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Total 6766 results found since Jan 2013.

Dense dopaminergic innervation of the peri ‐infarct cortex despite dopaminergic cell loss after a pure motor‐cortical stroke in rats
In this study, we assessed the reorganization of dopaminergic innervation of the PIC in a rat model of focal cortical stroke. Our data suggest a sprouting of dopaminergic fibers into the PIC and point to a role for dopaminergic signaling in reparative mechanisms post-stroke, potentially related to recovery. AbstractAfter ischemic stroke, the cortex directly adjacent to the ischemic core (i.e., the peri-infarct cortex, PIC) undergoes plastic changes that facilitate motor recovery. Dopaminergic signaling is thought to support this process. However, ischemic stroke also leads to the remote degeneration of dopaminergic midbrai...
Source: Journal of Neurochemistry - September 22, 2023 Category: Neuroscience Authors: Sibylle Frase, Julius Steddin, Enya Paschen, Maximilian Lenz, Pasquale Conforti, Carola A. Haas, Andreas Vlachos, Christian Schachtrup, Jonas A. Hosp Tags: ORIGINAL ARTICLE Source Type: research

Hemispheric Asymmetry in TMS-Induced Effects on Spatial Attention: A Meta-Analysis
AbstractHemispheric asymmetry is a fundamental principle in the functional architecture of the brain. It plays an important role in attention research where right hemisphere dominance is core to many attention theories. Lesion studies seem to confirm such hemispheric dominance with patients being more likely to develop left hemineglect after right hemispheric stroke than vice versa. However, the underlying concept of hemispheric dominance is still not entirely clear. Brain stimulation studies using transcranial magnetic stimulation (TMS) might be able to illuminate this concept. To examine the putative hemispheric asymmetr...
Source: Neuropsychology Review - September 22, 2023 Category: Neuroscience Source Type: research

Childhood stroke associated with protein C and S deficiency
CNS Neurosci Ther. 2023 Sep 21. doi: 10.1111/cns.14479. Online ahead of print.NO ABSTRACTPMID:37732533 | DOI:10.1111/cns.14479
Source: CNS Neuroscience and Therapeutics - September 21, 2023 Category: Neuroscience Authors: Hui Yu Yao Zhang Ting Wei Wenqian Luo Bin Liu Source Type: research

Autophagy in Intracerebral Hemorrhage: From Mechanism to Regulation
J Integr Neurosci. 2023 Sep 18;22(5):134. doi: 10.31083/j.jin2205134.ABSTRACTIntracerebral hemorrhage (ICH) is the most lethal type of stroke. Secondary injury from ICH determines the recovery, but there is still a lack of effective treatment. The identification of new therapeutic targets may address the current dilemma. The process of autophagy is mediated through the lysosomal pathway and is used to maintain cell homeostasis. Recent studies have advanced our knowledge of autophagy, and in particular its involvement in cell physiology and pathology. Autophagy involves multiple targets and signaling pathways and occurs in ...
Source: Journal of Integrative Neuroscience - September 21, 2023 Category: Neuroscience Authors: Jia Zheng Wei Zou Xueping Yu Source Type: research

Efficacy and Safety of Repetitive Transcranial Magnetic Stimulation for Poststroke Memory Disorder: A Meta-Analysis and Systematic Review
CONCLUSIONS: rTMS may improve memory function, global cognition, and the ability to perform ADL in patients with PSMD. LF-rTMS and HF-rTMS may have equal efficacy for treatment of PSMD. Future studies should consider extending the follow-up period to explore the safety and long-term efficacy of rTMS for treatment of PSMD and the appropriate choice of placebo for clinical trials of this treatment.PMID:37735134 | DOI:10.31083/j.jin2205131
Source: Journal of Integrative Neuroscience - September 21, 2023 Category: Neuroscience Authors: Haihua Xie Shiyang Luo Dan Xiong Pan Zhu Jie Chen Xin Tang Jie Tan Ning Zhao Source Type: research

