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Specialty: Neuroscience
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Total 6766 results found since Jan 2013.
Stroke mimics: A case report of cervical spondylosis with intravenous thrombolysis
CNS Neurosci Ther. 2023 Aug 31. doi: 10.1111/cns.14434. Online ahead of print.NO ABSTRACTPMID:37649425 | DOI:10.1111/cns.14434
Source: CNS Neuroscience and Therapeutics - August 31, 2023 Category: Neuroscience Authors: Yicong Wang Hui Qu Wanliang Du Yilong Wang Source Type: research
Safety and effectiveness assessment of endovascular recanalization for non-acute middle cerebral artery occlusion
CONCLUSION: Among patients with symptomatic nonacute middle cerebral artery occlusion with a short length of occlusion and a moderate-to-good collateral circulation, endovascular treatment seems to be safe. And endovascular treatment could reduce the recurrence rate of stroke.PMID:37641873 | DOI:10.1111/cns.14426
Source: CNS Neuroscience and Therapeutics - August 29, 2023 Category: Neuroscience Authors: Zhang Xi Duan Guangxin Zhang He Chen Zhibin Luo Yun Zhang Tingzheng Xu Yun Li Jingwei Source Type: research
Function and regulation of cis P ‐tau in the pathogenesis and treatment of conventional and nonconventional tauopathies
Cis –trans isomerization of protein plays an important role in protein folding, function, and degradation, which is regulated by peptidyl-proline isomerases (PPIases). The cis P-tau but not trans P-tau is resistant to protein dephosphorylation and degradation and also prone to protein aggregation and serves as an early driver of multiple neurodegenerative disease including Alzheimer disease (AD), traumatic brain injury (TBI), chronic traumatic encephalopathy (CTE), and vascular contributions to cognitive impairment and dementia (VCID). Cis P-tau antibody is the only clinical-stage therapeutic fo r AD that has shown the e...
Source: Journal of Neurochemistry - August 29, 2023 Category: Neuroscience Authors: Ruizhi Wang,
Kun Ping Lu,
Xiao Zhen Zhou Tags: REVIEW Source Type: research
Relief of post-stroke spasticity with acute vibrotactile stimulation: controlled crossover study of muscle and skin stimulus methods
ConclusionsCutaneous vibrotactile stimulation of the hand provides significant reductions in spastic hypertonia, compared to muscle stimulation.Clinical trial registrationwww.ClinicalTrials.gov, identifier: NCT03814889.
Source: Frontiers in Human Neuroscience - August 29, 2023 Category: Neuroscience Source Type: research
A Novel Neurorehabilitation Prognosis Prediction Modeling on Separated Left-Right Hemiplegia Based on Brain-Computer Interfaces Assisted Rehabilitation
It is essential for neuroscience and clinic to estimate the influence of neuro-intervention after brain damage. Most related studies have used Mirrored Contralesional-Ipsilesional hemispheres (MCI) methods flipping the axial neuroimaging on the x-axis in prognosis prediction. But left-right hemispheric asymmetry in the brain has become a consensus. MCI confounds the intrinsic brain asymmetry with the asymmetry caused by unilateral damage, leading to questions about the reliability of the results and difficulties in physiological explanations. We proposed the Separated Left-Right hemiplegia (SLR) method to model left and ri...
Source: IEE Transactions on Neural Systems and Rehabilitation Engineering - August 25, 2023 Category: Neuroscience Source Type: research
Current Topics in Technology-Enabled Stroke Rehabilitation and Reintegration: A Scoping Review and Content Analysis
Conclusion. The results indicate that IT-enabled stroke literature has focused on Functional outcomes and Robotic technologies, with lesser emphasis on Cognitive outcomes and combined interventions. We hope this review broadens awareness, usage and mainstream acceptance of novel technologies in rehabilitation and reintegration among clinicians, carers and patients.
Source: IEE Transactions on Neural Systems and Rehabilitation Engineering - August 23, 2023 Category: Neuroscience Source Type: research
Ketamine improves neuronal recovery following spreading depolarization in peri ‐infarct tissues
We examined spreading depolarization (SD) waves in a mouse stroke model. SDs were initiated by focal potassium chloride application and propagated through a region of graded perfusion deficit created by distal middle cerebral artery (dMCA) occlusion. Longer lasting depolarizations (DC shifts measured from local field potential (LFP) electrodes) and neuronal Ca2+ transients (epifluorescence GCaMP imaging) occurred at locations with larger perfusion deficits (proximal to occlusion), as compared with remote recording sites (laser speckle contrast imaging (LSCI) of cerebral perfusion). Ketamine, at concentrations that did not ...
Source: Journal of Neurochemistry - August 19, 2023 Category: Neuroscience Authors: Katelyn M. Reinhart,
Russell A. Morton,
K. C. Brennan,
Andrew P. Carlson,
C. William Shuttleworth Tags: ORIGINAL ARTICLE Source Type: research
Adapted Assistance and Resistance Training With a Knee Exoskeleton After Stroke
In this study, we investigated how stroke individuals responded to training for two weeks with a knee exoskeleton (ABLE-KS) using both Assistance and Resistance training modes together with auditory feedback to train peak knee flexion angle. During the training, the torque provided by the ABLE-KS and the biofeedback were systematically adapted based on the subject’s performance and perceived exertion level. We carried out a comprehensive experimental analysis that evaluated a wide range of biomechanical metrics, together with usability and users’ perception metrics. We found significant improvements in peak k...
Source: IEE Transactions on Neural Systems and Rehabilitation Engineering - August 18, 2023 Category: Neuroscience Source Type: research
Human umbilical cord derived mesenchymal stem cells overexpressing HO-1 attenuate neural injury and enhance functional recovery by inhibiting inflammation in stroke mice
CONCLUSION: The findings indicate that MSCs overexpressing HO-1 exhibited significant therapeutic effects against hyper-inflammatory injury after stroke in mice, ultimately promoting recovery after ischemic stroke.PMID:37592866 | DOI:10.1111/cns.14412
Source: CNS Neuroscience and Therapeutics - August 18, 2023 Category: Neuroscience Authors: Yu Yang Qianqian Liu Song Deng Qian Shao Long Peng Yuejuan Ling Yue Huang Siqi Zheng Qiaoji Jiang Dekang Nie Jian Chen Source Type: research
A novel stroke rehabilitation strategy and underlying stress granule regulations through inhibition of NLRP3 inflammasome activation
CONCLUSIONS: RIC followed by exercise induced a better rehabilitation in ischemic rats, while early RIC alleviated ischemia-reperfusion injury via stress-granule-mediated inhibition of NLRP3 inflammasome.PMID:37580991 | DOI:10.1111/cns.14405
Source: CNS Neuroscience and Therapeutics - August 15, 2023 Category: Neuroscience Authors: Qingzhu Wang Wesley Kohls Melissa Wills Fengwu Li Qi Pang Xiaokun Geng Yuchuan Ding Source Type: research
