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Total 388 results found since Jan 2013.

Microarray Data Analysis of Molecular Mechanism Associated with Stroke Progression
This study aimed to explore the molecular mechanism of stroke and provide a new target in the clinical management. The miRNA dataset GSE97532 (3 blood samples from middle cerebral artery occlusion (MCAO) and 3 from sham operation) and mRNA dataset GSE97533 (3 blood samples from MCAO and 3 from sham operation) were obtained from GEO database. Differentially expressed mRNA (DEGs) and miRNAs (DEMIRs) were screened out between MCAO and sham operation groups. Then, DEMIR –DEG interactions were explored and visualized using Cytoscape software. Moreover, the enrichment analysis was performed on these DEMIRs and DEGs. Furthermor...
Source: Journal of Molecular Neuroscience - January 4, 2019 Category: Neuroscience Source Type: research

Gene therapy of adeno-associated virus (AAV) vectors in preclinical models of ischemic stroke
CNS Neurosci Ther. 2023 Aug 8. doi: 10.1111/cns.14392. Online ahead of print.ABSTRACTStroke has been associated with devastating clinical outcomes, with current treatment strategies proving largely ineffective. Therefore, there is a need to explore alternative treatment options for addressing post-stroke functional deficits. Gene therapy utilizing adeno-associated viruses (AAVs) as a critical gene vector delivering genes to the central nervous system (CNS) gene delivery has emerged as a promising approach for treating various CNS diseases. This review aims to provide an overview of the biological characteristics of AAV vec...
Source: CNS Neuroscience and Therapeutics - August 8, 2023 Category: Neuroscience Authors: Jing Wang Mengna Zhu Jingyi Sun Lina Feng Mingfeng Yang Baoliang Sun Leilei Mao Source Type: research

Delivery of Hypoxia-Inducible Heme Oxygenase-1 Gene for Site-Specific Gene Therapy in the Ischemic Stroke Animal Model
Conclusions pEpo-SV-HO-1 induced HO-1 gene expression and therapeutic effect in the ischemic brain. Therefore, pEpo-SV-HO-1 may be useful for site-specific gene therapy of ischemic stroke.
Source: Pharmaceutical Research - July 30, 2016 Category: Drugs & Pharmacology Source Type: research

First non-human primate study showing promise of gene therapy for stroke repair
(Guangdong-Hongkong-Macau Institute of CNS Regeneration,Jinan University) Stroke is a leading cause of death and severe long-term disability with limited treatment available. A research team led by Prof. Gong Chen at Jinan University, Guangzhou, China recently reported the first non-human primate study demonstrating successful in vivo neural regeneration from brain internal glial cells for stroke repair. This work was published on Frontiers in Cell and Developmental Biology on November 5th, 2020.
Source: EurekAlert! - Medicine and Health - November 13, 2020 Category: International Medicine & Public Health Source Type: news

Mediterranean Diet May Counter Genetic Risk of Stroke
People who consumed plenty of nuts or olive oil fared better in study Source: HealthDay Related MedlinePlus Pages: Diets, Genes and Gene Therapy, Stroke
Source: MedlinePlus Health News - August 13, 2013 Category: Consumer Health News Source Type: news

Association of the CHGA gene polymorphism in patients with hemorrhagic stroke and/or aneurysm
Conclusion: The Glu264Asp CHGA polymorphism does not seem to contribute to the genesis of the CHGA protein expression in this patients group, but to understand whether or not there is a possible association of the pathology in question and whether the mutation will contribute in the gene therapy and thus to improve patients ’ quality of life.RESUMEN Introducci ón: Enfermedades cerebrovasculares han sido vinculadas a diversos genes. La cromogranina A (CgA) es utilizada como un marcador en enfermedades cardiovasculares. Por consiguiente, evaluar el polimorfismo y verificar la asociación con esa patología es muy importan...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 12, 2020 Category: Pathology Source Type: research

Advanced molecular therapies for neurological diseases: focus on stroke, alzheimer's disease, and parkinson's disease
AbstractNeurological diseases (NDs) are one of the leading causes of disability and the second leading cause of death globally. Among these stroke, Alzheimer's disease (AD), and Parkinson's disease (PD) are the most common NDs. A rise in the absolute number of individuals affected with these diseases indicates that the current treatment strategies in management and prevention of these debilitating diseases are not effective sufficiently. Therefore, novel treatment strategies are being explored to cure these diseases by addressing the causative mechanisms at the molecular level. Advanced therapies like gene therapy (gene ed...
Source: Neurological Sciences - September 6, 2022 Category: Neurology Source Type: research

