 per group) were randomly divided into 3 groups; 1) vehicle sham group, 2) vehicle ischemia group, and 3) F3.Olig2 ischemia group. After 1, 3, and 7 days...
Source: Cell Transplantation - July 19, 2016 Category: Cytology Authors: Ahn JH, Chen BH, Shin BN, Cho JH, Kim IH, Park JH, Lee JC, Tae HJ, Lee YL, Lee J, Byun K, Jeong GB, Lee B, Kim YM, Won MH, Choi SY Tags: Cell Transplant Source Type: research

Secondary release of exosomes from astrocytes contributes to the increase in neural plasticity and improvement of functional recovery after stroke in rats treated with exosomes harvested from microRNA 133b(-)overexpressed multipotent mesenchymal stromal cells.
Abstract We previously demonstrated that multipotent mesenchymal stromal cells (MSCs) with overexpressed microRNA 133b (miR-133b) significantly improve functional recovery in rats subjected to middle cerebral artery occlusion (MCAO) compared with naive MSCs, and that exosomes generated from naive MSCs mediate the therapeutic benefits of MSC therapy for stroke. Here, we investigated whether exosomes isolated from miR-133b(-)overexpressed MSCs (Ex-miR-133b(+)) exert amplified therapeutic effects. Rats subjected to 2 hours (h) of MCAO were intra-arterially injected with Ex-miR-133b(+), exosomes from MSCs infected by ...
Source: Cell Transplantation - September 25, 2016 Category: Cytology Authors: Xin H, Wang F, Li Y, Lu QE, Cheung WL, Zhang Y, Zhang ZG, Chopp M Tags: Cell Transplant Source Type: research

Cerebellar Fastigial Nucleus Electrical Stimulation Alleviates Depressive-Like Behaviors in Post-Stroke Depression Rat Model and Potential Mechanisms
Conclusion: FNS treatment alleviates depressive-like behaviors and rCBF in PSD rats model, which could be attributed to its ability to protect cerebellar Purkinje cells and decrease the mRNA level of inflammatory cytokines.Cell Physiol Biochem 2017;41:1403 –1412
Source: Cellular Physiology and Biochemistry - March 17, 2017 Category: Cytology Source Type: research

Evaluation of parametric response mapping to assess therapeutic response to human mesenchymal stem cells after experimental stroke.
Abstract Stroke is the leading cause of disability in adults. After the very narrow time frame during which treatment by thrombolysis and mechanical thrombectomy is possible, cell therapy has huge potential for enhancing stroke recovery. Accurate analysis of the response to new therapy, using imaging biomarkers, is needed to assess therapeutic efficacy. The aim of this study is to compare two analysis techniques: the parametric response map (PRM), a voxel-based technique, and the standard whole-lesion approach. These two analyses were performed on data collected at 4 time points in a transient middle cerebral arte...
Source: Cell Transplantation - May 9, 2017 Category: Cytology Authors: He R, Moisan A, Detante O, Rémy C, Krainik A, Barbier EL, Lemasson B Tags: Cell Transplant Source Type: research

Evaluation of Parametric Response Mapping to Assess Therapeutic Response to Human Mesenchymal Stem Cells after Experimental Stroke.
Abstract Stroke is the leading cause of disability in adults. After the very narrow time frame during which treatment by thrombolysis and mechanical thrombectomy is possible, cell therapy has huge potential for enhancing stroke recovery. Accurate analysis of the response to new therapy using imaging biomarkers is needed to assess therapeutic efficacy. The aim of this study was to compare 2 analysis techniques: the parametric response map (PRM), a voxel-based technique, and the standard whole-lesion approach. These 2 analyses were performed on data collected at 4 time points in a transient middle cerebral artery oc...
Source: Cell Transplantation - August 1, 2017 Category: Cytology Authors: He R, Moisan A, Detante O, Rémy C, Krainik A, Barbier EL, Lemasson B Tags: Cell Transplant Source Type: research

Inhibition of the SOCS1-JAK2-STAT3 Signaling Pathway Confers Neuroprotection in Rats with Ischemic Stroke
Conclusion: These data demonstrate that inhibiting the SOCS1-JAK2-STAT3 signaling pathway can reduce the loss of nerve function and apoptosis of neuronal cells, which provides a new target for the clinical treatment of ischemic stroke.Cell Physiol Biochem 2017;44:85 –98
Source: Cellular Physiology and Biochemistry - November 3, 2017 Category: Cytology Source Type: research

In Vivo Long-Term Tracking of Neural Stem Cells Transplanted into an Acute Ischemic Stroke model with Reporter Gene-Based Bimodal MR and Optical Imaging.
Abstract Transplantation of neural stem cells (NSCs) is emerging as a new therapeutic approach for stroke. Real-time imaging of transplanted NSCs is essential for successful cell delivery, safety monitoring, tracking cell fate and function, and understanding the interactions of transplanted cells with the host environment. Magnetic resonance imaging (MRI) of magnetic nanoparticle-labeled cells has been the most widely used means to track stem cells in vivo. Nevertheless, it does not allow for the reliable discrimination between live and dead cells. Reporter gene-based MRI was considered as an alternative strategy ...
Source: Cell Transplantation - October 1, 2017 Category: Cytology Authors: Zhang F, Duan X, Lu L, Zhang X, Chen M, Mao J, Cao M, Shen J Tags: Cell Transplant Source Type: research