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Therapy: Gene Therapy

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Total 388 results found since Jan 2013.

Intravenous Delivery of Adeno-Associated Viral Vector Serotype 9 Mediates Effective Gene Expression in Ischemic Stroke Lesion and Brain Angiogenic Foci Brief Reports
Conclusions— ssAAV9 could be a useful tool to deliver therapeutic genes to the ischemic stroke lesion or brain angiogenic foci.
Source: Stroke - December 24, 2012 Category: Neurology Authors: Shen, F., Kuo, R., Milon-Camus, M., Han, Z., Jiang, L., Young, W. L., Su, H. Tags: Cerebrovascular disease/stroke, Gene regulation, Acute Cerebral Infarction, Gene therapy Brief Reports Source Type: research

Delayed intramuscular human neurotrophin-3 improves recovery in adult and elderly rats after stroke
There is an urgent need for a therapy that reverses disability after stroke when initiated in a time frame suitable for the majority of new victims. We show here that intramuscular delivery of neurotrophin-3 (NT3, encoded by NTF3) can induce sensorimotor recovery when treatment is initiated 24 h after stroke. Specifically, in two randomized, blinded preclinical trials, we show improved sensory and locomotor function in adult (6 months) and elderly (18 months) rats treated 24 h following cortical ischaemic stroke with human NT3 delivered using a clinically approved serotype of adeno-associated viral vector (AAV1). Important...
Source: Brain - January 8, 2016 Category: Neurology Authors: Duricki, D. A., Hutson, T. H., Kathe, C., Soleman, S., Gonzalez-Carter, D., Petruska, J. C., Shine, H. D., Chen, Q., Wood, T. C., Bernanos, M., Cash, D., Williams, S. C. R., Gage, F. H., Moon, L. D. F. Tags: CNS Injury and Stroke Original Articles Source Type: research

Myoblast-Mediated Gene Therapy Improves Functional Collateralization in Chronic Cerebral Hypoperfusion Basic Sciences
Conclusions— Myoblast-mediated VEGF supplementation at the target site of an EMS could help overcome the clinical dilemma of poor surgical revascularization results and provide protection from ischemic stroke.
Source: Stroke - December 22, 2014 Category: Neurology Authors: Hecht, N., Marushima, A., Nieminen, M., Kremenetskaia, I., von Degenfeld, G., Woitzik, J., Vajkoczy, P. Tags: Cerebrovascular disease/stroke, By-pass procedures Basic Sciences Source Type: research

Targeted brain stimulation 'could aid stroke recovery'
Conclusion This mouse model of stroke has found that stimulating nerve cells in the part of the brain responsible for movement (the primary motor cortex) can lead to better blood flow and the expression of proteins that could promote recovery, as well as leading to functional recovery after stroke. But it remains to be determined whether a similar technique could be used in people who have had a stroke. The mice were genetically modified so nerve cells in the primary motor cortex produced an ion channel that could be activated by light. The nerve cells were then activated using a laser. To use this technique in humans, ...
Source: NHS News Feed - August 19, 2014 Category: Consumer Health News Tags: Neurology Source Type: news

Genes, Vol. 13, Pages 48: Ischemic Stroke Genetics: What Is New and How to Apply It in Clinical Practice?
Jatužis The etiology of ischemic stroke is multifactorial. Although receiving less emphasis, genetic causes make a significant contribution to ischemic stroke genesis, especially in early-onset stroke. Several stroke classification systems based on genetic information corresponding to various stroke phenotypes were proposed. Twin and family history studies, as well as candidate gene approach, are common methods to discover genetic causes of stroke, however, both have their own limitations. Genome-wide association studies and next generation sequencing are more efficient, promising and increasingly used for daily diagn...
Source: Genes - December 24, 2021 Category: Genetics & Stem Cells Authors: Aleksandra Ekkert Aleksandra Šliachtenko Julija Grigait ė Birut ė Burnytė Algirdas Utkus Dalius Jatu žis Tags: Review Source Type: research

Genes, Vol. 13, Pages 978: Stroke and Etiopathogenesis: What Is Known?
Conclusion: We summarize the latest evidence and perspectives of ischemic stroke genetics that may be of interest to the physician and useful for day-to-day clinical work in terms of both prevention and treatment of ischemic stroke.
Source: Genes - May 30, 2022 Category: Genetics & Stem Cells Authors: Tiziana Ciarambino Pietro Crispino Erika Mastrolorenzo Antonello Viceconti Mauro Giordano Tags: Review Source Type: research

