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Total 6766 results found since Jan 2013.

MiR-199a-5p enhances neuronal differentiation of neural stem cells and promotes neurogenesis by targeting Cav-1 after cerebral ischemia
CONCLUSION: MiR-199a-5p may target and inhibit Cav-1 to enhance neurogenesis and thus promote functional recovery after cerebral ischemia. These findings indicate that miR-199a-5p is a promising target for the treatment of ischemic stroke.PMID:37349971 | DOI:10.1111/cns.14323
Source: CNS Neuroscience and Therapeutics - June 23, 2023 Category: Neuroscience Authors: Hua-Qian Jin Wei-Feng Jiang Xin-Tian Zheng Lin Li Yan Fang Yan Yang Xiao-Wei Hu Li-Sheng Chu Source Type: research

Edaravone Dexborneol Alleviates Neuroinflammation by Reducing Neuroglial Cell Proliferation and Suppresses Neuronal Apoptosis/Autophagy in Vascular Dementia Rats
In this study, we established the VD model of rats by bilateral carotid artery occlusion to explore the neuroprotective effect of EDB and its mechanism. Morris Water Maze test was applied to assess the cognitive function of rats. H&E and TUNEL staining were applied to observe the cellular structure of the hippocampus. Immunofluorescence labeling was used to observe the proliferation of astrocytes and microglia. ELISA was applied to examine the levels of TNF-α, IL-1β and IL-6, and RT-PCR was applied to examine their mRNA expression levels. Western blotting was applied to examine apoptosis-related proteins (Bax, Bcl-2,...
Source: Neurochemical Research - June 20, 2023 Category: Neuroscience Authors: Jiawei Zhang Yining Xiao Hongna Liu Lili Xu Xing Guo Yaran Gao Meixi Li Jing Xu Qianqian Qi Peiyuan Lv Source Type: research

A Novel Model to Generate Heterogeneous and Realistic Time-Series Data for Post-Stroke Rehabilitation Assessment
The application of machine learning-based tele-rehabilitation faces the challenge of limited availability of data. To overcome this challenge, data augmentation techniques are commonly employed to generate synthetic data that reflect the configurations of real data. One such promising data augmentation technique is the Generative Adversarial Network (GAN). However, GANs have been found to suffer from mode collapse, a common issue where the generated data fails to capture all the relevant information from the original dataset. In this paper, we aim to address the problem of mode collapse in GAN-based data augmentation techn...
Source: IEE Transactions on Neural Systems and Rehabilitation Engineering - June 20, 2023 Category: Neuroscience Source Type: research

A Method for Quantification of Stretch Reflex Excitability During Ballistic Reaching
Stretch reflexes are crucial for performing accurate movements and providing rapid corrections for unpredictable perturbations. Stretch reflexes are modulated by supraspinal structures via corticofugal pathways. Neural activity in these structures is difficult to observe directly, but the characterization of reflex excitability during volitional movement can be used to study how these structures modulate reflexes and how neurological injuries impact this control, such as in spasticity after stroke. We have developed a novel protocol to quantify stretch reflex excitability during ballistic reaching. This novel method was im...
Source: IEE Transactions on Neural Systems and Rehabilitation Engineering - June 20, 2023 Category: Neuroscience Source Type: research

The NLRP3 inflammasome and gut dysbiosis as a putative link between HIV-1 infection and ischemic stroke
Trends Neurosci. 2023 Jun 15:S0166-2236(23)00134-0. doi: 10.1016/j.tins.2023.05.009. Online ahead of print.ABSTRACTHIV-associated comorbidities, such as ischemic stroke, are prevalent in people with HIV (PWH). Several studies both in animal models and humans have revealed an association between activation of the inflammasome in HIV-1 infection and stroke. The gut microbiota is an important component in controlling neuroinflammation in the CNS. It has also been proposed to be involved in the pathobiology of HIV-1 infection, and has been associated with an increase in activation of the inflammasome. In this review, we provid...
Source: Trends in Neurosciences - June 17, 2023 Category: Neuroscience Authors: Silvia Torices Leah Daire Sierra Simon Luisa Mendoza Destiny Daniels Joelle-Ann Joseph Nikolai Fattakhov Oandy Naranjo Timea Teglas Michal Toborek Source Type: research

Astrocyte-Neuronal Communication and Its Role in Stroke
Neurochem Res. 2023 Jun 17. doi: 10.1007/s11064-023-03966-0. Online ahead of print.ABSTRACTAstrocytes are the most abundant glial cells in the central nervous system. These cells are an important hub for intercellular communication. They participate in various pathophysiological processes, including synaptogenesis, metabolic transformation, scar production, and blood-brain barrier repair. The mechanisms and functional consequences of astrocyte-neuron signaling are more complex than previously thought. Stroke is a disease associated with neurons in which astrocytes also play an important role. Astrocytes respond to the alte...
Source: Neurochemical Research - June 17, 2023 Category: Neuroscience Authors: Zi-Meng Yao Xiao-Rong Sun Jie Huang Lei Chen Shu-Ying Dong Source Type: research

