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Total 6766 results found since Jan 2013.

Moderate-intensity cardiovascular exercise performed before motor practice attenuates offline implicit motor learning in stroke survivors but not age-matched neurotypical adults
Exp Brain Res. 2023 Jul 3. doi: 10.1007/s00221-023-06659-w. Online ahead of print.ABSTRACTThe acute impact of cardiovascular exercise on implicit motor learning of stroke survivors is still unknown. We investigated the effects of cardiovascular exercise on implicit motor learning of mild-moderately impaired chronic stroke survivors and neurotypical adults. We addressed whether exercise priming effects are time-dependent (e.g., exercise before or after practice) in the encoding (acquisition) and recall (retention) phases. Forty-five stroke survivors and 45 age-matched neurotypical adults were randomized into three sub-group...
Source: Experimental Brain Research - July 3, 2023 Category: Neuroscience Authors: Giordano Marcio Gatinho Bonuzzi Flavio Henrique Bastos Nicolas Schweighofer Eric Wade Carolee Joyce Winstein Camila Torriani-Pasin Source Type: research

Neuroinflammation in Acute Ischemic and Hemorrhagic Stroke
AbstractPurpose of ReviewThis review aims to provide an overview of neuroinflammation in ischemic and hemorrhagic stroke, including recent findings on the mechanisms and cellular players involved in the inflammatory response to brain injury.Recent FindingsNeuroinflammation is a crucial process following acute ischemic stroke (AIS) and hemorrhagic stroke (HS). In AIS, neuroinflammation is initiated within minutes of the ischemia onset and continues for several days. In HS, neuroinflammation is initiated by blood byproducts in the subarachnoid space and/or brain parenchyma. In both cases, neuroinflammation is characterized b...
Source: Current Neurology and Neuroscience Reports - July 3, 2023 Category: Neuroscience Source Type: research

Isoflurane Enhances Autophagy by Activating AMPK/ULK1, Inhibits NLRP3, and Reduces Cognitive Impairment After Cerebral Ischemia –Reperfusion Injury in Rats
AbstractCerebral ischemic stroke (CIS) has become the second leading cause of death worldwide, which is largely related to cerebral ischemia reperfusion injury (CIRI). Surgical intervention is a reliable treatment for CIS, which predictably causes cerebral reperfusion. Therefore, the choice of anesthetic drugs has important clinical significance. Isoflurane (ISO), one of the most used anesthetics, attenuates cognitive impairment and has brain protective effects. However, the role of isoflurane in regulating autophagy and its regulatory mechanism on inflammation in CIRI are still unclear. The middle cerebral artery occlusio...
Source: Journal of Molecular Neuroscience - June 30, 2023 Category: Neuroscience Source Type: research

Cerebral venous thrombosis in patients with autoimmune disease, hematonosis or coronavirus disease 2019: Many familiar faces and some strangers
CONCLUSION: A systematic understanding of particular risk factors that should not be neglected when unconventional cerebral venous thrombosis occurs and for a scientific understanding of pathophysiological mechanisms, clinical diagnosis, and treatment, thus contributing to knowledge on special types of venous stroke.PMID:37365966 | DOI:10.1111/cns.14321
Source: CNS Neuroscience and Therapeutics - June 27, 2023 Category: Neuroscience Authors: Yifan Zhou Huimin Jiang Huimin Wei Xuechun Xiao Lu Liu Xunming Ji Chen Zhou Source Type: research

Gene expression profiling in whole blood stimulated ex vivo with lipopolysaccharide as a tool to predict post ‐stroke depressive symptoms: Proof‐of‐concept study
We studied if blood gene expression could facilitate identification of persons who will develop depression 3 months after ischemic stroke. Venous blood samples were collected on day 3 after stroke. Obtained blood was stimulated in vitro with lipopolysaccharide, a powerful inducer of gene expression. After stimulation, RNA was isolated and sequenced. Expression of 510 genes differed between patients who developed depression and those who had not depression after stroke. Bioinformatic analysis revealed that expression of 6 genes (PKM, PRRC2C, NUP188, CHMP3, H2AC8, NOP10) accurately predicted a risk of depression. Our finding...
Source: Journal of Neurochemistry - June 27, 2023 Category: Neuroscience Authors: Marcin Piechota, Dzesika Hoinkis, Michal Korostynski, Slawomir Golda, Joanna Pera, Tomasz Dziedzic Tags: ORIGINAL ARTICLE Source Type: research

Immediate Effects of Intermittent Theta Burst Stimulation on Primary Motor Cortex in Stroke Patients: A Concurrent TMS-EEG Study
This study was to investigate the immediate effects of iTBS on intracortical excitatory and inhibitory circuits, neural connectivity, and network properties in patients with chronic stroke, using TMS-EEG and TMS-EMG approaches. In this randomized, sham-controlled, crossover study, 20 patients with chronic stroke received two separate stimulation conditions: a single-session iTBS or sham stimulation applied to the ipsilesional M1, in two separate visits, with a washout period of five to seven days between the two visits. A battery of TMS-EMG and TMS-EEG measurements were taken before and immediately after stimulation during...
Source: IEE Transactions on Neural Systems and Rehabilitation Engineering - June 27, 2023 Category: Neuroscience Source Type: research

Oral probiotic therapy improves motor function in a rodent model of sensorimotor stroke
In this study, we examined the effect of post-stroke oral probiotic therapy on motor behavior in the pre-clinical mouse endothelin-1 (ET-1) model of sensorimotor stroke. We found that post-stroke oral probiotic therapy with Cerebiome® (Lallemand, Montreal, Canada), containing B. longum R0175 and L. helveticus R0052, improved functional recovery and changed the composition of the post-stroke gut microbiota. Interestingly, oral Cerebiome® administration did not result in alterations of lesion volume or the number of CD8+/Iba1+ cells in the injured tissue. Overall, these findings suggest that probiotic treatment following i...
Source: Experimental Brain Research - June 26, 2023 Category: Neuroscience Authors: E Daniele Y Nazer I Kortebi D Lozano Casasbuenas Y Fan M Trinh T A Tompkins M Faiz Source Type: research