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Total 6766 results found since Jan 2013.

miR-146a and miR-196a2 Polymorphisms in Patients with Ischemic Stroke in the Northern Chinese Han Population.
This study indicates that miR-146a (rs2910164) might contribute to ischemic stroke susceptibility in the northern Chinese Han population. PMID: 24952884 [PubMed - as supplied by publisher]
Source: Neurochemical Research - June 22, 2014 Category: Neuroscience Authors: Zhu R, Liu X, He Z, Li Q Tags: Neurochem Res Source Type: research

Recurrent Stroke was Associated with Poor Quality of Life in Patients with Transient Ischemic Attack or Minor Stroke: Finding from the CHANCE Trial.
CONCLUSIONS: Stroke recurrence was associated with poor HRQOL in patients with TIA or minor strokes. Interventions focusing on controlling risk factors and prevention of worsening of neurological function may prevent poor HRQOL in these patients. PMID: 25307297 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - October 13, 2014 Category: Neuroscience Authors: Wang YL, Pan YS, Zhao XQ, Wang D, Johnston SC, Liu LP, Meng X, Wang AX, Wang CX, Wang YJ, The CHANCE investigators Tags: CNS Neurosci Ther Source Type: research

Effect of Sex and Age Interactions on Functional Outcome after Stroke.
Abstract Stroke is one of the leading causes of death and disability worldwide. Experimental and clinical studies showed that sex and age play an important role in deciding the outcome after stroke. At younger ages, males were shown to have a higher risk for stroke than females. However, this trend reverses in older ages particularly when females reach menopause. Many preclinical studies indicate that steroid hormones modulate the age-dependent differential stroke outcome. In addition, patterns of cell death pathways activated following cerebral ischemia are distinct between males and females, but independent of s...
Source: CNS Neuroscience and Therapeutics - November 18, 2014 Category: Neuroscience Authors: Kim T, Vemuganti R Tags: CNS Neurosci Ther Source Type: research

Splenic Responses in Ischemic Stroke: New Insights into Stroke Pathology.
Abstract In the past decade, the significant contribution of the spleen to ischemic brain damage has gained considerable attention in stroke research. As the largest natural reservoir of immune cells, the spleen establishes critical connections with the ischemic brain during the progression of stroke and mobilizes its cells to the site of injury. Multiple "alarm" signals released from the injured brain are essential for the initiation of brain-spleen communication. Spleen-derived cells, including neutrophils, lymphocytes, and monocytes/macrophages, are known to contribute significantly to ischemic brain damage. Un...
Source: CNS Neuroscience and Therapeutics - December 5, 2014 Category: Neuroscience Authors: Liu ZJ, Chen C, Li FW, Shen JM, Yang Y, Leak RK, Ji X, Du H, Hu X Tags: CNS Neurosci Ther Source Type: research

Clinical presentation and imaging characteristics of occult lung cancer associated ischemic stroke
Publication date: February 2015 Source:Journal of Clinical Neuroscience, Volume 22, Issue 2 Author(s): Hui Mai , Jun Xia , Yongjun Wu , Junlong Ke , Junliang Li , Jiangang Pan , Wubiao Chen , Yiming Shao , Zhi Yang , Saihua Luo , Yonghua Sun , Bin Zhao , Longxuan Li We investigated the clinical and imaging characteristics of initial and recurrent strokes in patients with occult lung cancer associated ischemic stroke (OLCA-stroke). A retrospective review of all ischemic stroke patients with occult lung cancer in the absence of conventional stroke etiologies between 2005 and 2013 was conducted. We compared the initial and ...
Source: Journal of Clinical Neuroscience - January 14, 2015 Category: Neuroscience Source Type: research

Development of Regional Stroke Programs
Abstract The organization of stroke care has undergone a dramatic evolution in the USA over the last two decades. Beginning with the recommendation for Primary Stroke Centers (PSCs) in 1994, there has been a concerted effort by physicians, the American Heart Association/American Stroke Association (AHA/ASA), National Institutes of Health (NIH), and state legislatures to advance an evidence-based system of care with several tiers of stroke centers. At the apex of this structure are Regional Stroke Centers (RSCs), which do not have official recognition like PSCs and Comprehensive Stroke Centers (CSCs), but their ex...
Source: Current Neurology and Neuroscience Reports - March 13, 2015 Category: Neuroscience Source Type: research

Prevention of post-stroke disuse muscle atrophy with a free radical scavenger.
Authors: Naritomi H, Moriwaki H Abstract In spite of appropriate treatment in the acute phase of stroke, quite a few patients with hemiparetic stroke become disabled and stay in a wheelchair or bedridden state in the chronic phase. In stroke patients, gait dysfunction results mainly from severe hemiparesis due to ischemic damage to the motor neuron tract and partly from disuse muscle atrophy in paretic and nonparetic legs. Disuse muscle atrophy occurs even in healthy subjects as early as 4 days after bed rest immobilization and progresses further correlating with the duration of immobilization. Although detailed me...
Source: Frontiers of Neurology and Neuroscience - December 2, 2015 Category: Neuroscience Tags: Front Neurol Neurosci Source Type: research

