Filtered By:
Therapy: Gene Therapy

This page shows you your search results in order of relevance. This is page number 17.

Order by Relevance | Date

Total 388 results found since Jan 2013.

CXCL12 Gene Therapy Ameliorates Ischemia-Induced White Matter Injury in Mouse Brain
This study has demonstrated for the first time that CXCL12 gene therapy significantly ameliorates brain ischemia-induced white matter injury and promotes oligodendrocyte progenitor cell proliferation in the subventricular zone and migration to the perifocal area in the ischemic mouse brain. Additional data showed that CXCR4 receptor plays an important role during the proliferation and migration of oligodendrocyte progenitor cells, and CXCR7 might play a role during maturation. In contrast to many experimental studies that provide treatment before ischemic insult, CXCL12 gene therapy was performed 1 week after brain ischemi...
Source: Stem Cells Translational Medicine - September 17, 2015 Category: Stem Cells Authors: Li, Y., Tang, G., Liu, Y., He, X., Huang, J., Lin, X., Zhang, Z., Yang, G.-Y., Wang, Y. Tags: Tissue-Specific Progenitor and Stem Cells, Neural/Progenitor Stem Cells Source Type: research

Neanderthal DNA May Play Role in Modern Human Health
Genetic legacy can affect risk for nicotine addiction, depression, blood clots and stroke, research suggests Source: HealthDay Related MedlinePlus Page: Genes and Gene Therapy
Source: MedlinePlus Health News - February 11, 2016 Category: Consumer Health News Source Type: news

Therapeutic Prospects of Gene Therapy for Atrial Fibrillation
Atrial Fibrillation (AF) is one of the most common types of cardiac arrhythmias experienced in clinical practice, increasing the risk of stroke, dementia, myocardial infarction and death. Currently available options for the treatment of AF use either pharmacological agents or catheter-based ablation therapies to restore sinus rhythm or control the ventricular response rate. These current treatment options are suboptimal at best, motivating research into discovering more effective and innovative ways to treat AF.
Source: Heart, Lung and Circulation - May 11, 2016 Category: Cardiology Authors: Melad Farraha, James J.H. Chong, Eddy Kizana Source Type: research

Pediatric Sickle Cell Disease - Past Successes and Future Challenges.
Abstract Once a fatal disease of childhood, more than 95% of patients born today with sickle cell disease (SCD) in developed countries are expected to survive into adulthood, largely because of improvements in supportive and preventive care (newborn screening, penicillin prophylaxis, transcranial Doppler (TCD) screening). Hydroxyurea (HU) therapy, the only oral medication currently available to prevent SCD complications, has become more widespread over the past 20 years. The NHLBI recommends that HU be offered to all patients with HbSS beginning at nine months of age, and the recently published Abnormal TCD with T...
Source: Pediatric Research - October 4, 2016 Category: Pediatrics Authors: Meier ER, Rampersad A Tags: Pediatr Res Source Type: research

The Genetics of Pain
This article aims to review some human pain conditions, both common and rare, and their possible association with ion channels, receptors and the genes involved. Current and ongoing research evidence of the involvement of multiple cellular and molecular pathways in pain, advances in gene therapy and new medications are mentioned, as well as their limitations due to the complexity of pain.
Source: Current Anesthesiology Reports - November 16, 2016 Category: Anesthesiology Source Type: research

Effect of combined VEGF165/SDF-1 gene therapy on vascular remodeling and blood perfusion in cerebral ischemia.
CONCLUSIONS Combined VEGF165 and SDF-1 gene therapy represents a potential strategy for improving vascular remodeling and recovery of neural function after cerebral infarction. PMID: 27982773 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - December 15, 2016 Category: Neurosurgery Authors: Hu GJ, Feng YG, Lu WP, Li HT, Xie HW, Li SF Tags: J Neurosurg Source Type: research

Nanocarriers as treatment modalities for hypertension.
Authors: Alam T, Khan S, Gaba B, Haider MF, Baboota S, Ali J Abstract Hypertension, a worldwide epidemic at present, is not a disease in itself rather it is an important risk factor for serious cardiovascular disorders including myocardial infarction, stroke, heart failure, and peripheral artery disease. Though numerous drugs acting via different mechanism of action are available in the market as conventional formulations for the treatment of hypertension but they face substantial challenges regarding their bioavailability, dosing and associated adverse effects which greatly limit their therapeutic efficacies. Vari...
Source: Drug Delivery - February 8, 2017 Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research