Pre‐existing interleukin 10 in cerebral arteries attenuates subsequent brain injury caused by ischemia/reperfusion
Abstract Recurrent stroke is difficult to treat and life threatening. Transfer of anti‐inflammatory gene is a potential gene therapy strategy for ischemic stroke. Using recombinant adeno‐associated viral vector 1 (rAAV1)‐mediated interleukin 10 (IL‐10), we investigated whether transfer of beneficial gene into the rat cerebral vessels during interventional treatment for initial stroke could attenuate brain injury caused by recurrent stroke. Male Wistar rats were administered rAAV1‐IL‐10, rAAV1‐YFP, or saline into the left cerebral artery. Three weeks after gene transfer, rats were subjected to occlusion of the...
Source: IUBMB Life - August 1, 2015 Category: Research Authors: Qiu‐Juan Liang, Mei Jiang, Xin‐Hong Wang, Li‐Li Le, Meng Xiang, Ning Sun, Dan Meng, Si‐Feng Chen Tags: Research Communication Source Type: research

Hypoxia-controlled matrix metalloproteinase-9 hyperexpression promotes behavioral recovery after ischemia
Abstract Matrix metalloproteinase-9 (MMP-9) plays a beneficial role in the sub-acute phase after ischemic stroke. However, unrestrained MMP-9 may disrupt the blood-brain barrier (BBB), which has limited its use for the treatment of brain ischemia. In the present study, we constructed lentivirus mediated hypoxia-controlled MMP-9 expression and explored its role after stroke. Hypoxia response element (HRE) was used to confine MMP-9 expression only to the hypoxic region of mouse brain after 120-min transient middle cerebral artery occlusion. Lentiviruses were injected into the peri-infarct area on day 7 after transie...
Source: Neuroscience Bulletin - May 14, 2015 Category: Neuroscience Source Type: research

Stem Cells for Cell-Based Therapies
The world of stem cells We know the human body comprises many cell types (e.g., blood cells, skin cells, cervical cells), but we often forget to appreciate that all of these different cell types arose from a single cell—the fertilized egg. A host of sequential, awe-inspiring events occur between the fertilization of an egg and the formation of a new individual: Embryonic stem (ES) cells are also called totipotent cells. The first steps involve making more cells by simple cell division: one cell becomes two cells; two cells become four cells, etc. Each cell of early development is undifferentiated; that is, it is...
Source: ActionBioscience - December 28, 2012 Category: Science Authors: Ali Hochberg Source Type: news

Neurons in the brain switch identity and re-route fibres | Mo Costandi
New findings could one day lead to gene therapies for stroke and spinal cord injuriesThese drawings by Santiago Ramón y Cajal show the cellular structure of three different areas of the human cerebral cortex. The cortex is the seat of higher mental functions such as language and decision-making, and contains dozens of distinct, specialised areas. As Cajal's drawings show, it has a characteristic layered structure, which differs somewhat from one area to the next, so that the layers vary in thickness according to the number of cells they contain. Cells throughout the cortex are arranged in a highly ordered manner. Those in...
Source: Guardian Unlimited Science - February 26, 2013 Category: Science Tags: Blogposts Health guardian.co.uk Neuroscience Source Type: news

Sulfiredoxin-1 protects primary cultured astrocytes from ischemia-induced damage
In this study, we used oxygen-glucose deprivation followed by recovery (OGD/R) and hydrogen peroxide (H2O2) to mimic stress from cerebral ischemic damage on primary cultured astrocytes. We found that knockdown of Srxn1 by two shRNAs resulted in decreased cell viability of astrocytes. Decreased level of Srxn1 also correlated with excessive levels of proinflammatory cytokines and chemokines such as TNF-α, MPO, IL-1β, and IL-6. In addition, Srxn1 appeared to influence the strength of TLR4 signaling pathway; the expression of COX-2, IL-6, and NOS2 were strongly induced by OGD/R and H2O2 in astrocyte cultures with Srxn1-shRNA...
Source: Neurochemistry International - January 26, 2015 Category: Neuroscience Source Type: research

Autism in the Son of a Woman with Mitochondrial Myopathy and Dysautonomia: A Case Report
Conclusion Given emerging evidence that mitochondrial dysfunction, particularly in the electron transport chain needed for cellular energy production, is an underlying pathophysiological mechanism for some varieties of ASD, clinicians should have a high index of suspicion for mitochondrial disease, especially when they encounter a patient with unusual neurological or constitutional symptoms. The prevalence of mitochondrial disease in ASD patients may be as high as five percent, which means that it is not the “zebra”[27] diagnosis that it might be in a non-ASD patient, where prevalence is about 0.01 percent.10 Reference...
Source: Innovations in Clinical Neuroscience - October 9, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Anxiety Disorders Asperger's syndrome Autism Behavioral and Cognitive Neurology Case Report Current Issue Intellectual Disability Neurologic Systems and Symptoms Pervasive Developmental Disorders ASD autism spectrum disorder dysauton Source Type: research