Deficits in motor abilities for multi-finger force control in hemiparetic stroke survivors.
This study aimed to investigate the effect of stroke-related constraints on multi-finger force control abilities in a visuomotor task. Impaired (IH) and less-impaired hands (LH) of 19 hemiparetic stroke survivors and 19 age-matched control subjects were examined. Each hand repeatedly produced isometric forces to match a target force of 5 N shown on a computer screen using all four fingers. The hierarchical variability decomposition (HVD) model was used to separate force-matching errors (motor performance) into task-relevant measures (accuracy, steadiness, and reproducibility). Task-irrelevant sources of variability in ind...
Source: Experimental Brain Research - April 11, 2016 Category: Neuroscience Authors: Kim Y, Kim WS, Koh K, Yoon B, Damiano DL, Shim JK Tags: Exp Brain Res Source Type: research

Role of serum ‐ and glucocorticoid‐inducible kinases in stroke
Abstract Increased expression of serum‐ and glucocorticoid‐inducible kinase 1 (SGK1) can be induced by stress and growth factors in mammals, and plays an important role in cancer, diabetes, and hypertension. A recent work suggested that SGK1 activity restores damage in a stroke model. To further investigate the role of SGKs in ischemic brain injury, we examined how SGK inhibitors influence stroke outcome in vivo and neurotoxicity in vitro. Infarct volumes were compared in adult mice with middle cerebral artery occlusion, followed by 24 h reperfusion, in the absence or presence of SGK inhibitors. Neurotoxicity assay,...
Source: Journal of Neurochemistry - May 24, 2016 Category: Neuroscience Authors: Koichi Inoue, Tiandong Leng, Tao Yang, Zhao Zeng, Takatoshi Ueki, Zhi ‐Gang Xiong Tags: Original Article Source Type: research

Partial MHC class II constructs as novel immunomodulatory therapy for stroke
Publication date: Available online 31 October 2016 Source:Neurochemistry International Author(s): Gil Benedek, Arthur A. Vandenbark, Nabil J. Alkayed, Halina Offner The worldwide prevalence of stroke continues to rise despite recent successes in treating acute ischemic stroke. With limited patient eligibility and associated risk of tPA and mechanical thrombectomy, new preventive and therapeutic modalities are needed to stave the rising wave of stroke. Inflammation plays a key role in brain damage after cerebral ischemia, and novel therapies that target pro-inflammatory cells have demonstrated promise for treatment for str...
Source: Neurochemistry International - October 31, 2016 Category: Neuroscience Source Type: research

Sex differences in stroke therapies
Stroke is the fifth leading cause of death and acquired disability in aged populations. Women are disproportionally affected by stroke, having a higher incidence and worse outcomes than men. Numerous preclinical studies have discovered novel therapies for the treatment of stroke, but almost all of these have been shown to be unsuccessful in clinical trials. Despite known sex differences in occurrence and severity of stroke, few preclinical or clinical therapeutics take into account possible sex differences in treatment. Reanalysis of data from studies of tissue plasminogen activator (tPA), the only currently FDA‐approved...
Source: Journal of Neuroscience Research - November 6, 2016 Category: Neuroscience Authors: Farida Sohrabji, Min Jung Park, Amanda H. Mahnke Tags: Review Source Type: research

Ischemic stroke damages the intestinal mucosa and induces alteration of the intestinal lymphocytes and CCL19 mRNA in rats
This study showed that ischemic stroke significantly damaged the intestinal epithelium and activated intestinal immunity.
Source: Neuroscience Letters - August 31, 2017 Category: Neuroscience Source Type: research

Dynamic reorganization of TMS-evoked activity in subcortical stroke patients
This study demonstrates that cortical activity increases dynamically in the early phases of recovery after stroke in the affected hemisphere. These findings point to TMS-evoked alpha oscillatory activity as a potential neurophysiological markers of stroke recovery and could be helpful to determine the temporal window in which neuromodulation should be potentially able to drive neuroplasticity in an effective functional direction.
Source: NeuroImage - April 14, 2018 Category: Neuroscience Source Type: research

Alterations of static functional connectivity and dynamic functional connectivity in motor execution regions after stroke
Publication date: Available online 6 September 2018Source: Neuroscience LettersAuthor(s): Jing Chen, Dalong Sun, Yonghui Shi, Wei Jin, Yanbin Wang, Qian Xi, Chuancheng RenAbstractThe aims of this study were to examine both static functional connectivity (FC) and dynamic FC alterations in motor execution regions after stroke and to investigate whether the altered static or dynamic FC was associated with the clinical behaviors in stroke patients. Seventy-six stroke patients and 55 healthy controls (HC) were recruited. Static FC and dynamic FC maps were computed based on the seeds of six core regions in motor execution networ...
Source: Neuroscience Letters - September 7, 2018 Category: Neuroscience Source Type: research

The Neuroprotective Roles of Sonic Hedgehog Signaling Pathway in Ischemic Stroke.
Abstract Ischemic stroke is characterized by high morbidity, mortality and disability rate worldwide. Because of its complexity in pathogenesis and lack of effective therapeutic strategies and drugs, great breakthrough has not yet been made in the treatment of cerebral ischemic stroke. Therefore, to explore a more effective and safer therapeutic strategy for cerebral ischemic stroke has been the focus of numerous researchers. Neuroprotective effects of sonic hedgehog (Shh) signaling pathway in ischemic stroke have been reported in recent studies, but have not been fully elucidated. In our review, we elaborate the ...
Source: Neurochemical Research - September 28, 2018 Category: Neuroscience Authors: Liu L, Zhao B, Xiong X, Xia Z Tags: Neurochem Res Source Type: research