Multiple Cell Transplant for Stroke Patients Multiple Cell Transplantation Based on an Intraparenchymal Approach for Patients with Chronic Phase Stroke.

Multiple Cell Transplant for Stroke Patients Multiple Cell Transplantation Based on an Intraparenchymal Approach for Patients with Chronic Phase Stroke.
Cell Transplant. 2013 Aug 29;
Authors: Chen L, Xi H, Huang H, Zhang F, Liu Y, Chen D, Xiao J
Abstract
Stroke is the third leading cause of death worldwide and a huge perpetrator in adult disability. This pilot clinical study investigates the possible benefits of transplanting multiple cells in chronic stroke. A total of ten consecutive stroke patients were treated by combination cell transplantation on the basis of an intraparenchymal approach from November 2003 to April 2011. There were 6 males and 4 females. Their age ranged from 42 to 87 years and course of disease varied from 6 months to 20 years. Six patients suffered cerebral infarction, and 4 patients suffered a brain hemorrhage. The olfactory ensheathing cells, neural progenitor cells, umbilical cord mesenchymal cells and Schwann cells were injected through selected routes including intracranial parenchymal implantation, intrathecal implantation, and intravenous administration, respectively. The clinical neurological function was assessed carefully and independently before treatment and during a long term follow-up using the Clinic Neurologic Impairment Scale and the Barthel Index. All patients were followed up successfully from 6 months to 2 years after cell transplantation. Every subject achieved neurological function amelioration in...

Source: Cell Transplantation - August 29, 2013 Category: Cytology Authors: Chen L, Xi H, Huang H, Zhang F, Liu Y, Chen D, Xiao J Tags: Cell Transplant Source Type: research