Nanoparticle-Based Gene Therapy Intervention for Stroke Treatment: a Systematic Review.
In conclusion, due to the inability of brain regeneration and the importance of genes in stroke-related complications, gene therapy seems to be a suitable treatment strategy. The use of suitable nanoparticles for transportation ensures the efficiency and usefulness of this method. PMID: 33045966 [PubMed - as supplied by publisher]
Source: Current Gene Therapy - October 12, 2020 Category: Genetics & Stem Cells Authors: Ghasemi S, Alavian K, Alavian F Tags: Curr Gene Ther Source Type: research

Clinical features, pathogenesis, and management of stroke-like episodes due to MELAS
AbstractMitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) is a disease that should be considered as a differential diagnosis to acute ischemic stroke taking into account its onset pattern and neurological symptoms, which are similar to those of an ischemic stroke. Technological advancements in neuroimaging modalities have greatly facilitated differential diagnosis between stroke and MELAS on diagnostic imaging. Stroke-like episodes in  MELAS have the following features: (1) symptoms are neurolocalized according to lesion site; (2) epileptic seizures are often present; (3) lesion distri...
Source: Metabolic Brain Disease - June 12, 2021 Category: Neurology Source Type: research

Focusing on claudin-5: a promising candidate in the regulation of BBB to treat ischemic stroke
Publication date: Available online 5 December 2017 Source:Progress in Neurobiology Author(s): Jianjun Lv, Wei Hu, Zhi Yang, Tian Li, Shuai Jiang, Zhiqiang Ma, Fulin Chen, Yang Yang Claudin-5 is a tight junction (TJ) protein in the blood-brain barrier (BBB) that has recently attracted increased attention. Numerous studies have demonstrated that claudin-5 regulates the integrity and permeability of the BBB. Increased claudin-5 expression plays a neuroprotective role in neurological diseases, particularly in cerebral ischemic stroke. Moreover, claudin-5 might be a potential marker for early hemorrhagic transformation detecti...
Source: Progress in Neurobiology - December 6, 2017 Category: Neuroscience Source Type: research

Promising Anti-stroke Signature of Voglibose: Investigation through In- Silico Molecular Docking and Virtual Screening in In-Vivo Animal Studies.
CONCLUSION: In-silico molecular docking and virtual screening studies and in-vivo studies in MCAo induced stroke, animal model outcomes support the strong anti-stroke signature for possible neuroprotective therapeutics. PMID: 33054705 [PubMed - in process]
Source: Current Gene Therapy - October 20, 2020 Category: Genetics & Stem Cells Authors: Shah P, Chavda V, Patel S, Bhadada S, Ashraf GM Tags: Curr Gene Ther Source Type: research

Coding and non-coding nucleotides': The future of stroke gene therapeutics
Genomics. 2021 Mar 4:S0888-7543(21)00084-7. doi: 10.1016/j.ygeno.2021.03.003. Online ahead of print.ABSTRACTStroke is the foremost cause of death ranked after heart disease and cancer. It is the fatal life-threatening event that requires immediate medical admissions to overcome following morbidity and mortality. The therapeutic advances in stroke therapy have been manipulated with diverse paths for last 5 years. Recent research and clinical trials have investigated a variety of anti-stroke agents including anti-coagulants, cerebro-protective agents, antiplatelet therapy, stem-cell therapy, and specified gene therapy. In re...
Source: Genomics - March 7, 2021 Category: Genetics & Stem Cells Authors: Vishal Chavda Kajal Madhwani Source Type: research

Genes, Vol. 13, Pages 144: Influence of Haptoglobin Polymorphism on Stroke in Sickle Cell Disease Patients
vain Doré This review outlines the current clinical research investigating how the haptoglobin (Hp) genetic polymorphism and stroke occurrence are implicated in sickle cell disease (SCD) pathophysiology. Hp is a blood serum glycoprotein responsible for binding and removing toxic free hemoglobin from the vasculature. The role of Hp in patients with SCD is critical in combating blood toxicity, inflammation, oxidative stress, and even stroke. Ischemic stroke occurs when a blocked vessel decreases oxygen delivery in the blood to cerebral tissue and is commonly associated with SCD. Due to the malformed red blood cells of s...
Source: Genes - January 14, 2022 Category: Genetics & Stem Cells Authors: Olivia Edwards Alicia Burris Josh Lua Diana J. Wilkie Miriam O. Ezenwa Sylvain Dor é Tags: Review Source Type: research