Soluble FLT1 Gene Therapy Alleviates Brain Arteriovenous Malformation Severity Brief Report
Background and Purpose—Brain arteriovenous malformation (bAVM) is an important risk factor for intracranial hemorrhage. Current therapies are associated with high morbidities. Excessive vascular endothelial growth factor has been implicated in bAVM pathophysiology. Because soluble FLT1 binds to vascular endothelial growth factor with high affinity, we tested intravenous delivery of an adeno-associated viral vector serotype-9 expressing soluble FLT1 (AAV9-sFLT1) to alleviate the bAVM phenotype.Methods—Two mouse models were used. In model 1, bAVM was induced in R26CreER;Eng2f/2f mice through global Eng gene deletion and ...
Source: Stroke - April 24, 2017 Category: Neurology Authors: Wan Zhu, Fanxia Shen, Lei Mao, Lei Zhan, Shuai Kang, Zhengda Sun, Jeffrey Nelson, Rui Zhang, Dingquan Zou, Cameron M. McDougall, Michael T. Lawton, Thiennu H. Vu, Zhijian Wu, Abraham Scaria, Peter Colosi, John Forsayeth, Hua Su Tags: Angiogenesis, Animal Models of Human Disease, Gene Therapy Brief Reports Source Type: research

Preclinical efficacy and safety of KCNH2-G628S gene therapy for post-operative atrial fibrillation
We examined preclinical efficacy and safety of KCNH2-G628S gene transfer to prevent POAF.
Source: The Journal of Thoracic and Cardiovascular Surgery - May 23, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Zhao Liu, Julie A. Hutt, Barur Rajeshkumar, Yoshihiro Azuma, Kailai L. Duan, J. Kevin Donahue Source Type: research

Preclinical efficacy and safety of KCNH2-G628S gene therapy for postoperative atrial fibrillation
We examined the preclinical efficacy and safety of KCNH2-G628S gene transfer to prevent POAF.
Source: The Journal of Thoracic and Cardiovascular Surgery - May 23, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Zhao Liu, Julie A. Hutt, Barur Rajeshkumar, Yoshihiro Azuma, Kailai L. Duan, J. Kevin Donahue Tags: Evolving technology Source Type: research

MicroRNAs Mediated MMP Regulation: Current Diagnostic and Therapeutic Strategies for Metabolic Syndrome.
Abstract Metabolic syndrome (MS) is a global socioeconomic problem rapidly progressing in accordance with increasing body mass index (BMI) and age. It is a consortium of risk factors, such as dyslipidaemia, insulin resistance, leptin resistance, reduced adiponectin, glucose intolerance, hyperglycemia, and hypertension. Collectively, these factors accelerate the onset of type 2 diabetes mellitus, cardiovascular disease, stroke, and certain cancers such as breast, liver pancreatic, and colon cancer. Extracellular matrix (ECM) and basement membrane remodeling play a central role during pathogenesis of MS as they regu...
Source: Current Gene Therapy - July 7, 2017 Category: Genetics & Stem Cells Authors: Saxena S, Jain A, Rani V Tags: Curr Gene Ther Source Type: research

Deficiency of Adenosine Deaminase 2 (DADA2), an Inherited Cause of Polyarteritis Nodosa and a Mimic of Other Systemic Rheumatologic Disorders
AbstractPurpose of ReviewA new autoinflammatory disease, deficiency of adenosine deaminase 2 (DADA2), caused by mutations in theCECR1 gene, was first reported in 2014. This review aims to update progress in defining, treating, and understanding this multi-faceted disorder.Recent FindingsDADA2 was first described in patients with systemic inflammation, mild immune deficiency, and vasculopathy manifested as recurrent stroke or polyarteritis nodosa (PAN). More than 125 patients have now been reported, and the phenotype has expanded to include children and adults presenting primarily with pure red cell aplasia (PRCA), or with ...
Source: Current Rheumatology Reports - October 5, 2017 Category: Rheumatology Source Type: research

Gene Addition Strategies for β-Thalassemia and Sickle Cell Anemia.
Authors: Dong AC, Rivella S Abstract Beta-thalassemia and sickle cell anemia are two of the most common diseases related to the hemoglobin protein. In these diseases, the beta-globin gene is mutated, causing severe anemia and ineffective erythropoiesis. Patients can additionally present with a number of life-threatening co-morbidities, such as stroke or spontaneous fractures. Current treatment involves transfusion and iron chelation; allogeneic bone marrow transplant is the only curative option, but is limited by the availability of matching donors and graft-versus-host disease. As these two diseases are monogenic ...
Source: Advances in Experimental Medicine and Biology - November 13, 2017 Category: Research Tags: Adv Exp Med Biol Source Type: research

Triple-Gene Therapy for Stroke: A Proof-of-Concept in Vivo Study in Rats
Mikhail E. Sokolov, Farid V. Bashirov, Vage A. Markosyan, Tatyana V. Povysheva, Filip O. Fadeev, Andrey A. Izmailov, Maxim S. Kuztetsov, Zufar Z. Safiullov, Maxim M. Shmarov, Boris S. Naroditskyi, Andr ás Palotás, Rustem R. Islamov
Source: Frontiers in Pharmacology - February 15, 2018 Category: Drugs & Pharmacology Source Type: research

Gene therapy may help brain heal from stroke, other injuries
(UT Southwestern Medical Center) Scientists have found a genetic trigger that may improve the brain's ability to heal from a range of debilitating conditions, from strokes to concussions and spinal cord injuries.
Source: EurekAlert! - Medicine and Health - March 27, 2018 Category: International Medicine & Public Health Source Type: news