The NLRP3 inflammasome and gut dysbiosis as a putative link between HIV-1 infection and ischemic stroke
Trends Neurosci. 2023 Jun 15:S0166-2236(23)00134-0. doi: 10.1016/j.tins.2023.05.009. Online ahead of print.ABSTRACTHIV-associated comorbidities, such as ischemic stroke, are prevalent in people with HIV (PWH). Several studies both in animal models and humans have revealed an association between activation of the inflammasome in HIV-1 infection and stroke. The gut microbiota is an important component in controlling neuroinflammation in the CNS. It has also been proposed to be involved in the pathobiology of HIV-1 infection, and has been associated with an increase in activation of the inflammasome. In this review, we provid...
Source: Trends in Neurosciences - June 17, 2023 Category: Neuroscience Authors: Silvia Torices Leah Daire Sierra Simon Luisa Mendoza Destiny Daniels Joelle-Ann Joseph Nikolai Fattakhov Oandy Naranjo Timea Teglas Michal Toborek Source Type: research

Astrocyte-Neuronal Communication and Its Role in Stroke
Neurochem Res. 2023 Jun 17. doi: 10.1007/s11064-023-03966-0. Online ahead of print.ABSTRACTAstrocytes are the most abundant glial cells in the central nervous system. These cells are an important hub for intercellular communication. They participate in various pathophysiological processes, including synaptogenesis, metabolic transformation, scar production, and blood-brain barrier repair. The mechanisms and functional consequences of astrocyte-neuron signaling are more complex than previously thought. Stroke is a disease associated with neurons in which astrocytes also play an important role. Astrocytes respond to the alte...
Source: Neurochemical Research - June 17, 2023 Category: Neuroscience Authors: Zi-Meng Yao Xiao-Rong Sun Jie Huang Lei Chen Shu-Ying Dong Source Type: research

The NLRP3 inflammasome and gut dysbiosis as a putative link between HIV-1 infection and ischemic stroke
Trends Neurosci. 2023 Jun 15:S0166-2236(23)00134-0. doi: 10.1016/j.tins.2023.05.009. Online ahead of print.ABSTRACTHIV-associated comorbidities, such as ischemic stroke, are prevalent in people with HIV (PWH). Several studies both in animal models and humans have revealed an association between activation of the inflammasome in HIV-1 infection and stroke. The gut microbiota is an important component in controlling neuroinflammation in the CNS. It has also been proposed to be involved in the pathobiology of HIV-1 infection, and has been associated with an increase in activation of the inflammasome. In this review, we provid...
Source: Trends in Neurosciences - June 17, 2023 Category: Neuroscience Authors: Silvia Torices Leah Daire Sierra Simon Luisa Mendoza Destiny Daniels Joelle-Ann Joseph Nikolai Fattakhov Oandy Naranjo Timea Teglas Michal Toborek Source Type: research

Modulation of the autophagy ‐lysosomal pathway and endoplasmic reticulum stress by ketone bodies in experimental models of stroke
We report for the first time that the protective effect of β-hydroxybutyrate (BHB) against stroke and glucose deprivation is enantiomer selective. We discovered that D-BHB treatment prevented the cleavage of the lysosomal membrane protein LAMP2, maintained lysosome integrity and stimulated the autophagic flux. Also, D-BHB notably reduced the activation of the PERK and IRE1α branches of the unfolded protein response (UPR), attenuating protein synthesis inhibition and preventing endoplasmic reticulum stress. Together our results support the therapeutic use of D-BHB treatment post-ischemia, by preventing the loss of proteos...
Source: Journal of Neurochemistry - June 17, 2023 Category: Neuroscience Authors: Teresa Montiel, Juan Carlos G ómora‐García, Cristian Gerónimo‐Olvera, Yessica Heras‐Romero, Berenice N. Bernal‐Vicente, Xochitl Pérez‐Martínez, Luis B. Tovar‐y‐Romo, Lourdes Massieu Tags: ORIGINAL ARTICLE Source Type: research

Electroencephalography-Derived Functional Connectivity in Sensorimotor Networks in Post Stroke Fatigue
CONCLUSION: High levels of small-worldness in somatosensory networks indicates altered processing of somesthetic input. Such altered processing would explain high effort perception within the sensory attenuation model of fatigue.PMID:37328707 | DOI:10.1007/s10548-023-00975-8
Source: Brain Topography - June 16, 2023 Category: Neuroscience Authors: Chi-Hsu Wu William De Doncker Annapoorna Kuppuswamy Source Type: research