Single-Cell RNA-Seq Reveals Changes in Cell Subsets in the Cortical Microenvironment during Acute Phase of Ischemic Stroke Rats
CONCLUSIONS: ScRNA-seq revealed the diversity of cell differentiation and the unique information of cell subpopulations in the cortex of rats with acute ischemic stroke, providing novel insight into the pathological process and drug discovery in stroke.PMID:37735120 | DOI:10.31083/j.jin2205128
Source: Journal of Integrative Neuroscience - September 21, 2023 Category: Neuroscience Authors: Yijin Zhao Chongwu Xiao Hui Chen Rui Zhu Meimei Zhang Haining Liu Xiaofeng Zhang Qing Zeng Guozhi Huang Source Type: research

Multi-Channel FES Gait Rehabilitation Assistance System Based on Adaptive sEMG Modulation
This study proposes a multi-channel FES gait rehabilitation assistance system based on adaptive myoelectric modulation. The proposed system collects sEMG of the vastus lateralis muscle on the non-affected side to predict the sEMG values of four targeted lower-limb muscles on the affected side using a bidirectional long short-term memory (BILSTM) model. Next, the proposed system modulates the real-time FES output frequency for four targeted muscles based on the predicted sEMG values to provide muscle force compensation. Fifteen healthy subjects were recruited to participate in an offline model-building experiment conducted ...
Source: IEE Transactions on Neural Systems and Rehabilitation Engineering - September 18, 2023 Category: Neuroscience Source Type: research

SERPINA3: A novel inflammatory biomarker associated with cerebral small vessel disease burden in ischemic stroke
CONCLUSION: In summary, among four inflammatory biomarkers that we investigated, SERPINA3 level at baseline was associated with WMH severity, which revealed a novel biomarker for CSVD and validated its relationship with inflammation and endothelial dysfunction.PMID:37721405 | DOI:10.1111/cns.14472
Source: CNS Neuroscience and Therapeutics - September 18, 2023 Category: Neuroscience Authors: Xiao Hu Zhong-Song Xiao Yi-Qing Shen Wen-Song Yang Peng Wang Pei-Zheng Li Zi-Jie Wang Ming-Jun Pu Li-Bo Zhao Peng Xie Qi Li Source Type: research

Role of TRPV1 in electroacupuncture-mediated signal to the primary sensory cortex during regulation of the swallowing function
CONCLUSION: The TRPV1 at CV23 after EA treatment might play a key role in mediating local blood perfusion but was not involved in transferring EA signals to the central nervous system (CNS). These findings collectively suggested that TRPV1 may be one of the important regulators involved in the mechanism of EA treatment for improving swallowing function in PSD.PMID:37718934 | DOI:10.1111/cns.14457
Source: CNS Neuroscience and Therapeutics - September 18, 2023 Category: Neuroscience Authors: Si Yuan Bo Qiu Ying Liang Bing Deng Jing Xu Xiaorong Tang Junshang Wu Sheng Zhou Zeli Li Hongzhu Li Qiuping Ye Lin Wang Shuai Cui Chunzhi Tang Wei Yi Lulu Yao Nenggui Xu Source Type: research

Neurophysiological characterization of stroke recovery: A longitudinal TMS and EEG study
CONCLUSION: Our results demonstrate prominent clinical implications for individualized stroke rehabilitation based on both functional integrity of the ipsilesional corticomotor pathway and motor function.PMID:37718708 | DOI:10.1111/cns.14471
Source: CNS Neuroscience and Therapeutics - September 18, 2023 Category: Neuroscience Authors: Qian Ding Jixiang Chen Shunxi Zhang Songbin Chen Xiaotong Li Yuan Peng Yujie Chen Junhui Chen Kang Chen Guiyuan Cai Guangqing Xu Yue Lan Source Type: research

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